Capital Hospital

Bhubaneshwar, India

Capital Hospital

Bhubaneshwar, India
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Panigrahi P.,University of Nebraska Medical Center | Parida S.,SCB Medical College | Nanda N.C.,Ispat General Hospital | Satpathy R.,Asian Institute of Public Health | And 12 more authors.
Nature | Year: 2017

Sepsis in early infancy results in one million annual deaths worldwide, most of them in developing countries. No efficient means of prevention is currently available. Here we report on a randomized, double-blind, placebo-controlled trial of an oral synbiotic preparation (Lactobacillus plantarum plus fructooligosaccharide) in rural Indian newborns. We enrolled 4,556 infants that were at least 2,000 g at birth, at least 35 weeks of gestation, and with no signs of sepsis or other morbidity, and monitored them for 60 days. We show a significant reduction in the primary outcome (combination of sepsis and death) in the treatment arm (risk ratio 0.60, 95% confidence interval 0.48-0.74), with few deaths (4 placebo, 6 synbiotic). Significant reductions were also observed for culture-positive and culture-negative sepsis and lower respiratory tract infections. These findings suggest that a large proportion of neonatal sepsis in developing countries could be effectively prevented using a synbiotic containing L. plantarum ATCC-202195. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.


Basu S.,LV Prasad Eye Institute | Monira S.,LV Prasad Eye Institute | Modi R.R.,LV Prasad Eye Institute | Choudhury N.,Bangabandhu Sheikh Mujib Medical University | And 5 more authors.
Journal of Ophthalmic Inflammation and Infection | Year: 2014

Background: Ocular tuberculosis (TB) can affect nearly every ocular tissue, leading to a variety of vision-threatening clinical manifestations. The goal of this study is to estimate the degree, duration, and causes of visual impairment in eyes affected by ocular TB. Results: This was a retrospective study of patients diagnosed as ocular TB based on polymerase chain reaction (PCR) for Mycobacterium tuberculosis complex. We applied the World Health Organization definition of visual impairment (VI) to affected eye(s), instead of better-seeing eye. Best-corrected visual acuity (BCVA) of <6/18 and >6/60 in the affected eye was classified as moderate VI and <6/60 and >3/60 as severe VI. Data collected included presenting and final BCVA of affected eyes and the worst BCVA during the study period. Sixty-one eyes of 40 patients were analyzed. Twenty-five patients (52.1%) had bilateral disease. The mean worst BCVA and mean final BCVA (logMAR) were 1.26 ± 0.87 and 0.61 ± 0.85, respectively, and their difference was highly significant (p < 0.0001, Friedman test). The median worst and final BCVA results were 1.30 (range 0.0 to 3.0) and 0.20 (range 0.0 to 3.0), respectively. The mean duration of follow-up was 98.34 ± 81.81 weeks. Moderate and severe VIs were seen in 14 (22.9%) and 12 (19.7%) eyes, respectively, during the course of follow up. Twenty eyes (32.8%) had BCVA of <3/60. Moderate VI or worse was most commonly seen in eyes with multifocal serpiginoid choroiditis (n = 6; 100%), retinal vasculitis (n = 25; 80.6%), and panuveitis (n = 12; 80%). The mean duration of visual loss was 25.2 ± 42.37 weeks (median 6.43 weeks, range 0 to 206.42 weeks). Vitreous hemorrhage, complicated cataract, and macular scarring were the common causes of VI. Conclusion: Ocular TB can result in prolonged visual impairment, more commonly in patients with posterior uveitis or panuveitis. © 2014 Basu et al.


Priyadarshi S.,Institute of Life science | Ray C.S.,Shrirama Chandra Bhanj SCB Medical College | Panda K.C.,Capital Hospital | Desai A.,Clinic and Research Center | And 3 more authors.
Journal of Bone and Mineral Research | Year: 2013

Otosclerosis (OTSC) is a common form of acquired hearing loss resulting from disturbed bone remodeling in the otic capsule of the middle ear. Transforming growth factor-beta1 (TGFB1) produced by osteoblasts is the most abundant growth factor in human bone. Previous studies have shown the contribution of single-nucleotide polymorphisms (SNPs) in TGFB1 toward the risk of developing OTSC in some ethnic populations. The present study was aimed at investigating the genetic association and expression profiles of TGFB1 in OTSC patients. Two SNPs (c.-800G > A and c.-509C > T) in the promoter region and three SNPs (c.29T > C, c.74G > C, and c.788C > T) in the coding region were genotyped in 170 cases and 170 controls. The genetic association analysis revealed the significant association between c.-509C > T (p = 0.0067; odds ratio [OR] = 1.562; 95% confidence interval [CI], 1.140-2.139) and OTSC. The increased minor allele "T" frequency in cases (0.42) compared to controls (0.31) indicates its possible role in the etiology of the disease. The minor allele frequencies for the SNPs c.-800G > A, c.29T > C, and c.74G > C were similar among the cases (0.04, 0.47, and 0.08, respectively) and controls (0.05, 0.42, 0.07, respectively). We found that c.788C > T was monomorphic in this population. Interestingly, a four-locus haplotype (G-T-T-G) from these SNPs was found to be significantly associated with OTSC (p = 0.0077). We identified a de novo heterozygous mutation c.-832G > A in the promoter region of TGFB1 in 1 patient. In a secondary analysis, we investigated the possibility of abnormal TGFB1 expression and irregular bone growth in OTSC by expression analysis of TGFB1 mRNA in disease tissue compared to control. We found relatively increased expression of TGFB1 mRNA in the stapes tissues of cases compared to controls (p = 0.0057). In conclusion, this study identified a risk variant c.-509C > T and a risk haplotype G-T-T-G in the TGFB1 gene that contribute toward the susceptibility to OTSC. © 2013 American Society for Bone and Mineral Research.


