Carbogen AMCIS AG

Hunzenschwil

Carbogen AMCIS AG

Hunzenschwil

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Walker A.J.,Glaxosmithkline | Adolph S.,Carbogen AMCIS AG | Connell R.B.,Glaxosmithkline | Laue K.,Carbogen AMCIS AG | And 5 more authors.
Organic Process Research and Development | Year: 2010

Control of trace inorganics and an understanding of reaction kinetics and impurity generation proved critical in allowing safe and reliable scale-up of a high-temperature Claisen reaction in support of multikilogram manufacture of a key chromene intermediate 4. Implementation of a Medicinal Chemistry route allowed for rapid early phase delivery of 1 to support early clinical studies. © 2010 American Chemical Society.

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