Time filter

Source Type

PubMed | Preclinical Therapeutics And Drug Delivery Research Program Hospital Sant Joan Of Deu Barcelona Barcelona Spain, Merck And Co., Cambridge Cancer Center Cambridge and Genentech
Type: | Journal: CPT: pharmacometrics & systems pharmacology | Year: 2016

We previously investigated novel therapies for pediatric ependymoma and found 5-fluorouracil (5-FU) i.v. bolus increased survival in a representative mouse model. However, without a quantitative framework to derive clinical dosing recommendations, we devised a translational pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation approach. Results from our preclinical PK-PD model suggested tumor concentrations exceeded the 1-hour target exposure (

Loading Cambridge Cancer Center Cambridge collaborators
Loading Cambridge Cancer Center Cambridge collaborators