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Ma Y.-Y.,Peking University | Zhang X.-L.,Capital Institute of Physical Education | Wu T.-F.,Peking University | Liu Y.-P.,Peking University | And 5 more authors.
Journal of Child Neurology

Mitochondrial oxidative phosphorylation defects are a common cause of mitochondrial diseases, which are characterized by multiorgan involvement and clinically heterogeneous manifestations. Diagnosis is difficult because of the lack of clinically feasible methods. In this study, mitochondrial complex I-V enzyme activity was measured in 64 patients with suspected mitochondrial disease and 200 healthy controls. Spectrophotometric assay was used for the analysis of mitochondrial complex I-V enzyme activity in peripheral leukocytes. Diagnosis was based on clinical presentation, magnetic resonance imaging (MRI), muscle pathology, and point mutation screening in mitochondrial DNA. The differential diagnosis of aminoacidopathies, organic acidurias, and fatty acid -oxidation defects was made. Thirty-five patients (54.7%) were diagnosed with Leigh syndrome based on characteristic brain MRI. Complex enzyme activity in controls was found to be stable. A deficiency in the oxidative phosphorylation was found in 29 patients (45.3%). Twenty (31.2%) patients had isolated complex defects, complex I deficiency (n = 2, 3.1%), complex II deficiency (n = 3, 4.7%), complex III deficiency (n = 5, 7.8%), complex IV deficiency (n = 5, 7.8%), and complex V deficiency (n = 5, 7.8%). Nine patients were found to have combined deficiencies, 3 (4.7%) had combined deficiencies of complex I and IV, 2 (3.1%) had combined deficiencies of complex III and V, and 2 (3.1%) had a combined deficiency of complex I and V. In conclusion, the peripheral leukocyte oxidative phosphorylation enzyme activity assay was found to be a reliable method for the diagnosis of mitochondrial diseases. © 2011 The Author(s). Source

Yu W.,Capital Institute of Physical Education | Su F.,Beijing Normal University
Proceedings - International Conference on Electrical and Control Engineering, ICECE 2010

Course of algorithm is a specialized course of computer science with both strong abstract nature and practicality, for which needs of algorithm visualization technique in CAI is prominent. This paper develops a visualized CAI aiming at the characteristics of the course of algorithm, which provides users with the functions like responding, changing, constructing and presenting, conforming to the engagement taxonomy defined by working group on "Improving the Educational Impact of Algorithm Visualization". © 2010 IEEE. Source

Yu R.,Capital Institute of Physical Education | Ma S.,China Pharmaceutical University | Wu H.,Capital Institute of Physical Education
Advanced Materials Research

The main purpose of this study was to examine the effects of polysaccharides from Ganoderma lucidum (GLP) supplementation on exhaustive exercise-induced apoptosis in mice liver. The mice were randomly divided into four groups of ten per group. One of the groups was the control group, the others were GLP treated groups (25, 50 and 100 mg/kg body weight). Exhaustive swimming exercise of mice were carried out after 28 days of GLP administration, and the expression of Bcl-2 and Bax proteins in the liver tissues were determined. The data showed that GLP supplementation was able to up-regulate the expression of Bcl-2 proteins and Bcl-2/Bax ratio, down-regulate the expression of Bax proteins. The results suggest that GLP supplementation prevents exhaustive exercise-induced apoptosis. © (2014) Trans Tech Publications, Switzerland. Source

Wang Y.,Capital Institute of Physical Education | Wisloff U.,Norwegian University of Science and Technology | Kemi O.J.,University of Glasgow
Physiological Research

Exercise training-induced cardiac hypertrophy occurs following a program of aerobic endurance exercise training and it is considered as a physiologically beneficial adaptation. To investigate the underlying biology of physiological hypertrophy, we rely on robust experimental models of exercise training in laboratory animals that mimic the training response in humans. A number of experimental strategies have been established, such as treadmill and voluntary wheel running and swim training models that all associate with cardiac growth. These approaches have been applied to numerous animal models with various backgrounds. However, important differences exist between these experimental approaches, which may affect the interpretation of the results. Here, we review the various approaches that have been used to experimentally study exercise training-induced cardiac hypertrophy; including the advantages and disadvantages of the various models. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic. Source

Chen C.,Capital Institute of Physical Education | Wang Y.,Capital Institute of Physical Education
Chinese Journal of Rehabilitation Medicine

Objective: To investigate the relationship between body balance and cognition function of sports college male students in different majors by evaluating their body balance ability and cognition function. Method: Forty eight college students from the majors of sports training, sports dance, Chinese traditional dance and kinesiology were recruited. All subjects understood the purpose of this experiment and agreed to participate in the experiment and had to complete the following experimental procedures. Firstly, they were tested by a body composition analyzer for their body composition information, including height, weight, body type, body mass index(BMI) and other indicators. Then they were tested for their static postural balance by using a system for stabalometric analysis (Postural Equa, Elettronica Pagani Co., Italy). All subjects were with opening eyes and closing eyes situations, for lasting 10s, respectively. Tested parameters of static postural balance included center of pressure (COP), total length of swinging pathway (TL), maximal length of swinging pathway (ML), area of swinging pathway (Area), lengch of stekokinesigram(LFS), distributions of pressure (DistrP). Finally they were tested for their simple reaction time and spatial positional memory span by PsyKey psychological system. Result: The results of body balance showed that, there was no significant difference of body balance in all majors of students between opening eyes and closing eyes situations (P>0.05). However, compared with closing eyes situations, all majors of students showed increased TL (P<0.01), ML (P<0.05) and area (P<0.01). The results of cognition showed that, the simple reaction time of sports training students was significantly shorter than that in Chinese traditional dance students (P<0.01) and sports dance students (P<0.05). The simple reaction time of kinesiology students was significantly shorter than that of Chinese traditional dance students (P<0.01). But there was no significant difference of spatial positional memory span in all majors of students (P> 0.05). For the relationship between body balance and cognition, the simple reaction time showed significant linear correlation with the area of swinging pathway in closing eyes situations (r=0.341, P<0.05). However, the spatial positional memory span had no correlation with any body balance parameters (P>0.05). Conclusion: These results suggest that balance ability is associated positively with cognition function in college male students, including the linear correlation between simple reaction time and the area of swinging pathway in closing eyes situations. The effect of different sports majors on correlation between body balance ability and cognition function in sports college students needs to be further studied. © 2016, Editorial Board of Chinese Journal of Rehabilitation Medicine. All right reserved. Source

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