Busan Paik Hospital

Busan, South Korea

Busan Paik Hospital

Busan, South Korea
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Kim E.Y.,Seoul National University | Chang S.M.,Kyungpook National University | Shim J.C.,Busan Paik Hospital | Joo E.J.,Eulji General Hospital | And 3 more authors.
Current Medical Research and Opinion | Year: 2013

Objective: The current study compared the long-term effectiveness, safety, and tolerability of paliperidone extended-release (ER) among patients with schizophrenia who had switched from risperidone (risperidone group) or other antipsychotic medications (non-risperidone group) due to lack of efficacy, intolerability, or non-adherence. Research design and methods: This open-label, prospective, multicenter, 48 week study utilized the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression-Severity scale (CGI-S), the Personal and Social Performance scale (PSP), and the Subjective Well-being under Neuroleptics scale (SWN) to assess patients with schizophrenia. Additionally, extrapyramidal symptoms (EPS) and subjective side effects were evaluated with validated scales. Clinical trial registration: Clinicaltrials.gov identifier: NCT00864045. Results: The completion rate for this study was 51.6% (95/184), and 169 patients finished with ≥1 post-baseline assessment (81 patients in the risperidone group, 88 in the non-risperidone group). The mean (SD) PANSS total score decreased significantly from 78.3 (18.8) to 65.5 (19.7) in the risperidone group and from 79.1 (19.8) to 65.4 (20.8) in the other group (all p < 0.001). Similar to PANSS, the severity rating for overall scores of the CGI-S and the PSP scores improved significantly from baseline (all p < 0.001). The magnitude of improvement in all effectiveness measures at 48 weeks did not differ between the two groups. EPS and subjective side effects improved significantly for all patients. Akathisia (18.5%) and increased weight (14.1%) were the main adverse events. Elevated prolactin levels were identified in female subjects in the non-risperidone group. Conclusions: Switching from previously unsuccessful antipsychotic treatments to paliperidone ER can be a useful option to achieve long-term improvement in symptoms and functioning for patients with schizophrenia. The clinical effectiveness appeared to be similar in patients who previously received risperidone and those treated with other antipsychotic medications. The open-label design and lack of a placebo group were limitations. © 2013 All rights reserved.

Bae S.K.,Catholic University of Korea | Shon J.-H.,Inje University | Shon J.-H.,Busan Paik Hospital
Archives of Pharmacal Research | Year: 2011

Innovative attempts have been made to overcome nonproductivity and high expenditure in the clinical stages of new drug development. Microdosing studies using subpharmacological doses provide early insight into the body's disposition toward candidate compounds, and are innovative exploratory trials that can promote productivity in drug development. Highly sensitive analytical technology is crucial in microdosing studies that employ qualitative and quantitative assays of target materials in humans. Accelerator mass spectrometry (AMS) has facilitated the adoption of a human microdosing study in the early phase of clinical drug development. Results derived from AMS microdosing studies using labeled compounds can provide various types of information for candidate selection, including pharmacokinetic characteristics and metabolic profiles of candidate compounds. The applicability of microdosing studies is currently expanding into absolute bioavailability and mass balance studies. Although it remains uncertain whether microdosing adequately predicts the pharmacokinetics of therapeutic doses, further development of microdosing studies using AMS may benefit the field of new drug development and could pose a new challenge to researchers. The use of advanced technology in candidate selection will contribute to improved productivity and competitiveness in pharmaceutical research and development. The introduction of microdosing studies using AMS in Korea will present a newly applicable method for innovative clinical trials and contribute to development potential in global competition. © 2011 The Pharmaceutical Society of Korea and Springer Netherlands.

