Rietveld L.,University of Victoria |
Stuss D.P.,University of Victoria |
Stuss D.P.,Camosun College |
McPhee D.,University of Victoria |
Delaney K.R.,University of Victoria
Frontiers in Cellular Neuroscience | Year: 2015
Rett syndrome (RTT) is a progressive neurological disorder primarily caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). The heterozygous female brain consists of mosaic of neurons containing both wild-type MeCP2 (MeCP2+) and mutant MeCP2 (MeCP2-). Three-dimensional morphological analysis was performed on individually genotyped layer V pyramidal neurons in the primary motor cortex of heterozygous (Mecp2+/-) and wild-type (Mecp2+/+) female mice (> 6 mo.) from the Mecp2tm1.1Jae line. Comparing basal dendrite morphology, soma and nuclear size of MeCP2+ to MeCP2− neurons reveals a significant cell autonomous, genotype specific effect of Mecp2. MeCP2- neurons have 15% less total basal dendritic length, predominantly in the region 70-130 µm from the cell body and on average three fewer branch points, specifically loss in the second and third branch orders. Soma and nuclear areas of neurons of mice were analyzed across a range of ages (5-21 mo.) and X-chromosome inactivation (XCI) ratios (12-56%). On average, MeCP2− somata and nuclei were 15 and 13% smaller than MeCP2+ neurons respectively. In most respects branching morphology of neurons in wild-type brains (MeCP2 WT) was not distinguishable from MeCP2+ but somata and nuclei of MeCP2 WT neurons were larger than those of MeCP2+ neurons. These data reveal cell autonomous effects of Mecp2 mutation on dendritic morphology, but also suggest non-cell autonomous effects with respect to cell size. MeCP2+ and MeCP2− neuron sizes were not correlated with age, but were correlated with XCI ratio. Unexpectedly the MeCP2− neurons were smallest in brains where the XCI ratio was highly skewed toward MeCP2+, i.e., wild-type. This raises the possibility of cell non-autonomous effects that act through mechanisms other than globally secreted factors; perhaps competition for synaptic connections influences cell size and morphology in the genotypically mosaic brain of RTT model mice. © 2015, Frontiers Research Foundation. All rights reserved.
News Article | February 17, 2017
VICTORIA, BC--(Marketwired - February 17, 2017) - Victoria's Bob Strachan, FCPA, FCMA, C.Dir was honoured with a Lifetime Achievement Award by the Chartered Professional Accountants of British Columbia (CPABC). The award recognizes Strachan's sustained distinction in his career, community service, and work within the accounting profession. Bob Strachan, FCPA, FCMA, C.Dir is principal of Bob Strachan & Associates. Before founding his firm in 2013, he held a number of management positions as an accountant with the Capital Regional District (CRD) from 1986 to 2013. Previously, he held roles with the Vancouver Island Health Authority and the Province of BC. While at the CRD, Strachan was a lead in the implementation of a new enterprise risk management program, enterprise information system, and corporate asset management program. Under his leadership, the CRD received numerous awards from the Government Finance Officers Association for excellence in financial reporting. Strachan is highly regarded for his contributions to the accounting profession, and played a pivotal role in the unification of Canada's profession. He led the CMA Canada board through merger discussions and developed unification strategies. In 2012, he was co-chair of the National Steering Committee that helped to develop the CPA Collaboration Accord and oversaw the formation of CPA Canada. Strachan went on to serve as vice-chair and chair of the CPA Canada board. Strachan worked with CPA boards in every province to ensure that unification of the profession was fully integrated within the national and provincial partnership. In addition, Strachan served on the CMABC board, including as chair (2001-2003), and on the CMA Canada board, including as chair (2009-2011). He is the former chair of CPA Canada's Nominating and Governance Committee, and chaired CPA Canada's President and CEO Search Committee. Today, Strachan is a member of CPA Canada's Corporate Oversight and Governance Board and the Chartered Professional Accountants' Education Foundation of BC. Strachan has generously shared his expertise with other organizations, including by serving on the boards of the Financial Management Institute of Canada (Victoria chapter) and Camosun College Foundation (chair), as well as with Royal Roads University's Master of Arts in Leadership program and the Province of BC's Accounting Policy Advisory Committee. He also makes time to volunteer. Strachan has served as a director of Leadership Victoria, and coached and served in executive positions with amateur sports organizations. Strachan obtained his CMA and fellowship designations in 1995 and 2004, respectively. Quote Richard Rees, FCPA, FCA, president and CEO, CPABC "Bob is truly deserving of the Lifetime Achievement Award. Throughout his career, he has dedicated his time towards the betterment of the accounting profession and his community. His contributions are invaluable and we are extremely proud of Bob's achievements." NOTE TO JOURNALISTS: Publication quality photos of the recipients are available. About CPA British Columbia The Chartered Professional Accountants of British Columbia (CPABC) is the training, governing, and regulatory body for almost 35,000 CPA members and 5,500 CPA students and candidates. CPABC carries out its primary mission to protect the public by enforcing the highest professional and ethical standards and contributing to the advancement of public policy. CPAs are recognized internationally for bringing superior financial expertise, strategic thinking, business insight, and leadership to organizations.
