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Cairo, Egypt

Cairo University is a public university in Giza, Egypt. It was founded on 21 December 1908. It is the second oldest institution of higher education in Egypt, notwithstanding the pre-existing higher professional schools that later became constituent colleges of the university, after Al Azhar University. It was founded and funded as the Egyptian University by a committee of private citizens with royal patronage in 1908 and became a state institution under King Fuad I in 1925. In 1940, four years following his death, the University was renamed King Fuad I University in his honor. It was renamed a second time after the Free Officer’s Coup of 1952.The University currently enrolls approximately 155,000 students in 22 faculties. It counts three Nobel Laureates among its graduates and is one of the 50 largest institutions of higher education in the world by enrollment. Wikipedia.

Ibrahim M.M.,Cairo University | Damasceno A.,Eduardo Mondlane University
The Lancet | Year: 2012

Data from different national and regional surveys show that hypertension is common in developing countries, particularly in urban areas, and that rates of awareness, treatment, and control are low. Several hypertension risk factors seem to be more common in developing countries than in developed regions. Findings from serial surveys show an increasing prevalence of hypertension in developing countries, possibly caused by urbanisation, ageing of population, changes to dietary habits, and social stress. High illiteracy rates, poor access to health facilities, bad dietary habits, poverty, and high costs of drugs contribute to poor blood pressure control. The health system in many developing countries is inadequate because of low funds, poor infrastructure, and inexperience. Priority is given to acute disorders, child and maternal health care, and control of communicable diseases. Governments, together with medical societies and non-governmental organisations, should support and promote preventive programmes aiming to increase public awareness, educate physicians, and reduce salt intake. Regulations for the food industry and the production and availability of generic drugs should be reinforced.

El-Nassan H.B.,Cairo University
European Journal of Medicinal Chemistry | Year: 2014

The "RAS/BRAF/MEK/ERK" pathway has been associated with human cancers due to the frequent oncogenic mutations identified in its members. In particular, BRAF is mutated at high frequency in many cancers especially melanoma. This mutation leads to activation of the MAPK signaling pathway, inducing uncontrolled cell proliferation, and facilitating malignant transformation. All these facts make BRAF an ideal target for antitumor therapeutic development. Many BRAF inhibitors have been discovered during the last decade and most of them exhibit potent antitumor activity especially on tumors that harbor BRAFV600E mutations. Some of these compounds have entered clinical trials and displayed encouraged results. The present review highlights the progress in identification and development of BRAF inhibitors especially during the last five years. © 2013 Elsevier Masson SAS. All rights reserved.

El-Kady M.F.,University of California at Los Angeles | El-Kady M.F.,Cairo University | Kaner R.B.,University of California at Los Angeles
Nature Communications | Year: 2013

The rapid development of miniaturized electronic devices has increased the demand for compact on-chip energy storage. Microscale supercapacitors have great potential to complement or replace batteries and electrolytic capacitors in a variety of applications. However, conventional micro-fabrication techniques have proven to be cumbersome in building cost-effective micro-devices, thus limiting their widespread application. Here we demonstrate a scalable fabrication of graphene micro-supercapacitors over large areas by direct laser writing on graphite oxide films using a standard LightScribe DVD burner. More than 100 micro-supercapacitors can be produced on a single disc in 30 min or less. The devices are built on flexible substrates for flexible electronics and on-chip uses that can be integrated with MEMS or CMOS in a single chip. Remarkably, miniaturizing the devices to the microscale results in enhanced charge-storage capacity and rate capability. These micro-supercapacitors demonstrate a power density of ∼200 W cm-3, which is among the highest values achieved for any supercapacitor. © 2013 Macmillan Publishers Limited.

El-Nassan H.B.,Cairo University
European Journal of Medicinal Chemistry | Year: 2013

Cancer is considered as one of the most serious health problems. Despite the presence of many effective chemotherapeutic agents, their severe side effects together with the appearance of mutant tumors limit the use of these drugs and increase the need for new anticancer agents. Eg5 represents an attractive target for medicinal chemists since Eg5 is overexpressed in many proliferative tissues while almost no Eg5 is detected in nonproliferative tissues. Many Eg5 inhibitors displayed potent anticancer activity against some of the mutant tumors with limited side effects. The present review provides an overview about the progress in the discovery of Eg5 inhibitors especially from 2009 to 2012 as well as the clinical trials conducted on some of these inhibitors. © 2012 Elsevier Masson SAS. All rights reserved.

Abdel Hameed R.M.,Cairo University
Biosensors and Bioelectronics | Year: 2013

A stable non-enzymatic glucose sensor was constructed by chemical deposition of nickel nanoparticles on carbon Vulcan XC-72R using microwave irradiation technique. The mode and time of microwave irradiation during nickel salt reduction were varied. This was found to affect the morphology of formed Ni/C powder as evidenced by TEM analysis. Nickel nanoparticles aggregation becomes more serious at longer microwave irradiation times. The electrocatalytic activity of different Ni/C samples towards glucose oxidation was studied in KOH solution by employing cyclic voltammetry and chronoamperometry techniques. Ni/C sample, prepared by pulse mode with total operating time of 150s, showed the highest oxidation current density. An excellent sensitivity value of 1349.7μAmM-1cm-2 with a detection limit of 0.232μM was gained by Ni/C sensor. It also exhibits good reproducibility and long-term stability, as well as high selectivity with insignificant interference from ascorbic acid. © 2013 Elsevier B.V.

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