Song M.-K.,Pusan National University |
Chung J.-S.,Pusan National University |
Shin H.-J.,Pusan National University |
Moon J.-H.,Daegu University |
And 6 more authors.
Cancer Science | Year: 2012
Primary gastrointestinal (PGI) diffuse large B cell lymphoma (DLBCL) is a relatively common disease. Recent studies indicate that measurement of maximum standardized uptake value (SUVmax) on pretreatment for 18F-fluorodeoxyglucose PET is an important prognostic factor in PGI DLBCL. However, there is still an association between initial tumor burden and prognosis. Thus, in the present study, we investigated whether tumor volume by PET could have a potential prognostic value to predict the outcome. From 2006 to 2009, 165 Stage I E/II E PGI DLBCL patients were enrolled in the study. One hundred and five patients received cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP) only, whereas 60 patients underwent surgery plus R-CHOP. Metabolic tumor volume (MTV) was defined initial tumor burden as target GI lesion above SUV, 2.5 by PET as a contouring border. Over a median follow-up period of 36.6 months, receiver operating characteristic (ROC) analysis indicated that the best cutoff values for MTV and SUVmax were 160.1 cm3 and 12.0, respectively. The estimated area under the ROC curve was higher for MTV than SUVmax. Thus, MTV was a better predictor for survival than SUVmax. In patients with a low MTV (<160.1 cm3), there were no significant differences in survival between patients undergoing R-CHOP alone and surgery plus R-CHOP (P = 0.347 for progressionfree survival [PFS]; P = 0.148 for overall survival [OS]). Conversely, in patients with a high MTV (>160.1 cm3), survival was longer in those who underwent surgery plus R-CHOP than in those treated with R-CHOP alone (P < 0.001 for PFS; P < 0.001 for OS). Multivariate analysis revealed that high MTV is an independent factor for predicting survival. Even in the era of rituximab, treatment of PGI DLBCL is not easy in patients with a high MTV. © 2011 Japanese Cancer Association.
Lee K.,Busan Paik Hospital
Asia Pacific Journal of Clinical Nutrition | Year: 2012
This study aimed to assess the prevalence of overweight misperception, unhealthy diet practices, and factors associated with these weight-related behaviors among Korean adolescverents. The subjects were a nationally representative sample of non-oweight students (52,515 in 2005, 64,084 in 2006, and 67,113 in 2007) in middle and high schools who completed the Korea Youth Risk Behavior Web-Based Survey. The prevalence of weightrelated behaviors and factors associated with these behaviors were assessed using a complex sampling design. Of non-overweight students, 14.9% of boys and 22.2% of girls reported their weight as overweight/obese. Dieting within the last year was reported by 19.8% of boys and 41.8% of girls. Of those who attempted dieting, 17.1% of boys and 24.6% of girls indicated practicing at least one unhealthy diet behavior within the last month. Overweight misperceptions were independently associated with diet attempts and unhealthy diets after adjustment for weight status, and demographic, social, and psychological factors. Additionally, these weight-related behaviors were also associated with psychosocial factors such as low school achievement, sadness, suicidal ideation, increased stress perception, and cigarette or alcohol use. In conclusion, the high prevalence of inappropriate weight-related behaviors suggests a need for comprehensive approaches to improve weight-related behaviors in non-overweight Korean adolescents.
