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Peron E.J.,U.S. Center for Disease Control and Prevention | Peron E.J.,Robert Koch Institute | Peron E.J.,National Institute of Public Health | Zaharia A.,National Institute of Public Health | And 12 more authors.
Eurosurveillance | Year: 2016

As at 29 February 2016, 15 cases of haemolytic uraemic syndrome with onset between 25 January and 22 February were reported among children between five and 38 months in Romania, and three of them died. Cases were mostly from southern Romania. Six cases tested positive for Escherichia coli O26 by serology. Fruits, vegetables, meat and dairy products were among the possible common food exposures. Investigations are ongoing in Romania to control the outbreak. © 2016, European Centre for Disease Prevention and Control (ECDC). All rights reserved. Source


Oprea M.,Cantacuzino National Institute of Research | Antohe F.,Institute Of Cellular Biology And Pathology N Simionescu
Biologicals | Year: 2013

Staphylococcus aureus is an opportunistic pathogen causing various inflammatory diseases from skin and tissue local infections, to serious life threatening infections including endocarditis. Experimental models for endocarditis demonstrated that virulence factors of S.aureus, that are very important in infection of heart vegetations, are surface proteins which promote bacterial adherence. Until now, efforts to develop effective vaccines against S.aureus were unsuccessful, partly due to the fact that different vaccine formulations have targeted mainly B-cell immunity. Reverse vaccinology is applied here, in order to identify potential vaccine epitope candidates. The basic epitopes prediction strategy relied on detection of a common antigenic 9-mer epitope meant to be able to stimulate both the B-cell and T-cell mediated immunity. Ten surface exposed proteins were chosen for antigenicity testing. Using a web-based system, five T-cell epitopes corresponding to fibronectin binding protein A (FDFTLSNNV and YVDGYIETI), collagen adhesin (FSINYKTKI), serine-rich adhesin for platelets (LTFDSTNNT) and elastin binding protein (FAMDKSHPE) were selected as potential vaccine candidates. Epitopes sequences were found to be conserved among the different S.aureus genomes screened from NCBI GenBank. Invitro and invivo immunological tests will be performed in order to validate the suitability of the epitopes for vaccine development. © 2013 The International Alliance for Biological Standardization. Source


Serban R.I.,National Institute of Public Health | Radu I.,National Institute of Public Health | Codita I.,Cantacuzino National Institute of Research | Codita I.,Carol Davila University of Medicine and Pharmacy
Revista Romana de Medicina de Laborator | Year: 2013

Introduction. Boutonneuse fever (BF) is an emerging infectious disease in Romania evolving in the southern part of the country, as revealed by the incidence rates registered in our previous epidemiological descriptive studies performed during last years. We aimed to evaluate the presence of Rickettsia conorii specific IgG antibodies in a population sample from the affected area. Methods. An ELISA serological survey was performed on 301 serum samples collected from the general population, living in an area most affected by BF, in southern Romania. One of the selection criteria was the absence of signs and symptoms of the disease during the seasonal development of BF. Data were processed in SPSS V.19 (indicators of central tendency, dispersion, frequency and benchmarking). Results. Serological results showed a general positivity rate of 25.2%, with the highest rate in the population group aged over 60 years, this age group accounting for 34.21 % of the whole sample (55.6% for Bucharest area and 63.16% for Tulcea district). Conclusions. By confirming the hypothesis based on our previous descriptive epidemiological studies that BF is fitting an endemic pattern in southern Romania, our study results strongly support the need to set up a national surveillance program, aiming at improving BF prevention, management and control in our country. To our knowledge, this is the first study on Rickettsia conorii specific IgG antibodies seroprevalence in Romania. Source


Dinu S.,Cantacuzino National Institute of Research | Nagy M.,Aurel Vlaicu University | Popovici E.D.,Victor Babes University of Medicine and Pharmacy Timisoara | Zota L.,National Institute of Public Health | And 2 more authors.
Eurosurveillance | Year: 2016

The novel GII.P17-GII.17 norovirus genotype has been reported as cause of gastroenteritis outbreaks in China and Japan since the winter season 2014/15, replacing the pandemic strain GII.4 Sydney 2012. These emergent strains have also been sporadically reported on other continents than Asia. GII.P17-GII.17 isolates, similar to Kawasaki308 2015, were identified in three patients during a large outbreak of acute gastroenteritis affecting 328 people in Romania, in neighbouring localities, in 2015. © 2016, European Centre for Disease Prevention and Control (ECDC). All rights reserved. Source


Wurtz N.,Aix - Marseille University | Papa A.,Aristotle University of Thessaloniki | Hukic M.,International BURCH University | Hukic M.,Academy of science and Arts of Bosnia and Herzegovina | And 15 more authors.
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2016

Laboratory-acquired infections due to a variety of bacteria, viruses, parasites, and fungi have been described over the last century, and laboratory workers are at risk of exposure to these infectious agents. However, reporting laboratory-associated infections has been largely voluntary, and there is no way to determine the real number of people involved or to know the precise risks for workers. In this study, an international survey based on volunteering was conducted in biosafety level 3 and 4 laboratories to determine the number of laboratory-acquired infections and the possible underlying causes of these contaminations. The analysis of the survey reveals that laboratory-acquired infections have been infrequent and even rare in recent years, and human errors represent a very high percentage of the cases. Today, most risks from biological hazards can be reduced through the use of appropriate procedures and techniques, containment devices and facilities, and the training of personnel. © 2016 Springer-Verlag Berlin Heidelberg Source

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