Feldman S.R.,Wake forest University |
Zhao Y.,Novartis |
Navaratnam P.,Business Development |
Friedman H.S.,DataMed Solutions |
And 2 more authors.
Journal of Managed Care Pharmacy | Year: 2015
BACKGROUND: Dose escalations of biologic agents may be attempted in the management of moderate-to-severe psoriasis. This has implications for the real-world cost of treatment. OBJECTIVE: To examine the utilization patterns and costs associated with the use of etanercept, adalimumab, and ustekinumab among patients with moderate-to-severe psoriasis. METHODS: This was a retrospective cross-sectional study. Patients with 2 or more medical claims with a diagnosis of psoriasis (excluding psoriatic arthritis) who were enrolled in large employer-sponsored health plans (including a pharmacy benefit) in the United States from January 2007 to March 2012 were identified and extracted from the MarketScan Commercial Encounters Database. Patients aged at least 18 years were required to have 2 or more pharmacy claims for etanercept, adalimumab, or ustekinumab; the index date was the first biologic fill date. Demographics and comorbidities were identified during the 1-year pre-index period, and medication utilization and costs were evaluated in the 1-year post-index period after a titration period according to the product prescribing information (2 weeks to 12 weeks). Medication utilization parameters such as dose escalation, dose reduction, persistence, switching, discontinuation, and restarts were assessed at 6, 9, and 12 months from the end of the dose titration window. RESULTS: A total of 4,309 patients were included with a mean average age of 46 years, and 55% were male. Fifty-seven percent of the patients were started on etanercept, 39% on adalimumab, and 5% on ustekinumab. Patients had substantial dose escalation rates (etanercept: 41%; adalimumab: 37%; ustekinumab: 36%, P < 0.05) and discontinuation rates (etanercept: 35%; adalimumab: 27%; ustekinumab: 16%, P < 0.05) over the 12-month post-titration period. Many patients also restarted the same biologic (etanercept: 37%; adalimumab: 10%; ustekinumab: 6%, P < 0.05) or switched to another biologic (etanercept: 15%; adalimumab: 10%; ustekinumab: 5%, P < 0.05) over the 12-month post-titration period. The persistence rates over 12 months were 19%, 53%, and 71% for etanercept, adalimumab, and ustekinumab, respectively (P < 0.05). Close to one-third of the patients at 6 months and 39% at 12 months postdose titration experienced a dose escalation. Approximately half of the patients who experienced a dose escalation also had a discontinuation or a dose reduction over the 12-month post-titration period. CONCLUSIONS: Over one-third of psoriasis patients experienced a dose escalation of their biologic agents, and most of the dose escalation occurred during the first 6 months. Restarting, switching, and discontinuing index biologics were also common. © 2015, Academy of Managed Care Pharmacy.
Kapur A.,Business Development |
Sen K.,Institute for International Management and Technology
Worldwide Hospitality and Tourism Themes | Year: 2012
Purpose: The Indian hotel industry is poised for growth but there are a number of issues that are impeding a much-awaited boom in this sector. This paper seeks to provide a first-hand perspective on the challenges faced in setting up a hotel in India. It aims to identify the issues that can be quite frustrating for a hotelier as well as for investors in India and to provide practical solutions that could lead to a higher growth rate for the industry. Design/methodology/approach: The authors have drawn together practitioner insights from open-ended discussions with several senior managers in leadership positions representing national and international brands experts who are developing hotel properties in India. Findings: The capital expenditure for building/acquiring a hotel in India is measurably higher when compared to those in most developed countries. The major factors driving this higher capital expenditure are the land costs, complexities relating to land acquisition and construction thereof, tax structure, the complex regulatory environment, and promoter preferences. If these could be eased through a visionary change by the policy-making bodies, it would provide a boost not only to this sector but also an assured contribution to the economy. Originality/value: The literature reveals that various issues and challenges relating to hotel development have been identified including some of the issues mentioned here. However, there is almost no literature that addresses the specific challenges of setting up a hotel in India. © Emerald Group Publishing Limited.
Path B.,Business Development
World Energy Engineering Congress 2012, WEEC 2012 | Year: 2012
District energy has been around for hundreds of years, but its newfound appeal to meet facility, building or campuswide heating and cooling needs is on the rise. District energy, especially when it is paired with Combined Heat and Power (CHP), give building owners a practical and proven solution to the challenges of heating and cooling their facilities in a sustainable, economical and highly manageable fashion. District energy networks reduce greenhouse gas emissions when thermal energy is produced using CHP technology. Typically, when power and heat are produced separately, only 50% of the fuel consumed is converted into useful energy, and the remainder is expelled as waste heat. In contrast, CHP recycles the waste heat and can convert 85% of the fuel to useful energy. This equates to approximately 40% less fuel consumed than when heat and power are produced separately, which results in a significant reduction in greenhouse gas emissions. This presentation will explore the concept of district energy and CHP as a sustainable energy model by examining the drivers toward implementation and outlining the key advantages of these energy systems. The focus of the presentation will concentrate on electrical and thermal supply-side energy efficiency techniques, providing improved reliability, lower cost of energy, lower emissions, design flexibility, and a host of other economic and environmental benefits. Overall, district energy and CHP offer a versatile solution as a sustainable energy model, addressing concerns such as rising energy costs, fears of inadequate energy supplies, reducing environmental pollution, and optimizing power usage effectiveness. The presentation will be leverage Veolia Energy's expertise as a leading the world's leading operator of district energy networks, operating 900 networks globally, including extensive systems and operations in major cities across the continental U.S.
