CAS Fujian Institute of Research on the Structure of Matter

Fuzhou, China

CAS Fujian Institute of Research on the Structure of Matter

Fuzhou, China

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Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2017-02-01

This invention relates to a rare earth nanomaterial labeled biomolecule, its labeling method and a dissolution-enhanced time-resolved fluoroimmunoassay based on the rare earth nanomaterial. The rare earth nanomaterial serves as a label having stable properties, large specific surface area, strong modifiability, low-cost and thousands of lanthanide ions contained in each nanocrystal, the labeling ratio of rare earth ions can be greatly improved. Furthermore, the rare earth nanomaterial can be less affected by exogenous rare earth ions, unaffected by anticoagulants, and has broader applicability; after the immune complex was formed by labeling the biomolecules with the nanomaterial containing rare earth, an enhancer solution was added to allow the rare earth nanomaterial to dissolve into the rare earth ions, which can in turn form new signaling molecules with the chelates in the enhancer solution to induce intramolecular and intermolecular energy transfer, thereby significantly increasing fluorescence intensity by about a million times to greatly enhance the detection sensitivity by using time-resolved fluorescence assay.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2014-08-22

This invention relates to a rare earth nanomaterial labeled biomolecule, its labeling method and a dissolution-enhanced time-resolved fluoroimmunoassay based on the rare earth nanomaterial. The rare earth nanomaterial serves as a label having stable properties, large specific surface area, strong modifiability, low-cost and thousands of lanthanide ions contained in each nanocrystal, the labeling ratio of rare earth ions can be greatly improved. Furthermore, the rare earth nanomaterial can be less affected by exogenous rare earth ions, unaffected by anticoagulants, and has broader applicability; after the immune complex was formed by labeling the biomolecules with the nanomaterial containing rare earth, an enhancer solution was added to allow the rare earth nanomaterial to dissolve into the rare earth ions, which can in turn form new signaling molecules with the chelates in the enhancer solution to induce intramolecular and intermolecular energy transfer, thereby significantly increasing fluorescence intensity by about a million times to greatly enhance the detection sensitivity by using time-resolved fluorescence assay.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2017-06-21

A medical implant porous scaffold structure having low modulus, wherein said structure is formed by multiple basic units superposed sequentially along the three-dimensional directions in three-dimensional space, each of the basic units is composed of a quadrangular prism or hexagonal prism having central interconnected pores encircled by four or six side walls, each of the side walls is composed by a X-type frame structure formed by two crossed ribs, and the central interconnected pores of the adjacent basic units arranged along the axis direction of the quadrangular prism or the hexagonal prism are interconnected to each other. The structure could not only reduce the modulus of the implant, make the modulus of the implant and strength achieve an ideal match, improve the configuration of traditional metal implants to optimize the distribution of mechanical and weaken the stress shielding effect; but also has a regular interconnected pores structure which is conducive to bone tissue in-growth, and can increase mutual locking of bone tissue and implant and shorten the recovery time of patients.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2015-06-23

A medical implant porous scaffold structure having low modulus, wherein said structure is formed by multiple basic units superposed sequentially along the three-dimensional directions in three-dimensional space, each of the basic units is composed of a quadrangular prism or hexagonal prism having central interconnected pores encircled by four or six side walls, each of the side walls is composed by a X-type frame structure formed by two crossed ribs, and the central interconnected pores of the adjacent basic units arranged along the axis direction of the quadrangular prism or the hexagonal prism are interconnected to each other. The structure could not only reduce the modulus of the implant, make the modulus of the implant and strength achieve an ideal match, improve the configuration of traditional metal implants to optimize the distribution of mechanical and weaken the stress shielding effect; but also has a regular interconnected pores structure which is conducive to bone tissue in-growth, and can increase mutual locking of bone tissue and implant and shorten the recovery time of patients.


Zheng S.-T.,CAS Fujian Institute of Research on the Structure of Matter | Yang G.-Y.,CAS Fujian Institute of Research on the Structure of Matter | Yang G.-Y.,Beijing Institute of Technology
Chemical Society Reviews | Year: 2012

During the past decade, research into transition-metal-substituted polyoxometalate self-assembly has been greatly developed. This review summarizes the conventional solution syntheses and hydrothermal syntheses of novel substituted polyoxometalates based on the incorporation of paramagnetic transition metals Mn, Fe, Co, Ni, and Cu, with an emphasis on the variety of nuclearities and configurations of encapsulated transition metal cores and the rich architectures of overall polyoxometalates. © The Royal Society of Chemistry 2012.


Yin Z.,CAS Fujian Institute of Research on the Structure of Matter | Zheng Q.,CAS Fujian Institute of Research on the Structure of Matter
Advanced Energy Materials | Year: 2012

The past decade has witnessed increasing attention in the synthesis, properties, and applications of one-dimensional (1D) conducting polymer nanostructures. This overview first summarizes the synthetic strategies for various 1D nanostructures of conjugated polypyrrole (PPy), polyaniline (PANI), polythiophene (PTh), poly(p-phenylenevinylene) (PPV) and derivatives thereof. By using template-directed or template-free methods, nanoscale rods, wires/fibers, belts/ribbons, tubes, arrays, or composites have been successfully synthesized. With their unique structures and advantageous characteristics (e.g., high conductivity, high carrier mobility, good electrochemical activity, large specific surface area, short and direct path for charge/ion transportation, good mechanical properties), 1D conducting polymer nanostructures are demonstrated to be very useful for energy applications. Next, their applications in solar cells, fuel cells, rechargeable lithium batteries, and electrochemical supercapacitors are highlighted, with a strong emphasis on recent literature examples. Finally, this review ends with a summary and some perspectives on the challenges and opportunities in this emerging area of research. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhang J.,CAS Fujian Institute of Research on the Structure of Matter
Nanoscale | Year: 2010

