Cancer Genetics Research Unit
Cancer Genetics Research Unit
Hessami Arani S.,University of Sfax |
Kerachian M.A.,Mashhad University of Medical Sciences |
Kerachian M.A.,Cancer Genetics Research Unit
Current Oncology | Year: 2017
Background Colorectal cancer (crc) is one of the most prevalent cancers in the world. Although the incidence of crc is currently very low in the older Iranian population compared with Western populations, young Iranians show a rising trend of crc—that is, the age-adjusted rate is close in the young Iranian population compared with the U.S. population, and the rate in older Iranians is much lower. Methods To assess a putative relationship between diet and a rising rate of crc in younger Iranians, a combined text word and mesh heading search strategy identified relevant studies through Google Scholar and medline. Results A critical look at diet among Iranians shows major issues that might be raising the risk for crc. There are also scenarios other than diet for the rise, such as the young age structure of the country. However, the actual scenario is more complex. Conclusions In Iran, crc is one of the most common incident cancers and a common cause of cancer death. Primary and secondary prevention—with attention to a healthy lifestyle, physical activity, and screening—should be enhanced in the general population. © 2017 Multimed Inc.
Kormi S.M.A.,Cancer Genetics Research Unit |
Kormi S.M.A.,University of Zabol |
Seghatchian J.,International Consultancy in Blood Components Quality Safety Improvement
Transfusion and Apheresis Science | Year: 2017
Blood transfusion is a clinical replacement therapy with many successes with some benefit and, also, some harm. Cancer is a multifaceted disease potentially associated with the immune system's weakness where the cancerous tumor cells escape from the immune system. Allogeneic blood transfusion, through five major mechanisms including the lymphocyte-T set, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), natural killer cells (NKCs), and dendritic cells (DCs) can help the recipient's defense mechanisms. On the other hand, the role for each of the listed items includes activation of the antitumor CD8+ cytotoxic T lymphocytes (CD8+/CTL), temporal inactivation of Tregs, inactivation of the STAT3 signaling pathway, the use of bacteria to enhance the antitumor immune response and cellular immunotherapy. The above issues are concisely addressed in this manuscript based on a literature survey on this topic carried out by the first author. © 2017 Elsevier Ltd
Baharara J.,Islamic Azad University at Mashhad |
Amini E.,Kharazmi University |
Afzali M.,Islamic Azad University at Mashhad |
Nikdel N.,Islamic Azad University at Mashhad |
And 3 more authors.
Iranian Journal of Basic Medical Sciences | Year: 2016
Objective(s): Sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. The present investigation attempted to evaluate the potential of anti-cancer Persian Gulf sea cucumber species Holothuria arenicola (H. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in vivo. Materials and Methods: The CT26 carcinoma cells were treated with various concentrations of extract in 24 and 48 hr, and then its anti-proliferative effect was measured by MTT assay and morphological observations. The apoptotic effect was examined by fluorescence microscopy (DNA fragmentation assay), Flow cytometry, caspase-3 and -9 colorimetric assays. The in vivo anti-tumor efficacy of sea cucumber extract on CT26 tumor cells transplanted in BALB/c mice was also investigated. Results: The results showed that the water extract of sea cucumber revealed remarkable antiproliferative effect on CT26 tumor cells with IC50= 31 µg/ml with recruitment of intrinsic apoptotic pathway in vitro. In addition, the colon tumor volume in treated groups remarkably reduced in homozygous mice. Histopathological examination elucidated that sea cucumber extract attenuated tumor size and volume along with apoptosis characteristics. Moreover, RT-PCR analysis revealed that sea cucumber extract induced intrinsic apoptosis in vivo through suppression of Bcl-2 expression. Conclusion: Our data confirmed this notion that sea cucumber administrates anti-cancer effect that can be used as complementary in preclinical experiments, so further characterization are recommended for detection sea cucumber metabolites and clinical application. © 2016, Mashhad University of Medical Sciences. All rights reserved.