Fifth Street, PA, United States
Fifth Street, PA, United States

Carlow University is a Roman Catholic university founded in Pittsburgh, Pennsylvania, USA, on September 24, 1929, by the Sisters of Mercy from Carlow, Ireland. Originally called Mount Mercy College, the name was changed to Carlow College in April 1969. In 2004, Carlow College achieved university status. It was originally a women's college until 1945 when men were admitted. In 2013-2014, the student body is 91% women and 9% men. Wikipedia.


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Caron W.P.,University of North Carolina at Chapel Hill | Morgan K.P.,University of North Carolina at Chapel Hill | Zamboni B.A.,Carlow University | Zamboni W.C.,University of North Carolina at Chapel Hill | And 2 more authors.
Clinical Cancer Research | Year: 2013

Purpose: Nanoparticles or carrier-mediated agents have been designed to prolong drug circulation time, increase tumor delivery, and improve therapeutic index compared to their small-molecule counterparts. The starting dose for phase I studies of small molecules and nanoparticles anticancer agents is based on the toxicity profile of the most sensitive species (e.g., rat or canine), but the optimal animal model for these studies of nanoparticles is unclear. The objective of this study was to evaluate the design, progression, and outcomes of phase I studies of nanoparticles compared with small-molecule anticancer agents. Experimental design: In preclinical studies, the maximum tolerated dose (MTD) in rats and dogs was evaluated for nanoparticles and their respective small molecules. In phase I clinical trials in patients with advanced solid tumors, the basis for starting dose, the number of dose escalations, number of patients enrolled, and the ratio of MTD to starting dose was determined for nanoparticles and small molecules. Results: The mean ratio of MTD to starting dose in clinical phase I studies was significantly greater for nanoparticles (13.9 ± 10.8) compared with small molecules (2.1 ± 1.1; P = 0.005). The number of dose levels in a clinical phase I study was also significantly greater for nanoparticles (7.3 ± 2.9) compared with small molecules (4.1 ± 1.5; P = 0.008). Conclusions: The degree of dose escalation from starting dose to MTD was significantly greater for nanoparticles as compared with small-molecule anticancer drugs. These findings necessitate the need to identify the most appropriate preclinical animal model to use when evaluating nanoparticles toxicity. © 2013 American Association for Cancer Research.


News Article | February 17, 2017
Site: www.prweb.com

The Coro Center for Civic Leadership, Pittsburgh announced today that Sabrina Saunders Mosby has been named President and CEO, beginning April 3rd. She succeeds Dr. Greg Crowley who is relocating to New Hampshire. Saunders joins Coro from Strong Women, Strong Girls, Pittsburgh, a nationally recognized mentoring program empowering elementary school girls to develop the social-emotional and leadership skills necessary to cultivate high ambitions and achieve lifelong success, where for the past three years she's served as executive director. She brings to the position over a decade of combined non-profit and government sector experience in executive leadership, fundraising, program development, and operations, as well as a deep commitment to the Greater Pittsburgh region. Saunders previously served as Director of Education and Youth Development at the Urban League of Greater Pittsburgh, Youth Policy Manager in the Office of the Mayor in Pittsburgh and as an aide for the Honorable Congressman Mike Doyle, PA-14. Saunders is a graduate of Edinboro University and also holds a masters degree in Professional Leadership from Carlow University. She serves on many nonprofit boards, including A+ Schools, Mount Ararat Community Activity Center, NeighborWorks Western Pennsylvania, Oakland Catholic High School, YouthPlaces. After spending most of her professional career focusing on addressing the needs of Pittsburgh's most vulnerable communities, Saunders is excited to switch gears. “Coro is a community gem and I’m honored to take the helm of an organization that’s training emerging leaders who in turn work to positively improve communities. Building a pipeline of talent is vital to our region's sustainability and growth,” said Saunders. Dr. Greg Crowley is stepping down as President and CEO and moving to Hanover, New Hampshire, where his wife, Dr. Amber Barnato, has been recruited to serve as the Richard and Susan Levy Professor of Health Policy and Clinical Practice at the Dartmouth Medical School. Dr. Crowley started with Coro in 2004 as Director of Research. He became a Vice President in 2008 and has served as President and CEO since 2012. He says “the work that Coro does to build inclusive communities by advancing leadership has never been more important. The most significant social innovations improving lives in America today are occurring locally. It has been a joy to have contributed to this trend by working with such a dedicated staff and board to engage over 1000 diverse people in Coro Pittsburgh’s leadership program.” In Hanover, Greg looks forward to teaching, writing and community organizing. “We are sorry to see Greg leave Pittsburgh. He has a tremendous passion for developing new leaders and has been the key leader in shaping Coro’s programs to have real impacts in struggling neighborhoods,” remarked Mr. Richard Ekstrom, Board Chair, Coro. “At the same time, we are delighted and fortunate that Sabrina is joining Coro. Her experiences demonstrate a passion for helping young people and community leadership.” The Coro Center for Civic Leadership, Pittsburgh was founded in 1999 and is one of five independent organizations that offer Coro’s values-based, experiential leadership training. Saunders will be the fifth CEO of Coro Pittsburgh. In addition to Greg Crowley, previous CEOs include Diana Bucco, President of the Buhl Foundation, Paul Leger, City of Pittsburgh Finance Director, and Sala Udin, former Pittsburgh City Council member.


