PubMed | SOFIE Biosciences Los Angeles, University of Wisconsin - Madison and Carbone Cancer Center Madison
Type: Journal Article | Journal: American journal of nuclear medicine and molecular imaging | Year: 2016
Positron emission tomography (PET) phantoms are used to calibrate PET scanners so that inter-scanner and inter-isotope comparison can be made between PET datasets. Hot rod style phantoms have a hole pattern, which is filled with a positron-emitting isotope and typically involves using two radioisotope reservoirs with the pattern created with channels in between. However, this configuration is difficult to fill and requires an excess of activity and volume. Here we present an alternative design, a phantom that is linearly filled-one channel at a time. The process of fabrication of prototypes of the design is described and PET images of the prototyped phantom are also shown for a variety of commonly used radioisotopes ((52)Mn, (64)Cu, (76)Br, (124)I). This design allows for a large reduction in isotope volume and required filling time making a quality assurance (QA) protocol safer, more efficient and less costly.
PubMed | Carbone Cancer Center Madison
Type: Journal Article | Journal: Clinical advances in hematology & oncology : H&O | Year: 2015
Mantle cell lymphoma (MCL) is a unique subtype of non-Hodgkin lymphoma (NHL). MCL accounts for approximately 6% of new lymphoma cases each year.1 Because it is a relatively uncommon form of lymphoma, it is more difficult to study than other lymphoma subtypes. There are many single-arm, phase 2 trials in the MCL literature, but there is a relative paucity of large, randomized, phase 3 trials. As a result, comparisons are often made across trials, and observations are based on extrapolation.