Carol Davila University of Medicine and Pharmacy

www.umf.ro
Bucharest, Romania

Carol Davila University of Medicine and Pharmacy is a state-run health science University in Bucharest, Romania. It is the largest institution of its kind in Romania with over 2.865 employees, 1.654 teachers and over 4.800 students. The University is using the facilities of over 20 clinical hospitals all over Bucharest.It was initially established in 1857 under the name National School of Medicine and Pharmacy by the French expatriate physician, Carol Davila. In 1869 it was incorporated as a department in the newly created University of Bucharest. The first doctoral degrees were granted in 1873, and the doctoral degree became the de facto graduation in 1888.The School of Pharmacy was founded in 1889 and it was renamed, as the Faculty of Pharmacy in 1923. The Faculty of Pharmacy of Carol Davila University is the place where insulin was isolated for the first time by Nicolae Paulescu in 1921. Wikipedia.


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Sever Surdulescu, MD, Pulmonologist and Critical Care Physician currently on staff at Lake Norman Pulmonary & Critical Care, and affiliated with the Lake Norman Regional Medical Center and Huntersville Medical Center, has been named a 2017 Top Doctor in Mooresville, North Carolina. Top Doctor Awards is dedicated to selecting and honoring those healthcare practitioners who have demonstrated clinical excellence while delivering the highest standards of patient care. Dr. Sever Surdulescu is a highly experienced physician, having been in practice for over 24 years. His career in medicine started in his native country Romania in 1992, when he graduated from the Carol Davila University of Medicine and Pharmacy in the capital city of Bucharest. After moving to the United States, he completed an internship and residency at St. Luke’s Hospital, prior to a fellowship at the University of Cincinnati College of Medicine in Ohio. Dr. Surdulescu is certified by the American Board of Internal Medicine in both Pulmonary Disease and Critical Care Medicine. He treats a wide range of conditions for patients of all ages, including asthma and bronchitis, Chronic Obstructive Pulmonary Disease, emphysema and lung cancer. Expert procedures carried out by him include bronchoscopy, thoracentesis, and Continuous Positive Airway Pressure. Dr. Surdulescu is also recognized as an expert in sleep medicine. He is board certified in Sleep Medicine, and serves as a physician at the Piedmont Sleep Center, treating conditions ranging from sleep apnea to insomnia and restless leg syndrome. His expertise and dedication make Dr. Sever Surdulescu a very worthy winner of a 2017 Top Doctor Award. Top Doctor Awards specializes in recognizing and commemorating the achievements of today’s most influential and respected doctors in medicine. Our selection process considers education, research contributions, patient reviews, and other quality measures to identify top doctors.


Rodica Elena Petrea, MD, Neurologist for Alegent Creighton Clinic Neurology, and affiliated with Creighton University Medical School for the past 5 years, has been named a 2017 Top Doctor in Omaha, Nebraska. Top Doctor Awards is dedicated to selecting and honoring those healthcare practitioners who have demonstrated clinical excellence while delivering the highest standards of patient care. Dr. Rodica Elena Petrea is an experienced and respected neurologist. Her career in medicine began in her native Romania, when she graduated from the Carol Davila University of Medicine and Pharmacy in the capital city of Bucharest. After moving to the United States, she completed an internship in the Fairview Health System, followed by a residency and a vascular neurology fellowship at the Boston University Medical Center and Boston University in Massachusetts. Dr. Petrea is a Diplomate of the American Board of Psychiatry and Neurology, and provides expert treatments for patients of all ages. Conditions treated by her range from Parkinson’s Disease and Multiple Sclerosis to epilepsy, migraine headaches and dementia. She is however, especially renowned for her expertise as a stroke neurologist due to her fellowship in stroke and special interest in stroke.The majorities of patients she takes care of and gives advice on are acute and chronic stroke patients ranging from administering iv tPA in acute ischemic stroke in patients coming through the Emergency Department to stroke prevention with novel therapies, very familiar with novel antithrombotic therapies, treatments for hyperhomocysteinemia, atherothrombosis in the outpatient setting for patients with ischemic strokes, arterial or venous thrombosis or more rare genetic causes of stroke. She has a special interest in cardiac disease and stroke, aortic atheromatosis and special disorders of the brain such as white matter disease, CADASIL or vasculitis, reversible vasoconstrictive syndromes. She also sees patients with hemorrhagic strokes in a team approach with neurosurgery and interventional neuroradiology, for acute medical treatment and follow up brain imaging for underlying causes of the hemorrhagic stroke. Dr. Petrea has had a number of papers published in medical Journals, numerous awards, scholarships, she has been a lecturer over the years in the United States and in her own country and has become renowned across Nebraska for both her expertise and her patient centric approach to neurology.  She also has an interest in dysphagia related to stroke and had a paper published with her own idea on a new innovative rehabilitation method for a particular type of dysphagia in patients with stroke and opercular syndrome. She plans on focusing on Telestroke and Teleneurology which would provide access to a larger population and patients with stroke and neurological disease here in Nebraska and across the country. Her commitment and dedication makes Dr. Rodica Elena Petrea a very deserving winner of a 2017 Top Doctor Award. Top Doctor Awards specializes in recognizing and commemorating the achievements of today’s most influential and respected doctors in medicine. Our selection process considers education, research contributions, patient reviews, and other quality measures to identify top doctors.


