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Karaagac K.,Bursa Postdoctorate Training and Research Hospital | Yildiz A.,Uludag University | Tenekecioglu E.,Bursa Postdoctorate Training and Research Hospital | Ozluk O.A.,Bursa Postdoctorate Training and Research Hospital | And 2 more authors.
Journal of Clinical and Analytical Medicine | Year: 2016

Aim: Chronic renal failure (CRF) is a major factor for ventricular arrhythmia. Chronic inflammation and other factors contribute to formation of arrhyth-mogenic substrate. The aim of our study was to assess ventricular repo-larization in CRF patients receiving hemodialysis, by using QT dispersion, T wave peak to T wave end interval (Tp-e interval), Tp-e/QT ratio, and Tp-e/QTc ratio. Material and Method: Electrocardiogram of 35 CRF patients receiving hemodialysis were studied. T wave peak to end interval, QT and corrected QT intervals and some other ECG intervals were measured. Electrocardiograms of age and sex matched 30 healthy individuals were also analyzed for com-parison. Results: CRF group and control group were significantly different from each other for calculated Tp-e (92.9±24.7 vs 77.0±9.6, p=0.002), Tp-e/QTc (0.20±0.0 vs 0.18±0.0, p=0.007), QTd (58.9±45.6 vs 27.3±7.6, p=0.001), and Tp-e/QT (0.24±0.1 vs 0.21±0.0, p=0.034)values. QTc (457.9±50.8 e karşı 436.4±43.1, p=0.077) values were similar in both groups. Discussion: QTd, Tp-e, Tp-e/QT and Tp-e/QTc are relatively new markers which also indicate repolarization defects. Our findings indicate that these new markers may be useful in determination of ventricular electrical instability in CRF patients receiving hemodialysis. © Journal of Clinical and Analytical Medicine. Source


Yontar O.C.,Bursa Postdoctorate Training and Research Hospital | Karaagac K.,Bursa Postdoctorate Training and Research Hospital | Tenekecioglu E.,Bursa Postdoctorate Training and Research Hospital | Tutuncu A.,Bursa Postdoctorate Training and Research Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2014

Mitral valve prolapse (MVP) has been long known for causing susceptibility for ventricular arrhythmogenesis, and this risk was evaluated by various methods, mostly by using QT interval related measurements on surface electrocardiogram. T wave peak to end (Tp-e) interval is a relatively new marker for ventricular arrhythmogenesis and repolarization heterogeneity. Prolongation of this interval represents a period of potential vulnerability to re-entrant ventricular arrhythmias. However, there is no information available assessing the Tp-e interval and related calculations in patients with MVP. The aim of this study was to assess ventricular repolarization in patients with MVP by using QT, corrected QT (QTc) and Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Electrocardiogram of consecutive 72 patients, who were followed by outpatient clinic because of mitral valve prolapse, were obtained and scanned. Electrocardiograms of age and sex matched 60 healthy control individuals were also gained for comparison. QT, QTc, Tp-e/QT and Tp-e/QTc were calculated. Baseline characteristics were similar in both groups. QT (405.1±64.3 vs. 362.1±39.1; p<0.001), QTc (457.6±44.4 vs. 428.3±44.7; p<0.001), Tp-e (100.2±22.1 vs. 74.6±10.2; p<0.001) and Tp-e/QT (0.24 vs. 0.20; p<0.001) and Tp-e/QTc (0.21 vs. 0.17; p<0.001) were significantly worse in MVP group. Our study revealed that Tp-e interval and Tp-e/QT ratio were increased in MVP patients. Tp-e interval and Tp-e/QT ratio might be a useful marker of cardiovascular morbidity and mortality due to ventricular arrhythmias in patients with MVP. © 2014, E-Century Publishing Corporation. All rights reserved. Source


Yontar O.C.,Bursa Postdoctorate Training and Research Hospital | Tenekecioglu E.,Bursa Postdoctorate Training and Research Hospital | Karaagac K.,Bursa Postdoctorate Training and Research Hospital | Tutuncu A.,Bursa Postdoctorate Training and Research Hospital | And 3 more authors.
Acta Medica Mediterranea | Year: 2015

