Issy-les-moulineaux, France
Issy-les-moulineaux, France
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Zykovich A.,The Landing | Kinkade R.,The Landing | Royal G.,C Way Inc. | Zankel T.,The Landing
Molecular Genetics and Metabolism Reports | Year: 2015

Patient samples play an important role in the study of inherited metabolic disorders. Open-access biorepositories distribute such samples. Unfortunately, not all clinically-characterized samples come with reliable genotype information. During studies directed toward population frequency assessments of cystinosis, a rare heritable disorder, we sequenced the CTNS gene from 14 cystinosis-related samples obtained from the Coriell Cell Repository. As a result, the disease genotypes of 7 samples were determined for the first time. The reported disease genotypes of 2 additional samples were found to be incorrect. Furthermore, we identified and experimentally confirmed a novel mutation, c.225 + 5G > A, which causes skipping of the 5th exon and is associated with infantile nephropathic cystinosis. © 2015 The Authors.


Menaa B.,C Way Inc. | Montoneri C.,University of Bologna | Menaa F.,C Way Inc. | Montoneri E.,University of Turin | And 2 more authors.
International Journal of Nanotechnology | Year: 2011

The role of fluorine and phosphonate groups on protein structure and biocompatibility has been probed by protein encapsulation in tetramethoxysilane (TMOS)-based sol-gel glass and assessed by circular dichroism spectroscopy (CD). Apomyoglobin (apoMb) is known as a model protein for the study of protein folding. Thus, we demonstrated the increase of apoMb helicity in phosphonate and fluorinated phosphonate-based sol-gel glasses via the addition of methane diphosphonic acid (MDPA) and difluoromethane diphosphonic acid (DFMDPA) during the hydrolysis/ polycondensation of TMOS precursor forming a nanoporous sol-gel glass host matrix for the protein. Alternatively to silica surface functionalisation using organosilane modifiers, functional organic molecules or nano-agents can be doped directly during the sol-gel process. Since TMOS is not functionalised, we can probe the role of some organic molecules as intermediates as well as their surface hydration effect contributing to the protein folding process. The presence of both fluorine and phosphonate groups in TMOS glass folded the protein to its native state as function of its molar content. The protein ellipticity has been enlightened by CD with signals observable at 222 nm characterising the secondary protein structure at the far UV. The incorporation of these groups to the sol-gel glass systems to mimic the behaviour and conformation of protein as function of its surrounding environment brings both steric and hydrophobic properties to enhance the protein folding. These results are important from the point of view of potential applications in bio-nanotechnology with the design of efficient biomaterials but also to probe the role of fluorine and phosphonate groups in protein folding for the human healthcare. © 2011 Inderscience Enterprises Ltd.


Menaa F.,C Way Inc. | Menaa A.,Center Medical des Guittieres | Menaa B.,C Way Inc. | Treton J.,French Institute of Health and Medical Research
European Journal of Nutrition | Year: 2013

Introduction: Trans-fatty acids (TFAs) can be produced either from bio-hydrogenation in the rumen of ruminants or by industrial hydrogenation. While most of TFAs' effects from ruminants are poorly established, there is increasing evidence that high content of industrial TFAs may cause deleterious effects on human health and life span. Material and methods: Indeed, several epidemiological and experimental studies strongly suggest that high content of most TFA isomers could represent a higher risk of developing cardiovascular diseases by a mechanism that lowers the "good HDL cholesterol" and raises the "bad LDL cholesterol." Results: With respect to the general precautionary principle and considering the existence of an international policy consensus regarding the need for public health action, some industrialized countries, such as France, are still not sufficiently involved in preventive strategies that aim to efficiently reduce TFAs content and TFAs consumption and produce alternative healthier fat sources. Conclusion: In this manuscript, we provide an overview about TFAs origins, their use and consumption among French population. We also discuss their potential human health implications as well as the preventive and regulatory measures undertaken in France. © 2012 Springer-Verlag Berlin Heidelberg.


Menaa F.,C Way Inc. | Menaa A.,Center Medical des Guittieres | Treton J.,French Institute of Health and Medical Research | Menaa B.,C Way Inc.
Journal of Food Science | Year: 2013

Trans fatty acids (TFAs) mainly arise from 2 major sources: natural ruminal hydrogenation and industrial partial catalytic hydrogenation. Increasing evidence suggests that most TFAs and their isomers cause harmful health effects (that is, increased risk of cardiovascular diseases). Nevertheless, in spite of the existence of an international policy consensus regarding the need for public health action, several countries (for example, France) do not adopt sufficient voluntary approaches (for example, governmental regulations and systematic consumer rejections) nor sufficient industrial strategies (for example, development of healthier manufacturing practices and innovative processes such as fat interesterifications) to eliminate deleterious TFAs from processed foods while ensuring the overall quality of the final product (for example, nutritional value and stability). In this manuscript, we first review the physical-chemical properties of TFAs, their occurrence in processed foods, their main effects on health, and the routine analytical methods to characterize TFAs, before emphasizing on the major industrial methods (that is, fat food reformulation, fat interesterification, genetically modified FAs composition) that can be used worldwide to reduce TFAs in foods. © 2013 Institute of Food Technologists®.