Mihai C.,Carol Davila University of Medicine and Pharmacy | Tervaert J.W.C.,Maastricht University
Annals of the Rheumatic Diseases | Year: 2010

Anti-endothelial cell antibodies (AECA) are a heterogeneous class of antibodies whose role in the pathogenesis of autoimmune diseases with vascular involvement has been extensively studied. Systemic sclerosis (SSc) is one of the systemic autoimmune diseases in which endothelial dysfunction is well defined and important in the development of the disease. AECA are present in the serum samples of many patients with SSc. Depending on the detection method and on patient selection, 22-86% of patients test positive for AECA. Among the demonstrated clinical associations, lung and peripheral vascular involvement are the most common. In this paper, the methods of detection, various molecular specificities and the possible pathogenic mechanisms of AECA in SSc are reviewed.


Tanasescu R.,Carol Davila University of Medicine and Pharmacy | Constantinescu C.S.,University of Nottingham
Immunobiology | Year: 2010

Cannabinoids can influence the immune network. Data on the impact of exogenous cannabinoid ligands on immune function serve not only to understand how the endocannabinoid system modulates immune phenomena associated with infection or inflammation, but also to identify therapeutic targets for immune diseases. Cannabinoids can modulate immune reactions in the periphery but also in the brain, influence T cell subset balance and cytokine expression and play a role in the balance between neuroinflammation and neurodegeneration. Immune cells can synthesize endocannabinoids and also be influenced by cannabinoid analogues. Cannabinoid receptors show different expression on immune cells depending on activation status and stimuli. The complexity of relation between cannabinoid ligands of various classes and cannabinoid receptors brought the need to refine the simple conceptual frame of agonist-antagonists and offered potential implications for understanding interactions in pathological conditions. The immune influence of cannabinoid ligands is not fully elucidated. However, aspects of their immunomodulatory effects provide the basis for a context-dependent targeted therapeutic approach, thus leading to the possibility for the use of cannabinoids in the treatment of inflammatory disease. © 2010 Elsevier GmbH.


Uivarosi V.,Carol Davila University of Medicine and Pharmacy
Molecules | Year: 2013

Quinolones are synthetic broad-spectrum antibiotics with good oral absorption and excellent bioavailability. Due to the chemical functions found on their nucleus (a carboxylic acid function at the 3-position, and in most cases a basic piperazinyl ring (or another N-heterocycle) at the 7-position, and a carbonyl oxygen atom at the 4-position) quinolones bind metal ions forming complexes in which they can act as bidentate, as unidentate and as bridging ligand, respectively. In the polymeric complexes in solid state, multiple modes of coordination are simultaneously possible. In strongly acidic conditions, quinolone molecules possessing a basic side nucleus are protonated and appear as cations in the ionic complexes. Interaction with metal ions has some important consequences for the solubility, pharmacokinetics and bioavailability of quinolones, and is also involved in the mechanism of action of these bactericidal agents. Many metal complexes with equal or enhanced antimicrobial activity compared to the parent quinolones were obtained. New strategies in the design of metal complexes of quinolones have led to compounds with anticancer activity. Analytical applications of complexation with metal ions were oriented toward two main directions: determination of quinolones based on complexation with metal ions or, reversely, determination of metal ions based on complexation with quinolones. © 2013 by the authors.


