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Edmonton, Canada

The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippocampus is a region that is known to play a role in cognition and depression, and the hippocampus receives sole noradrenergic innervation from LC neurons. However, it is unclear how the loss of LC noradrenergic neurons contributes to these common symptoms in these two disorders. Epilepsy is not considered a neurodegenerative disorder, but the hippocampus is severely affected in temporal lobe epilepsy. Of interest, cognitive impairment and depression are also common comorbid disorders in temporal lobe epilepsy. This article describes common symptoms among these three neurologic disorders and a possible role of the noradrenergic nervous system. © 2012 International League Against Epilepsy. Source


Conrad P.,Community Pharmacy | Adams C.,Care Network
Complementary Therapies in Clinical Practice | Year: 2012

Objectives: The aim of this study was to determine if aromatherapy improves anxiety and/or depression in the high risk postpartum woman and to provide a complementary therapy tool for healthcare practitioners. Design: The pilot study was observational with repeated measures. Setting: Private consultation room in a Women's center of a large Indianapolis hospital. Subjects: 28 women, 0-18 months postpartum. Interventions: The treatment groups were randomized to either the inhalation group or the aromatherapy hand m'technique. Treatment consisted of 15 min sessions, twice a week for four consecutive weeks. An essential oil blend of rose otto and lavandula angustifolia @ 2% dilution was used in all treatments. The non-randomized control group, comprised of volunteers, was instructed to avoid aromatherapy use during the 4 week study period. Allopathic medical treatment continued for all participants. Outcome measurements: All subjects completed the Edinburgh Postnatal Depression Scale (EPDS) and Generalized Anxiety Disorder Scale (GAD-7) at the beginning of the study. The scales were then repeated at the midway point (two weeks), and at the end of all treatments (four weeks). Results: Analysis of Variance (ANOVA) was utilized to determine differences in EPDS and/or GAD-7 scores between the aromatherapy and control groups at baseline, midpoint and end of study. No significant differences were found between aromatherapy and control groups at baseline. The midpoint and final scores indicated that aromatherapy had significant improvements greater than the control group on both EPDS and GAD-7 scores. There were no adverse effects reported. Conclusion: The pilot study indicates positive findings with minimal risk for the use of aromatherapy as a complementary therapy in both anxiety and depression scales with the postpartum woman. Future large scale research in aromatherapy with this population is recommended. © 2012 Elsevier Ltd. Source


Chalasani N.P.,Indiana University | Hayashi P.H.,University of North Carolina at Chapel Hill | Bonkovsky H.L.,CarolinasHealthCare System | Navarro V.J.,Care Network | And 2 more authors.
American Journal of Gastroenterology | Year: 2014

Idiosyncratic drug-induced liver injury (DILI) is a rare adverse drug reaction and it can lead to jaundice, liver failure, or even death. Antimicrobials and herbal and dietary supplements are among the most common therapeutic classes to cause DILI in the Western world. DILI is a diagnosis of exclusion and thus careful history taking and thorough work-up for competing etiologies are essential for its timely diagnosis. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis and management of DILI with special emphasis on DILI due to herbal and dietary supplements and DILI occurring in individuals with underlying liver disease. © 2014 by the American College of Gastroenterology. Source


Mills K.L.,Care Network
Marine Ornithology | Year: 2016

I investigated diet of migratory owls on Southeast Farallon Island (SEFI), California, United States, including how diet changed in response to time of year and prey availability. I analyzed 523 pellets collected at SEFI from at least four different owl species during 2000-2003 (as well as 99 pellets for other time periods) and quantified the proportion of mice, insects and birds within pellets. The non-native House Mouse Musmusculus was the most abundant diet item across all four years, followed by birds and then insects. Examination of diet composition within each year revealed that between November and February owls primarily consumed mice, while they ate more birds between March and June. Between July and October, consumption of mice and birds was about equal. Previous mouse-trapping studies have shown an abundant mouse population on SEFI during autumn, when owls arrive, while winter mouse populations decrease in response to rains that flood burrows and lower food supplies. My study indicates that, as wintering owls lose a primary food source, they shift their diet from mice to other prey. Included in the shift were storm-petrels (Ashy Oceanodroma homochroa and Leach’s O. leucorhoa), mostly consumed by Burrowing Owls Athene cunicularia, as well as Cassin’s Auklets Ptychoramphus aleuticus, mostly consumed by Barn Owls Tyto alba. The presence of mice on SEFI may be indirectly affecting seabird populations by keeping migrating owls on the islands longer than they would stay if mice were absent. © 2016, Marine Ornithology. All rights reserved. Source


Patent
INC Research, Aska Pharmaceutical CO., Care Network and Hitachi Ltd. | Date: 2011-03-04

Demyelinated axons were remyelinated in the demyelinated rat model by collecting bone marrow cells from mouse bone marrow and transplanting the mononuclear cell fraction separated from these bone marrow cells.

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