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Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2017-02-01

This invention relates to a rare earth nanomaterial labeled biomolecule, its labeling method and a dissolution-enhanced time-resolved fluoroimmunoassay based on the rare earth nanomaterial. The rare earth nanomaterial serves as a label having stable properties, large specific surface area, strong modifiability, low-cost and thousands of lanthanide ions contained in each nanocrystal, the labeling ratio of rare earth ions can be greatly improved. Furthermore, the rare earth nanomaterial can be less affected by exogenous rare earth ions, unaffected by anticoagulants, and has broader applicability; after the immune complex was formed by labeling the biomolecules with the nanomaterial containing rare earth, an enhancer solution was added to allow the rare earth nanomaterial to dissolve into the rare earth ions, which can in turn form new signaling molecules with the chelates in the enhancer solution to induce intramolecular and intermolecular energy transfer, thereby significantly increasing fluorescence intensity by about a million times to greatly enhance the detection sensitivity by using time-resolved fluorescence assay.


Zheng S.-T.,CAS Fujian Institute of Research on the Structure of Matter | Yang G.-Y.,CAS Fujian Institute of Research on the Structure of Matter | Yang G.-Y.,Beijing Institute of Technology
Chemical Society Reviews | Year: 2012

During the past decade, research into transition-metal-substituted polyoxometalate self-assembly has been greatly developed. This review summarizes the conventional solution syntheses and hydrothermal syntheses of novel substituted polyoxometalates based on the incorporation of paramagnetic transition metals Mn, Fe, Co, Ni, and Cu, with an emphasis on the variety of nuclearities and configurations of encapsulated transition metal cores and the rich architectures of overall polyoxometalates. © The Royal Society of Chemistry 2012.


Lin Z.-J.,CAS Fujian Institute of Research on the Structure of Matter | Lu J.,CAS Fujian Institute of Research on the Structure of Matter | Hong M.,CAS Fujian Institute of Research on the Structure of Matter | Cao R.,CAS Fujian Institute of Research on the Structure of Matter
Chemical Society Reviews | Year: 2014

Metal-organic frameworks (MOFs), also known as coordination polymers (CPs), are crystalline materials constructed from metal ions or clusters bridged by organic ligands to form one-, two-, or three-dimensional infinite networks. In contrast with the prolific production of MOFs based on rigid ligands (RL-MOFs), the design, syntheses and applications of MOFs based on flexible ligands (FL-MOFs) are somewhat overlooked. Although sacrificing a measure of control, the use of flexible ligands may provide unique opportunities to obtain novel crystalline framework materials exhibiting desirable attributes. In this review, emphasis has been placed on the design and the structural diversity of FL-MOFs. Homochiral FL-MOFs and dynamic frameworks induced by flexible ligands are also briefly outlined. An overview is also shown for the applications of FL-MOFs as platforms for gas adsorption, heterogeneous catalysis, proton conduction etc. This journal is © the Partner Organisations 2014.


Yin Z.,CAS Fujian Institute of Research on the Structure of Matter | Zheng Q.,CAS Fujian Institute of Research on the Structure of Matter
Advanced Energy Materials | Year: 2012

The past decade has witnessed increasing attention in the synthesis, properties, and applications of one-dimensional (1D) conducting polymer nanostructures. This overview first summarizes the synthetic strategies for various 1D nanostructures of conjugated polypyrrole (PPy), polyaniline (PANI), polythiophene (PTh), poly(p-phenylenevinylene) (PPV) and derivatives thereof. By using template-directed or template-free methods, nanoscale rods, wires/fibers, belts/ribbons, tubes, arrays, or composites have been successfully synthesized. With their unique structures and advantageous characteristics (e.g., high conductivity, high carrier mobility, good electrochemical activity, large specific surface area, short and direct path for charge/ion transportation, good mechanical properties), 1D conducting polymer nanostructures are demonstrated to be very useful for energy applications. Next, their applications in solar cells, fuel cells, rechargeable lithium batteries, and electrochemical supercapacitors are highlighted, with a strong emphasis on recent literature examples. Finally, this review ends with a summary and some perspectives on the challenges and opportunities in this emerging area of research. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu Y.,CAS Fujian Institute of Research on the Structure of Matter | Tu D.,CAS Fujian Institute of Research on the Structure of Matter | Zhu H.,CAS Fujian Institute of Research on the Structure of Matter | Chen X.,CAS Fujian Institute of Research on the Structure of Matter
Chemical Society Reviews | Year: 2013

Lanthanide-doped inorganic nanoparticles possess superior physicochemical features such as long-lived luminescence, large antenna-generated Stokes or anti-Stokes shifts, narrow emission bands, high resistance to photobleaching and low toxicity, and thus are regarded as a new generation of luminescent bioprobes as compared to conventional molecular probes like organic dyes and lanthanide chelates. These functional nanoparticles, although most of their bulk counterparts were well studied previously, have attracted renewed interest for their biomedical applications in areas as diverse as biodetection, bioimaging, and disease diagnosis and therapeutics. In this review, we provide a comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes, which covers areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields, with an emphasis on heterogeneous and homogeneous in vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues. Some future prospects and challenges in this rapidly growing field are also summarized. © 2013 The Royal Society of Chemistry.


