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North Vancouver, Canada

Capilano University is an undergraduate-focused, public, coeducational, teaching-intensive university located in the District of North Vancouver in British Columbia, Canada. It is enabled by the University Act, enrolling its first students in 1968. The school was established by local school boards and residents of the North Shore and Howe Sound on the need for a public institution serving the local communities. Initial enrollment was 784 students in 1968, and as of 2009, student enrollment has grown to 7,500 students. Under the direction of President Greg Lee, Capilano was redesignated from a community college to a university in 2008. Capilano's academic offerings include liberal arts, professional, and career programs, leading to certificates, diplomas, and degrees at the primarily undergraduate level.The university has two regional campuses located in the British Columbian cities of Squamish and Sechelt. Capilano serves the North Shore, Howe Sound, and Sunshine Coast communities, a region spanning from Metro Vancouver to Whistler.Capilano's sports teams are nicknamed the Blues, and periwinkle blue is the official school colour. The Blues have won numerous national titles in the Canadian Colleges Athletic Association, and even more provincial titles in the British Columbia Colleges Athletic Association. Wikipedia.

Yen L.,Capilano University | Yen L.,Simon Fraser University
Discrete Mathematics and Theoretical Computer Science

The equidistribution of many crossing and nesting statistics exists in several combinatorial objects like matchings, set partitions, permutations, and embedded labelled graphs. The involutions switching nesting and crossing numbers for set partitions given by Krattenthaler, also by Chen, Deng, Du, Stanley, and Yan, and for permutations given by Burrill, Mishna, and Post involved passing through tableau-like objects. Recently, Chen and Guo for matchings, and Marberg for set partitions extended the result to coloured arc annotated diagrams. We prove that symmetric joint distribution continues to hold for arc-coloured permutations. As in Marberg's recent work, but through a different interpretation, we also conclude that the ordinary generating functions for all j-noncrossing, k-nonnesting, r-coloured permutations according to size n are rational functions. We use the interpretation to automate the generation of these rational series for both noncrossing and nonnesting coloured set partitions and permutations. © 2013 Discrete Mathematics and Theoretical Computer Science (DMTCS). Source

Nategholeslam M.,University of Guelph | Gray C.G.,University of Guelph | Tomberli B.,Capilano University
Journal of Physical Chemistry B

We present a new sampling and analysis scheme for calculating the potential of mean force (PMF) of systems studied by steered molecular dynamics simulations. This scheme, which we call the bin-passing method, is based on the forward-reverse (FR) method (due to I. Kosztin and co-workers, Kosztin et al. J. Chem. Phys. 2006, 124(6), 064106) and arguments based on the second law of thermodynamics. Applying the bin-passing method results in enhanced sampling, better separation of the reversible and irreversible work distributions, and faster convergence to the underlying PMF of the system under study. Post-simulation analysis is performed using a purpose-built software that we have made publicly available at https://github.com/1particle/bin-passing-analyzer under the terms of the GNU General Public License (version 3). Three examples are provided, for systems of varying sizes and complexities, to demonstrate the efficiency of this method and the quality of the results: for the dissociation PMF of NaCl in water, the bin-passing method obtains PMFs in excellent agreement with that obtained for the same system and using the same force-field through static (equilibrium) methods. The bin-passing method gives a very symmetric PMF for passage of a single water molecule through a DPPC bilayer, and the resultant PMF leads to permeability values in better agreement with experiments than those obtained through previous simulation studies. Finally, we consider the interaction of the antimicrobial peptide HHC-36 with two model membranes and employ the bin-passing method to obtain the PMFs for peptide adsorption to the membranes. The characteristics of these PMFs are consistent with the qualities established for the HHC-36 peptide through in vivo and in vitro experiments, as a non-toxic strong antimicrobial agent. © 2014 American Chemical Society. Source

Kao R.Y.,University of Hong Kong | Yang D.,University of Hong Kong | Lau L.-S.,University of Hong Kong | Tsui W.H.W.,University of Hong Kong | And 13 more authors.
Nature Biotechnology

Influenza A remains a significant public health challenge because of the emergence of antigenically shifted or highly virulent strains. Antiviral resistance to available drugs such as adamantanes or neuraminidase inhibitors has appeared rapidly, creating a need for new antiviral targets and new drugs for influenza virus infections. Using forward chemical genetics, we have identified influenza A nucleoprotein (NP) as a druggable target and found a small-molecule compound, nucleozin, that triggers the aggregation of NP and inhibits its nuclear accumulation. Nucleozin impeded influenza A virus replication in vitro with a nanomolar median effective concentration (EC 50) and protected mice challenged with lethal doses of avian influenza A H5N1. Our results demonstrate that viral NP is a valid target for the development of small-molecule therapies. © 2010 Nature America, Inc. All rights reserved. Source

Sudarevic T.,University of Novi Sad | Surjanovic I.,Capilano University | Vlahovic B.,University of Novi Sad
Journal of International Food and Agribusiness Marketing

The authors explore the application of viral marketing in the food industry in Canada (as a representative of a high-income country) vs. Serbia (a middle-income country). A theoretical background on the scope of viral marketing is given at the beginning. The initial secondary research pointed out that there was a great number of viral marketing campaigns in the food industry, in both high- and middle-income countries. The primary research showed a high degree of use of viral marketing in the food industry in general, as well as a number of similarities between the two countries. Positive experiences with viral marketing in the food industry were far more common than negative experiences. Most marketing professionals, in both countries, believed that a viral marketing program would benefit their company, and they planned to run a viral marketing campaign again in the future. © 2015, Copyright © Taylor & Francis Group, LLC. Source

Miller W.C.,University of British Columbia | Miller W.C.,GF Strong Rehabilitation Research Laboratory | Garden J.,Capilano University | Mortenson W.B.,Simon Fraser University | Mortenson W.B.,University of Montreal
Spinal Cord

Study design:One-week retest methodological study.Objectives:To assess the reliability and validity of the wheelchair outcome measure (WhOM) in a sample of individuals with spinal cord injury (SCI).Setting:Vancouver, British Columbia, Canada.Methods:The WhOM measures the impact of wheelchair interventions on a user's self-selected participation outcomes. The WhOM was administered to 50 participants on two occasions by the same rater, 1 week apart, to assess test-retest reliability. To determine inter-rater reliability, the WhOM was administered a third time approximately 72 h later by a different rater. Validity was evaluated by correlating scores from the WhOM with scores from the Assessment of Life Habits (LIFE-H).Results:The test-retest intraclass correlation coefficients (ICC 2, 2) for the WhOM satisfaction (Sat) and WhOM importance (Impt) × Sat scores were 0.83 (95% confidence interval (CI), 0.72-0.90) and 0.88 (95% CI, 0.79-0.93), respectively. The inter-rater ICC for the WhOM Sat and WhOM Impt × Sat scores were 0.91 (95% CI, 0.85-0.95) and 0.90 (95% CI, 0.83-0.94), respectively. As hypothesized, most scores on the WhOM were fair to moderate (r=0.3-0.5) and positively correlated with scores on the LIFE-H.Conclusion:The WhOM is a new outcome measure that demonstrates good reliability and validity among individuals with SCI. It is designed to assist wheelchair users identify and evaluate the impact of wheelchair interventions on participation level outcomes. The WhOM may be applicable for clinical-or research-oriented purposes. © 2011 International Spinal Cord Society. All rights reserved. Source

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