Tokyo, Japan
Tokyo, Japan

Canon Inc. Kyanon kabushiki-gaisha is a Japanese multinational corporation specialized in the manufacture of imaging and optical products, including cameras, camcorders, photocopiers, steppers, computer printers and medical equipment. Its headquarters are located in Ōta, Tokyo, Japan.Canon has a primary listing on the Tokyo Stock Exchange and is a constituent of the TOPIX index. It has a secondary listing on the New York Stock Exchange. Wikipedia.


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The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature each heater electrode by determining the resistance of each heater electrode.


Patent
Canon Inc. | Date: 2017-01-06

A system for amplifying nucleic acids is disclosed which, in one embodiment, includes a fluidic device having a sample channel and a heat exchange channel disposed sufficiently close to the sample channel such that a heat exchange fluid in the heat exchange channel can cause a sample in the sample channel to gain or lose heat at desired levels. In one illustrative embodiment, the system further includes three reservoirs coupled to the heat exchange channel and a temperature control system configured to heat fluids stored in the respective reservoirs at different temperatures. One or more pumps and a controller are configured to cause fluid stored in the reservoirs to enter and flow through the heat exchange channel at different times.


The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, a microfluidic device is provided that includes a microfluidic chip having a plurality of microfluidic channels and a plurality of multiplexed heater electrodes, wherein the heater electrodes are part of a multiplex circuit including a common lead connecting the heater electrodes to a power supply, each of the heater electrodes being associated with one of the microfluidic channels. The microfluidic device also includes a control system configured to regulate power applied to each heater electrode by varying a duty cycle, the control system being further configured to determine the temperature each heater electrode by determining the resistance of each heater electrode.


The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. A method according to one embodiment of the invention may include the steps of: forcing a sample of a solution containing real-time PCR reagents to move though a channel; and while the sample is moving through an analysis region of the channel, performing the steps of: (a) cycling the temperature of the sample until the occurrence of a predetermined event; (b) after performing step (a), causing the samples temperature to gradually increase from a first temperature to a second temperature; and (c) while the step of gradually increasing the samples temperature is performed, using an image sensor to monitor emissions from the sample.


Patent
Canon Inc. | Date: 2017-03-13

The present invention relates to methods for amplifying nucleic acids in micro-channels. More specifically, the present invention relates to methods for performing a real-time polymerase chain reaction (PCR) in a continuous-flow microfluidic system and to methods for monitoring real-time PCR in such systems.


Patent
Canon Inc. | Date: 2017-05-31

An encoder includes a scale (10,40) including a continuous part (103) where physical characteristics varies and a discontinuous part (104) that interrupts the continuous part, a detector (20) that be relatively displaced with respect to the scale and that detects the physical characteristics of the scale, and a processor (30,31) that detects an origin of the scale on the basis of a signal for displacement detection output from the detector. The detector includes a sensitive part (2021) having sensitivity contributing to the signal for displacement detection and an insensitive part (2022) having no sensitivity contributing to the signal for displacement detection. The processor detects the origin on the basis of signal intensity of each of signals for displacement detection that the detector outputs when the sensitive and insensitive parts detect physical characteristics of the discontinuous part.


Patent
Canon Inc. | Date: 2016-11-22

An encoder includes a scale having a continuous part where physical characteristics varies and a discontinuous part that interrupts the continuous part, a detector that be relatively displaced with respect to the scale and that detects the physical characteristics of the scale, and a processor that detects an origin of the scale on the basis of a signal for displacement detection output from the detector. The detector includes a sensitive part having sensitivity contributing to the signal for displacement detection and an insensitive part having no sensitivity contributing to the signal for displacement detection. The processor detects the origin on the basis of signal intensity of each of signals for displacement detection that the detector outputs when the sensitive and insensitive parts detect physical characteristics of the discontinuous part.


A microfluidic chip having integrated heaters and a method for manufacturing the microfluidic chip is provided. Specifically, the microfluidic chip comprises a first substrate having a microchannel formed therein. The second substrate is bonded to the first substrate to encapsulate the microchannel. An integrated heating element, that is hermetically sealed and electrically isolated from the microchannel, is formed on the top surface the second substrate after the first and second substrates are bonded together. A biological reaction can be performed in the microchannel of the microfluidic chip while the fluid in the microchannel is heated by electrical current passing through the integrated heating element.


Patent
Canon Inc. | Date: 2017-02-03

Exemplary apparatus and methods are provided for analyzing a medium. The apparatus, which may be a diffusing wave spectroscopy apparatus, comprises a first beam splitter for splitting a light from the laser light source into an excitation light and a reference light. The excitation light is directed on to a first portion of the medium and then multiply scattered light is collected at a second portion of the medium, the second portion being different from the first portion. The reference light, which has been attenuated, is combined with the multiply scattered light and either a power spectrum or an autocorrelation function is calculated.


Patent
Canon Inc., Brigham and Women's Hospital | Date: 2017-07-19

A positioning apparatus including a needle holder having a through hole for regulating needle placement and movement, a needle positioning unit, and an engagement member that fixes a position of the needle holder with respect to the needle positioning unit. The needle holder is either least partially detachably attached to the needle positioning unit or deformable. The positioning apparatus may be designed to accommodate the placement of multiple needles.

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