Zhang J.,CAS Fujian Institute of Research on the Structure of Matter
Nanoscale | Year: 2010

The crystal growth mechanism, kinetics, and microstructure development play a fundamental role in tailoring the materials with controllable sizes and morphologies. The classical crystal growth kinetics-Ostwald ripening (OR) theory is usually used to explain the diffusion-controlled crystal growth process, in which larger particles grow at the expense of smaller particles. In nanoscale systems, another significant mechanism named "oriented attachment (OA)" was found, where nanoparticles with common crystallographic orientations directly combine together to form larger ones. Comparing with the classical atom/molecular-mediated crystallization pathway, the OA mechanism shows its specific characteristics and roles in the process of nanocrystal growth. In recent years, the OA mechanism has been widely reported in preparing low-dimension nanostructural materials and reveals remarkable effects on directing and mediating the self-assembly of nanocrystals. Currently, the interests are more focused on the investigation of its role rather than the comprehensive insight of the mechanism and kinetics. The inner complicacy of crystal growth and the occurrence of coexisting mechanisms lead to the difficulty and lack of understanding this growth process by the OA mechanism.In this context, we review the progress of the OA mechanism and its impact on materials science, and especially highlight the OA-based growth kinetics aiming to achieve a further understanding of this crystal growth route. To explore the OA-limited growth, the influence of the OR mechanism needs to be eliminated. The introduction of strong surface adsorption was reported as the effective solution to hinder OR from occurring and facilitate the exclusive OA growth stage. A detailed survey of the nanocrystal growth kinetics under the effect of surface adsorption was presented and summarized. Moreover, the development of OA kinetic models was systematically generalized, in which the "molecular-like" kinetic models were built to take the OA nanocrystal growth behavior as the collision and reaction between molecules. The development of OA growth kinetics can provide a sufficient understanding of crystal growth, and the awareness of underlying factors in the growth will offer promising guidance on how to control the size distribution and shape development of nanostructural materials.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2015-01-28

The present disclosure provides GaN based LED epitaxial structure and a method for manufacturing the same. The GaN based LED epitaxial structure may comprise: a substrate; and a GaN based LED epitaxial structure grown on the substrate, wherein the substrate is a substrate containing a photoluminescence fluoresent material. The photoelectric efficiency of the LED epitaxial structure is enhanced and the amount of heat generated from a device is reduced by utilizing a rare earth element doped Re_(3)Al_(5)O_(12) substrate; since the LED epitaxial structure takes a fluorescence material as a substrate, a direct white light emission may be implemented by such a LED chip manufactured by the epitaxial structure, so as to simplify the manufacturing procedure of the white light LED light source and to reduce the production cost. The defect density of the epitaxial structure is reduced by firstly epitaxial growing, pattering the substrate and then laterally growing a GaN based epitaxial structure.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2016-09-09

This disclosure provides a second harmonic generator and an optical parametric oscillator, the second harmonic generator and the optical parametric oscillator comprise one or more nonlinear optical frequency conversion crystal and a pump laser source, the nonlinear optical frequency conversion crystal is a monoclinic Ga_(2)S_(3 )crystal, the space group of the monoclinic Ga_(2)S_(3 )crystal is Cc, and the unit cell parameters are a=11.1 , b=6.4 , c=7.0 , =90,=121, =90, and Z=4.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2015-02-11

This invention provides thieno[2,3-d]pyrimidine derivatives containing isoxazole heterocycle represented by formula (I), or pharmaceutically acceptable salts thereof_(1) and R_(2) may be the same or different and is independently to each other selected from H, C_(1-6) alkyl, C_(1-6) alkoxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy, aryl group optionally substituted by R^(7) or heteroaryl group optionally substituted by R^(8); or R_(1) and R_(2) together with the carbon atoms to which they are attached, may form a 4- to 6-membered carbocyclic ring or heterocyclic ring; said carbocyclic ring or heterocyclic ring is optionally substituted by H, C_(1-6) alkyl, halogen, nitro, or amino; said heterocyclic ring contains at least one heteroatom selected from N, O or S; Z is -NR_(6)-, C(R_(6))_(2), -S- or -O-, in which R_(5) is H or C_(1-6) alkyl, and R_(6) is the same or different, selected from H, C_(1-6) alkyl or hydroxyl substituted C_(1-6) alkyl; R_(3) is selected from H, halogen, C_(1-6) alkyl, C_(1-6) alkoxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy; n is an integer of 0-5; R_(4) is selected from H, C_(1-6) alkyl, C_(1-6) alkoxy or halo-C_(1-6) alkyl, aryl group optionally substituted by R^(9), or heteroarylgroup optionally substituted by R^(10); R^(7), R^(8), R^(9) or R^(10) independently to each other, is selected from H, hydroxy, mercapto, cyano, amino, nitro, halogen, C_(1-6) alkyl, C_(1-6) alkoxy, C_(1-6) alkylthio, carboxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy. This invention also provides the preparation method and medicinal uses of the compounds of formula (I) and pharmaceutically acceptable salts thereof. and this class of compounds can be used as medicants or lead compounds for the treatment of diseases such as tumors, cancers.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2014-07-18

A GaN based LED epitaxial structure and a method for manufacturing the same. The GaN based LED epitaxial structure may include: a substrate; and a GaN based LED epitaxial structure grown on the substrate, wherein the substrate is a substrate containing a photoluminescence fluorescent material. The photoelectric efficiency of the LED epitaxial structure is enhanced and the amount of heat generated from a device is reduced by utilizing a rare earth element doped Re_(3)Al_(5)O_(12 )substrate; since the LED epitaxial structure takes a fluorescence material as a substrate, a direct white light emission may be implemented by such an LED chip manufactured by the epitaxial structure, so as to simplify the manufacturing procedure of the white light LED light source and to reduce production cost. The defect density of the epitaxial structure is reduced by firstly epitaxial growing, patterning the substrate and then laterally growing a GaN based epitaxial structure.

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