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Qiu D.,Cancer Hospital of Guizhou Province | Wang W.-L.,Cancer Hospital of Guizhou Province | Zhou J.-J.,Cancer Hospital of Guizhou Province
Chinese Journal of Oncology | Year: 2011

Objective: By quantitative detection of telomerase expression, we investigated the relationship between telomerase expression and malignant behavior and prognosis in gastric carcinoma. Methods: A real-time quantitative RT-PCR (RQ-PCR) was used to quantify the hTERT mRNA copy numbers in 89 samples of gastric carcinoma and corresponding non-cancerous tissues. The clinicopathological data of enrolled patients such as age, sex, tumor size, tumor site, pathologic type, histodifferentiation, infiltration depth, lymph node metastasis, stage and survival were obtained, and were made one factor analysis of variance and COX regression prognostic analysis with those above mentioned markers. Follow-up was completed as of February 28, 2010. The median follow-up was 24 months. Results: hTERT from gastric carcinomas and corresponding non-cancerous tissues was 16.98 ± 3.56 and 11.37 ± 2.15, respectively (P < 0.05), the telomerase activity in gastric cancer was significantly higher than that in non-cancerous tissue (P < 0.05). Telomerase activity showed a positive correlation with depth of invasion, tumor differentiation and nodal metastasis (P < 0.01), and negative correlation with survival. Conclusions: Gastric cancer with high hTERT mRNA expression indicates a more malignant potential. Detection of hTERT mRNA in gastric cancer may be useful in a better understanding of invasion, metastasis, as well as prognosis of gastric cancer and provide a more efficient therapy. The quantitative expression of hTERT mRNA, infiltration depth and pTNM stage are significant afactors affecting the prognosis of patients with gastric carcinoma.

Li Y.,Cancer Hospital of Guizhou Province | Jin F.,Cancer Hospital of Guizhou Province | Wu W.,Cancer Hospital of Guizhou Province | Chen H.,Cancer Hospital of Guizhou Province | And 6 more authors.
Chinese Journal of Clinical Oncology | Year: 2013

Objective: The present study aimed to investigate the short-term efficacy and adverse effects of induction chrono-chemotherapy including docetaxel (TXT), cisplatin (DDP), and 5 fluorouracil (5-FU) followed by concomitant chemoradiotherapy in loco-regionally advanced nasopharyngeal carcinoma (NPC). Methods: Newly diagnosed locally advanced (III-IVb) NPC patients were enrolled in this study. All patients received three cycles of TPF regimen. The TPF chemotherapy regimen was administered as follows: TXT, 75 mg/m2, i.v. infusion, d1; DDP, 75 mg/m2, bolus infusion from 10:00 to 22:00, d1-5; and 5-FU 750 mg/m2/d bolus infusion from 22:00 to 10:00, d1-5, with 21 days each cycle, followed by concomitant IMRT and chemotherapy (paclitaxel 135 mg/m2 i.v. infusion, with 21 days each cycle and a total of 2 courses). Acute and late toxicities were graded according to the Common Terminology Criteria for Adverse Events v3.0 scoring criteria. Tumor response was evaluated using 2000 Response Evaluation Criteria in Solid Tumors criteria. Results: The CR and PR rates of induction chemotherapy were 23.8% and 68.6%, respectively; whereas the CR and PR rates of the combined modality treatment were 64.8% and 31.4%, respectively. Two-year overall survival rate was 91.4%, two-year progression free survival rate was 87.0%, and two-year distant metastasis-free survival rate was 88.4%. The main side effects from induction chemotherapy include an over grade 3 granulocytopenia of 28.6%. Major toxicity from concurrent chemo-radiotherapy was oral mucositis (81.0%); grade 3 to 4 oral mucositis was 16%. No treatment-related deaths occurred in this study. Conclusion: Induction chrono-chemotherapy using TPF followed by concurrent chemoradiotherapy of paclitaxel is a well-tolerated treatment with short-term efficacy and severity for locally advanced NPC. Further follow-up is required to assess the late effects and long-term efficacy.

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