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Larenkov A.A.,Burnazyan Federal Medical Biophysical Center | Bruskin A.B.,Burnazyan Federal Medical Biophysical Center | Kodina G.E.,Burnazyan Federal Medical Biophysical Center
Radiochemistry | Year: 2014

Ion-exchange behavior of 68Ga in the mixed HCl-acetone medium on cation and anion exchangers was studied. The equilibrium gravimetric distribution coefficients of 68Ga on Dowex AG 50W×8 strongly acidic cation exchanger in the H+ form and on Dowex AG 1×8 strongly basic anion exchanger in the Cl- form in mixed HCl-acetone solutions at HCl concentrations in the range 0.1-3 M and acetone volume fractions in the range 0-90% were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl-acetone solutions were studied. A process based on the data obtained was developed for preparing 68Ga solutions in 0.1 MHCl of high chemical and radiochemical purity, suitable for producing 68Ga radiopharmaceuticals of required quality (radiochemical purity 98.1 ± 1.4%). © 2014 Pleiades Publishing, Inc.


Bogomolov A.V.,Russian Academy of Sciences | Dragan S.P.,Burnazyan Federal Medical Biophysical Center
Doklady Biochemistry and Biophysics | Year: 2015

A new approach to studying the tympanic membrane impedance characteristics, based on the analysis of polyharmonic acoustic signals reflected by the tympanic membrane, is described. For this purpose, the acoustic pressure and the phase difference between the acoustic vibrations in two sections of a waveguide sealingly connecting the external auditory meatus and a generator of polyharmonic audio signals is measured. By processing the results of measurements, the estimates of the frequency-dependent reflection coefficients, absorption coefficients, and components of the acoustic impedance of the tympanic membrane are calculated. The features that principally distinguish the developed approach from other approaches are the absence of the necessity to create a positive pressure in the external auditory meatus, the absence of ultrasonic radiation into the external auditory meatus and a high-intensity sound, and the possibility of direct measurement of the tympanic membrane impedance in the audio frequency range with any step. © 2015, Pleiades Publishing, Ltd.


Bogomolov A.V.,Burnazyan Federal Medical Biophysical Center | Dragan S.P.,Burnazyan Federal Medical Biophysical Center
Doklady Biochemistry and Biophysics | Year: 2015

A new method for measuring a complex frequency-dependent acoustic impedance of the respiratory tract based on two-microphone method was developed. The measuring device consists of a waveguide connected through a mouthpiece to the patient’s mouth. A sound field with a frequency range from 5 to 100 Hz is created in the waveguide. The impedance of the respiratory tract is determined at free respiration of the patient in the set frequency range; the duration of examination does not exceed 15 s. The criteria for the recognition of respiratory tract pathologies are proposed. © 2015, Pleiades Publishing, Ltd.


Guskova A.K.,Burnazyan Federal Medical Biophysical Center
Atomic Energy | Year: 2013

Comparison of urgent decisions and retrospective analysis of the assessments made during the early stages of the Chernobyl accident shows that the early measures were consistent with the information available at the time. Subsequently, only some quantitative refinements, characterizing the health consequences, were introduced. The sources of errors in the data interpretation, resulting in social stress and making no positive contributions to the physical and psychological health of the participants in the accident, are identified. The public health consequences of the emissions due to the accident and the principles for subsequent observation of these consequences are evaluated. © 2012 Springer Science+Business Media New York.


Koshelev Y.A.,Burnazyan Federal Medical Biophysical Center
Molecular Biology | Year: 2014

Affinity chromatography with the subsequent identification of selectively binding proteins can be an efficient way to detect biologically significant molecular interactions. To optimize this method, it is necessary to take into account the structure of the molecule and its surface charge, as well as the possibilities to control its conformational changes, which can affect the hydrophobic properties of the surface. Using this approach, we identified several new target proteins of S100A4, including cytoskeleton proteins Sept2, Sept7, Sept11, and the transcriptional cofactor Ddx5. Interaction with septins may explains how S100A4 can affect cell motility, while its complex formation with Ddx5 apparently regulates the expression of E-cadherin, p21 (Waf1/Cip1), Bnip3, and other genes. The proposed protocol can be applied to search for target proteins of other S100 family members, since their amino aside sequences and spatial structures are highly homologous. © 2014, Pleiades Publishing, Inc.


