News Article | May 19, 2017
National Prevention Week: The Effectiveness of Worksite Programs in Reducing Opioid Abuse Dr. Joel Bennett CEO and Founder Organizational Wellness & Learning Systems, Inc. (OWLS) While the opioid and prescription drug epidemic has received considerable attention given the over 300,000 people it affects annually, relatively few realize the impact it's also having on the nation's workforce. It's become increasingly commonplace for employees to use prescription medication outside of intended use to improve job performance, overcome lack of sleep, or to alleviate pain. Although 70% of employers are negatively impacted by Rx abuse, less than 25% educate workers on prevention. Thirty percent do not provide access to alternative treatments. Says Dr. Bennett: "Employers are starting to realize the negative effects of Rx abuse on employee readiness, morale and productivity. But prevention programs can be a hard sell -- it's a challenge to demonstrate a concrete business return. Employers need to know that worksite awareness and education programs can be very effective in engaging people at the earliest stages of their Rx use and in a non-threatening way, steer them to safe alternatives. SAMHSA (Substance Abuse and Mental Health Services Administration) has laid out criteria and guidelines for evidence-based programs that produce positive outcomes; if properly implemented at the worksite, these programs have the potential to effectively educate a sizeable portion of at-risk employees who are otherwise hard to identify, let alone reach." Dr. Bennett is a widely sought-after speaker, consultant, and source on issues pertaining to evidence-based wellness. He has also published in a broad variety of academic, industry and business publications and consults internationally. ProfNet Profile: http://www.profnetconnect.com/joel_bennett Website: http://organizationalwellness.com Contact: Charles Epstein, email@example.com AI and Machine Learning in Medical Imaging Martin Hedlund Chief Technology Officer ContextVision "The concept of AI and machine learning has the potential to change the game of medical imaging. We can train neural networks with much more data than humans experience during a lifetime. This means that we can reproduce the competence of the best experts, or even outperform them! We can guarantee reproducibility in exams and diagnosis, and avoid human subjectivity and variations. With active learning models, results can continuously be improved. With better ground truth, i.e. data from different sources, time or outcome, AI can make better predictions, solve more complex tasks and make new discoveries." Based in Stockholm, Sweden, Hedlund is the chief technology officer and one of the founders of ContextVision. He finished his M.Sc. degree of Technology followed by further studies and research in image processing and GOP theory at Linköping University. He was R&D and site manager in Linköping until 1999 and has since served as CTO by focusing on strategic product and business development. Hedlund is spearheading the research and development of ContextVision's first AI-based imaging technology. By using algorithms, the product will be able to evaluate and enhance image quality automatically without the direct involvement of a clinical expert. This will improve workflow and improve diagnosis, and ultimately aid both patients and radiologists. Website: www.contextvision.com Contact: Stephanie Ross, firstname.lastname@example.org The Most Important Body Part You're Not Working Out Jonathan Jordan Personal Trainer, Nutrition Coach and Fitness Blogger Jonathan Jordan Fitness "As a successful personal trainer for Equinox in San Francisco, I've worked with hundreds of clients. They want to be lean. They want to be strong. They want to be healthy. But no one ever says, 'I want strong feet and mobile ankles.' Yet weak feet are often the biggest roadblocks to achieving their health goals. The ankle is one of our most important and commonly overlooked joints. Pain and injuries in the knees, hips and lower back can often be traced to issues at the ankle joint. Think of how often and how many ways we use our ankles: walking, running, biking, squatting, yoga, balancing, dancing -- you get the idea. If the muscles acting on your ankle are chronically tight or if the joint itself is jammed or lacks proper mobility, the impact can be painful and damaging, as the body will compensate at other joints to accommodate movement." Jordan recently wrote a blog post (see link below) that goes deep into the anatomy of the foot and includes an interview with physical therapist Dr. Sarah Jay. He has also included videos for his three favorite ankle mobility drills. He is available for interviews to help your readers, listeners, or viewers improve their ankle mobility, reduce pain and improve performance in their workouts Blog post: http://www.jj-fit.com/blog/ankle ProfNet Profile: http://www.profnetconnect.com/jonathan_jordan Website: http://www.jj-fit.com Expert Contact: email@example.com Can Stress Actually Kill You? Dr. Frieda Birnbaum Research Psychologist, Psychoanalyst Stress may take a toll on your mind, body, and heart, according to a new study from Massachusetts General Hospital and the Icahn School of Medicine at Mount Sinai. Researchers observed a strong correlation between activity in the amygdala -- the part of the brain activated by stress -- and subsequent cardiac events, such as heart attack, stroke, and angina. Says Dr. Birnbaum: "Our bodies are constantly reacting and responding to how we are thinking. If we stay locked into a state of high stress and anxiety for a prolonged period of time, our physical health will be affected for the worse. Yes, stress can kill you. However, there are many things a person can do to help manage their stress or remove it all