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Edmonton, Canada

The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippocampus is a region that is known to play a role in cognition and depression, and the hippocampus receives sole noradrenergic innervation from LC neurons. However, it is unclear how the loss of LC noradrenergic neurons contributes to these common symptoms in these two disorders. Epilepsy is not considered a neurodegenerative disorder, but the hippocampus is severely affected in temporal lobe epilepsy. Of interest, cognitive impairment and depression are also common comorbid disorders in temporal lobe epilepsy. This article describes common symptoms among these three neurologic disorders and a possible role of the noradrenergic nervous system. © 2012 International League Against Epilepsy. Source

Chalasani N.P.,Indiana University | Hayashi P.H.,University of North Carolina at Chapel Hill | Bonkovsky H.L.,CarolinasHealthCare System | Navarro V.J.,Care Network | And 2 more authors.
American Journal of Gastroenterology | Year: 2014

Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among the most common therapeutic classes to cause DILI in the Western world. DILI is a diagnosis of exclusion and thus careful history taking and thorough work-up for competing etiologies are essential for its timely diagnosis. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis and management of DILI with special emphasis on DILI due to herbal and dietary supplements and DILI occurring in individuals with underlying liver disease. © 2014 by the American College of Gastroenterology. Source

Mills K.L.,Care Network
Marine Ornithology | Year: 2016

I investigated diet of migratory owls on Southeast Farallon Island (SEFI), California, United States, including how diet changed in response to time of year and prey availability. I analyzed 523 pellets collected at SEFI from at least four different owl species during 2000-2003 (as well as 99 pellets for other time periods) and quantified the proportion of mice, insects and birds within pellets. The non-native House Mouse Musmusculus was the most abundant diet item across all four years, followed by birds and then insects. Examination of diet composition within each year revealed that between November and February owls primarily consumed mice, while they ate more birds between March and June. Between July and October, consumption of mice and birds was about equal. Previous mouse-trapping studies have shown an abundant mouse population on SEFI during autumn, when owls arrive, while winter mouse populations decrease in response to rains that flood burrows and lower food supplies. My study indicates that, as wintering owls lose a primary food source, they shift their diet from mice to other prey. Included in the shift were storm-petrels (Ashy Oceanodroma homochroa and Leach’s O. leucorhoa), mostly consumed by Burrowing Owls Athene cunicularia, as well as Cassin’s Auklets Ptychoramphus aleuticus, mostly consumed by Barn Owls Tyto alba. The presence of mice on SEFI may be indirectly affecting seabird populations by keeping migrating owls on the islands longer than they would stay if mice were absent. © 2016, Marine Ornithology. All rights reserved. Source

INC Research, Aska Pharmaceutical CO., Care Network and Hitachi Ltd. | Date: 2011-03-04

Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells.

Goh Y.P.,Care Network
American journal of orthopedics (Belle Mead, N.J.) | Year: 2012

As described in this case report, the use of the 320-Multidetector Computed Tomography scanner (Aquilion One, Toshiba Medical Systems, Japan) to produce continuous 3-dimensional images in real time, over a distance of 16 cm in the z-axis, proved to aid in the diagnosis of a patient's restrictive elbow joint. This state-of-the-art scanner allows fast and noninvasive dynamic-kinematic functional evaluation of the elbow joint in vivo. It will also be applicable to kinematic studies of other joints. Source

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