Pittsburgh, PA, United States
Pittsburgh, PA, United States

Carnegie Mellon University is a private research university in Pittsburgh, Pennsylvania.The university began as the Carnegie Technical Schools founded by Andrew Carnegie in 1900. In 1912, the school became the Carnegie Institute of Technology and began granting four-year degrees. In 1967, the Carnegie Institute of Technology merged with the Mellon Institute of Industrial Research to form Carnegie Mellon University. The university's 140-acre main campus is 3 miles from Downtown Pittsburgh and abuts the Carnegie Museums of Pittsburgh, the main branch of the Carnegie Library of Pittsburgh, the Carnegie Music Hall, Schenley Park, Phipps Conservatory and Botanical Gardens, the Pittsburgh Golf Club, and the campus of the University of Pittsburgh in the city's Oakland and Squirrel Hill neighborhoods, partially extending into Shadyside.Carnegie Mellon has seven colleges and independent schools: the Carnegie Institute of Technology , College of Fine Arts, Dietrich College of Humanities and Social science, Mellon College of Science, Tepper School of Business, H. John Heinz III College and the School of Computer Science. Carnegie Mellon fields 17 varsity athletic teams as part of the University Athletic Association conference of the NCAA Division III. Wikipedia.

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Carnegie Mellon University | Date: 2016-07-28

Provided herein are methods of suppressing viral nucleic acid, e.g. double-stranded (ds) DNA, genome release from or packaging of viruses having their nucleic acid genome packaged under stress in their capsid, and compositions useful for that purpose. The methods alter the ionic environment of the nucleic acid within the capsid and thereby prevent release of, and/or interfere with packaging of the viral genome.

Carnegie Mellon University | Date: 2016-09-19

The disclosure describes a prism containing a microfluidic channel. By coupling bulk acoustic wave generators to opposing sides of the prism, a standing bulk acoustic wave field can be excited in the prism and in the microfluidic channel. Because the microfluidic channel is titled with respect to the nodes of the bulk acoustic wave field, the prism microfluidic channel device can be used to separate microparticles and biological cells by size, compressibility, density, shape, or mass distribution. This technology enables high throughput cell sorting for biotechnology applications such as cancer cell detection.

Carnegie Mellon University | Date: 2015-05-08

A method of making optically pure preparations of chiral PNA (gamma peptide nucleic acid) monomers is provided. Nano structures comprising chiral PNA structures also are provided. Methods of amplifying and detecting specific nucleic acids, including in situ methods are provided as well as compositions and kits useful in those methods. Lastly, methods of converting nucleobase sequences from right-handed helical PNA, nucleic acid and nucleic acid analog structures to left-handed PNA, and vice-versa, are provided.

Carnegie Mellon University and Regents Of The University Of California | Date: 2015-03-13

A computer-implemented method includes accessing a plurality of sets of outputs for an interactive animation, with each set of outputs being associated with a different sequence of a plurality of sequences of discrete control inputs, and with each set of outputs comprising an output that provides a stored portion of the animation; and transmitting, to a client device, information indicative of at least one of the plurality of sets of outputs for the animation and the output that provides the stored portion of the animation, which when rendered by the client device causes the animation to be presented to a user.

Carnegie Mellon University | Date: 2015-03-17

This invention describes methods and systems for use of computer vision systems for classification of biological cells as an aid in disease diagnostics. More particularly the present invention describes a process comprising employing a robust and discriminative color space which will help provide segmentation of the cells; employing a segmentation algorithm, such as a feature-based level set, that will be able to segment the cells using a different k-phase-segmentation process, which detect for example, if a while blood cell occurs for segmenting the internal components of the cell robustly; employing a combination of different type of features including shape, texture, and invariant information, and employing a classification step to associate abnormal cell characteristics with disease states.