Song M.-K.,Pusan National University | Chung J.-S.,Pusan National University | Shin H.-J.,Pusan National University | Lee S.-M.,Busan Paik Hospital | And 5 more authors.
Annals of Hematology | Year: 2012

The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL).We evaluated 169 patients with nodal stages II and III DLBCL who underwent measurements with PET prior to rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP). Cutoff point of MTV was measured using the receiver operating characteristic (ROC) curve. During a median period of 36 months, stage II was 59.2% and III was 40.8%. Using the ROC curve, the MTVof 220 cm 3 was the cutoff value. The low MTV group (<220 cm 3) had longer progression-free survival (PFS) and overall survival (OS), compared with the high MTV group (≥220 cm 3) (p<0.001, p<0.001). Stage II patients had longer survival than those in stage III (PFS, p=0.011; OS, p= 0.001). The high MTV group had lower PFS and OS patterns, regardless of stage, compared with the low MTV group (p<0.001, p<0.001). Multivariate analysis revealed an association of the high MTV group with lower PFS and OS (PFS, hazard ratio (HR)=5.300, p<0.001; OS, HR= 7.009, p<0.001), but not stage III (PFS, p=0.187; OS, p= 0.054). Assessment of MTV by PET had more potential predictive power than Ann Arbor stage in the patients that received R-CHOP. © Springer-Verlag 2012.

Park J.-Y.,Shoulder | Kim J.-H.,Busan Paik Hospital | Lhee S.-H.,Shoulder | Lee S.J.,Pusan National University
Journal of Shoulder and Elbow Surgery | Year: 2012

Hypothesis: Inferomedial support may affect the results of the hot air balloon technique for the treatment of displaced, 3-part fractures of the proximal humerus. Methods: Forty-three patients with displaced, 3-part fractures of the proximal humerus treated with the hot air balloon technique between 1995 and 2007 were included in the study. All patients were classified into 4 subgroups based on the presence or absence of medial buttress restoration and inferomedial screw insertion (R+, restored with inferomedial screw; R-, restored without inferomedial screw; NR+, non-restored with inferomedial screw; and NR-, non-restored without inferomedial screw). Assessment of radiologic and clinical outcome among subgroups was based on evaluation of neck-shaft angle, American Shoulder and Elbow Surgeons score, and Neer score. Results: The mean follow-up duration was 65 ± 29.7 months. The change in the neck-shaft angle in the R+, R-, NR+, and NR- groups was 3°, 2°, 3°, and 11°, respectively. The mean American Shoulder and Elbow Surgeons scores in the R+, R-, NR+, and NR- groups were 91 ± 4.8, 86 ± 5.4, 85 ± 1.9, and 77 ± 5.8, respectively. The mean Neer scores in the R+, R-, NR+, and NR- groups were 92 ± 4.3, 88 ± 4.0, 87 ± 2.1, and 76 ± 8.2, respectively. Conclusions: Medial buttress restoration and inferomedial screw insertion affect bone-nail construct stability and clinical outcomes. © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees.

Song M.-K.,Pusan National University | Chung J.-S.,Pusan National University | Shin H.-J.,Pusan National University | Moon J.-H.,Daegu University | And 6 more authors.
Cancer Science | Year: 2012

Primary gastrointestinal (PGI) diffuse large B cell lymphoma (DLBCL) is a relatively common disease. Recent studies indicate that measurement of maximum standardized uptake value (SUVmax) on pretreatment for 18F-fluorodeoxyglucose PET is an important prognostic factor in PGI DLBCL. However, there is still an association between initial tumor burden and prognosis. Thus, in the present study, we investigated whether tumor volume by PET could have a potential prognostic value to predict the outcome. From 2006 to 2009, 165 Stage I E/II E PGI DLBCL patients were enrolled in the study. One hundred and five patients received cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP) only, whereas 60 patients underwent surgery plus R-CHOP. Metabolic tumor volume (MTV) was defined initial tumor burden as target GI lesion above SUV, 2.5 by PET as a contouring border. Over a median follow-up period of 36.6 months, receiver operating characteristic (ROC) analysis indicated that the best cutoff values for MTV and SUVmax were 160.1 cm3 and 12.0, respectively. The estimated area under the ROC curve was higher for MTV than SUVmax. Thus, MTV was a better predictor for survival than SUVmax. In patients with a low MTV (<160.1 cm3), there were no significant differences in survival between patients undergoing R-CHOP alone and surgery plus R-CHOP (P = 0.347 for progressionfree survival [PFS]; P = 0.148 for overall survival [OS]). Conversely, in patients with a high MTV (>160.1 cm3), survival was longer in those who underwent surgery plus R-CHOP than in those treated with R-CHOP alone (P < 0.001 for PFS; P < 0.001 for OS). Multivariate analysis revealed that high MTV is an independent factor for predicting survival. Even in the era of rituximab, treatment of PGI DLBCL is not easy in patients with a high MTV. © 2011 Japanese Cancer Association.