Nemec J.M.,Camosun College |
Nemec J.M.,International Statistics and Research Corporation |
Cohen J.G.,California Institute of Technology |
Ripepi V.,National institute for astrophysics |
And 6 more authors.
Astrophysical Journal | Year: 2013
Spectroscopic iron-to-hydrogen ratios, radial velocities, atmospheric parameters, and new photometric analyses are presented for 41 RR Lyrae stars (and one probable high-amplitude δ Sct star) located in the field-of-view of the Kepler space telescope. Thirty-seven of the RR Lyrae stars are fundamental-mode pulsators (i.e., RRab stars) of which sixteen exhibit the Blazhko effect. Four of the stars are multiperiodic RRc pulsators oscillating primarily in the first-overtone mode. Spectroscopic [Fe/H] values for the 34 stars for which we were able to derive estimates range from -2.54 ± 0.13 (NR Lyr) to -0.05 ± 0.13 dex (V784 Cyg), and for the 19 Kepler-field non-Blazhko stars studied by Nemec et al. the abundances agree will with their photometric [Fe/H] values. Four non-Blazhko RR Lyrae stars that they identified as metal-rich (KIC 6100702, V2470 Cyg, V782 Cyg and V784 Cyg) are confirmed as such, and four additional stars (V839 Cyg, KIC 5520878, KIC 8832417, KIC 3868420) are also shown here to be metal-rich. Five of the non-Blazhko RRab stars are found to be more metal-rich than [Fe/H] ∼-0.9 dex while all of the 16 Blazhko stars are more metal-poor than this value. New P - [Fe/H] relationships are derived based on ∼970 days of quasi-continuous high-precision Q0-Q11 long- and short-cadence Kepler photometry. With the exception of some Blazhko stars, the spectroscopic and photometric [Fe/H] values are in good agreement. Several stars with unique photometric characteristics are identified, including a Blazhko variable with the smallest known amplitude and frequency modulations (V838 Cyg). © 2013. The American Astronomical Society. All rights reserved.
Benskin J.P.,Canadian Department of Fisheries and Oceans |
Ikonomou M.G.,Canadian Department of Fisheries and Oceans |
Surridge B.D.,Camosun College |
Dubetz C.,Canadian Department of Fisheries and Oceans |
Klaassen E.,Canadian Department of Fisheries and Oceans
Aquaculture Research | Year: 2016
The commercial chemotherapeutant formulations SLICE® and AlphaMax® [active ingredients emamectin benzoate (EB) and deltamethrin respectively] are used in fin fish aquaculture to control parasitic sea lice. In some regions, the use of these substances has drawn concern from the commercial fishing industry regarding potential adverse effects on non-target organisms. In the present work, biodegradation of EB and deltamethrin, and their commercial formulations, was investigated over 135 days at 4 and 10°C in fresh marine sediments collected from underneath an active open net-pen salmon farm. EB incubated as either pure substance or commercial formulation was recalcitrant at both temperatures under abiotic and biotic conditions. Deltamethrin incubated alone or as its commercial formulation degraded slowly at 10°C (t1/2 = 330 ± 107 and 201 ± 27.1 days respectively). At 4°C, deltamethrin degradation was only significant following incubation as commercial formulation (t1/2 = 285 ±112 days). Degradation rates of EB and deltamethrin as pure substances versus their commercial formulations were not statistically different. Depletion of deltamethrin was observed in 10°C inactive sediments indicating that transformation occurred (at least in part) via an abiotic pathway. Overall, these data provide further insight into the fate and persistence of EB from the ongoing use of SLICE® in British Columbia's salmon aquaculture industry. AlphaMax® is not registered in Canada but is used in other salmon farming countries to control sea lice. © 2016 John Wiley & Sons Ltd.
Balona L.A.,South African Astronomical Observatory |
Nemec J.M.,Camosun College
Monthly Notices of the Royal Astronomical Society | Year: 2012
The SX Phe stars are Population II pulsating variables lying below the horizontal branch. Their pulsation characteristics resemble those of δ Sct stars. Since old stars in the Kepler field situated in the thick disc or halo are likely to have kinematics different from δ Sct stars, we use proper motions and tangential velocities to search for possible SX Phe variables among 1424 Kepler δ Scuti stars. Tangential velocities derived from distances obtained from the photometric calibration in the Kepler input catalogue appear to be an effective method of separation between thin-disc and thick-disc/halo stellar populations. Using this method, 34 candidate SX Phe stars are identified, eight of which are located more than 0.5 kpc above the galactic plane. We find that the light curves of these stars cannot be distinguished from those of normal δ Scuti stars. It is generally thought that field SX Phe stars have high amplitudes and only one or two frequencies, but such light curves are rare among the candidate SX Phe stars in the Kepler field. We suggest that the relatively high amplitudes, which until now have been a defining characteristic of field SX Phe stars, are merely a selection effect. This supports the recent finding of several low-amplitude multiperiodic SX Phe stars in some globular clusters. © 2012 The Authors, Monthly Notices of the Royal Astronomical Society.
