Visani E.,Carlo Besta IRCCS Neurological Institute |
Minati L.,Carlo Besta IRCCS Neurological Institute |
Canafoglia L.,Carlo Besta IRCCS Neurological Institute |
Gilioli I.,Carlo Besta IRCCS Neurological Institute |
And 7 more authors.
Computational Intelligence and Neuroscience | Year: 2010
We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related esynchronization/ synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD. Copyright © 2010 Elisa Visani et al.