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Winterthur, Switzerland

Pasyechnikova N.V.,State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine | Naumenko V.O.,State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine | Korol A.R.,State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine | Zadorozhnyy O.S.,State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine | And 4 more authors.
Ophthalmologica | Year: 2015

Purpose: It was the aim of this study to determine the efficacy of intravitreal ranibizumab as treatment of choroidal neovascularizations associated with pathologic myopia. Materials and Methods: In an uncontrolled, prospective time series cohort study, 65 eyes of 64 consecutive patients with choroidal neovascularization associated with pathologic myopia were treated with intravitreal ranibizumab and observed over 12 months. The change in best-corrected visual acuity (BCVA) at 6 and 12 months served as primary end point. Safety, central retinal thickness, neovascularization activity on fluorescein angiography and the number of ranibizumab injections were secondary end points. Results: BCVA improved significantly throughout the follow-up (p = 0.001). The mean BCVA was 0.2 at baseline (SD 0.13) and 0.4 at 12 months (SD 0.21). Improvement was strongest within the first 3 months (p = 0.0001). The mean central retinal thickness showed a reduction from 313 μm (SD 82) to 243.5 μm (SD 31; p = 0.0001). Conclusion: Intravitreal ranibizumab offers a safe and effective treatment for choroidal neovascularizations in pathologic myopia. © 2014 S. Karger AG, Basel. Source


Schubert T.,University of Basel | Jacob A.L.,University of Basel | Pansini M.,University of Basel | Liu D.,University of British Columbia | And 2 more authors.
CardioVascular and Interventional Radiology | Year: 2013

Purpose: The present study was designed to evaluate the geometrical accuracy and clinical applicability of a new, free-hand, CT-guided, optical navigation system. Methods: Fifteen procedures in 14 consecutive patients were retrospectively analyzed. The navigation system was applied for interventional procedures on small target lesions, in cases with long needle paths, narrow access windows, or when an out-of-plane access was expected. Mean lesion volume was 27.9 ml, and mean distance to target measured was 107.5 mm. Eleven of 15 needle trajectories were planned as out-of-plane approaches regarding the axial CT plane. Results: Ninety-one percent of the biopsies were diagnostic. All therapeutic interventions were technically successful. Targeting precision was high with a mean distance of the needle tip from planned target of 1.98 mm. Mean intervention time was 1:12 h. A statistically significant correlation between angular needle deviation and intervention time (p = 0.007), respiratory movement of the target (p = 0.008), and body mass index (p = 0.02) was detected. None of the evaluated parameters correlated significantly with the distance from the needle tip to the planned target. Conclusions: The application of a navigation system for complex CT-guided procedures provided safe and effective targeting within a reasonable intervention time in our series. © 2012 Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). Source

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