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Bhubaneshwar, India

Patnaik M.,Regional Medical Research Center | Patnaik M.,Kalinga Institute of Industrial Technology | Pati P.,Regional Medical Research Center | Swain S.N.,Capital Hospital | And 4 more authors.
Journal of Genetics | Year: 2014

Essential hypertension which accounts 90-95% of the total hypertension cases is affected by both genetic and environmental factors. This study was undertaken to investigate the association of aldosterone synthase C-344T, angiotensin II type I receptor A1166C and 11-β hydroxysteroid dehydrogenase type 2 G534A polymorphisms with essential hypertension in the population of Odisha, India. A total of 246 hypertensive subjects (males, 159; females, 87) and 274 normal healthy individuals (males, 158; females, 116) were enrolled in this study based on the inclusion and exclusion criteria. Analysis of genetic and biochemical data revealed that in this population the CT and TT genotypes of aldosterone synthase C-344T polymorphism, frequency of alcohol consumption and aldosterone levels were significantly high among the total as well as male hypertensives, while the AC and CC genotypes of angiotensin II type I receptor A1166C polymorphism were significantly high among the total as well as female hypertensives. High density lipoprotein levels were higher in male hypertensives. © 2014, Indian Academy of Sciences.

Patnaik M.,Regional Medical Research Center | Pati P.,Regional Medical Research Center | Swain S.N.,Capital Hospital | Mohapatra M.K.,VSS Medical College | And 3 more authors.
Annals of Human Biology | Year: 2014

Background: Hypertension is a serious health issue worldwide and essential hypertension, which includes 90-95% of the cases, is influenced by both genetic and environmental factors. Identification of these factors may help in control of this disease. The Insertion/Deletion (I/D) polymorphism in Angiotensin-Converting Enzyme (ACE) gene and rs2106809 (C > T) polymorphism in Angiotensin-Converting Enzyme 2 (ACE2) gene have been reported to be associated with essential hypertension in different populations. Aim: To investigate the association of ACE I/D and ACE2 rs2106809 polymorphisms with essential hypertension in the population of Odisha, an eastern Indian state. Subjects and methods: A total of 246 hypertensives (159 males and 87 females) and 274 normotensives (158 males and 116 females) were enrolled in the study. Detailed anthropometric data, tobacco, alcohol and food habits were recorded and 2 ml of venous blood was collected for biochemical and genetic analysis. Results: The DD genotype of ACE and TT genotype of ACE2 were significantly high among female hypertensives, while T allele of ACE2 was linked to male hypertensives. In the male population, alcohol was also identified as a potential risk factor. Conclusion: Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population. © 2014 Informa UK Ltd.

Mishra J.P.,Capital Hospital | Mishra J.,KIIT University | Padhi R.K.,KIIT University | Mishra S.,KIIT University | Manjareeka M.,KIIT University
Journal of Basic and Clinical Physiology and Pharmacology | Year: 2014

Background: Neonatal morbidity due to neonatal jaundice is an alarming situation, which needs to be detected and managed at the earliest possible. Many different etiologies come into play together, and at times, it is difficult to isolate the cause of neonatal jaundice. Certain diagnostic tests such as hemoglobin levels, reticulocyte count, leukocyte count, and blood grouping might hasten the diagnosis. This study analyzes the different parameters of hematological profile and how they influence the various etiologies of neonatal jaundice. Methods: One hundred jaundiced neonates admitted to the pediatric care unit of MKCG Medical Hospital, Odisha, were considered as subjects for this study. Blood tests were done, and accordingly, the neonates were grouped into three depending on the leukocyte count, reticulocyte count, and hemoglobin levels. Blood grouping of mother and baby was done to see the pattern of ABO incompatibility. Results: Physiological jaundice cases showed no significant variations in hematological profile, while jaundice due to ABO incompatibility, septicemia, Rh incompatibility, intracranial hemorrhage, and G6PD deficiency had anemia, reticulocytosis, and leukocytosis. Conclusions: The results can be used for early and simple investigation method for the diagnosis of neonatal jaundice. © 2014 by Walter de Gruyter Berlin/Boston.

Jha A.K.,B.P. Koirala Memorial Cancer Hospital | Hamal P.K.,Capital Hospital | Jha J.,B.P. Koirala Memorial Cancer Hospital | Banthia P.,Xenomed Foundation | And 2 more authors.
Journal of the Nepal Medical Association | Year: 2010

Introduction: Breast Cancer is the second commonest cause of cancer death in women. Almost all women survive breast cancer if it is detected before it starts to spread. The aim of the study is to analyze the demographical profile, stage of presentation, histological type, and treatment modalities of breast cancer in a tertiary care setting.&Methods: Total 1141 cases of breast cancer had been followed retrospectively from 1999 to 2006 A.D. in a tertiary care center and their patterns were analyzed. Results: The mean age of presentation of breast cancer was 47.30±11.57 years in female and 59.03±14.63 in male, 31 (2.1%) cases of breast cancer were male. There were 123 (10.78%) stage I, 281 (24.62%) stage II, 466 (40.84%) stage III, and 271 (23.75%) stage IV patients. Infiltrating ductal carcinoma was the commonest variety 610 (53.5%). Chemotherapy was the mainstay for treatment of breast cancer341 (29.9%) followed by surgery 287 (25.2%).& Conclusions: Breast cancer trend is rising with more in late and advanced stages, mostly due to lack of awareness. Infiltrating ductal carcinoma is the commonest variety. Chemotherapy is the most commonly used modality of treatment. Male breast cancer present late and is not so uncommon.

Ramchander P.V.,Institute of Life science | Panda K.C.,Capital Hospital | Panda A.K.,Capital Hospital
Genetic Testing and Molecular Biomarkers | Year: 2010

Mutations in the GJC3 gene are known to cause nonsyndromic hearing impairment (NSHI). In this study, we screened for mutations in the connexin 29 (Cx29) gene in peripheral blood collected from patients with NSHI. DNA was extracted from peripheral blood cells of 123 NSHI patients and 127 normal-hearing control subjects. Coding regions of Cx29 were amplified by polymerase chain reaction using primer pairs flanking both exons. Sequences were analyzed and compared with the published Cx29 sequence. On comparison with control subjects, only one patient and her normal-hearing mother showed a novel heterozygous variant in exon 1 c.569T>A (p. Ile190Asn), which most likely represents a rare polymorphism. From the study, we conclude that mutations in the Cx29 gene do not play a role in the causation of NSHI in Indian population. © 2010, Mary Ann Liebert, Inc.

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