Ikonomou M.G.,Northwest Atlantic Fisheries Center |
Surridge B.D.,Camosun College
International Journal of Environmental Analytical Chemistry | Year: 2013
Two of the most common products currently used to control parasitic sea lice in fin fish aquaculture, salmon in particular, are Slice® and AlphaMax®. Emamectin benzoate (EB) is the active ingredient in Slice® and deltamethrin is the active ingredient in AlphaMax®. Several analytical methods have been developed for the determination of the active ingredients in these products but these have been focused on specific matrices and lack the sensitivity and versatility required in environmental monitoring. Here we present a validated, versatile, and simple analytical method for the determination of EB, its desmethyl degradation product (AB), and deltamethrin in a wide range of environmental matrices (sea water, marine sediment, and tissue). Sediments and tissues were extracted by accelerated solvent extraction (ASE®) and sample cleanup was achieved by solid phase extraction (SPE) while sea water was extracted using SPE disks. Analyte identification and quantification was based on liquid chromatography tandem mass spectrometry (LC-MS/MS) instrumentation with electrospray ionization, and multiple reaction monitoring (MRM). Method detection limits for the target analytes was in the parts per trillion (pg g-1) level for tissue and sediment and parts per quadrillion (pg L-1) for water. Except for deltamethrin in sea water, method performance in terms of analyte recoveries was better than 60%, and the method precision was RSD<20%. The method was used to determine EB and AB concentrations in water, sediment and prawn tissue samples collected near salmon aquaculture sites treated with Slice®. A distinct concentration gradient was observed in the immediate vicinity (within 50 to 100 m radius) of the salmon aquaculture sites where EB was detected at low ng g-1 levels for tissue (EB ranged from 0.041 to 3.0 ng g-1) and sediment (EB ranged from 0.051 to 35 ng g-1) and pg L-1 levels (EB ranged from 3 to 209 pg L-1) for water samples. © 2013 Copyright Taylor and Francis Group, LLC.
Nair R.,Camosun College
Current Orthopaedic Practice | Year: 2016
Total wrist arthroplasty for chronic arthritis has become increasingly popular because it provides excellent relief, but its longevity remains unclear. The purpose of this study was to provide an evidence-based summary on implant survivorship, with a focus on mid- to long-term results. First generation implants had a mid-term survivorship of only 42%. Second and third generation implants have had varying results in both midto long-term studies. A long-term registry study of three third generation implants also showed differing results among prostheses. Fourth generation implants have had better durability with survivorship reported to be greater than 90%, but there are only published data for one type of implant. No formal Kaplan-Meier survivorship data have been published for any other type of implant from this generation. Wrist arthroplasty is still an evolving procedure, as current fourth generation implants have shown good mid-term survivorship. Long-term prospective studies of the various implants and their survivorship are still lacking. However, multicenter trials will assist in providing a larger sample size, better methodology, and cost sharing. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Tarnai-Lokhorst K.V.,Camosun College
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2015
The population of engineers is insufficient to meet long-term demand; although immigration is boosting the numbers and adding diversity to the mix, women are still severely underrepresented 1,2. The recruitment of women into these programs is a clear opportunity to meet industry demand for engineers. Young women occupy an increasing percentage of the seats in high school physics classrooms 3,4. This paper presents evidence from the British Columbia school system depicting trends in the number of young women completing high school physics and the careers they choose to pursue. The data is interpreted through a review of the history of feminist influences on education in British Columbia and on Canadian society. © American Society for Engineering Education, 2015.
Hadian S.,Camosun College
Proceedings - Frontiers in Education Conference, FIE | Year: 2015
Colleges provide professional development opportunities to faculty to promote knowledge growth and improvement of skills. At Camosun College, Scheduled Development (SD) time for faculty is based on the educational practice and recognition of the need for continuous professional development of faculty members. The paper presents the development of an online environment to enhance and promote active collaboration among faculty in the context of professional development. The Scheduled Development (SD) Connect tool is under development, implementation and is currently undergoing testing. SDConnect® is a multi-facet targeted software tool that aids in dissemination, tracking, integration, and collaboration, of faculty SD for post secondary institutions. The tool will also enable Camosun College faculty and staff to access the information database on SD activities, with the goal that it may lead to active collaborations and synergies among the faculty, departments and schools. This project will also enable the administration to efficiently administer SD proposals and approvals and to establish historical records and trends of the SD activities of faculty for better resource management. SDConnect® is part of an ongoing project called DEAL (Diversity In an Environment of Accessible Learning) at Camosun College. © 2014 IEEE.
Van De Vegte J.,Camosun College
IMSCI 2013 - 7th International Multi-Conference on Society, Cybernetics and Informatics, Proceedings | Year: 2013
A series of learning units was developed as a high-interest STEM teaching tool for a group of Aboriginal high school students. The units integrated e-learning, classroom learning and technology in a way designed to spark interest in subject matter, and to help students see links between mathematics and engineering and the real world. The series, entitled "Digital Music Math," culminated in a field trip to the local college to construct an electronic game, and each learning unit was connected in a material way to this final project.