Moon C.-S.,Catholic University of Pusan | Lee C.K.,Busan Paik Hospital | Hong Y.S.,Dong - A University | Ikeda M.,Kyoto Industrial Health Association
Asia Pacific Journal of Clinical Nutrition | Year: 2014

This survey was initiated to examine possible coastal-inland differences in cadmium (Cd) burden in general Korean populations. In total, 268 healthy non-smoking middle-aged women (30 to 49 years; 88 residents in 8 coastal areas and 180 residents in 15 inland areas) participated in the study. They offered peripheral blood and spot urine samples so that cadmium in blood (Cd-B) and urine (Cd-U) were taken as exposure markers. Determination of Cd-B and Cd-U was carried out by graphite furnace atomic absorption spectrophotometry. With regard to Cd burden, geometric means for the coastal and inland residents were 1.70 and 1.72 μg/L for Cd-B, 1.54 and 1.00 μg/L for Cd-U as observed (Cd-U), 2.59 and 1.81 μg/g creatinine for Cd-U as corrected for creatinine (Cd-Ucr), respectively. Cd-U and Cd-Ucr were higher in the coastal areas than in inland areas. Reasons for higher Cd-U in the coastal areas than in the inland areas were are discussed in relation to major sources of Cd in daily life of the residents. Attention was paid to consumption of fish and shellfish in the coastal areas as major sources of dietary Cd intake. This study shows that Cd burdens were higher in coastal areas than in inland areas in Korea.

Yang J.W.,Busan Paik Hospital | Choi J.-W.,Busan Paik Hospital | Lee S.G.,Busan Paik Hospital | Kim D.S.,Choi Eye Clinic
Orbit | Year: 2011

Background: The long-term use of an artificial eyes can lead to complications. Persistent physical stimulation and foreign body contact cause secondary infections. Secondary infection is an important complication after the placement of a artificial eyes and may be difficult to control without removing the artificial eyes. Because of these complications, patients get difficulties to wear prosthesis. Furthermore artificial eyes can change the normal bacterial flora of the patient's conjunctiva. Such postoperative infections might be overcome by improving the antimicrobial properties of the prosthesis surface. Methods: The space in the mold previously occupied by wax was filled with polymethyl methacrylate (PMMA) resin containing silver at a concentration of 300-700 ppm (parts per million) and the prosthesis was then heat cured. Microorganisms were grown on the treated and control surfaces. We cultured for 24 hours, then counted the number of bacteria in resin compositions containing nano-sized silver particles and controls (Stomacher 400® POLY-BAG). Results: The surface of the artificial eye containing silver grew significantly fewer Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli on in vitro bacterial cultures. The antimicrobial activity was 4.8-6.2 times stronger than for the controls. The numbers of bacteria decreased by 99.9% using the PMMA resin containing silver. Conclusion: The artificial eyes containing silver that were produced in this study have antibacterial activity, cause little eye discharge, and emit far-infrared rays and anions, all of which promote the ocular health of the person wearing the artificial eye. © 2011 Informa Healthcare USA, Inc.