Lee K.,Busan Paik Hospital
Nutrition Research and Practice | Year: 2012
This study assessed the association between vitamin D sufficiency (serum 25(OH)D ≥30 ng/mL) and alcohol consumption using data from the Korea National Health and Nutrition Examination Survey conducted in 2009. The following characteristics were obtained in 7,010 Korean participants ≥19-years-of-age: serum 25(OH)D level, alcohol consumption (drinking frequency, drinking number of alcoholic beverages on a typical occasion, average daily-alcohol intake), and potential confounders (age, residence, housing status, occupation, total fat and lean mass, smoking, physical activity, history of liver diseases, liver function, and daily intake of energy, protein, and calcium). After adjusting for confounders, vitamin D sufficiency in men was significantly associated with drinking frequency, number of alcoholic drinks consumed, and average daily alcohol intake; odds ratio of 1.21-1.72, 2.17-3.04, and 2.27-3.09, respectively. Increase in the three alcohol drinking-related behaviors was also linearly associated with increase in serum 25(OH)D level in men. By comparison, there was no significant association between alcohol intake and serum 25(OH)D level in women. The positive association between vitamin D sufficiency and alcohol consumption was evident only in Korean men. © 2012 The Korean Nutrition Society and the Korean Society of Community Nutrition.
Lee K.,Busan Paik Hospital
Journal of Bone and Mineral Metabolism | Year: 2013
The aim of this study was to examine sexspecific relationships between insulin resistance (IR) and bone mineral content (BMC) according to age group and weight status. A population-based sample of 618 Korean adolescents (315 male and 303 female), aged 10-19 years from the Fourth Korea National Health and Nutrition Examination Survey, 2009. They were divided into three age groups (10-12;13-16;17-19 years) and two weight groups (non-overweight vs. overweight). IR was assessed using the homeostatic model of assessment of IR (HOMA-IR). Soft tissue composition (fat and lean mass) and BMC of the whole body, proximal femur, and lumbar spine were measured by dual energy X-ray absorptiometry. Adiposity (body mass index, waist circumference, or soft tissue composition), age, height, total cholesterol, triglycerides, high density lipoprotein cholesterol, alkaline phosphatase, serum vitamin D, dietary calcium and energy intake, and menarche for females were adjusted using general linear models of a complex sampling design. Higher HOMA-IR was associated with a decrease in BMC in male adolescents aged 13-19 years after adjustment for adiposity and other confounders, while the associations were not significant in male adolescents aged 10-12 years and female adolescents. After adjustment for adiposity and confounders, the inverse associations between HOMA-IR and BMC were more consistent in non-overweight male adolescents than in other weight groups (overweight males and non-overweight and overweight females). The unfavorable effect of IR on BMC appears to be more obvious in males aged 13-19 years or non-overweight males than in females. © The Japanese Society for Bone and Mineral Research and Springer Japan 2012.
Park J.-Y.,Shoulder |
Kim J.-H.,Busan Paik Hospital |
Lhee S.-H.,Shoulder |
Lee S.J.,Pusan National University
Journal of Shoulder and Elbow Surgery | Year: 2012
Hypothesis: Inferomedial support may affect the results of the hot air balloon technique for the treatment of displaced, 3-part fractures of the proximal humerus. Methods: Forty-three patients with displaced, 3-part fractures of the proximal humerus treated with the hot air balloon technique between 1995 and 2007 were included in the study. All patients were classified into 4 subgroups based on the presence or absence of medial buttress restoration and inferomedial screw insertion (R+, restored with inferomedial screw; R-, restored without inferomedial screw; NR+, non-restored with inferomedial screw; and NR-, non-restored without inferomedial screw). Assessment of radiologic and clinical outcome among subgroups was based on evaluation of neck-shaft angle, American Shoulder and Elbow Surgeons score, and Neer score. Results: The mean follow-up duration was 65 ± 29.7 months. The change in the neck-shaft angle in the R+, R-, NR+, and NR- groups was 3°, 2°, 3°, and 11°, respectively. The mean American Shoulder and Elbow Surgeons scores in the R+, R-, NR+, and NR- groups were 91 ± 4.8, 86 ± 5.4, 85 ± 1.9, and 77 ± 5.8, respectively. The mean Neer scores in the R+, R-, NR+, and NR- groups were 92 ± 4.3, 88 ± 4.0, 87 ± 2.1, and 76 ± 8.2, respectively. Conclusions: Medial buttress restoration and inferomedial screw insertion affect bone-nail construct stability and clinical outcomes. © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees.