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Chapel Hill, NC, United States

Though not necessarily one of the stated goals, tihs book goes a long way toward helping touch to shed its undeserved underdog status. The authors situate perception by touch (perhaps in its rightful place) at the intersection of a number of disciplines including psychophysics, cognitive psychology, neuroscience, low vision and blindness, applied psychology, and engineering. The authors have had long and distinguished careers investigating perception by touch in both visually impaired and sighted individuals and have made important contributions in these areas. To some extent, this book is an overview of this (and related) research, though it is also much more than that. As the title implies, the book places particular emphasis on the haptic abilities of visually impaired and blind individuals. However, it also focuses on using the haptic abilities of sighted individuals to understand those of blind individuals, and vice versa. This is perhaps its most valuable contribution. In addition, it provides useful historical and theoretical context for research on the haptic abilities of both populations of people. Finally, it not only provides an overview of the ground already covered but also a preview of the ground yet to be covered, especially considering the recent technological advances in haptic interfaces and related technology. © 2008-2011 IEEE.

This essay examines examples from the field of nuclear energy, including the 2011 disaster at Fukushima-Daiichi, through perspectives drawn from phenomenology, social systems theory, and constitutive communication theory. The essay argues that although prevailing approaches to nuclear risk analysis and risk communication seek to represent a world of preexisting phenomena, they also fundamentally constitute the world on which decision-makers, organizations, and communities act. Representations of nuclear risk are inevitably and problematically limited, with important implications for policy, practice, and communicative action. © 2012 Copyright Taylor and Francis Group, LLC.

Meltzer-Brody S.,Campus Box | Meltzer-Brody S.,University of North Carolina at Chapel Hill | Brandon A.R.,University of North Carolina at Chapel Hill | Pearson B.,University of North Carolina at Chapel Hill | And 4 more authors.
Archives of Women's Mental Health | Year: 2014

Women experiencing severe perinatal mental illness during pregnancy or postpartum have unique needs when psychiatric hospitalization is indicated. Although many countries have established mother-baby psychiatric units, similar facilities have not been available in the US. In 2011, the University of North Carolina at Chapel Hill inaugurated the first Perinatal Psychiatry Inpatient Unit in the US. We describe the unique characteristics of the patient population and report clinical outcomes guiding development and refinement of treatment protocols. Ninety-two perinatal patients were admitted between September 2011 and September 2012, and 91 completed self-report measures at admission and discharge. Perinatal unipolar mood disorder was the most frequent primary diagnosis (60.43 %), and 11 patients (12 %) were admitted with psychosis. The data document clinically and statistically significant improvements in symptoms of depression, anxiety, and active suicidal ideation between admission and discharge (p < 0.0001), as assessed by the Edinburgh Postnatal Depression Scale, Patient Health Questionnaire, and Generalized Anxiety Disorder Scale. Overall functioning was also improved, demonstrated by a significant mean difference of -10.96 in total scores of the Work and Social Adjustment Scale (p < 0.0001). Data suggest that delivering specialized and targeted interventions for severe maternal mental illness in a safe and supportive setting produces positive patient outcomes. © 2013 Springer-Verlag.

Oladipupo S.S.,Campus Box | Hu S.,Brookings Biomedical | Santeford A.C.,Campus Box | Yao J.,Brookings Biomedical | And 7 more authors.
Blood | Year: 2011

Neovascularization is a crucial component of tumor growth and ischemia. Although prior work primarily used disease models, delineation of neovascularization in the absence of disease can reveal intrinsic mechanisms of microvessel regulation amenable to manipulation in illness. We created a conditional model of epithelial HIF-1 induction in adult mice (TetON-HIF-1 mice). Longitudinal photoacoustic microscopy (L-PAM) was coincidentally developed for noninvasive, labelfree serial imaging of red blood cellperfused vasculature in the same mouse for weeks to months. TetON-HIF-1 mice evidenced 3 stages of neovascularization: development, maintenance, and transgene-dependent regression. Regression occurred despite extensive and tight pericyte coverage. L-PAM mapped microvascular architecture and quantified volumetric changes in neocapillary morphogenesis, arteriovenous remodeling, and microvessel regression. Developmental stage endothelial proliferation downregulation was associated with a DNA damage checkpoint consisting of p53, p21, and endothelial γ-H2AX induction. The neovasculature was temporally responsive to VEGFR2 immuno-blockade, with the developmental stage sensitive, and the maintenance stage resistant, to DC101 treatment. L-PAM analysis also pinpointed microvessels ablated or resistant to VEGFR2 immuno-blockade. HIF-1-recruited myeloid cells did not mediate VEGFR2 inhibitor resistance. Thus, HIF-1 neovascularization in the absence of disease is self-regulated via cell autonomous endothelial checkpoints, and resistant to angiogenesis inhibitors independent of myeloid cells. © 2011 by The American Society of Hematology.

Griffiths K.L.,Campus Box | Khader S.A.,Campus Box
Current Opinion in Immunology | Year: 2014

Vaccination against intracellular pathogens requires generation of a pool of memory T cells able to respond upon infection and mediate either killing of the infected cell or induce killing mechanisms in the infected cell. T cell-inducing vaccines must aim to target the antigen to antigen-presenting cells (APCs) so that it can be presented on MHC molecules on the cell surface. Methods to do this include making use of vectors such as plasmid DNA or viruses, live attenuated pathogens or subunit vaccines targeted and enhanced using adjuvants. The choice of approach should be guided by the phenotype and localization of the desired T cell response. This review will discuss current approaches in the pipeline for the development of T cell-inducing vaccines, including vectored, live attenuated, and subunit vaccines. © 2014 Elsevier Ltd.

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