News Article | February 17, 2017
Site: www.prweb.com

The Regional Board of Directors of Strong Women, Strong Girls Pittsburgh (SWSG) today announced the resignation of Executive Director Sabrina Saunders Mosby, who is leaving on March 24 after three years with SWSG to assume the role of president and CEO of Pittsburgh’s Coro Center for Civic Leadership. According to SWSG Regional Board Chair Beth Marcello, SWSG expects to hire an interim executive while it conducts a search for a new director. “Sabrina has overseen a tremendous amount of growth at SWSG and we are grateful for her leadership,” Marcello stated. “Our growing number of foundation and corporate partners reflect Sabrina’s achievements as well as a universal movement toward gender equity,” Marcello added. “The mission of Strong Women, Strong Girls to uplift and empower girls in their formative years especially resonates in this environment.” In addition to mentoring grade school girls, SWSG Pittsburgh has become a training ground for young, diverse talent, developing a staff that includes university interns and a pipeline of recruits from Coro through the Public Allies program. An innovative four-credit, service-learning course at Carlow University called Girls in American Society was also developed under Saunders’ tenure. “I’m proud of what we’ve accomplished together with our mentors, volunteers, schools, communities, and university partners throughout the greater Pittsburgh region,” said Saunders. “And while I’m excited to take on this new challenge with Coro, I am confident that SWSG is positioned to continue making a great impact on girls in this region and beyond.” “Sabrina laid a strong foundation that will help us transition to a new leader,” remarked SWSG Executive Board Chair Louise Herrle. “We look forward to the future and to more opportunities to help young girls realize their inner strengths to dream and do whatever their hearts desire.” Strong Women, Strong Girls (SWSG) Pittsburgh is a nationally recognized mentoring program empowering elementary school girls to develop the social-emotional and leadership skills necessary to cultivate high ambitions and achieve lifelong success. Founded in 2004, the mission of SWSG is to empower girls to imagine a broader future though a curriculum grounded on female role models delivered by college women mentors, who are themselves mentored by professional women. To achieve this mission, SWSG implements an innovative program model that utilizes the study of contemporary and historic female role models, skill-building activities, and relationships with college women who volunteer as mentors to support the girls. SWSG serves close to 700 girls in greater Pittsburgh, and engages 200 college-aged women as mentors annually. Learn more at http://www.swsg.org. Find SWSG on Twitter (@SWSG_Tweets), Facebook (Strong Women, Strong Girls), and Instagram (@strongwomenstronggirls).