together. One of the first things is to get to the root cause of the matter and resolve it, especially if it has something to do with guilt. Guilt is a powerful negative emotion that can prolong stress. If your boss or fellow employees have become a cause of stress, do whatever you can to be as far removed from them as possible, even if it means leaving your job. Any form or daily meditating or walking is another means of quieting your mind and opening doors of inner peace. Listening to peaceful music is also helpful. Stress is reactionary -- and you have the power to change how to react." Based in the New York metro area, Dr. Birnbaum is author of "Life Begins at 60: A New View on Motherhood, Marriage, and Reinventing Ourselves." She's an expert on depression, women's issues, and attaining happiness. Website: http://www.doctorfrieda.com Contact: Ryan McCormick, firstname.lastname@example.org Showtime's 'Billions' Predicts the Future Michael Klein, PsyD Psychologist, Principal MK Insights LLC Dr. Klein is available to speak about the relevance of the TV character Wendy Rhodes, an in-house psychiatrist in the fictitious firm of Axe Capital, as well as the history and trends behind this role. As a psychologist, he can address how personality, emotional intelligence, and motivators impact decision-making, management style, and potential "de-railing" behaviors: "It is impossible to work effectively in any job without running into roadblocks periodically. In-house psychiatrists and psychologists don't provide therapy at work but, rather, apply sound psychological insights and tools to help employees and managers be effective at work based on their own interest in achievement and managing psychological barriers." Dr. Klein is a psychologist, workplace coach, and in-house performance consultant. He is also author of "Trapped in the Family Business: A practical guide to understanding and managing this hidden dilemma." Book: www.trappedinthefamilybusiness.com Website: www.mkinsights.com Expert Contact: email@example.com Fireworks Safety Jenny Ziembicki, M.D. Medical Director, UPMC Mercy Burn Center Assistant Professor of Surgery, University of Pittsburgh School of Medicine Faculty Member, McGowan Institute for Regenerative Medicine "Each year, around 4th of July celebrations, we treat many people, especially children and teens, who have been injured by fireworks. Many of those injuries involve an amputation of a limb or loss of vision. We want to remind everyone that fireworks should only be handled by professionals and enjoyed at a safe distance." Dr. Ziembicki has a special interest in the development of the comprehensive outpatient burn therapy program at UPMC Mercy, which allows patients a more expedient return to a productive lifestyle. She also is a dedicated advocate in burn injury prevention, especially in the geriatric and pediatric population. Bio: http://www.mirm.pitt.edu/our-people/faculty-staff-bios/jenny-ziembicki-md/ Contact: Stephanie Stanley, firstname.lastname@example.org Skin Damage and Car/Home Windows Darrell Smith Executive Director International Window Film Association "Whether you're spending the summer on the road or enjoying the warm sunshine streaming through your home's windows, you may be doing serious damage to your skin without even realizing. The average window only blocks about 25% of UV rays from passing through and car windows aren't much better -- blocking about 40% of UV rays. In America, nearly 53% of skin cancer cases occur on the left, or driver's side, of the body. Why? Because, we enjoy sunshine but aren't fully protected against damaging UV rays -- and spend a lot of time in the car! Professionally installed window film can help block up to 99% of UV rays from passing through a window, ultimately protecting your skin and eyes from cumulative damage." Website: www.iwfa.com Contact: Amber Joy Dempsey, email@example.com Fabric and Clothing Tips for Summer James Pruden Senior Director Cotton Incorporated Pruden can provide expert summer safety tips when it comes to anything and everything summer clothing, including what to wear for the best UV protection; what fabrics keep you cooler during the warm summer months; and the health benefits of natural fibers vs. synthetic fibers. Says Pruden: "All apparel provides some degree of UV protection. UV protection in apparel is dependent on a variety of factors, including thickness of fabric (thicker fabrics absorb more UV rays), tightness of construction and the fabric's color (darker colors provide more UV protection)." Pruden is senior director of public relations at Cotton Incorporated, where he oversees brand image management for the not-for-profit company. Contact: Caleb Fernandez, firstname.lastname@example.org Pool Safety Tips for Parents, Children and Pets Tom Casey Vice President of Sales Anthony & Sylvan Pools Casey is available to share pool safety tips for parents, children, and pets: "Pools are fun for the whole family, and pool safety is crucial when it comes to enjoying your pool to its fullest. By following just a few safety tips, you'll be sure to keep this season fun and safe." Casey is vice president of sales for Anthony & Sylvan Pools, the leading swimming pool and spa builder in the U.S. Contact: John Reynolds, email@example.com Tips for an Injury-Free Summer Dr. Benjamin Domb "As the weather gets warmer and the days get longer, adults and kids alike love to engage in outdoor sports and fitness activities. This increase in physical activity can lead to an increased risk of injury." Through his experience working with athletes, both professional and amateur, as well as fitness enthusiasts like CrossFitters and runners, Dr. Domb is available to provide effective tips for an injury-free summer. Dr. Domb is a nationally recognized orthopedic surgeon specializing in sports medicine and arthroscopic