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Gupta B.K.,Jadavpur University | Chakraborty M.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Pal R.N.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Debnath R.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | And 2 more authors.
Asian Journal of Chemistry | Year: 2010

In this paper, sibutramine hydrochloride monohydrate was formulated in the form of microcapsules in lieu of conventional tablet dosage form available to achieve its slower release rate and reduce the possible side effects of dry mouth, anorexia, insomnia, constipation and headache using ionotropic gel entrapment method with different ratio of biodegradable polymethacrylate polymers Eudragit RS-100 and RL-100. There was significant increase in half-life from 1.1-5.0 h. with entrapment up to 88%. The physicochemical studies like bulk density, tapped density, carr's index confirmed free flowing natures of the granules. FTIR studies showed no interaction between drugs and polymer. SEM studies confirmed smooth topography of microcapsules. The in vitro dissolution studies showed maximum release of 82% for best formulated batch B2 (1:2 drug polymer ratio) out of 5 batches B1, B2, B3, B4 and B5. The release was controlled upto 11 h. The release pattern was diffusion rate controlled and followed Higuchi pattern.


Pal R.N.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Chakraborty M.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Gupta B.K.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Gupta B.K.,Jadavpur University | And 3 more authors.
Asian Journal of Chemistry | Year: 2010

The aim of the study is to prepare and evaluate Eudragit micro spheres containing indomethacin. Micro spheres were prepared by solvent evaporation method using acetone/liquid paraffin system. The influence of formulation factors (stirring speed, polymer: drug ratio, type of polymers, ratio of the combination of polymers) on particle size, encapsulation efficiency and in vitro release characteristics of micro spheres were investigated. The yield of preparation and the encapsulation efficiency were obtained. Mean particle size changed by changing concentration of the polymer: drug ratio or stirring speed of the system. Although indomethacin release rates from Eudragit RS micro spheres were very fast and incomplete for all formulation, drug release were very slow from micro spheres prepared with Eudragit RL100 only. When Eudragit RS 100 was added to Eudragit RL100 during preparation of micro spheres, release rates become controlled and achieved the release profile suitable for peroral administration.


Chakraborty M.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Kumar G.B.,Jadavpur University | Debnath R.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Pal R.N.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Rajib K.,Calcutta Institute of Pharmaceutical Technology and Allied Health science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

In the present study, Forskolin, a natural root extract from the Coleus Forskohlii, was developed into a gastro retentive floating drug delivery system, using different grades of HPMC. The drug is used as anti-obesity agent reducing fat in body muscles. Forskolin increases cAMP accumulation, and therefore stimulates lipolysis. So, with high concentrations of forskolin, cAMP and lipolysis increases Enhanced lipolysis increases fat degradation and fat usage as a fuel in the body. This may promote fat and weight loss. It is thought that supplementing with forskolin may enhance fat loss without loss of muscle mass.Presently the drug is available in conventional capsule dosage form with effect on systolic blood pressure. In floating drug delivery,the release rate of drug was controlled minimizing dose related side effects. The cumulative drug release was fitted in different kinetic models and statistically validated.


Pal N.R.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Chakraborty M.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Debnath R.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Gupta B.K.,Calcutta Institute of Pharmaceutical Technology and Allied Health science
Asian Journal of Chemistry | Year: 2010

A simple and sensitive UV spectrophotometric method for determination of leflunomide in bulk and tablets has been developed. Beer' law is obeyed in the concentration of 8-30 mcg/mL of leflunomide. The method was found to be simple, precise, accurate and cheap for routine analysis with recovery of 99.06 ± 0.7593 %. The method does not require any separation of soluble excipient in the tablet as they do not interfere in the estimation. Results of analysis was verified statistically and by recovery studies thus the method can be used for routine, quality control of bulk and other formulations.


Dan S.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Malik J.K.,NRI Institute of Pharmaceutical science | Singh N.,NRI Institute of Pharmaceutical science | Bharati D.,NRI Institute of Pharmaceutical science | Bose A.,NRI Institute of Pharmaceutical science
Asian Journal of Chemistry | Year: 2011

For the development of double walled microspheres, two polymers i.e., chitosan and eudragit E100 were selected . The inner core which is made up of polymer chitosan will contain drug; propranolol hydrochloride and outer shell which is made up of polymer eudragit E100 contain; frusemide. Since eudragit E100 is dissolving below pH 5, will release the drug (furosemide) and attain therapeutic plasma concentration, which reduces the body fluid thus reduces blood pressure then the inner core chitosan's is a mucoadhesive, contains propranolol hydrochloride, adhesive to mucous layer of stomach or GIT will provide the sustain release of the drug for a longer period (24 h). Therefore, it is the goal of present study to adapt methods of double-walled fabrication with modifications, for the successful encapsulation of water-soluble. Propanolol hydrochloride and water insoluble furosemide, resulting in reduced-initial bursts as well as sustained release profiles suitable for the treatment of hypertension.


Majumdar S.,Calcutta Institute of Pharmaceutical Technology and Allied Health science | Lukka V.K.,Calcutta Institute of Pharmaceutical Technology and Allied Health science
Trends in Biomaterials and Artificial Organs | Year: 2012

The main objective in relation to this study was development of an oral controlled release multiparticulate colon-specific formulation of Ketoprofen by Powder Layering Technology. The intention was to prepare a formulation, using a combination of polymers as excipients that allowed drug liberation by depending on the bacterial enzyme in colon and absorption after a lag time of about 5-6 hours in the fasting state. Because of its rapid absorption and metabolism at the upper GI tract, development of a colon-specific delivery system of Ketoprofen becomes important for the treatment of colonic diseases such as colonic inflammation, Corn's disease etc. Hence, Ketoprofen-loaded Pectin/EC beads were developed as multi-particulate colon-specific delivery system. Beads prepared with 64.06%w/v in ethyl alcohol and 35.94% Pectin HM (59% methoxilation) in acetone: isopropyl alcohol (40:60) with 18.63% coating level were observed to be the best formulations as they could encapsulate more than 80 % of the drug and in-vitro investigation proved desire drug release pattern of the statistically optimized formulation. Very high amount of Ketoprofen can be encapsulated into these beads without altering the Ketoprofen retention pattern in simulated GI conditions. Our study showed that the beads were able to prevent release of Ketoprofen in simulated upper GI conditions and release at simulated colonic condition.


PubMed | Calcutta Institute of Pharmaceutical Technology and Allied Health science
Type: Journal Article | Journal: Die Pharmazie | Year: 2011

The aim of the present study was to prepare a colon targeted pellet formulation of secnidazole and to evaluate the formulation in vitro and in vivo by a gamma scintigraphy method. Pectin/ethyl cellulose in different ratios and in different coating labels with plasticizer was used to prepare secnidazole pellets by a powder layering technique. The formulations were tagged with 99mTC-DTPA, a tracer in gamma scintigraphy to evaluate its transit behavior in rabbits. Morphology and compatibility were studied using Scanning Electron Microscopy, IR spectroscopy and Differential Scanning Calorimetry were used for the characterization of prepared pellets. The in-vitro study suggested that pectin (59%) esterification and ethyl cellulose 45cps at 20% coating label led to an optimum bacterial enzyme dependent released behavior. The optimized formulation was subjected to an in-vivo transit study. Scintigraphy images clearly indicated that the formulation can delay the drug release prior to the colon. The average time of gastric emptying and colon arrival was 57 min and 6.08 h, respectively. The coated pellets prepared by powder layering technology successfully released drug in the colon indicating that site specificity has been achieved with pectin 59% esterification and ethyl cellulose 45 cps at 1:2 ratio with 20% coating label.

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