Kelley F.A.,Carlow University | Gelso C.J.,University of Maryland University College | Fuertes J.N.,Adelphi University | Marmarosh C.,George Washington University | Lanier S.H.,Baylor College of Medicine
Psychotherapy | Year: 2010

The development and validation of a client version of the Real Relationship Inventory (RRI-C) is reported. Using a sample of clients (n = 94) who were currently in psychotherapy, a 24-item measure was developed consisting of two subscales (Realism and Genuineness) and a total score. This 24-item version and other measures used for validation were completed by 93 additional clients. Results of the present study offer initial support for the validity and reliability of the RRI-C. The RRI-C correlated significantly in theoretically expected ways with measures of the client-rated working alliance and therapists' congruence, clients' observing ego, and client ratings of client and therapist real relationship on an earlier measure of the real relationship (Eugster & Wampold, 1996). A nonsignificant relation was found between the RRI-C and a measure of social desirability, providing support for discriminant validity. A confirmatory factor analysis supported the two theorized factors of the RRI-C. The authors discuss the importance of measuring clients' perceptions of the real relationship. © 2010 American Psychological Association.


La-Beck N.M.,University of North Carolina at Chapel Hill | La-Beck N.M.,Texas Tech University | Zamboni B.A.,Carlow University | Gabizon A.,Hebrew University of Jerusalem | And 4 more authors.
Cancer Chemotherapy and Pharmacology | Year: 2012

Purpose: There is significant inter-patient variability in the pharmacokinetics of pegylated liposomal doxorubicin (PLD). Identification of factors affecting the pharmacokinetics of PLD would enable personalization of therapy. We previously reported that age, gender, body composition, and monocytes affect the clearance of other liposomal agents. Therefore, we evaluated how these factors affect the pharmacokinetics of PLD. Methods: Pharmacokinetic studies of PLD were performed as part of phase I and II studies in 70 patients with solid tumors or Kaposi's sarcoma. The effects of monocyte count, age, gender, and body composition on PLD clearance were examined. Results: There was a 15.3-fold variability in PLD clearance. Body surface area-based dosing did not significantly reduce the variability in PLD clearance. The mean ± SD clearance for patients <60 years old and ≥60 years old were 54.6 ± 28.5 and 23.3 ± 10.8 mL/h/m 2, respectively (P < 0.0001), and for female and male patients were 23.7 ± 18.8 and 55.6 ± 26.8 mL/h/m 2, respectively (P < 0.0001). A reduction in pre-cycle monocyte count was associated with a greater reduction in PLD clearance. Conclusions: Age, gender, and monocyte counts appear to correlate with PLD clearance. Further investigation of the association between these factors, PLD pharmacokinetics, and clinical outcomes (efficacy and toxicity) is warranted. These effects on the pharmacokinetics of PLD may be an approach for personalizing PLD therapy and may affect other pegylated liposomes and nanoparticle agents. © 2011 Springer-Verlag.


Zalonis R.,Jefferson Regional Medical Center | Slota M.,Carlow University
Clinical Journal of Oncology Nursing | Year: 2014

This article explores barriers to informed decision making in health care, and it proposes palliative care as one means of responding to the challenge of a widespread lack of autonomy in decision making. Through an exploration of research in the fields of autonomy and palliative care, the advantages of informed decision making and advance care planning by patients with advanced illness are discussed, and the implications for clinical practice and patient outcomes are described. Continuity, collaboration, and communication have a synergistic effect on autonomy. The expectation that the palliative care team will be in constant communication with the attending physician, nurses, and other specialists also promotes autonomous decision making. Patients who receive palliative care may have multiple advantages, including increased survival, improved quality of life, and opportunities for the exercise of autonomy. © 2014, Oncology Nursing Society.


Balaban I.,University of Zagreb | Mu E.,Carlow University | Divjak B.,University of Zagreb
Computers and Education | Year: 2013

This research has two main goals: to develop an instrument for assessing Electronic Portfolio (ePortfolio) success and to build a corresponding ePortfolio success model using DeLone and McLean's information systems success model as the theoretical framework. For this purpose, we developed an ePortfolio success measurement instrument and structural model, at the individual level of analysis, using responses from 186 ePortfolio student users from higher education institutions worldwide. Academic institutions can use the results of this research to assess the success of their ePortfolio implementations from their students' perspective. The ePortfolio success model can also help to improve the implementation and use of ePortfolio systems through the analysis of the causal relationships of their different dimensions. Finally, initial guidelines about how to use the instrument as part of an ePortfolio system review process are also discussed. © 2012 Elsevier Ltd. All rights reserved.