The crystal growth mechanism, kinetics, and microstructure development play a fundamental role in tailoring the materials with controllable sizes and morphologies. The classical crystal growth kinetics-Ostwald ripening (OR) theory is usually used to explain the diffusion-controlled crystal growth process, in which larger particles grow at the expense of smaller particles. In nanoscale systems, another significant mechanism named "oriented attachment (OA)" was found, where nanoparticles with common crystallographic orientations directly combine together to form larger ones. Comparing with the classical atom/molecular-mediated crystallization pathway, the OA mechanism shows its specific characteristics and roles in the process of nanocrystal growth. In recent years, the OA mechanism has been widely reported in preparing low-dimension nanostructural materials and reveals remarkable effects on directing and mediating the self-assembly of nanocrystals. Currently, the interests are more focused on the investigation of its role rather than the comprehensive insight of the mechanism and kinetics. The inner complicacy of crystal growth and the occurrence of coexisting mechanisms lead to the difficulty and lack of understanding this growth process by the OA mechanism.In this context, we review the progress of the OA mechanism and its impact on materials science, and especially highlight the OA-based growth kinetics aiming to achieve a further understanding of this crystal growth route. To explore the OA-limited growth, the influence of the OR mechanism needs to be eliminated. The introduction of strong surface adsorption was reported as the effective solution to hinder OR from occurring and facilitate the exclusive OA growth stage. A detailed survey of the nanocrystal growth kinetics under the effect of surface adsorption was presented and summarized. Moreover, the development of OA kinetic models was systematically generalized, in which the "molecular-like" kinetic models were built to take the OA nanocrystal growth behavior as the collision and reaction between molecules. The development of OA growth kinetics can provide a sufficient understanding of crystal growth, and the awareness of underlying factors in the growth will offer promising guidance on how to control the size distribution and shape development of nanostructural materials.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2015-01-28

The present disclosure provides GaN based LED epitaxial structure and a method for manufacturing the same. The GaN based LED epitaxial structure may comprise: a substrate; and a GaN based LED epitaxial structure grown on the substrate, wherein the substrate is a substrate containing a photoluminescence fluoresent material. The photoelectric efficiency of the LED epitaxial structure is enhanced and the amount of heat generated from a device is reduced by utilizing a rare earth element doped Re_(3)Al_(5)O_(12) substrate; since the LED epitaxial structure takes a fluorescence material as a substrate, a direct white light emission may be implemented by such a LED chip manufactured by the epitaxial structure, so as to simplify the manufacturing procedure of the white light LED light source and to reduce the production cost. The defect density of the epitaxial structure is reduced by firstly epitaxial growing, pattering the substrate and then laterally growing a GaN based epitaxial structure.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2016-09-09

This disclosure provides a second harmonic generator and an optical parametric oscillator, the second harmonic generator and the optical parametric oscillator comprise one or more nonlinear optical frequency conversion crystal and a pump laser source, the nonlinear optical frequency conversion crystal is a monoclinic Ga_(2)S_(3 )crystal, the space group of the monoclinic Ga_(2)S_(3 )crystal is Cc, and the unit cell parameters are a=11.1 , b=6.4 , c=7.0 , =90,=121, =90, and Z=4.


Patent
CAS Fujian Institute of Research on the Structure of Matter | Date: 2015-02-11

This invention provides thieno[2,3-d]pyrimidine derivatives containing isoxazole heterocycle represented by formula (I), or pharmaceutically acceptable salts thereof_(1) and R_(2) may be the same or different and is independently to each other selected from H, C_(1-6) alkyl, C_(1-6) alkoxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy, aryl group optionally substituted by R^(7) or heteroaryl group optionally substituted by R^(8); or R_(1) and R_(2) together with the carbon atoms to which they are attached, may form a 4- to 6-membered carbocyclic ring or heterocyclic ring; said carbocyclic ring or heterocyclic ring is optionally substituted by H, C_(1-6) alkyl, halogen, nitro, or amino; said heterocyclic ring contains at least one heteroatom selected from N, O or S; Z is -NR_(6)-, C(R_(6))_(2), -S- or -O-, in which R_(5) is H or C_(1-6) alkyl, and R_(6) is the same or different, selected from H, C_(1-6) alkyl or hydroxyl substituted C_(1-6) alkyl; R_(3) is selected from H, halogen, C_(1-6) alkyl, C_(1-6) alkoxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy; n is an integer of 0-5; R_(4) is selected from H, C_(1-6) alkyl, C_(1-6) alkoxy or halo-C_(1-6) alkyl, aryl group optionally substituted by R^(9), or heteroarylgroup optionally substituted by R^(10); R^(7), R^(8), R^(9) or R^(10) independently to each other, is selected from H, hydroxy, mercapto, cyano, amino, nitro, halogen, C_(1-6) alkyl, C_(1-6) alkoxy, C_(1-6) alkylthio, carboxy, halo-C_(1-6) alkyl or halo-C_(1-6) alkoxy. This invention also provides the preparation method and medicinal uses of the compounds of formula (I) and pharmaceutically acceptable salts thereof. and this class of compounds can be used as medicants or lead compounds for the treatment of diseases such as tumors, cancers.

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