surgery of the hip, shoulder and knee. Website: http://www.benjamindombmd.com Contact: Rachel Prude, Rachel.firstname.lastname@example.org Summer BBQ Safety Tips Peter Duncanson Director, Disaster Restoration Business Operations ServiceMaster Restore Duncanson is available for interviews on summer BBQ safety tips, including proper charcoal grill safety, how to use a gas grill wisely, and how to practice good grilling habits: "Set your grill up at a safe distance from structures and overhangs, including your main building, shed, garage, trees and other potentially flammable objects. Never use your grill inside, in a tent or under an outdoor awning or carport. Doing so can pose a serious fire hazard and potentially cause carbon monoxide poisoning if you're using a gas grill. Light your gas or charcoal grill using special long-length lighters or long matches to avoid getting burned. Keep all ignition sources out of the reach of children. Never leave an actively burning grill unattended, and let your grill fully cool before you cover or store it. Clean your grill thoroughly and often to reduce flammable buildup inside." Contact: Bristol Whitcher, email@example.com Summer Safety Jared Staver Attorney Staver Law Group. P.C. Staver is available to discuss various summer safety topics, including sun glare accidents, motorcycle safety, pool/water safety, heat exhaustion and more. On motorcycle safety: "During the summer months, drivers and motorcyclists should take extra precautions to avoid accidents. Statistics show that more than 50% of motorcycle accidents involve riders with less than five months of riding experience. To minimize the risk of accidents, motorcyclists should always wear protective gear including proper eyewear and helmets. Make sure your bike is properly maintained before taking it out for the first summer ride and keep a toolkit on your bike at all times. Mechanical defects can contribute to road crashes." Staver is a Chicago personal injury attorney and owner of Staver Law Group, P.C. His practice focuses on representing people seeking compensation after being hurt in the Chicago area, whether by a car accident, slip and fall, workplace accident, dog bite, or from an act of medical malpractice. An experienced and dedicated litigator, Jared has recovered tens of millions of dollars in settlements and verdicts for his clients. Bio: https://www.chicagolawyer.com/about-staver-law-group/jared-staver/ Website: https://www.chicagolawyer.com Contact: John Branham, firstname.lastname@example.org How to Stay Safe on the Job/Keep Employees Safe David Quezada Vice President of Loss Control EMPLOYERS "Working in hot and sunny environments or near heat sources all day can wear employees down. To help employees rest and recharge, encourage them to take regular breaks in the shade or other cool environments. Build break times into employees' schedules to help enforce the practice. Make sure employees know how to recognize the signs of heat-related illness and the immediate steps they need to take to help themselves or their co-workers. In the event of a medical emergency, contact 911 immediately, but also train employees so they can be proactive before professional help arrives. Fostering a safe and comfortable work environment is an important commitment every day of the year, but especially when new risks, such as extreme heat, are introduced." EMPLOYERS is a specialty workers' compensation insurance carrier. Website: www.employers.com Contact: Alexandra Gardell Kreuter, EmployersInsurance@allisonpr.com Managing Medications During the Summer Jon Michaeli EVP of Marketing and Business Development Medisafe Michaeli is available to discuss the importance of managing your medications during the summer months, whether it's during vacations or ensuring that your children are keeping up with their medications while they're at summer camp. Managing medications essentially helps you to manage your conditions, resulting in improved outcomes. Contact: Kendra Lee, email@example.com What to Do During a Power Outage Keith Pinkerton Owner Mr. Electric, Huntsville, Ala. Pinkerton is available to discuss weather precautions and backup generators during storm season. He can advise homeowners what to do when there is a power outage and how to ensure electrical safety around the house in general. He is the owner of the Huntsville, Ala., branch of Mr. Electric, a national brand of electrical installation and repair centers. Website: https://mrelectric.com/huntsville Contact: Elise Rose, firstname.lastname@example.org Safety When Completing House Projects J.B. Sassano President Mr. Handyman Sassano is available to discuss safety when completing house projects, such as using power washers, power drills, climbing on ladders for gutter cleaning, etc. He is president of Mr. Handyman, the nation's leading home repair and maintenance franchise. Website: https://www.mrhandyman.com Contact: Elise Rose, email@example.com Injury Trends Darshan Patel, M.D. Chief of Pediatric Emergency Medicine Maria Fareri Children's Hospital Dr. Patel can provide commentary on a wide variety of summer conditions and their recommended treatment, as well as injury trends. As Section Chief, Dr. Patel serves as head of the Pediatric Emergency Department. He and his team are the first line of care for children in needing immediate care after injuries or at the onset of illnesses. Maria Fareri Children's Hospital, a member of the Westchester Medical Center Health Network, is the Level 1 pediatric trauma center for a region with more than 3 million people. In the past, Dr. Patel has been a media resource for summer safety topics, including ATV and water safety, as well as injuries caused by trampolines and fireworks. He has also contributed to reports regarding dehydration and heat stroke. He has television, radio and print