Introduction: Among the markers of inflammation, in coronary artery disease neutrophil-lymphocyte ratio has been reported the greatest predictive power for poor outcomes in patients with coronary artery disease. Microvascular perfusion failure due to infarct related artery reduces either myocardial tissue salvage or recovery of myocardial functions. Thrombus aspiration can theoretically protect the microcirculation from distal embolization. The aim of this study was to investigate the relation between the neutrophil- lymphocyte ratio (NLR) and the cardiac enzymes with thrombus aspiration in patients with acute ST segment elevated myocardial infarction (STEMI). Methods: Retrospective data of 350 consecutive patients were evaluated for this study. After exclusions, remaining 163 patients with acute anterior STEMI who had undergone primary PCI were recruited. Results: There was significant negative correlation between thrombus aspiration and peak troponin value (r=-0.18 p=0.031), there was a significant positive correlation between NLR and peak troponin value (r=0.26 p=0.003). In multivariate linear regression analysis, thrombus aspiration and NLR were found to be independent predictors of peak troponin increase in all patients enrolled for the study. Conclusion: NLR is already an available biomarker that provides important information about the inflammatory activity during acute phase of acute coronary syndromes and may help in risk stratification of patients with STEMI beyond conventional risk scores. Thrombus aspiration seems effective in decreasing myocardial injury, which might lead to better in-hospital prognosis. In patients with anterior STEMI, thrombus aspiration and initial lower NLR values may predict less myocardial injury. Source


Yontar O.C.,Bursa Postdoctorate Training and Research Hospital | Karaagac K.,Bursa Postdoctorate Training and Research Hospital | Tenekecioglu E.,Bursa Postdoctorate Training and Research Hospital | Tutuncu A.,Bursa Postdoctorate Training and Research Hospital | And 2 more authors.
Biomedical Research (India) | Year: 2014

Atrioventricular nodal reentry tachycardia (AVNRT) is known to be associated with increased risk of susceptibility for ventricular arrhythmias and sudden death. Studies indicate that prolongation of the interval between the peak and end of the T wave (Tpeak to Tend, Tp-e) on the 12-lead ECG is a marker of ventricular arrhythmogenesis. The aim of this study was to assess ventricular repolarization in patients with AVNRT by using Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio. Patient records of Bursa Postdoctorate Training and Research Hospital were retrospectively analyzed. Electrocardiogram of 62 patients, who were diagnosed with AVNRT by electrophysiological study, were obtained and scanned. T wave peak to end interval, QT and corrected QT intervals and some other ECG intervals were measured. Electrocardiograms by age and sex were matched with 34 healthy individuals who were compared as controls. Patients with critical coronary stenosis, moderate or severe valvular disease, left and/or right heart failure, left and/or right ventricle hypertrophy, atrial fibrillation, right or left bundle block or patients who got pacemaker or ICD implanted were excluded from this study. Both groups did not differ in patient demography. Mean values for AVNRT patients and control group were: QT (362.7±43.7 vs 364.1± 34.1), QTc (417.8±43.2 vs 438.3±44.2) and Tp-e interval (83.5±16.6 vs 77.0±9.7). Tpe/ QT and Tp-e/QTc ratio were also higher in the AVNRT group. T wave peak to end interval is a measure of transmural dispersion of repolarization in the left ventricle and accepted as a surrogate for increased risk of ventricular arrhythmogenesis. Tp-e/QT and Tp-e/QTc are relatively new markers; which also indicate repolarization defects. Our results show that Tpe (p=0.018), Tp-e/QT (0.23 vs 0.21; p=0,008) and Tp-e/QTc (0.20 vs 0.17; p=0.000) were significantly higher in AVNRT group; which correspond to previous studies about strong relationship between AVNRT and ventricular arrhythmia. © 2014, Scientific Publishers of India. All rights reserved. Source

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