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Canadian Phytopharmaceuticals Corporation | Date: 2011-07-19

vitamin and mineral supplements; herbal, food, and dietary supplements, namely, supplements containing mushrooms, ginseng, amino acids, astragalus, bee propolis, bee pollen, beta carotene, bilberry, black cohosh, blueberries, burdock, cats claw root and bark, chamomile, cordyceps, dandelion, epimedium, devils claw, Dong Quai, evening primrose oil, Echinacea, Enzymes, fennel, folic acid, ginger, Goldenseal, gotu cola, grape seed extract, green tea, guarana, hawthorn, licorice, milk thistle, passion flower, pine bark extracts, peppermint, prebiotic preparations, probiotic preparations, red clover, red yeast rice, salmon oil, schisandra, valerian, alga, animal cartilage, aloe vera, angelica, astragalus, artichoke, bromelain, burdock, carrageenan, chlorella, chondroitin, cinnamon, citrus extracts, collagen, cranberry, essential fatty acids, essential oil, feverfew, fish liver oil, fish oil, flax seed, garlic, ginkgo biloba, glucosamine, horsetail, fo ti, kelp, kuzu, lecithin, lutein, lycopene, maca, marine phytoplankton, olive extracts, raspberry, red wine extracts, rhodiola, rhubarb, royal jelly, rutin, saw palmetto, seal oil, soy isoflavone, soy protein, St. Johns wort, stevia, tribulus terrestrial, turmeric, wolfberry, white kidney bean; processed and unprocessed medicinal herbs, herbal supplements, vitamin supplements, botanical dietary supplements, traditional Chinese herbal supplements, homeopathic dietary supplements and naturopathic dietary supplements, for use as an anti-inflammatory, anti-microbial, anti-oxidant, body detoxifier, liver detoxifier treatments and liver function treatment, and for the treatment or amelioration of high blood pressure, high blood cholesterol levels, low bone density, obesity, sleep disorders, the common cold, pre and post menstrual syndromes and disorders, and immune system disorders.

Ma Y.-C.,Canadian Phytopharmaceuticals Corporation | Ma Y.-C.,Canadian Institute of Medicinal Plants | Ma Y.-C.,Hubei University of Chinese Medicine | Mani A.,Canadian Phytopharmaceuticals Corporation | And 12 more authors.
Phytomedicine | Year: 2016

Background Ginkgo biloba L. (Ginkgoaceae) leaf extract is one of the most popular herbal products on the market, as it contains flavone glycosides (≥ 24%) and terpene lactones (≥ 6%), which are proposed to have significant physiological effects. Unfortunately, the challenging financial climate has resulted in a natural health product market containing adulterated ginkgo products. Purpose 42 ginkgo samples were analyzed to establish an HPLC profile for authentic ginkgo and common ginkgo adulterants, and to develop a method capable of easily detecting adulteration in ginkgo commercial products. Method In this study an efficient and targeted HPLC analysis method was established that is capable of distinguishing flavonol glycosides and aglycones simultaneously for the evaluation of ginkgo powdered extracts (PEs) and finished products in a single, 13 min run. Thirteen ginkgo leaf samples, fifteen standardized powdered extracts, and fourteen commercially available ginkgo products have been analyzed using this new HPLC method. Chromatograms were compared to six standard reference materials: One flavonol glycoside (rutin), three aglycones (quercetin, kaempferol and isorhamnetin), and two isoflavones (genestin and genistein). The quantitative chromatographic data was interpreted by principal component analysis (PCA), which assisted in the detection of unexpected chromatographic features in various adulterated botanical products. Results Only three of the commercially available ginkgo finished products tested in this study were determined to be authentic, with flavonol glycoside rutin, and aglycones quercetin, kaempferol, and isorhamnetin found to be common adulterants in the ginkgo powdered extract and finished product samples. Conclusion Despite evidence of adulteration in most of the samples, each of the samples discussed herein met most of the current pharmacopeial standards. It is therefore critical that a preliminary evaluation be utilized to detect adulteration in commercial ginkgo products, prior to the acid hydrolysis procedure utilized in the current testing methods. © 2016 Elsevier GmbH. All rights reserved.