media experience, and is adept at breaking down complex medical topics for families. He is available for media interviews when requests do not interfere with patient care. Contact: Andy LaGuardia, firstname.lastname@example.org Water Safety Tips Ann Marie Buerkle Acting Chairman U.S. Consumer Product Safety Commission Buerkle is available to discuss the many steps that parents can take to improve safety in and around water. As acting chairman of the U.S. Consumer Product Safety Commission (CPSC), Buerkle offers a unique perspective into the importance of safety in and around water. One of the national public education campaigns the Chairman oversees is the Pool Safely campaign, which is aimed at reducing child drownings and non-fatal submersions, as well as entrapments in public swimming pools and spas. The campaign was launched in 2010 and has a network of over 1,000 partners that are dedicated to promoting and benefitting from the campaign. Website: https://www.poolsafely.gov Contact: Christina Saull: Christina.Saull@finnpartners.gov Following are links to job listings for staff and freelance writers, editors and producers. You can view these and more job listings on our Job Board: https://prnmedia.prnewswire.com/community/jobs/ Following are links to other news and resources we think you might find useful. If you have an item you think other reporters would be interested in and would like us to include in a future alert, please drop us a line. PROFNET is an exclusive service of PR Newswire. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/profnet-experts-available-on-summer-safety-opioid-abuse-stress-more-300460792.html
News Article | May 10, 2017
The Get With the Guidelines-Stroke and Target: Stroke programs honored Grady for its outstanding stroke measures and its door to needle time for IV Alteplase, the FDA approved medication for dissolving blood clots. Grady Health System is one of the largest safety net health systems in the United States. Grady consists of the 953-bed Grady Memorial Hospital, six neighborhood health centers, Crestview Health & Rehabilitation Center, and Children's Healthcare of Atlanta at Hughes Spalding, which is operated as a Children's affiliate. With its nationally acclaimed emergency medical services, Grady has the premier Level I trauma center in the Metro Atlanta region and serves as the 911 ambulance provider for the city of Atlanta. Grady's American Burn Association/American College of Surgeons verified Burn Center is one of only two in the state. And the Marcus Stroke and Neuroscience Center is a Joint Commission designated Advanced Comprehensive Stroke Center. Other key services/distinctions include Grady's Regional Perinatal Center with its Neonatal Intensive Care Unit, Georgia's first Cancer Center for Excellence, The Avon Comprehensive Breast Center, the Georgia Comprehensive Sickle Cell Center, and the Ponce de Leon Center - one of the top HIV/AIDS outpatient clinics in the country. Grady is one of an elite group of hospitals to earn the Baby-Friendly USA international recognition as a Baby-Friendly Designated birth facility. In 2017, Grady earned the prestigious Stage 7 on the HIMSS Analytics Electronic Medical Record Adoption Model, becoming Georgia's first adult acute care hospital to earn the highest rating for improving patient care and safety through health information technology. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/grady-receives-top-stroke-award-300455217.html
Grieb G.,Yale University |
Grieb G.,Burn Center |
Grieb G.,RWTH Aachen |
Merk M.,Yale University |
And 2 more authors.
Drug News and Perspectives | Year: 2010
Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. Multiple clinical studies have indicated the utility of MIF as a biomarker for different diseases that have an inflammatory component; these include systemic infections and sepsis, autoimmune diseases, cancer, and metabolic disorders such as type 2 diabetes and obesity. The identification of functional promoter polymorphisms in the MIF gene (MIF) and their association with the susceptibility or severity of different diseases has not only served to validate MIF's role in disease development but also opened the possibility of using MIF genotype information to better predict risk and outcome. In this article, we review the clinical data of MIF and discuss its potential as a biomarker for different disease applications. Copyright © 2010 Prous Science, S.A.U. or its licensors. All rights reserved.
Van Hattem S.,University of Groningen |
Beerthuizen G.I.,Burn Center |
Kardaun S.H.,University of Groningen
British Journal of Dermatology | Year: 2014
Acute generalized exanthematous pustulosis (AGEP) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse drug reactions. Especially in TEN, large areas of the skin and mucosae may become detached. Although AGEP and SJS/TEN are distinct entities with a different clinical picture, pathogenesis, prognosis and treatment, they may share some features, raising the hypothesis of overlap between both entities. We present a severe case of AGEP, caused by flucloxacillin, clinically presenting with TEN-like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS/TEN or a supposed overlap with SJS/TEN. What's already known about this topic? Acute generalized exanthematous pustulosis (AGEP) can be accompanied by mild systemic involvement. Coalescence of pustules in AGEP can result in clinically toxic epidermal necrolysis (TEN)-like cutaneous features. Histopathology can assist in the differential diagnosis between AGEP and Stevens-Johnson syndrome or TEN. What does this study add? Flucloxacillin may cause AGEP. Severe neutrophilia in AGEP can contribute to the severity of systemic involvement. A literature review could not substantiate the existence of an AGEP-TEN overlap. © 2014 British Association of Dermatologists.