Cojocaru I.M.,Carol Davila University of Medicine and Pharmacy
Romanian journal of internal medicine = Revue roumaine de médecine interne | Year: 2013

Oxidative stress is involved in the pathogenesis of acute ischemic stroke. Antioxidants are consumed in the reaction with free radicals generated during the oxidative stress. The aim of the study was the to evaluate the oxidative stress in patients with acute ischemic stroke. Malondialdehyde (MDA), plasma glutathione, plasma glutathione peroxidase (GPX), catalase (CAT), uric acid, bilirubin, plasma superoxide dismutase (SOD), red blood cells superoxide dismutase (RBS SOD) (spectrophotometric assay), total antioxidant capacity (TAC) (enhanced chemiluminescence), ceruloplasmin, C-reactive protein (CRP), albumin, transferrin (nephelometric assay) were performed in 57 patients (mean age 73.4 +/- 6.5 years) with acute ischemic stroke within 24 hours and at 7 days after stroke onset as compared to 51 age-and sex-matched controls. Significantly lower values in the first 24 hours were: plasma glutathione, CAT, plasma SOD, RBS SOD (p < 0.001), plasma GPX, TAC, transferrin (p < 0.05). Significantly higher values in the first 24 hours were: CRP (p < 0.001), MDA, uric acid (p < 0.05). Significantly lower values at 7 days were: TAC, albumin, transferrin (p < 0.001), plasma glutathione, plasma SOD, CAT (p < 0.05). Significantly higher values at 7 days were: MDA, plasma GPX, RBC SOD, CRP, uric acid, bilirubin (p < 0.001), ceruloplasmin (p < 0.05). These results indicate that oxidative stress is increased and that the majority of antioxidants are reduced; this suggests the possibility of therapeutic intervention with antioxidant agents.


Popa C.,Carol Davila University of Medicine and Pharmacy
Journal of medicine and life | Year: 2010

The aim of this article is to analyze the vascular dysfunctions occurring after spinal cord injury (SCI). Vascular dysfunctions are common complications of SCI. Cardiovascular disturbances are the leading causes of morbidity and mortality in both acute and chronic stages of SCI. Neuroanatomy and physiology of autonomic nervous system, sympathetic and parasympathetic, is reviewed. SCI implies disruption of descendent pathways from central centers to spinal sympathetic neurons, originating in intermediolateral nuclei of T1-L2 cord segments. Loss of supraspinal control over sympathetic nervous system results in reduced overall sympathetic activity below the level of injury and unopposed parasympathetic outflow through intact vagal nerve. SCI associates significant vascular dysfunction. Spinal shock occurs during the acute phase following SCI and it is a transitory suspension of function and reflexes below the level of the injury. Neurogenic shock, part of spinal shock, consists of severe arterial hypotension and bradycardia. Autonomic dysreflexia appears during the chronic phase, after spinal shock resolution, and it is a life-threatening syndrome of massive imbalanced reflex sympathetic discharge occurring in patients with SCI above the splanchnic sympathetic outflow (T5-T6). Arterial hypotension with orthostatic hypotension occurs in both acute and chronic phases. The etiology is multifactorial. We described a few factors influencing the orthostatic hypotension occurrence in SCI: sympathetic nervous system dysfunction, low plasma catecholamine levels, rennin-angiotensin-aldosterone activity, peripheral alpha-adrenoceptor hyperresponsiveness, impaired function of baroreceptors, hyponatremia and low plasmatic volume, cardiovascular deconditioning, morphologic changes in sympathetic neurons, plasticity within spinal circuits, and motor deficit leading to loss of skeletal muscle pumping activity. Additional associated cardiovascular concerns in SCI, such as deep vein thrombosis and long-term risk for coronary heart disease and systemic atherosclerosis are also described. Proper prophylaxis, including non-pharmacologic and pharmacological strategies, diminishes the occurrence of the vascular dysfunction following SCI. Each vascular disturbance requires a specific treatment.


