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Gardner A.W.,The University of Oklahoma Health Sciences Center | Gardner A.W.,Veterans Affairs Medical Center | Parker D.E.,OUHSC | Montgomery P.S.,The University of Oklahoma Health Sciences Center | And 5 more authors.
International Journal of Vascular Medicine | Year: 2014

We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 156 subjects with peripheral artery disease (PAD) and 16 healthy control subjects. Furthermore, we compared circulating inflammatory, antioxidant capacity, and vascular biomarkers between the two groups. The PAD group had a 164% higher value for endothelial cell apoptosis (P < 0.001) and a 62% higher value for endothelial cellular reactive oxygen species production (P < 0.001) than the control group. Furthermore, the PAD group had lower systemic antioxidant capacity measured by hydroxyl radical antioxidant capacity activity (P < 0.001), higher inflammatory and vascular measures of high-sensitivity C-reactive protein (P < 0.001), interleukin-8 (P < 0.001), serum amyloid A (P < 0.001), vascular cell adhesion molecule-1 (P < 0.001), adiponectin (P < 0.001), apolipoprotein B (P = 0.013), apolipoprotein CIII (P = 0.035), lower vascular endothelial growth factor-A (P < 0.001), and hepatocyte growth factor (P < 0.001) than the control group. Subjects with PAD have greater endothelial apoptosis and oxidative stress than control subjects with low burden of comorbid conditions and cardiovascular risk factors. Furthermore, subjects with PAD have lower systemic antioxidant capacity and angiogenic measures and higher circulating inflammatory parameters. © 2014 Andrew W. Gardner et al. Source


Kusunose K.,Tokushima University | Yamada H.,Tokushima University | Nishio S.,Tokushima University | Mizuguchi Y.,Cardiovascular Section | And 12 more authors.
Circulation Journal | Year: 2011

Background: Automated function imaging (AFI) is a recently developed method of calculating the longitudinal peak systolic strains (LS) of the regional left ventricular (LV) wall using speckle tracking echocardiography and displaying them on a single bull's-eye map. The feasibility of AFI in patients with regional LV wall motion abnormalities caused by myocardial infarction (MI) was evaluated by comparison with visual assessment and myocardial perfusion single-photon emission computed tomography (SPECT). Methods and Results: Segmental LS was measured by AFI in 60 patients with MI (67±11 years) and 58 controls (71±9 years). Wall thickening (WT) was measured by SPECT in 20 patients with MI. There was a strong positive linear relationship between the wall motion score index by expert visual assessment and global LS. The receiver-operating characteristic analysis revealed the best cutoff value of -11% Source


This article reviews the beginnings and history of the physicians' antinuclear movement. The role of Victor W. Sidel, MD, is described, particularly his involvement with Physicians for Social Responsibility (PSR) and International Physicians for the Prevention of Nuclear War (IPPNW). Source


Gardner A.W.,University of Oklahoma | Gardner A.W.,University of Maryland, Baltimore | Gardner A.W.,Veterans Affairs Medical Center | Montgomery P.S.,University of Oklahoma | And 5 more authors.
Angiology | Year: 2011

We compared exercise performance, daily physical activity, and health-related quality of life in 115 participants with stable angina and 441 controls without coronary artery disease or stable angina. Participants with stable angina had shorter 6-min walk distance (P =.003), and lower total leisure-time physical activity (P =.003) than the controls. Group differences in these measures remained (P <.05) after adjusting for age, race, current smoking, diabetes, hypertension, and obesity. Participants with stable angina also had lower health-related quality of life for physical function (P <.001), general health (P =.002), and vitality (P <.001), but group differences did not remain (P >.05) after adjustment for comorbid conditions. Participants with stable angina have impaired exercise performance and reduced daily physical activity. Thus, they are prime candidates for exercise interventions designed to improve daily physical activity and exercise performance. © 2011 The Author(s). Source


Gardner A.W.,The University of Oklahoma Health Sciences Center | Gardner A.W.,Veterans Affairs Medical Center | Parker D.E.,University of Oklahoma | Montgomery P.S.,The University of Oklahoma Health Sciences Center | And 6 more authors.
Angiology | Year: 2014

We compared apoptosis, cellular oxidative stress, and inflammation of cultured endothelial cells treated with sera from 130 patients with peripheral artery disease (PAD) and a control group of 36 patients with high burden of comorbid conditions and cardiovascular risk factors. Second, we compared circulating inflammatory, antioxidant capacity, and vascular biomarkers between the groups. The groups were not significantly different (P >.05) on apoptosis, hydrogen peroxide, hydroxyl radical antioxidant capacity, and nuclear factor κ-light-chain enhancer of activated B cells. Circulating tumor necrosis factor α (TNF-α; P =.016) and interleukin 8 (IL-8; P =.006) were higher in the PAD group, whereas vascular endothelial growth factor A (VEGF-A; P =.023) was lower. The PAD does not impair the endothelium beyond that which already occurs from comorbid conditions and cardiovascular risk factors in patients with claudication. However, patients with PAD have lower circulating VEGF-A than the control group and higher circulating inflammatory parameters of TNF-α and IL-8. © The Author(s) 2013. Source

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