News Article | December 20, 2016
DALLAS - Dec. 20, 2016 - A new way to fight multidrug-resistant bacteria by blinding them rather than killing them proved highly effective in a model of burn injuries, UT Southwestern Medical Center research shows. "In the United States, there are more than 1 million burn injuries and 100,000 hospitalizations annually. Up to 75 percent of the mortality in burn patients is associated with infections, which are particularly common in patients who suffer extensive burns -- those that cover 40 percent or more of the body," said Dr. Steven Wolf, Section Chief for Burns and Professor of Surgery at UT Southwestern Medical Center. Dr. Wolf, one of three senior authors of the study published today in Scientific Reports, is also a former Director of the Burn Center at the U.S. Army Institute of Surgical Research in San Antonio, Texas. "Rather than killing the bacteria, we blinded them so they could not find the places where they normally stick to the host (body's) cells. If bacteria cannot bind, they cannot grow," said Dr. Wolf, who is also Surgery's Vice Chair for Research and holder of the Golden Charity Guild Charles R. Baxter, M.D. Chair. The study done in rats targeted one of the most lethal pathogens: multidrug-resistant Pseudomonas aeruginosa, which is found in approximately 33 percent of all burn cases and in 59 percent of extensive burns. The researchers showed that topical application of an engineered adhesion inhibitor molecule - Multivalent Adhesion Molecule 7, or MAM7 - substantially decreased the bacterial levels in wounds in the first 24 hours after administration and prevented the spread of the infection to adjacent tissue for three more days. In addition, the experimental molecule aided wound healing and maintained normal inflammatory responses to the burn, the researchers report. "Antibiotic-resistant bacteria are an increasingly prevalent problem in the clinic and hospital, so new ways to prevent and treat infections are direly needed. Antibiotics work by killing bacteria, which places microbes under extreme pressure to develop antibiotic resistance," said co-senior author Dr. Kim Orth, Professor of Molecular Biology and Biochemistry at UT Southwestern. "Our approach doesn't target bacterial survival; rather it targets the microbes' ability to damage the host - its virulence. There is no reason for the bacteria to become resistant to this approach. Being unable to bind to wounded tissue is an inconvenience, and the bacteria move on," Dr. Orth said. She compared the situation to the search for parking at a shopping mall. "If all the parking spaces are filled, then the bacteria have no place to park," said Dr. Orth, a Howard Hughes Medical Institute Investigator who also holds the Earl A. Forsythe Chair in Biomedical Science and is a W.W. Caruth, Jr. Scholar in Biomedical Research at UT Southwestern. The experimental molecule was developed in the Orth laboratory and grew out of the postdoctoral research project of the study's third senior author, Dr. Anne-Marie Krachler, now with the McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth). When working at UT Southwestern, Dr. Krachler studied a group of adhesion molecules called adhesins that are created by bacteria to bind, or stick to cells in an early and crucial step in causing infection. Although most adhesins are specific to various pathogens, members of the adhesion family she identified - Multivalent Adhesion Molecules, including MAM7 - are used by most gram-negative bacteria, including the type used in this burn study. In one UTSW experiment, Dr. Krachler detached MAM7 from the bacteria that produce it and showed that the lack of MAM7 made the bacteria much less able to cause infection. In 2013, Dr. Orth gave a UT Southwestern President's Lecture describing the molecular activity of MAM7. Dr. Wolf was in attendance, and approached Dr. Orth about a collaboration to test the efficacy of MAM7 using a fluorescent strain of antibiotic-resistant bacteria in a live animal model. That led to the multiyear effort to develop the recombinant MAM7 inhibitor attached to a scaffold made of bacteria-sized polymer microbeads that was used in this study. UT Southwestern has an international patent application filed on the molecule. "We attached lots of copies of MAM7 to the microbeads. In this study, we found that topically applied MAM7-coupled microbeads reach the cells' binding sites first and - for at least four days in this experiment - stay there, without hindering wound healing. The MAM7 adhesion inhibitors remain on the wounds and prevent the bacteria from binding to the tissue," Dr. Orth said. In addition to burns, Dr. Krachler said, this strategy could work against diabetic ulcers and surgical wounds that can become infected. "What's exciting about MAM7 is that the agent is so broad-spectrum. Most bacteria have their own specific type of adhesion molecules. For instance Vibrio uses one kind and Salmonella uses a different one and multidrug-resistant bacteria another, but almost all of them want to park in the same place. "Antibiotics are amazing drugs, and they have saved countless lives since their discovery more than 80 years ago. But there is a challenge - the challenge of antibiotic resistance that has made many antibiotics ineffective. A material that targets virulence instead of killing bacteria could be a way to treat infections that are resistant to antibiotics," she said. "This is a trial in rats. A future goal is to use this strategy in patients." Following the success of this proof-of-concept study, additional steps include testing whether the anti-adhesion strategy might also block infection of bacteria that can cause lethal infections during surgery, Dr. Orth said. UT Southwestern co-authors include: lead author Dr. Ryan Huebinger, Assistant Professor of Surgery; Dr. Marcela de Souza Santos, a postdoctoral researcher in Molecular Biology; Dr. Deborah Carlson, Assistant Professor of Surgery and Pediatrics; and Dr. Juquan Song, Assistant Professor of Surgery. Researchers at the University of Birmingham, United Kingdom, also participated. The research received support from the Biotechnology and Biological Sciences Research Council in the United Kingdom; the National Institutes of Health; Once Upon a Time...; the Welch Foundation; the Howard Hughes Medical Institute; the Golden Charity Guild Charles R. Baxter Chair in Burn Surgery, which provided additional research funding; and the Burroughs Welcome Fund. The U.S. Army Institute for Surgical Research provided the bioluminescent strain of P. aeruginosa used in this study. UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty includes many distinguished members, including six who have been awarded Nobel Prizes since 1985. The faculty of almost 2,800 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide medical care in about 80 specialties to more than 100,000 hospitalized patients and oversee approximately 2.2 million outpatient visits a year. This news release is available on our website at http://www. To automatically receive news releases from UT Southwestern via email, subscribe at http://www.