PubMed | Institute of Life science, Capital Hospital, Nose and Throat Clinic and Research Center and Shrirama Chandra Bhanj SCB Medical College
Type: Journal Article | Journal: Annals of human genetics | Year: 2015

Otosclerosis (OTSC) is a late-onset hearing disorder characterized by increased bone turnover in the otic capsule. Disturbed osteoprotegerin expression has been found in the otosclerotic foci which may have an important role in the pathogenesis of OTSC. To identify the genetic risk factors, we sequenced the coding region and exon-intron boundaries of the OPG gene in 254 OTSC patients and 262 controls. Sequence analysis identified five known polymorphisms c.9C>G, c.30+15C>T, c.400+4C>T, c.768A>G, and c.817+8A>C. Testing of these SNPs revealed sex specific association with c.9C>G in males and c.30+15C>T in females after multiple correction. Furthermore, meta-analysis provided evidence of association of the c.9C>G polymorphism with OTSC. In secondary analysis, we investigated the mRNA expression of OPG and associated genes RANK and RANKL in otosclerotic tissues compared to controls. Expression analysis revealed significantly missing/reduced OPG expression only in otosclerotic tissues. However, the signal sequence polymorphism c.9C>G has shown no effect on OPG mRNA expression. In conclusion, our results suggest that the risk of OTSC is influenced by variations in the OPG gene along with other factors which might regulate its altered expression in otosclerotic tissues. Further research is warranted to elucidate the mechanisms underlying these observations.


Patnaik M.,Regional Medical Research Center | Patnaik M.,Kalinga Institute of Industrial Technology | Pati P.,Regional Medical Research Center | Swain S.N.,Capital Hospital | And 4 more authors.
Journal of Genetics | Year: 2014

Essential hypertension which accounts 90-95% of the total hypertension cases is affected by both genetic and environmental factors. This study was undertaken to investigate the association of aldosterone synthase C-344T, angiotensin II type I receptor A1166C and 11-β hydroxysteroid dehydrogenase type 2 G534A polymorphisms with essential hypertension in the population of Odisha, India. A total of 246 hypertensive subjects (males, 159; females, 87) and 274 normal healthy individuals (males, 158; females, 116) were enrolled in this study based on the inclusion and exclusion criteria. Analysis of genetic and biochemical data revealed that in this population the CT and TT genotypes of aldosterone synthase C-344T polymorphism, frequency of alcohol consumption and aldosterone levels were significantly high among the total as well as male hypertensives, while the AC and CC genotypes of angiotensin II type I receptor A1166C polymorphism were significantly high among the total as well as female hypertensives. High density lipoprotein levels were higher in male hypertensives. © 2014, Indian Academy of Sciences.


Patnaik M.,Regional Medical Research Center | Pati P.,Regional Medical Research Center | Swain S.N.,Capital Hospital | Mohapatra M.K.,VSS Medical College | And 3 more authors.
Annals of Human Biology | Year: 2014

Background: Hypertension is a serious health issue worldwide and essential hypertension, which includes 90-95% of the cases, is influenced by both genetic and environmental factors. Identification of these factors may help in control of this disease. The Insertion/Deletion (I/D) polymorphism in Angiotensin-Converting Enzyme (ACE) gene and rs2106809 (C > T) polymorphism in Angiotensin-Converting Enzyme 2 (ACE2) gene have been reported to be associated with essential hypertension in different populations. Aim: To investigate the association of ACE I/D and ACE2 rs2106809 polymorphisms with essential hypertension in the population of Odisha, an eastern Indian state. Subjects and methods: A total of 246 hypertensives (159 males and 87 females) and 274 normotensives (158 males and 116 females) were enrolled in the study. Detailed anthropometric data, tobacco, alcohol and food habits were recorded and 2 ml of venous blood was collected for biochemical and genetic analysis. Results: The DD genotype of ACE and TT genotype of ACE2 were significantly high among female hypertensives, while T allele of ACE2 was linked to male hypertensives. In the male population, alcohol was also identified as a potential risk factor. Conclusion: Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population. © 2014 Informa UK Ltd.