Gerwe G.,Business Development
Battery Power 2011 | Year: 2011
OEMs have an opportunity to participate in wireless power Select the right positioning method and coil type for your application No other component has a larger influence on system efficiency and performance Utilize the right coupling, charging solution for your power requiremetns Several solutions available Low power, Qi compliant - from RRC or TI Medium power, 5 - 500W - from RRC Evaluation kit - great opportunity to "test drive" the technology. Copyright © (2011) by Webcom Communications.
Naeem M.,Business Development
Manufacturing Engineering | Year: 2014
Several types of lasers are currently used for materials processing in the aerospace industry. The advantages of high-power fiber laser for drilling cooling holes in aerospace engine components is well documented. Fiber laser welding of joints has a speed advantage over the riveting process. While joining parts on a fuselage shell can take five hours using current riveting processes. The laser beam can be focused to submilimeter diameters, which in combination with multi-kilowatt laser beams, produces power densities. Titanium and nickel alloys are readily laser weldable, however, special attention must be given to joint cleanliness and gas shielding.
Abushaban R.M.,Business Development
Proceedings of the 4th IEEE Global Humanitarian Technology Conference, GHTC 2014 | Year: 2014
Crowdfunding has been gaining in popularity as means for creators and entrepreneurs to get funding and launch their ideas and projects and is considered as an alternative financing model for start-up funding by many, where the market leading platform Kickstarter received about USD$480 million in 2013 alone. However, this increasing popularity has not yet gained foot in many developing countries that do not lack talent or innovative ideas, but that lack funding for innovation endeavors in business and development works. Many developing countries in the Middle East and North Africa in particular that are facing grim financial situations could greatly benefit from Crowdfunding towards creating a positive impact on deprived societies in the region. This paper investigates the process of Crowdfunding and its impact on innovative projects and businesses in developing countries of the Middle East, and analyzes its potential for humanitarian and society development. The paper further contributes to this emerging field by and addressing obstacles and possibilities for campaigners on Crowdfunding platforms. © 2014 IEEE.
Kuzdzal M.J.,Business Development
Carbon Management Technology Conference 2015: Sustainable and Economical CCUS Options, CMTC 2015 | Year: 2015
• The integrally geared (IG) compressor is the current benchmark for overall shaft power, but is large and incorporates many coolers, bearings and seals. • In-line centrifugal have less bearings and seals, but will consume more power: • Will have a reduced footprint relative to IG • Much of power penalty mitigated with water cooled diaphragms. • Internally-cooled inline centrifugal test results show up to a 8% power savings over the same non-cooled inline centrifugal • Slight increase of compressor costs due to manufacture of liquid-cooled diaphragms. • DATUM® S: • High ratio results in increase of shaft horsepower • Single rotating disk results in smaller footprint, reduced CAPEX and commissioning costs • Size reduction of 33% percent compared to inline centrifugal • Delivers usable heat which, when integrated into the system, will produce the lowest overall power for the compression service - lowest OPEX solution if waste heat can be integrated.
Lawrence P.A.,Business Development
85th Annual International School of Hydrocarbon Measurement 2010 | Year: 2010
This technical paper will describe how generic differential pressure cone meters whilst similar in principle differ operationally from other differential pressure meters and how they are used for the measurement of liquid and gas. The cone meter has become synonymous with specialist metering applications over many years due to special traits that are inherent in this type of meter design. The original cone meter concept was taken from the "Venturi" original design in 1791 by Hershel and other variants like Burton Dunlingson's Inverse Venturi (which was Patented in the UK ,in 1935). Generic Differential Pressure (DP) Cone Meters have been used to meter many fluids such as Steam, Wet Gas , Liquids that have trash, asphaltenes and wax in pipes together with applications that have pipeline installation issues such as short meter runs lengths (usually off-shore). They have also been used for custody transfer with user-party agreements and have been quite successful through the years in other industrial applications such as water measurement, some of the key ideas that enabled these concepts will be shown in this paper. Trade Marks, or Meter Trade Names will not be mentioned in this paper.
Carley J.A.,Business Development
Carbon Management Technology Conference 2013, CMTC 2013 | Year: 2013
• Breakthrough technology for low-cost, operationally elegant CO2 capture • Leverages existing known equipment for speed to market • Broad patent barrier • Development milestones met and exceeded to date • Pursuing commercial applications in near-term where CO2 can be profitably utilized.
Latawiec R.,Business Development
Electronic Products | Year: 2013
The nature of embedded systems is being changed with the advent of graphical, intelligent human-machine interfaces and the Internet of Things. Every imaginable system, from coffee makers and washing machines to health-monitoring and industrial control, are offering improved user experience by providing excellent human interfaces. The C language uses an imperative programming paradigm (procedural) that keeps data and processing separated. Like assembly language, C programmers can decide about data representation in memory since data are not strongly typed and an directly manipulate address pointers using arithmetic to access to data areas. This perfectly fits actual processor architectures whose hardware resources or peripherals can be accessed through data registers and buffers using address pointers. The Java technology is an opportunity to redefine the goal of simulation.