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Wankhede S.,SrimatiKashibaiNavale Medical College | Langade D.,BVDU Dental College and Hospital | Joshi K.,BharatiVidyapeeth Medical College and Hospital | Sinha S.R.,SirJamshedjeeJeejeebhoy Group of Hospitals | Bhattacharyya S.,NSHM Knowledge Campus
Journal of the International Society of Sports Nutrition

Background: Withania somnifera (ashwagandha) is a prominent herb in Ayurveda. This study was conducted to examine the possible effects of ashwagandha root extract consumption on muscle mass and strength in healthy young men engaged in resistance training. Methods: In this 8-week, randomized, prospective, double-blind, placebo-controlled clinical study, 57 young male subjects (18-50 years old) with little experience in resistance training were randomized into treatment (29 subjects) and placebo (28 subjects) groups. Subjects in the treatment group consumed 300 mg of ashwagandha root extract twice daily, while the control group consumed starch placebos. Following baseline measurements, both groups of subjects underwent resistance training for 8 weeks and measurements were repeated at the end of week 8. The primary efficacy measure was muscle strength. The secondary efficacy measures were muscle size, body composition, serum testosterone levels and muscle recovery. Muscle strength was evaluated using the 1-RM load for the bench press and leg extension exercises. Muscle recovery was evaluated by using serum creatine kinase level as a marker of muscle injury from the effects of exercise. Results: Compared to the placebo subjects, the group treated with ashwagandha had significantly greater increases in muscle strength on the bench-press exercise (Placebo: 26.4 kg, 95 % CI, 19.5, 33.3 vs. Ashwagandha: 46.0 kg, 95 % CI 36.6, 55.5; p = 0.001) and the leg-extension exercise (Placebo: 9.8 kg, 95 % CI, 7.2,12.3 vs. Ashwagandha: 14.5 kg, 95 % CI, 10.8,18.2; p = 0.04), and significantly greater muscle size increase at the arms (Placebo: 5.3 cm2, 95 % CI, 3.3,7.2 vs. Ashwagandha: 8.6 cm2, 95 % CI, 6.9,10.8; p = 0.01) and chest (Placebo: 1.4 cm, 95 % CI, 0.8, 2.0 vs. Ashwagandha: 3.3 cm, 95 % CI, 2.6, 4.1; p < 0.001). Compared to the placebo subjects, the subjects receiving ashwagandha also had significantly greater reduction of exercise-induced muscle damage as indicated by the stabilization of serum creatine kinase (Placebo: 1307.5 U/L, 95 % CI, 1202.8, 1412.1, vs. Ashwagandha: 1462.6 U/L, 95 % CI, 1366.2, 1559.1; p = 0.03), significantly greater increase in testosterone level (Placebo: 18.0 ng/dL, 95 % CI, -15.8, 51.8 vs. Ashwagandha: 96.2 ng/dL, 95 % CI, 54.7, 137.5; p = 0.004), and a significantly greater decrease in body fat percentage (Placebo: 1.5 %, 95 % CI, 0.4 %, 2.6 % vs. Ashwagandha: 3.5 %, 95 % CI, 2.0 %, 4.9 %; p = 0.03). Conclusion: This study reports that ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program. © 2015 Wankhede et al. Source

Ambiye V.R.,Mahalaxmi Clinic | Langade D.,BVDU Dental College and Hospital | Dongre S.,Santati Fertility Center | Aptikar P.,Arya Clinic | And 2 more authors.
Evidence-based Complementary and Alternative Medicine

Ashwagandha (Withania somnifera) has been described in traditional Indian Ayurvedic medicine as an aphrodisiac that can be used to treat male sexual dysfunction and infertility. This pilot study was conducted to evaluate the spermatogenic activity of Ashwagandha root extract in oligospermic patients. Forty-six male patients with oligospermia (sperm count < 20 million/mL semen) were enrolled and randomized either to treatment (n = 21) with a full-spectrum root extract of Ashwagandha (675 mg/d in three doses for 90 days) or to placebo (n = 25) in the same protocol. Semen parameters and serum hormone levels were estimated at the end of 90-day treatment. There was a 167% increase in sperm count (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 106/mL; P < 0.0001), 53% increase in semen volume (1.74 ± 0.58 mL to 2.76 ± 0.60 mL; P < 0.0001), and 57% increase in sperm motility (18.62 ± 6.11% to 29.19 ± 6.31%; P < 0.0001) on day 90 from baseline. The improvement in these parameters was minimal in the placebo-treated group. Furthermore, a significantly greater improvement and regulation were observed in serum hormone levels with the Ashwagandha treatment as compared to the placebo. The present study adds to the evidence on the therapeutic value of Ashwagandha (Withania somnifera), as attributed in Ayurveda for the treatment of oligospermia leading to infertility. © 2013 Vijay R. Ambiye et al. Source

