Sagamihara, Japan
Sagamihara, Japan

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This invention provides an effective means for inhibiting the growth of microorganisms in a concentrate-type milk-based acidic beverage that contains milk after a package is opened. The concentrate-type milk-based acidic beverage of the invention comprises (A) milk, (B) -polylysine, and (C) at least one member selected from among benzoic acid, p-hydroxybenzoic acid esters, and a salt of either thereof, wherein the milk solids-non-fat content is 1.5% to 4.5% by weight, and the Brix value is 40 to 60.


This invention provides a means for screening for lactic acid bacteria having immunoregulatory functions in a simple and rapid manner. This invention provides a method for screening for or producing lactic acid bacteria having immunoregulatory functions comprising determining the number of the test lactic acid bacteria bound to the uromodulin (Umod) protein, lactic acid bacteria obtained by such method, and an immunoregulatory composition comprising such lactic acid bacteria.


The invention provides a method for preparing a peptide for improving brain function, comprising hydrolyzing milk casein with an enzymatic catalyst comprising a protease to produce a hydrolysate comprising: (i) a peptide consisting of the amino acid sequence shown in SEQ ID NO: 1 or a variant thereof; (ii) a peptide consisting of the amino acid sequence shown in SEQ NO: 2 or a variant thereof; or (iii) a mixture of the peptides of (i) and (ii), wherein the production yield of each of the peptides is 2% or more, or the total production yield of the mixture is 10% or more. The invention also provides a food or drink or a pharmaceutical composition containing the hydrolysate.


This invention provides the use of a microorganism capable of improving both lipid metabolism and sugar metabolism. Specifically, the invention relates to: a lipid metabolism and/or sugar metabolism improver comprising, as an active ingredient, a bacterial cell selected from bacteria belonging to the genus Lactobacillus and the genus Bifidobacterium, a treated product of the bacterial cell, or a mixture thereof, having dual-agonistic activities to peroxisome proliferator activated receptor (PPAR) and peroxisome proliferator activated receptor (PPAR); to a food or a beverage comprising the improver; and to a pharmaceutical composition comprising the improver.


This invention relates to a sterilization agent for livestock bedding or a composting accelerator for organic waste or livestock bedding, comprising at least one Bacillus coagulans thermophilic bacterium or a combination of the at least one Bacillus coagulans thermophilic bacterium and at least one Bacillus subtilis mesophilic bacterium, as an active ingredient, wherein the Bacillus coagulans thermophilic bacterium as a preferable bacterium is viable at a temperature of 40 to 60 C. and the Bacillus subtilis mesophilic bacterium is viable at a temperature of 30 to 50 C., and the mesophilic bacterium also has a sterilizing effect on harmful bacteria in bedding; and to a method for sterilizing livestock bedding or a method for accelerating composting of organic waste or livestock bedding by using these agents each as an active ingredient.


Provided is an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.


The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present invention is a composition for improving brain function, comprising, as an active ingredient, X-Pro-Pro-Y or a salt thereof, wherein X represent Val, Ile or Asn-Ile and Y represent Phe or Leu.


The present invention provides a simple and efficient method for preparing safer compounds which prevent and ameliorate conditions and diseases caused by reduction in brain function and are suitable for use in medicines and food products. Specifically, the present invention provides: a method for preparing peptides each consisting of an amino acid sequence shown in any of SEQ ID NOs: 1-4 or 16, said method being characterized in that mammalian milk or milk protein is fermented using at least one lactic acid bacterium and/or a processed product thereof, and then the peptides are collected from the resultant fermented milk.


The present application provides Lactobacillus gasseri CP2305 strain (FERM BP-11331), Lactobacillus gasseri CP2305s strain (NITE BP-1405), or, a derivative strain (for example, a cold-tolerant derivative strain) derived from Lactobacillus gasseri CP2305 strain (FERM BP-11331) or the CP2305s strain, a method for producing the same, a stress-induced bowel disorder-alleviating agent comprising the derivative strain, a treated product thereof, or a mixture thereof as an active ingredient, and food additives, animal additives, animal feeds, and pharmaceutical compositions containing the agent.


The present invention provides: a method for producing a compost, comprising composting plant-derived organic waste at a weight reduction rate of 95% or more by fermentation treatment, specifically by subjecting the organic waste to fermentation treatment comprising a primary fermentation, which comprises an intermittently agitated fermentation, and a secondary fermentation, which comprises an aerated fermentation, using a microorganism of Bacillus subtilis strain C-3102 (FERM BP-1096) or a mutant strain thereof; the compost produced by the above method; and a method for producing vegetables using the compost.

Loading Calpis Co. collaborators
Loading Calpis Co. collaborators