Menaa F.,C Way Inc. | Menaa B.,C Way Inc.
Current Medicinal Chemistry | Year: 2012

Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with a poor prognosis. Treatment options for advanced ACC are limited. Indeed, radical tumor resection can lead to local or metastatic recurrence, and mitotane (Lysodren®), the only recognized adrenolytic drug, offers modest response rates, notably due to some of its physico-chemical and pharmacological properties (i.e. hydrophobicity, low bioavailability). Meantime, high cumulative doses of Lysodren® usually cause systemic toxicities. To reduce adverse health effects, the search of safe and efficient mitotane nano-formulations as well as the full characterization and testing of its enantiomers can represent valuable therapeutic options. Interestingly, recent investigations showed that solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) could considerably improve the efficacy of mitotane (i.e. enhanced solubility and bioavailability, progressive release of the loaded drug into blood and targeted tissues) as well as its safety (i.e. lower toxicity, higher biocompatibility). These two nano-carriers for mitotane delivery and targeting are of particular interest over other polymeric particles (i.e. low-cost, efficient and simple scaling to an industrial production level following green methods). Besides, emerging studies suggested that the S-(-)-mitotane is more potent than the R-(+)-mitotane for ACC treatment. Therefore, the production of pure and active S-(-)-mitotane might offer synergic or additive benefits for ACC patients when combined to solid lipid-based nanocarriers. In this review, we first provide an updated overview of the ACC disease before emphasizing on the promising mitotane drug nano-systems, as well as on the separation, purification and production of single mitotane enantiomer using state-of-art chromatographic-based methods. © 2012 Bentham Science Publishers.


Weil G.J.,C Way Inc.
American Water Works Association Annual Conference and Exposition 2011, ACE 2011 | Year: 2011

Leaks exist in virtually all Water Distribution, Wastewater Collection and Sewer Systems across the world. Traditionally, these leaks are only discovered when they have reached the surface, often times creating a large void or sinkhole in the process. In recent years, leak detection devices have aided companies in finding water & wastewater leaks. These devices include: pressure monitoring devices, digital ultrasonic correlating loggers, sonic & ultrasonic listening devices, internal & external flow meters, and pressure wave sensors. All these devices have several things in common: they must all be in direct contact with the pipeline in order to be effective. They also require ground personnel to continually install and operate pipeline equipment. Most importantly, many of these listening devices only work when there is significant ultrasonic noise produced with either high pressure or forced flows through very small corrosion pinholes. Therefore, leaks are often not discovered and remain a problem for almost every water distribution, wastewater & sewer collection company worldwide. This paper will compare the traditional tools & techniques used for pipeline leak detection and pipeline repairs along with the latest leak detection systems based upon Infrared (IR) Energy Pattern Analysis and Ground Penetrating Microwave Radar. In addition, it will be shown how these new techniques, with their extreme accuracy, allow for surgical repairs based upon chemical grouting.


Trademark
C Way Inc. | Date: 2013-09-16

Scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signaling, checking (supervision), life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; apparatus for recording, transmission or reproduction of sound or images; magnetic recording media, sound recording disks; compact disks, DVDs and other digital recording media; mechanisms for coin-operated apparatus; calculating machines, data processing equipment and computers; software (recorded programs). Games, toys; controls for game consoles; apparatus for physical education or gymnastics; balls for games or play balloons; billiard tables, cues or balls; playing cards or board games; protective paddings (parts of sports suits). Telecommunications; telecommunication information; communications by computer terminals or by fiber-optic networks; communications by radio or telephone; cellular telephone communication services; provision of user access to global computer networks; provision of on-line forums; provision of access to databases; electronic bulletin board services (telecommunication services); providing telecommunication connections to a global computer network; news agencies; rental of telecommunication apparatus; radio or television programs (broadcasts); teleconferencing or videoconferencing services; electronic messaging services; rental of access time to global computer networks.


PubMed | C Way Inc.
Type: Journal Article | Journal: Journal of chemical ecology | Year: 2013

Female Douglas-fir beetles,Dendroctonus pseudotsugae, produced an average 4555 mixture of the (S)-(-)- and (R)-(+)-enantiomers of 1-methylcyclohex-2-en-1-ol (MCOL). The (S)-(-)(R)-(+) ratio of 3-methylcyclohex-2-en-1-ol (seudenol) produced by this population of females was 3466. Lindgren funnel traps baited with (R)-(+)-MCOL attracted significantly more males and females than (S)-(-)-MCOL-baited traps, which captured significantly more beetles than unbaited controls. The combined effect of the enantiomers was additive, rather than synergistic. Either enantiomer of MCOL increased catches by frontalin-baited traps. Racemic MCOL can be used for trapping Douglas-fir beetles in south-central British Columbia.


PubMed | C Way Inc.
Type: Journal Article | Journal: Current medicinal chemistry | Year: 2013

Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with a poor prognosis. Treatment options for advanced ACC are limited. Indeed, radical tumor resection can lead to local or metastatic recurrence, and mitotane (Lysodren()), the only recognized adrenolytic drug, offers modest response rates, notably due to some of its physico-chemical and pharmacological properties (i.e. hydrophobicity, low bioavailability). Meantime, high cumulative doses of Lysodren() usually cause systemic toxicities. To reduce adverse health effects, the search of safe and efficient mitotane nano-formulations as well as the full characterization and testing of its enantiomers can represent valuable therapeutic options. Interestingly, recent investigations showed that solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) could considerably improve the efficacy of mitotane (i.e. enhanced solubility and bioavailability, progressive release of the loaded drug into blood and targeted tissues) as well as its safety (i.e. lower toxicity, higher biocompatibility). These two nano-carriers for mitotane delivery and targeting are of particular interest over other polymeric particles (i.e. low-cost, efficient and simple scaling to an industrial production level following green methods). Besides, emerging studies suggested that the S-(-)- mitotane is more potent than the R-(+)-mitotane for ACC treatment. Therefore, the production of pure and active S-(-)-mitotane might offer synergic or additive benefits for ACC patients when combined to solid lipid-based nanocarriers. In this review, we first provide an updated overview of the ACC disease before emphasizing on the promising mitotane drug nano-systems, as well as on the separation, purification and production of single mitotane enantiomer using state-of-art chromatographic-based methods.

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