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Molokanov A.A.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Kukhta B.A.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Yatsenko V.N.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Bolshakova L.I.,Center for Hygiene and Epidemiology No 51 Federal Medical Biological Agency
Radiation Protection Dosimetry | Year: 2011

An example of a numerical method application for minimum detectable annual dose calculation that can be guaranteed by the operating monitoring programmes for plutonium and uranium is presented. The method analyses the frequency distribution for a total number of counts obtained in n measurements performed during n monitoring intervals that are inside the calendar year. Urine sample radiometric measurement technique for plutonium and uranium operating monitoring programmes is investigated, showing dependences of the detection limits on the frequency of measurements, on number of calendar years under observation and on the activity median aerodynamic diameter (AMAD). Only a probability density function (PDF), for the background number of counts, stochastic variability of urine excretion and uncertainty of the intake pattern were taken into account as the main variables influencing the calculated detection limits. But there is no limitation for the proposed method to include the variability of other influencing model parameters in the calculation procedure. © The Author 2010. Published by Oxford University Press. All rights reserved. Source


Maruk A.Y.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Klementyeva O.E.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Lesik E.I.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Larenkov A.A.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency | Bruskin A.B.,Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency
World Academy of Science, Engineering and Technology | Year: 2011

Alpfa-fetoprotein and its fragments may be an important vehicle for targeted delivery of radionuclides to the tumor. We investigated the effect of conditions on the labeling of biologically active synthetic peptide based on the (F-afp) with technetium-99m. The influence of the nature of the buffer solution, pH, concentration of reductant, concentration of the peptide and the reaction temperature on the yield of labeling was examined. As a result, the following optimal conditions for labeling of (F-afp) are found: pH 8.5 (phosphate and bicarbonate buffers) and pH from 1.7 to 7.0 (citrate buffer). The reaction proceeds with sufficient yield at room temperature for 30 min at the concentration of SnCl 2 and (Fafp) (F-afp) is to be less than 10 mkg/ml and 25 mkg/ml, respectively. Investigations of the test drug accumulation in the tumor cells of human breast cancer were carried out. Results can be assumed that the in vivo study of the (F-afp) in experimental tumor lesions will show concentrations sufficient for imaging these lesions by SPECT. Source

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