Srilatha,BVDU Dental College and Hospital | Joshi S.,KLE University | Chhasatia N.,Manubhai Patel Dental College and Hospital | Rani P.J.,SGT Dental College | Mathur E.,Mahatma Gandhi Dental College and Hospital
Journal of Contemporary Dental Practice

Aim: The aim of this in vitro study was to evaluate and compare the shear bond strength of teeth reattached with sixth generation dentin bonding agent: Xeno III and microhybrid resin composite: Esthet-X, using three different techniques: (1) Simple reattachment, (2) overcontour and (3) internal dentinal groove. Methodology: A total of 70 human maxillary central incisors were selected and divided into four groups as follows. Group I: Control group comprised of 10 samples. Group II: Simple reattachment, group III: Overcontour and group IV: Internal dentinal groove. Groups II, III and IV comprised of 20 samples each. The teeth in three study groups were sectioned using a diamond disk and the fragment was reattached with Esthet-X and Xeno III using three different techniques. Specimens were stored in tap water for 24 hours and shear bond strength was determined using universal testing machine using a knifeedge chisel (0.5 mm in cross-section) at a crosshead speed of 1 mm/minute. Results: The results of this study showed following mean value of fracture strength in Kgf: Group I: Control-27.71; group II: Simple reattachment-9.78; group III: Overcontour-24.41; group IV: Internal dentinal groove-23.83. Conclusion: The overcontour technique had the highest strength recovery while the simple reattachment had the lowest. Clinical significance: The overcontour technique provided strength recovery almost similar to intact teeth emphasizing that tooth preparation influenced fracture resistance. Source

Dongre S.,Trupti Hospital and Santati Fertility Center | Langade D.,BVDU Dental College and Hospital | Bhattacharyya S.,NSHM Knowledge Campus
BioMed Research International

Background. Many women experience sexual dysfunction where there are orgasm disorders and sexual difficulties. Ashwagandha (Withania somnifera) is a herb known to improve the body's physical and psychological condition. Objective. The purpose of the study was to determine the efficacy and safety of a high-concentration ashwagandha root extract (HCARE) supplementation for improving sexual function in healthy females. Methods. In this pilot study, 50 study subjects were randomized to either (i) HCARE-treated group or (ii) placebo-(starch-) treated group. The subjects consumed either HCARE or placebo capsules of 300mg twice daily for 8 weeks. Sexual function was assessed using two psychometric scales, the Female Sexual Function Index (FSFI) Questionnaire and the Female Sexual Distress Scale (FSDS), and by the number of total and successful sexual encounters. Results. The analysis indicates that treatment with HCARE leads to significantly higher improvement, relative to placebo, in the FSFI Total score (p < 0.001), FSFI domain score for "arousal" (p < 0.001), "lubrication" (p < 0.001), "orgasm" (p = 0.004), and "satisfaction" (p < 0.001), and also FSDS score (p < 0.001) and the number of successful sexual encounters (p < 0.001) at the end of the treatment. Conclusions. This study demonstrated that oral administration of HCARE may improve sexual function in healthy women. The present study is registered in the Clinical Trial Registry, Government of India, with a number CTRI/2015/07/006045. © 2015 Swati Dongre et al. Source

Joseph R.,BVDU Dental College and Hospital | Pandit V.,BVDU Medical College | Deshmane G.,BVDU Dental College and Hospital
International Journal of Phytomedicine

Epilepsy is the most common chronic neurological disorder characterized by episodes of recurrent unprovoked seizures Unmadgajakesar(UGK) is a herbomineral formulation claimed to be useful in epilepsy in traditional medicine. Lack of scientific evidence of UGK for its use in epilepsy lead to the objective of the present work. To evaluate the antiepileptic activity of Unmadgajakesari in animal models After doing the acute toxicity study of UGK, it was evaluated for its antiepileptic activity in Maximal Electroshock(MES) and Pentylenetetrazole(PTZ) induced seizures models in albino wistar rats. For each study animals were divided into 6 groups, each group comprising of 6 animals . Group I -Normal control, Group II-Vehicle control(ghrita), Group III- Drug control(positive control). In test groups(IV-VI) UGK was administered in doses of 70, 140 and 280mg/kg orally for 8days. Antiepileptic activity was evaluated on day land 8. UGK was found to be nontoxic upto dose of 2000mg/kg. Significant antiepileptic activity was observed in both the groups on 8th day of UGK administration. In the MES model, significant abolition of tonic hind limb extension was observed in dose of 280mg/kg. In PTZ model, UGK was most effective in the dose of 70mg/kg in delaying the onset and reducing the severity of clonic convulsions. No adverse effects or mortality was seen in this study. UGK appears to have significant antiepileptic activity after repeated administration. With wide spectrum of action, this drug may be useful addition to antiepileptic agents. © 2015, Advanced Research Journals, All rights reserved. Source

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