News Article | October 29, 2015
Troy Patchin practices getting in and out of a car as part of his physical therapy at The Ohio State University Wexner Medical Center. Patchin was burned over nearly half his body in a work accident, and as part of his treatment at Ohio State's More Dr. Larry Jones, director of the< a href="http://wexnermedical.osu.edu/patient-care/healthcare-services/burn-care">Comprehensive Burn Center at The Ohio State University Wexner Medical Center, contributed this column to Live Science's Expert Voices: Op-Ed & Insights. Patients with severe burns, understandably, suffer from substantially diminished appetites because they're in a considerable amount of pain and are often sedated, as a result. So it may seem counterintuitive to ask severely burned patients to consume considerably more calories than they're used to while in the hospital. Despite these challenges, when burn patients are admitted to the Comprehensive Burn Center at The Ohio State University Wexner Medical Center, we make nutrition a priority, often beginning a feeding tube within 6 hours. It's an aggressive approach that helps burn patients heal faster and recently earned international recognition. When someone experiences a severe burn, defined as a second- or third-degree burn that covers at least 20 percent of the body, the hypermetabolic response is extreme. Second- and third-degree burns occur when damage extends beyond the top layer of the skin. With a second-degree burn, the skin blisters and can become extremely red and sore. Third-degree burns are the worst type, extending through every layer of the skin. The damage can even seep into the bloodstream, bones and major organs. After the body's initial shock response to the injury wears off, metabolism rates can increase up to 180 percent, heart rates can jump by up to 150 percent and the liver can increase in size by up to 200 percent. In short, the body goes into hyperdrive to heal wounds, and it looks for nutrients wherever it can find them. Unless the patient receives large amounts of supplemental nutrients, the body will rob itself of core nutrients. Essentially, if patients aren't able to meet the high calorie and protein requirements it takes to heal, their body will start consuming its own muscle mass in order to deliver nutrition. Muscle wasting is most obvious in the arms, legs and abdomen. Once patients lose that muscle mass, their ability to exercise, undergo rehabilitation and fight infection are severely compromised. Doctors need to intervene early in this process to prevent muscle loss and give the patient's body the nutrients it desperately needs to heal. Upon admission to the burn center, patients are evaluated by a dietitian to determine their energy and protein needs. Many are given a feeding tube almost immediately, through which we provide them with up to three to four times the amount of protein they normally receive in a day and 140 percent more calories. Each case is different, of course, so nurses monitor a patient's weight and caloric intake daily and dietitians adjust nutrients as needed. As a patient's burns heal, they are transitioned to oral meals during the day, with supplemental feedings overnight through the tube. Among other ingredients, the feeding solution contains proteins, which are used by the body to repair and close wounds caused by the burn; glucose, which fuels the healing efforts; vitamin D, which helps modulate cell grown and, along with omega-3 fatty acids, helps control inflammation. Ingesting such a high volume of calories and supplements can be a challenge. Severe pain is associated with a marked loss of appetite and excessive intake can lead to nausea. When necessary, we may also prescribe patients medication to allow them to tolerate the additional feedings. The healing process continues long after discharge. At a microscopic level, severe burns can take anywhere from a year to 18 months to heal — in some cases, even longer. My colleagues and I at the burn center are currently studying whether nutritional support should continue after discharge. As patients prepare to leave the burn center, dietitians help develop personalized meal plans for use at home that are high in protein and carbohydrates to stimulate continued healing. When patients return to the burn center for follow-up care for their wounds, we re-evaluate their nutritional status as well.
