Endo Y.,Cancer and Infectious Disease Center Komagome Hospital |
Endo Y.,Takashimadaira Chuo General Hospital |
Hayashi S.,Tokyo Metropolitan Health and Medical Treatment Corporation Ohkubo Hospital |
Ohsawa Y.,Cancer and Infectious Disease Center Komagome Hospital |
And 2 more authors.
Acta Hepatologica Japonica | Year: 2016
Aims: Progression of chronic hepatitis C virus (HCV) infection to end-stage liver disease is accelated in patients coinfected with human immunodeficiency virus (HIV). Treatment of HCV is less effective than in HCV monoinfected persons. Mehods: We examined 13 HCV/HIV coinfected patients, and evaluated the efficacy and safety. The treatments were Peg-IFNα2a (n=3), Peg-IFNα2a/2b+Ribavirin (RBV) (n=10), Peg-IFNα2b/RBV/ Telaprevir (TVR) (n=1). Complications were hemophiliacs (n=2), chronic hepatitis B (n=1). The mean CD4+lymphocyte count was 477 /μl. HIV load was < 20 copies in 12 patients. Results: Five of eight patients (63%) with genotype 1 and all patients (100%) with genotype 2 achieved SVR. The count of CD4+lymphocyte decreased during treatment and recover after treatment. HIV load revealed no remarkable change during treatment. Conclusions: These results support the use of Pegylated Interferon therapy in HCV/HIV co-infected patients. © 2016 The Japan Society of Hepatology.
PubMed | Cancer and Infectious Disease Center Komagome Hospital
Type: Case Reports | Journal: Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2011
The patient suffering from getting something lodged was admitted to our hospital in October 2008. He was diagnosed as hypopharyngeal cancer (cT2N1M0, cStage III) and cervical esophageal cancer (cT2N1M0, cStage III). Firstly he was administered 5-FU, DXR and CDDP as induction chemotherapy. The response evaluation was PR according to RECIST criteria. After the induction chemotherapy, he was treated with chemoradiotherapy (64.8 Gy/54 fr, concurrent with weekly DOC 10 mg/m2). Since cervical lymph node metastases were still remaining with complete response of the primary sites, we performed a neck lymph node dissection as salvage surgery in July 2009. There has been no evidence of recurrence after the salvage surgery.