Lee K.,Busan Paik Hospital
Asia Pacific Journal of Clinical Nutrition | Year: 2012

This study aimed to assess the prevalence of overweight misperception, unhealthy diet practices, and factors associated with these weight-related behaviors among Korean adolescverents. The subjects were a nationally representative sample of non-oweight students (52,515 in 2005, 64,084 in 2006, and 67,113 in 2007) in middle and high schools who completed the Korea Youth Risk Behavior Web-Based Survey. The prevalence of weightrelated behaviors and factors associated with these behaviors were assessed using a complex sampling design. Of non-overweight students, 14.9% of boys and 22.2% of girls reported their weight as overweight/obese. Dieting within the last year was reported by 19.8% of boys and 41.8% of girls. Of those who attempted dieting, 17.1% of boys and 24.6% of girls indicated practicing at least one unhealthy diet behavior within the last month. Overweight misperceptions were independently associated with diet attempts and unhealthy diets after adjustment for weight status, and demographic, social, and psychological factors. Additionally, these weight-related behaviors were also associated with psychosocial factors such as low school achievement, sadness, suicidal ideation, increased stress perception, and cigarette or alcohol use. In conclusion, the high prevalence of inappropriate weight-related behaviors suggests a need for comprehensive approaches to improve weight-related behaviors in non-overweight Korean adolescents.

This study assessed the association between vitamin D sufficiency (serum 25(OH)D ≥30 ng/mL) and alcohol consumption using data from the Korea National Health and Nutrition Examination Survey conducted in 2009. The following characteristics were obtained in 7,010 Korean participants ≥19-years-of-age: serum 25(OH)D level, alcohol consumption (drinking frequency, drinking number of alcoholic beverages on a typical occasion, average daily-alcohol intake), and potential confounders (age, residence, housing status, occupation, total fat and lean mass, smoking, physical activity, history of liver diseases, liver function, and daily intake of energy, protein, and calcium). After adjusting for confounders, vitamin D sufficiency in men was significantly associated with drinking frequency, number of alcoholic drinks consumed, and average daily alcohol intake; odds ratio of 1.21-1.72, 2.17-3.04, and 2.27-3.09, respectively. Increase in the three alcohol drinking-related behaviors was also linearly associated with increase in serum 25(OH)D level in men. By comparison, there was no significant association between alcohol intake and serum 25(OH)D level in women. The positive association between vitamin D sufficiency and alcohol consumption was evident only in Korean men. © 2012 The Korean Nutrition Society and the Korean Society of Community Nutrition.

Lee K.,Busan Paik Hospital
Journal of Bone and Mineral Metabolism | Year: 2013

The aim of this study was to examine sexspecific relationships between insulin resistance (IR) and bone mineral content (BMC) according to age group and weight status. A population-based sample of 618 Korean adolescents (315 male and 303 female), aged 10-19 years from the Fourth Korea National Health and Nutrition Examination Survey, 2009. They were divided into three age groups (10-12;13-16;17-19 years) and two weight groups (non-overweight vs. overweight). IR was assessed using the homeostatic model of assessment of IR (HOMA-IR). Soft tissue composition (fat and lean mass) and BMC of the whole body, proximal femur, and lumbar spine were measured by dual energy X-ray absorptiometry. Adiposity (body mass index, waist circumference, or soft tissue composition), age, height, total cholesterol, triglycerides, high density lipoprotein cholesterol, alkaline phosphatase, serum vitamin D, dietary calcium and energy intake, and menarche for females were adjusted using general linear models of a complex sampling design. Higher HOMA-IR was associated with a decrease in BMC in male adolescents aged 13-19 years after adjustment for adiposity and other confounders, while the associations were not significant in male adolescents aged 10-12 years and female adolescents. After adjustment for adiposity and confounders, the inverse associations between HOMA-IR and BMC were more consistent in non-overweight male adolescents than in other weight groups (overweight males and non-overweight and overweight females). The unfavorable effect of IR on BMC appears to be more obvious in males aged 13-19 years or non-overweight males than in females. © The Japanese Society for Bone and Mineral Research and Springer Japan 2012.

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