News Article | February 16, 2017
When we think about safety net hospitals, the narrative often turns into one of facilities struggling to make use of limited resources to serve some of the most complex and challenging patient populations. Rarely do we align safety net hospitals with leading edge cognitive technology. But that is exactly what is happening at Grady Health System in Atlanta. Grady Health System (Grady) comprises a network of providers, clinics, and inpatient services that combine to deliver care for metro Atlanta. The system has served the community since 1892 and acted as a healthcare safety net for a diverse and growing population. As of last year, Grady treated almost 41,000 adult and newborn patients admitted to the main hospital and conducted close to 500,000 outpatient visits. Caring for such a large population requires innovation and focus. In 2016, system leadership wanted to find a way to better target resources and identify patients at risk of returning to the hospital within 30 days of discharge. These readmissions pose a real threat to patient health and provider viability. Government mandates focused on reducing preventable readmissions impose hefty fines for performance that doesn’t meet established thresholds. “We landed on Jvion’s Cognitive Clinical Success Machine,” explained Ben McKeeby, Grady’s Chief Information Officer. Cognitive Clinical Success Machine Technology leverages the same power as well know and established search engines and cognitive technologies that understand, reason, and learn. What makes Jvion’s Cognitive Clinical Success Machine unique is its ability to drive patient-specific prioritizations, predictions, recommendations, and interventions that are precise, integrated directly into the clinical workflow, and delivered in a matter of weeks. “The Cognitive Clinical Success Machine that Grady is using leverages self-learning Eigen sphere technology to deliver an ultra-high definition view into the future state of the patient. This view accounts for the tens of thousands of exogenous factors that impact a patient’s risk along with the clinical context provided during the episode of care,” explained Todd Schlesinger, Vice President at Jvion. The machine is making a significant impact on a hard to reach and treat population. In addition to targeting readmissions broadly, the Grady team is using the cognitive science solution to specifically identify those patients with Congestive Heart Failure. Teams across the facility—from inpatient nursing staff to case managers and EMTs—use recommendations from Jvion’s Cognitive Clinical Success Machine to most effectively lower a patient’s risk. “With Jvion’s solution we have a remarkable cognitive appliance that works as seamlessly as any diagnostic test to deliver the most precise and actionable interventions for our patient population,” said McKeeby. “This kind of technology is the future. And with Jvion, cognitive power is finally within reach for healthcare providers.” About Grady Health System Grady Health System is one of the largest safety net health systems in the United States. Grady consists of the 953-bed Grady Memorial Hospital, six neighborhood health centers, Crestview Health & Rehabilitation Center, and Children's Healthcare of Atlanta at Hughes Spalding, which is operated as a Children's affiliate. With its nationally acclaimed emergency medical services, Grady has the premier level I trauma center in the Metro Atlanta region and serves as the 911 ambulance provider for the city of Atlanta. Grady’s American Burn Association/American College of Surgeons verified Burn Center is one of only two in the state. And the Marcus Stroke and Neuroscience Center is a Joint Commission designated Advanced Comprehensive Stroke Center. Other key services include Grady’s Regional Perinatal Center with its Neonatal Intensive Care Unit, Georgia’s first Cancer Center for Excellence, The Avon Comprehensive Breast Center, the Georgia Comprehensive Sickle Cell Center, and the Ponce de Leon Center - one of the top three HIV/AIDS outpatient clinics in the country. About Jvion Jvion delivers a Cognitive Clinical Success Machine that serves as a high-performance appliance for providers and the healthcare community. It activates recommendations that help healthcare providers who need ultra-definition patient-level predictions, prioritizations, interventions, and suggestions produced with unmatched speed, clinical applicability, and verity. The machine delivers the action-level recommendations that will best reduce the likelihood of an adverse event. This capability is enabled by a cognitive engine driven by horsepower that is based on more than a quadrillion clinical and non-clinical considerations and thousands of data elements. The machine’s thousands of self-learning Eigen spheres are applied to this data for each patient in real time to help hundreds of hospitals across the nation reduce target illnesses and diseases. Jvion’s Cognitive Clinical Success Machine includes broad clinical application vectors that, when applied to specific patients, deliver individualized prioritizations, interventions, and suggestions within two weeks. One of the reasons Jvion’s solution is independently ranked number one in clinical predictive science is because the machine is more than accurate, it is effective. Our approach mitigates the “accuracy fallacy” perpetuated within the industry by delivering a true picture of individual patient risk along with the actions that will lead to better health outcomes. Because Jvion’s machine works as a cognitive appliance, it plugs in directly to the existing Electronic Medical Record/clinical systems to deliver recommendations seamlessly into the organic workflow. Clinician and caregiver adoption of Jvion’s recommendations is accelerated because of the “on-demand” nature of the information. The machine outperforms and outsmarts even the highest performing predictive solutions/approaches available. And this performance hasn’t gone unnoticed; Jvion’s solution has won numerous external awards including designation as the #1 Predictive Provider in Healthcare by Black Book Market Research. http://www.jvion.com ###
Warner P.M.,University of Cincinnati |
Coffee T.L.,Burn Center |
Yowler C.J.,Burn Center |
Yowler C.J.,Case Western Reserve University
Surgical Clinics of North America | Year: 2014
Most burn patients have injuries that may be treated on an outpatient basis. Newer silver-based dressings and improved medications for the treatment of pain and pruritus have led to further growth of outpatient care. The final barrier of distance from the burn center will decrease with the growth of telemedicine. It is incumbent for burn centers to develop outpatient guidelines to facilitate this growth of outpatient care. © 2014 Elsevier Inc.