Mu E.,Carlow University | Carroll J.,Carlow University
International Journal of Production Economics | Year: 2016

Among the different risks a manufacturing firm faces, one of the most devastating may be caused by internal fraud. Corporate Fraud Investigation Units receive dozens of reports about possible fraud allegations annually. While all allegations should be addressed, it is not possible to investigate all cases immediately due to resource limitations. However, fraud may cause serious production and financial losses at any stage in the supply chain. Thus, it is necessary to find a method to prioritize the fraud risk of cases for the purpose of allocating resources and to determine how quickly they must be addressed. The Analytic Hierarchy Process (AHP) stands out as the most widely used prioritization methodology due to its intuitive simplicity and mathematical rigor. This study combines current SCM risk frameworks with extant fraud investigation literature and best-practices to develop an AHP ratings model for the prioritization of alleged fraud reports in a corporate setting, more specifically in the context of a large metals and mining manufacturing company. © 2015 Elsevier B.V. All rights reserved.


Kelley F.A.,Carlow University
Psychotherapy | Year: 2015

This study investigated the role of therapy practices and the therapy relationship on lesbian and gay clients' feelings about their current therapist. Participants were 76 lesbian and 40 gay male clients ranging in age from 19 to 69 years. The real relationship was found to predict an additional 8% of variance in clients' positive feelings about their therapist above and beyond months in therapy, therapy practices, and the working alliance. However, therapy practices did not add significance in predicting lesbian and gay clients' feelings about their therapist beyond the working alliance and the real relationship. Fifty-three of the participants responded to a question about their current experiences in therapy, and the data were analyzed using consensual qualitative research-modified (CQR-M; Spangler, Liu, & Hill, 2012). Thirty percent of clients indicated a preference for a lesbian or gay therapist, or gay-friendly therapist. Only 25% found that their therapist lacked knowledge about lesbian and gay issues, but 21% indicated that their therapist was dismissive of and/or viewed their sexual orientation as a problem. More than two-thirds of the participants indicated they had a positive therapy relationship with their therapist. Results highlight the important role that therapy practices and the therapy relationship play in lesbian and gay clients perceptions' of their therapist. The findings also provide support for heterosexual therapists' ability to develop a positive therapy relationship and be effective with lesbian and gay clients. © 2014 American Psychological Association.


Ucar H.,Carnegie Mellon University | Craven M.,Carlow University | Laughlin D.E.,Carnegie Mellon University | McHenry M.E.,Carnegie Mellon University
Journal of Electronic Materials | Year: 2014

Nanocrystalline powders of (Fe70Ni30)100-x MOx (x = 1 to 4) were produced by high-energy (SPEX) mechanical alloying. Increasing the Mo content was found to stabilize the face-centered cubic phase in mechanically alloyed nanopowders. To obtain a single γ-phase, a powdered sample was solution annealed in the γ-phase field and water quenched. The Curie temperature, T C, of the alloys was lowered with Mo addition, without decreasing the refrigeration capacity (RC), due to the additional temperature broadening of the magnetic entropy change. Based on previous study on the role of disorder, the additional temperature broadening was attributed to increased positional disorder and changes in the distribution of ferromagnetic exchange bonds introduced by Mo addition into the γ-FeNi system. (Fe70Ni30) 97Mo3 and (Fe70Ni30) 96Mo4 alloys have RCFWHM values of ∼440 J/kg and ∼432 J/kg at 5 T, comparable to other prominent magnetic refrigerants operating near room temperature. The economic viability of these alloys, along with their competitive magnetocaloric properties and potential for scalable production, make them good candidate magnetic refrigerants without critical rare-earth materials. © 2013 TMS.

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