Inglewood, CA, United States
Inglewood, CA, United States

Time filter

Source Type

Since the discovery of magainins, cecropins and defensins 30 years ago, antimicrobial peptides (AMPs) have been hailed as a potential solution to the dearth of novel antibiotic development. AMPs have shown robust activity against a wide variety of pathogens, including drug-resistant bacteria. Unlike small-molecule antibiotics, however, AMPs have failed to translate this success to the clinic. Only the polymyxins, gramicidins, nisin and daptomycin are currently approved for medical use; the latter is the only example to have been developed in the last several decades. Nonetheless, researchers continue to isolate, modify and develop novel AMPs for therapeutic applications. Efforts have focused on increasing stability, reducing cytotoxicity, improving antimicrobial activity and incorporating AMPs in novel formulations, including nanoscale particles. As peptide synthesis and recombinant production methodologies improve, and more relevant bioassays become available, it becomes increasingly likely that AMPs will break the regulatory barrier and enter the marketplace as valuable antimicrobial weapons in the next 10 years. © 2011 Future Medicine Ltd.


Patent
The Regents Of The University Of California and C3 Jian Inc. | Date: 2014-10-14

This invention provides novel methods for inducing hair growth and/or inhibiting hair loss and/or inducing nail growth in a mammal. In various embodiments the methods involve administering, e.g., to a mammal in need thereof, a calcium-binding peptide and/or peptide-like moiety in an amount sufficient to induce hair growth and/or to inhibit hair loss. In certain embodiments the agent is topically and/or transdermally administered.


The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.


Patent
C3 Jian Inc. | Date: 2014-04-17

This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.


In certain embodiments, constructs are provided that selectively/preferentially inhibit and/or kill Clostridium difficile. In certain embodiments the constructs comprise a peptide that binds C. difficile attached directly or through an amino acid or a linker to an antimicrobial peptide.


In certain embodiments, novel targeting peptides that specifically/preferentially bind to S. mutans are provided. The targeting peptides can be attached to effectors (e.g., detectable labels, drugs, antimicrobial peptides, etc.) to form chimeric constructs for specifically/preferentially delivering the effector to and/or into the target organism. In certain embodiments the targeting peptides attached, e.g., to antimicrobial peptides can be used to selectively inhibit and/or kill S. mutans and, when used in the oral cavity of a mammal, can be effective to reduce the incidence and/or severity of dental caries and/or the incidence and/or severity of periodontal disease.


In various embodiments compositions are provided for the whitening, and/or brightening, and/or restoration of a tooth. In various embodiments the compositions, referred to herein as dental care compositions typically comprise a binding moiety that binds to calcium and/or to tooth enamel and/or to pellicle attached to an active agent. The active agent is selected to deliver a particular activity (e.g., whitening, remineralization, desensitization, brightening, etc.) to the tooth.


Patent
C3 Jian Inc. | Date: 2012-10-16

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.


Patent
The Regents Of The University Of California and C3 Jian Inc. | Date: 2014-11-12

The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.


Patent
C3 Jian Inc. and The Regents Of The University Of California | Date: 2014-02-11

The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e.g., P. aeruginosa or S. mutans), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.

Loading C3 Jian Inc. collaborators
Loading C3 Jian Inc. collaborators