Capsum

Marseille, France
Marseille, France
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Patent
Capsum | Date: 2013-01-31

The present invention relates to a method for preparing capsules comprising a liquid core, a stiffened intermediate envelope and a gelled external envelope, comprising a step of forming a multi-component liquid drop, a gelification step and a stiffening step. The present invention also relates to a method for preparing capsules comprising a liquid core and a stiffened envelope, comprising a step of forming a multi-component liquid drop, a gelification step, a stiffening step and a depolymerizing step.


Patent
Capsum | Date: 2013-01-31

A capsule containing at least one mammalian cell, includes a liquid core, and at least one external envelope totally encapsulating the liquid core at its periphery, the external envelope including at least one gelled polyelectrolyte and/or a stiffened biopolymer and being able to retain the liquid core when the capsule is immersed in a gas. The present invention further relates to the method for preparing such a capsule, to a method for screening cosmetic active ingredients as well as a culture method using such capsules.


This invention concerns a nanoparticle comprising:


This device comprises a hollow body, the hollow body defining: an internal conduit for distributing the first fluid, the internal conduit defining an inner volume; an external conduit or distributing the second fluid, the internal conduit and the external conduit extending coaxially along a longitudinal axis (AA). It at least comprises one metal tube extending along the longitudinal axis (AA) and being positioned in the inner volume of the internal conduit and/or in the downstream extension of the internal conduit and/or of the external conduit.


Each capsule comprises a liquid core (14) and a gelled shell (16) comprising a gelled polyelectrolyte completely encapsulating the liquid core (14) at the periphery thereof. The gelled shell (16) is suitable for retaining the liquid core (14) when the capsule (12) is immersed in a gas. The liquid core (14) comprises an intermediate drop (18) of an intermediate phase, the intermediate phase being placed in contact with the gelled shell (16), and at least one internal drop (20) of an internal phase placed in the intermediate drop (18). The ratio of the volume of the core (14) to the volume of the gelled shell (16) is greater than 2, advantageously is greater than 50.


This method comprises the following steps: flowing drops of a first phase, through a circulation duct, into a second phase that is substantially immiscible with the first phase, each drop comprising a core formed from the first phase and a shell formed from a layer of coacervate inserted between the first phase and the second phase; recovering a dispersion containing drops and the second phase in a container; injecting a solution for increasing the viscosity of the second phase in the circulation duct or at the outlet of the circulation duct, upstream from the container.


The device (110) for dispensing a fluid composition includes: a container (30) containing a heterogeneous mixture (14);


A composition includes:


A dispersion including a plurality of bodies dispersed in a continuous phase. Each dispersed body including an internal drop formed with an internal phase miscible with the continuous phase, the internal drop (16) receiving an active product. Each dispersed body including, around the internal drop, a membrane formed with an intermediate phase immiscible with the continuous phase and totally surrounding the internal drop. The ratio R1 of the average thickness (e) of the membrane over the average transverse dimension (D_(c)) of the active volume delimited by the internal drop and the membrane is greater than 0.05, and is advantageously less than 0.5. The ratio R2 of the partition coefficient of the active product between the intermediate phase forming the membrane and the internal phase forming the internal drop over the viscosity of the membrane is less than 1 s^(1)Pa^(1).


A kit comprising two separate compositions (A) and (B). Composition (A) is an aqueous gel with a viscosity of less than 11 Pas and contains at least one capsule including: a liquid core with at least one active ingredient and a gelled envelope totally encapsulating the liquid core. The gelled envelope includes at least one polyelectrolyte in the gelled state. Composition (B) includes a depolymerizing agent.

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