Mishra J.P.,Capital Hospital | Mishra J.,KIIT University | Padhi R.K.,KIIT University | Mishra S.,KIIT University | Manjareeka M.,KIIT University
Journal of Basic and Clinical Physiology and Pharmacology | Year: 2014

Background: Neonatal morbidity due to neonatal jaundice is an alarming situation, which needs to be detected and managed at the earliest possible. Many different etiologies come into play together, and at times, it is difficult to isolate the cause of neonatal jaundice. Certain diagnostic tests such as hemoglobin levels, reticulocyte count, leukocyte count, and blood grouping might hasten the diagnosis. This study analyzes the different parameters of hematological profile and how they influence the various etiologies of neonatal jaundice. Methods: One hundred jaundiced neonates admitted to the pediatric care unit of MKCG Medical Hospital, Odisha, were considered as subjects for this study. Blood tests were done, and accordingly, the neonates were grouped into three depending on the leukocyte count, reticulocyte count, and hemoglobin levels. Blood grouping of mother and baby was done to see the pattern of ABO incompatibility. Results: Physiological jaundice cases showed no significant variations in hematological profile, while jaundice due to ABO incompatibility, septicemia, Rh incompatibility, intracranial hemorrhage, and G6PD deficiency had anemia, reticulocytosis, and leukocytosis. Conclusions: The results can be used for early and simple investigation method for the diagnosis of neonatal jaundice. © 2014 by Walter de Gruyter Berlin/Boston.


Mallik S.,Government of Odisha | Singh S.R.,All India Institute of Medical Sciences | Mohanty M.K.,All India Institute of Medical Sciences | Padhy N.,Capital Hospital
Medicine, Science and the Law | Year: 2016

Snake bite is an important public health issue in India and is almost always accidental in manner. Suicide by snake bite or injection of snake venom is extremely rare. Suicidal ideation and behavior is known to be influenced by various socio-economic and psychological factors. The method employed for suicide is also influenced by the occupation of the victim. We report a case where a snake charmer had attempted suicide by inflicting a bite by a monocled cobra. © 2016, © The Author(s) 2016.


Balne P.K.,L V Prasad Eye Institute | Modi R.R.,L V Prasad Eye Institute | Choudhury N.,Bangabandhu Sheikh Mujib Medical University | Mohan N.,L V Prasad Eye Institute | And 5 more authors.
Journal of Ophthalmic Inflammation and Infection | Year: 2014

Background: Polymerase chain reaction (PCR) assay can be a useful method for definitive diagnosis in paucibacillary infections such as ocular tuberculosis (TB). In this study, we have evaluated factors affecting PCR outcomes in patients with clinically suspected ocular TB. Patients with clinically suspected ocular TB were investigated by PCR of aqueous or vitreous samples. Three control groups were also tested: group 1 included culture-proven non-tuberculous endophthalmitis, group 2 culture-negative non-tuberculous endophthalmitis, and group 3 patients undergoing surgery for uncomplicated cataract. PCR targeted one or more of following targets: IS6110, MPB64, and protein b genes of Mycobacterium tuberculosis complex. Multiple regression analysis (5% level of significance) was done to evaluate the associations between positive PCR outcome and laterality of disease, tuberculin skin test (TST)/interferon-gamma release assay (IGRA), chest radiography, and type of sample (aqueous or vitreous). The main outcome measures were positive PCR by one or more gene targets, and factors influencing positive PCR outcomes. Results: All 114 samples were tested for MPB64,110 for protein b, and 88 for IS61 10. MPB64 was positive in 70.2% (n = 80) of tested samples, protein b in 40.0% (n=44), and IS6110 in only 9.1% (n = 8). DNA sequencing of amplicons from four randomly chosen PCR reactions showed homology for M. tuberculosis complex. Of the 80 PCR-positive patients, 71 completed a full course of antitubercular therapy, of which 65 patients (91.5%) had complete resolution of inflammation at final follow-up. Among controls, 12.5% (3 out of 24) in group 1 and 18.7% (6 out of 32) in group 2 also tested positive by PCR. No PCR-positive outcome was observed in control group 3 (n = 25). Multiple regression analysis revealed significant association of positive PCR outcome with bilateral presentation, but not with a positive TST/IGRA, chest radiography, or type of sample (aqueous/vitreous) used. Conclusions: Careful selection of gene targets can yield high PCR positivity in clinically suspected ocular TB. Bilateral disease presentation but not any evidence of latent systemic TB influences PCR outcomes. False-positive results may be seen in ocular inflammation unrelated to ocular TB. © 2014 Balne et al.


PubMed | Government of Odisha, Capital Hospital and All India Institute of Medical Sciences
Type: | Journal: Medicine, science, and the law | Year: 2016

Snake bite is an important public health issue in India and is almost always accidental in manner. Suicide by snake bite or injection of snake venom is extremely rare. Suicidal ideation and behavior is known to be influenced by various socio-economic and psychological factors. The method employed for suicide is also influenced by the occupation of the victim. We report a case where a snake charmer had attempted suicide by inflicting a bite by a monocled cobra.

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