Cangzhou Central Hospital Cangzhou

Cangzhou, China

Cangzhou Central Hospital Cangzhou

Cangzhou, China

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PubMed | Cangzhou Peoples Hospital Cangzhou and Cangzhou Central Hospital Cangzhou
Type: Journal Article | Journal: International journal of clinical and experimental pathology | Year: 2015

Glycitein is an O-methylated isoflavone which accounts for 5-10% of the total isoflavones in soy food products. Cell proliferation studies on the dietary phytoestrogen, glycitein against human breast carcinoma SKBR-3 cells showed that glycitein exhibits biphasic regulation on SKBR-3 cells. At concentrations of less than 10 mg/mL, cells respond to glycitein by increasing cell growth and de novo DNA synthesis whereas the addition of glycitein at concentrations greater than 30 mg/mL significantly inhibited cell growth and DNA synthesis in a dose-dependent manner. Cells treated with 60 mg/mL of glycitein did not regain normal growth after treatment was stopped. Glycitein was found to be cytostatic at low concentrations and cytotoxic at higher concentrations. Treatment with 100 mg/mL of glycitein severely altered the cell morphology. Collective results showed that glycitein damaged the cell membranes by increasing membrane permeability and suggested possible mechanisms of the action of dietary phytoestrogens on human breast carcinoma SKBR-3 cells.


PubMed | Wuhan University and Cangzhou Central Hospital Cangzhou
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

Puerarin is an effective ingredient isolated from Radix Puerariae, a leguminous plant. In China, a large number of early studies suggest that puerarin may be used in the treatment of coronary heart disease. In recent years, puerarin injection has been widely used to treat coronary heart disease and angina pectoris.To systematically evaluate the clinical efficacy and safety of puerarin injection in the treatment of unstable angina pectoris (UAP).Data were retrieved from digital databases, including PubMed, Excerpt Medica Database (EMBASE), China Biology Medicine (CBM), the Cochrane Library, and Chinese databases.Compared with patients who were treated with conventional Western medicines alone, the patients who were treated with conventional Western medicines in combination with puerarin injection exhibited significant improvements in the incidence of angina pectoris, electrocardiogram findings, nitroglycerin consumption and plasma endothelin levels.Strong evidence suggests that, the use of puerarin in combination with conventional Western medicines is a better treatment option for treating UAP, compared with the use of conventional Western medicines alone.


PubMed | Cangzhou Central Hospital Cangzhou
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2015

To assess the clinical outcomes of percutaneous coronary intervention (PCI) with single-stent versus double-stents implantation in distal unprotected left main coronary artery (ULMCA) bifurcation lesions and evaluate their merits and demerits in this clinical setting.88 patients with distal ULMCA bifurcation lesions and treated with PCI with single or double stents implantation (50 in the one-stent group and 38 in the two-stent group) was included.No significant difference in the number of left main and multivessel disease, stenosis rate of left main, inner diameter of left main vessel, and distal bifurcation angle was noted. The procedural success rate was 100%. Single-stent group had significantly lower ostial residual stenosis of left anterior descending and higher ostial residual stenosis of left circumflex as compared to double-stent group. During the hospitalization period, no major adverse cardiovascular events were observed in the two groups. During the follow-up period, restenosis was observed in 1 case in single-stent group and in 2 cases in double-stent group, respectively. Recurrence of angina and target lesion revascularization was observed in 6 and 1 case in single-stent group, and 4 and 2 cases in double-stent group, respectively. There was no acute myocardial infarction, in-stent thrombosis and cardiac death in both of the groups.Both stenting strategies were feasible for distal ULMCA bifurcation lesions with a high operation success rate and safety. Single-stent technique had lower ostial residual stenosis of left anterior descending whereas double-stents technique had lower ostial residual stenosis of left circumflex.

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