Identifying a masked suspect is one of the toughest challenges in biometrics that exist. This is an important problem faced in many law-enforcement applications on almost a daily basis. In such situations, investigators often only have access to the periocular region of a suspects face and, unfortunately, conventional commercial matchers are unable to process these images in such a way that the suspect can be identified. Herein, a practical method to hallucinate a full frontal face given only a periocular region of a face is presented. This approach reconstructs the entire frontal face based on an image of an individuals periocular region. By using an approach based on a modified sparsifying dictionary learning algorithm, faces can be effectively reconstructed more accurately than with conventional methods. Further, various methods presented herein are open set, and thus can reconstruct faces even if the algorithms are not specifically trained using those faces.

Carnegie Mellon University | Date: 2017-02-01

An articulated probe (10), comprising: a first mechanism (12, 14) comprised of a plurality of links; a second mechanism (12, 14) comprised of a plurality of links; a first wire extending through either said plurality of links of said first mechanism (12, 14) or said plurality of links of said second mechanism (12, 14) and a plurality of wires running through the other of said plurality of links of said first mechanism (12, 14) or said plurality of links of said second mechanism (12, 14); a device for producing command signals; and an electromechanical feeder (16) responsive to said command signals, said electromechanical feeder (16) capable of alternating each of said first mechanism (12) and second mechanism (14) between a limp mode and a rigid mode and comprising: a first motor for controlling the tension of said first wire or said plurality of wires, one of said first mechanism or said second mechanism being responsive to said first motor; and a second motor for controlling the tension of the other of said first wire or said plurality of wires, the other of said first mechanism or said second mechanism being responsive to said second motor and a method of moving the articulated probe.

Schwartz R.,Carnegie Mellon University
Nature Reviews Genetics | Year: 2017

Rapid advances in high-throughput sequencing and a growing realization of the importance of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies of tumour progression. These studies have yielded not only new insights but also a plethora of experimental approaches, sometimes reaching conflicting or poorly supported conclusions. Here, we consider this body of work in light of the key computational principles underpinning phylogenetic inference, with the goal of providing practical guidance on the design and analysis of scientifically rigorous tumour phylogeny studies. We survey the range of methods and tools available to the researcher, their key applications, and the various unsolved problems, closing with a perspective on the prospects and broader implications of this field. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Jin R.,Carnegie Mellon University
Nanoscale | Year: 2015

Controlling nanoparticles with atomic precision has long been a major dream of nanochemists. Breakthroughs have been made in the case of gold nanoparticles, at least for nanoparticles smaller than ∼3 nm in diameter. Such ultrasmall gold nanoparticles indeed exhibit fundamentally different properties from those of the plasmonic counterparts owing to the quantum size effects as well as the extremely high surface-to-volume ratio. These unique nanoparticles are often called nanoclusters to distinguish them from conventional plasmonic nanoparticles. Intense work carried out in the last few years has generated a library of stable sizes (or stable stoichiometries) of atomically precise gold nanoclusters, which are opening up new exciting opportunities for both fundamental research and technological applications. In this review, we have summarized the recent progress in the research of thiolate (SR)-protected gold nanoclusters with a focus on the reported stable sizes and their optical absorption spectra. The crystallization of nanoclusters still remains challenging; nevertheless, a few more structures have been achieved since the earlier successes in Au102(SR)44, Au25(SR)18 and Au38(SR)24 nanoclusters, and the newly reported structures include Au20(SR)16, Au24(SR)20, Au28(SR)20, Au30S(SR)18, and Au36(SR)24. Phosphine-protected gold and thiolate-protected silver nanoclusters are also briefly discussed in this review. The reported gold nanocluster sizes serve as the basis for investigating their size dependent properties as well as the development of applications in catalysis, sensing, biological labelling, optics, etc. Future efforts will continue to address what stable sizes are existent, and more importantly, what factors determine their stability. Structural determination and theoretical simulations will help to gain deep insight into the structure-property relationships. © The Royal Society of Chemistry 2015.

Matyjaszewski K.,Carnegie Mellon University
Macromolecules | Year: 2012

Current status and future perspectives in atom transfer radical polymerization (ATRP) are presented. Special emphasis is placed on mechanistic understanding of ATRP, recent synthetic and process development, and new controlled polymer architectures enabled by ATRP. New hybrid materials based on organic/inorganic systems and natural/synthetic polymers are presented. Some current and forthcoming applications are described. © 2012 American Chemical Society.

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