Rublevskiy V.P.,Burnazyan Federal Medical Biophysical Center
Atomic Energy | Year: 2012

Total 14C emission from stopped commercial uranium-graphite and heavy water reactors over their operating time and the effect of this emission on the radiation conditions were studied. Waste gas was collected by passing it through a bubbler with a Ba(OH)2 solution, which catches CO2. Before the measurements were performed, the foreign radioactive and organic impurities were removed from the BaCO3 powder obtained. The 14C content in some biological objects at the reactor sites was determined at the same time. The carbon in the biological samples was converted by chemical methods into benzene (14C6H6) and measured by liquid scintillation. It is possible to suggest an ecologically acceptable method of burning irradiated graphite, which will make it possible to discharge into the atmosphere technogenic 14C in the form 14CO2 and 14CO without additional exposure of live organism.


Guskova A.K.,Burnazyan Federal Medical Biophysical Center
Atomic Energy | Year: 2012

Data on the health consequences of the 1986 Chernobyl accident are generalized. The volume and quality of the information available at different times after the accident which is required for diagnostics of the prognosis and for picking methods for minimizing the consequences of the accident are evaluated. The decisions made during the early period using the limited information available at the time but requiring that immediate measures be taken, whose accuracy can be evaluated in the future, are compared. Three basic groups of individuals drawn into the accident situation with a different combination of health risk factors are singled out: emergency shift workers, participants in post-accident cleanup, and the population in the accidental emission zone. The health consequences for these groups and the principles of their observation in the future are evaluated. © 2012 Springer Science+Business Media New York.


PubMed | Burnazyan Federal Medical Biophysical Center and Moscow State Technical University
Type: Journal Article | Journal: Doklady. Biochemistry and biophysics | Year: 2016

The results of an experimental study of manifestations of the acoustic reflex with contralateral auditory stimulation at a frequency of 1 kHz are presented, and the principal possibility and informativeness of its use for diagnosing the diseases of the organ of hearing are demonstrated. The principal difference of the developed approach is the use of polyharmonic signal for measuring acoustic reflex manifestations during contralateral stimulation, which allows accelerating the examination procedure.


PubMed | Burnazyan Federal Medical Biophysical Center and Russian Academy of Sciences
Type: | Journal: Doklady. Biochemistry and biophysics | Year: 2015

A new approach to studying the tympanic membrane impedance characteristics, based on the analysis of polyharmonic acoustic signals reflected by the tympanic membrane, is described. For this purpose, the acoustic pressure and the phase difference between the acoustic vibrations in two sections of a waveguide sealingly connecting the external auditory meatus and a generator of polyharmonic audio signals is measured. By processing the results of measurements, the estimates of the frequency-dependent reflection coefficients, absorption coefficients, and components of the acoustic impedance of the tympanic membrane are calculated. The features that principally distinguish the developed approach from other approaches are the absence of the necessity to create a positive pressure in the external auditory meatus, the absence of ultrasonic radiation into the external auditory meatus and a high-intensity sound, and the possibility of direct measurement of the tympanic membrane impedance in the audio frequency range with any step.


PubMed | Burnazyan Federal Medical Biophysical Center
Type: | Journal: Doklady. Biochemistry and biophysics | Year: 2015

A new method for measuring a complex frequency-dependent acoustic impedance of the respiratory tract based on two-microphone method was developed. The measuring device consists of a waveguide connected through a mouthpiece to the patients mouth. A sound field with a frequency range from 5 to 100 Hz is created in the waveguide. The impedance of the respiratory tract is determined at free respiration of the patient in the set frequency range; the duration of examination does not exceed 15 s. The criteria for the recognition of respiratory tract pathologies are proposed.

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