Radulescu L.,Carol Davila University of Medicine and Pharmacy
Journal of medicine and life | Year: 2013

The prevalence of maternal obesity has been increasing dramatically in the recent years (body mass index ≥ 30 kg/m2). Maternal obesity is associated with an unequivocal increase in maternal and fetal complications of pregnancy and more than that, these complications also extend beyond fetal life in childhood and adulthood. Objective. The aim of this study was to evaluate maternal and neonatal complications at birth associated with maternal obesity. The study included all women who gave birth between January 1, 2012 and December 31, 2012 at Bucharest University Emergency Hospital. Collected data included information about maternal health (the degree of obesity, associated complications of birth, anemia, and type of birth) and neonatal status (birth weight, gestational age, associated diseases and Apgar score). A higher incidence of IUGR, as well as an increased frequency of infants who needed intensive care after birth, a higher rate of cesarean surgery and a higher frequency of thromboembolic complications were observed in patients with associated obesity. Complications grow both in number and severity with increasing obesity. Diagnosis of the fetuses with IUGR is important for the monitoring and management of the pregnancy associated with obesity and it involves a close collaboration between obstetrician, family physician and neonatologist.


Matei C.,Carol Davila University of Medicine and Pharmacy
Journal of medicine and life | Year: 2013

Photodynamic therapy (PDT) is a medical procedure based on the activation of the molecules of various exogenous or endogenous chemical substances called photosensitizers by a light source emitting radiation of an adequate wavelength, usually situated in the visible spectrum; photosensitizers are chemical compounds bearing the capacity to selectively concentrate in the neoplastic cells. The energy captured by the molecules of these substances pervaded in the tumor cells is subsequently discharged in the surrounding tissue, triggering certain photodynamic reactions that result in the destruction of the tumor. The procedure is applicable in numerous medical fields. Skin basal cell carcinoma (BCC), the most frequent type of cancer of the human species, is a cutaneous tumor that responds very well to this innovative treatment method. By reviewing numerous recent studies in the field, this article aims to present the role and the indications of photodynamic therapy in the management of basal cell carcinoma, as well as the most important results achieved so far by this therapy in the field of dermato-oncology.


Baculescu N.,Carol Davila University of Medicine and Pharmacy
Journal of medicine and life | Year: 2013

Polycystic ovary syndrome (PCOS), one of the most common and complex endocrine disorders affecting up to 15 % of reproductive age women, is considered a predominantly hyperandrogenic syndrome according to the Androgen Excess Society. It is generally accepted that androgens determine the characteristic features of PCOS; in this context, a hyperactive androgen receptor (AR) at the levels of the GnRH pulse generator in the hypothalamus and at the granulosa cells in the ovary, skeletal muscle or adipocytes senses initially normal testosterone and dihydrotestosterone as biochemical hyperandrogenism and might be a crucial connection between the vicious circles of the PCOS pathogenesis. Polymorphism of the AR gene has been associated with different androgen pattern diseases. Several studies have demonstrated an association between AR with increased activity encoded by shorter CAG repeat polymorphism in the exon 1 of the AR gene and PCOS, although there are conflicting results in this field. The phenomenon is more complex because the AR activity is determined by the epigenetic effect of X chromosome inactivation (XCI). Moreover, we must evaluate the AR as a dynamic heterocomplex, with a large number of coactivators and corepressors that are essential to its function, thus mediating tissue-specific effects. In theory, any of these factors could modify the activity of AR, which likely explains the inconsistent results obtained when this activity was quantified by only the CAG polymorphism in PCOS.

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