Ma Y.-C.,Canadian Phytopharmaceuticals Corporation | Ma Y.-C.,Canadian Institute of Medicinal Plants | Wang X.-Q.,Canadian Phytopharmaceuticals Corporation | Wang X.-Q.,Canadian Institute of Medicinal Plants | And 9 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

Shuang-Huang-Lian (SHL) is a traditional Chinese formula which comprises of three medicinal herbs: Flos Lonicerae, Radix Scutellariae and Fructus Forsythiae, and is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. A simple, reliable and reproducible rapid resolution liquid chromatography (RRLC) method was developed for the quality control of SHL preparations, which baseline separates the major bioactive compounds within 6. min. The method uses a C18-HST column (2.5 μm, 100. mm × 3.0. mm) kept at 40 °C. The mobile phases consist of 0.1% phosphoric acid aqueous solution and acetonitrile. Flow rate is 1.0. ml/min and UV detection is performed at 327. nm from 0 to 4. min and 229. nm from 4 to 7. min. This method was further validated according to the ICH guidelines. Eight batches of commercial SHL preparations obtained from different pharmaceutical manufacturers as well as individual herbs were examined and their chromatographic profiles were compared. The stability test revealed that chlorogenic acid is stable only at acidic pH, and hence it is necessary to further evaluate and optimize the preparatory procedures and storage conditions for commercial SHL preparations. © 2010 Elsevier B.V.

Jie M.,Canadian Phytopharmaceuticals Corporation | Jie M.,Canadian Institute of Medicinal Plants | Jie M.,University of Portsmouth | Ma Y.-C.,Canadian Phytopharmaceuticals Corporation | And 8 more authors.
Natural Product Communications | Year: 2011

Two Rapid Resolution Liquid Chromatography (RRLC) methods have been developed and validated for simultaneous quantification of eight major ginsenosides from Panax species, namely, R1, Rg1, R e, Rf, Rb1, Rb2, Rc, and Rd, and flavonoids from Epimedium species, namely, epimedins A, B, and C and icariin. The analyses were performed using an Agilent 1200 series RRLC system with Phenomenex Luna C18-HST and Zorbax Eclipse XDB columns. The separation was performed with a gradient mobile phase of A (pure water) and B (acetonitrile) at a flow rate of 1.0 mL/ min and 2.5 mL/min, respectively. Both columns were kept at 40°C with the detection wavelength set at 203 nm. Specific eluted compounds were identified by using reference samples of ginsenosides R1, Rg1, Re, Rf, R b1, Rc, Rb2, and Rd, and epimedins A, B, C and icariin. Baseline separation was achieved in less than 15 minutes for the Phenomenex Luna column and 4 minutes for the Zorbax Eclipse column. Characteristic RRLC profiles were established for complex mixtures of ginsenosides from Panax species and flavonoids from Epimedium species. Both methods developed here are effective for the quality control of formulated products containing both Panax and Epimedium varieties.

Ma Y.-C.,Canadian Phytopharmaceuticals Corporation | Ma Y.-C.,Canadian Institute of Medicinal Plants | Wang X.-Q.,Canadian Phytopharmaceuticals Corporation | Wang X.-Q.,Canadian Institute of Medicinal Plants | And 12 more authors.
Natural Product Communications | Year: 2011

A simple, sensitive and reliable reversed phase Rapid Resolution Liquid Chromatography (RRLC) method was developed and validated for six biologically active compounds (salidroside, tyrosol, rosarin, rosavin, rosin and rosiridin) in Rhodiola rosea L. roots and powder extracts. The method uses a Phenomenex C18 (2)-HST column at 40°C with a neutral gradient system mobile phase (H 2O and acetonitrile), a flow rate of 1.0 mL/min, and UV detection wavelengths set at 205 and 254 nm, simultaneously. Baseline separation of the six active compounds was achieved within 8 minutes. The average percentages of rosavins (rosarin, rosavin, and rosin) in authentic R. rosea roots and root powder extracts were quantitatively determined and a characteristic R. rosea roots RRLC profile was established. The RRLC method is accurate and sensitive; in addition, it effectively increases the sample analysis throughput compared with conventional HPLC.

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