Larsen M.,Mayo Medical School |
Pelzer M.,Burn Center |
Friedrich P.F.,Mayo Medical School |
Wood C.M.,Mayo Medical School |
Bishop A.T.,Mayo Medical School
Journal of Bone and Joint Surgery - Series A | Year: 2011
Background: Segmental bone defects pose reconstructive challenges. Composite tissue allotransplantation offers a potential solution but requires long-term immunosuppression with attendant health risks. This study demonstrates a novel method of composite-tissue allotransplantation, permitting long-term drug-free survival, with use of therapeutic angiogenesis of autogenous vessels to maintain circulation. Methods: Ninety-three rats underwent femoral allotransplantation, isotransplantation, or allografting. Group-1 femora were transplanted across a major histocompatibility complex barrier, with microsurgical pedicle anastomoses. The contralateral saphenous artery and vein (termed the AV bundle) of the recipient animal were implanted within the medullary canal to allow development of an autogenous circulation. In Group 2, allotransplantation was also performed, but with AV bundle ligation. Group 3 bones were frozen allografts rather than composite-tissue allotransplantation femora, and Group 4 bones were isotransplants. Paired comparison allowed evaluation of AV bundle effect, bone allogenicity (isogeneic or allogeneic), and initial circulation and viability (allotransplant versus allograft). Two weeks of immunosuppression therapy maintained blood flow initially, during development of a neoangiogenic autogenous blood supply from the AV bundle in patent groups. At eighteen weeks, skin grafts from donor, recipient, and third-party rats were tested for immunocompetence and donor-specific tolerance. At twenty-one weeks, bone circulation was quantified and new bone formation was measured. Results: Final circulatory status depended on both the initial viability of the graft and the successful development of neoangiogenic circulation. Median cortical blood flow was highest in Group 1 (4.6 mL/min/100 g), intermediate in Group 4 isotransplants (0.4 mL/min/100 g), and absent in others. Capillary proliferation and new bone formation were generally highest in allotransplants (15.0%, 6.4 μm3/μm2/yr) and isotransplants with patent AV bundles (16.6%, 50.3 μm3/μm2/yr) and less in allotransplants with ligated AV bundles (4.4%, 0.0 μm3/μm 2/yr) or allografts (8.1%, 24.1 μm3/μm 2/yr). Donor and third-party-type skin grafts were rejected, indicating immunocompetence without donor-specific tolerance. Conclusions: In the rat model, microvascular allogeneic bone transplantation in combination with short-term immunosuppression and AV bundle implantation creates an autogenous neoangiogenic circulation, permitting long-term allotransplant survival with measurable blood flow. Clinical Relevance: These methods may allow future composite-tissue allotransplantation of bone without the appreciable health risks that are associated with long-term immunosuppression or immune tolerance induction. Copyright © 2011 by The Journal of Bone and Joint Surgery, Incorporated.
News Article | November 17, 2016
Attorney Bert Louthian says that the e-cigarette industry faces the potential of a consumer protection crisis if devices aren't made safer COLUMBIA, SC--(Marketwired - November 17, 2016) - In the face of growing concerns about e-cigarette safety and a number of medical facilities reporting injuries due to exploding e-cigarette batteries, one South Carolina attorney is calling for greater consumer protection for users of these devices. "Exploding e-cigarettes have caused users serious burns, disfigurement and other costly injuries," said Bert Louthian of Louthian Law Firm P.A. "The Centers for Disease Control and Prevention said that nearly four percent of adults regularly use e-cigarettes. With an increase in the popularity of these devices, comes the responsibility to ensure the safety of e-cig users." At least 134 reports of explosions, overheating and fires related to e-cigarettes have been made since 2009, according to the Wall Street Journal. E-cigarette review and news site eCig One has discovered reports of over 180 e-cig explosions. Louthian said that this issue should be of great concern to both users and e-cigarette business owners. While many in the industry feel under siege by the regulatory uncertainty hovering over the e-cigarette industry, everyone can agree that users should be as safe as possible, he said. "Nobody wants to see people injured by these devices," Louthian said. "It's bad for stores that sell e-cigarettes. It's bad for the industry as a whole. Most importantly, it's bad for consumers. We have to make sure that these products are safe before they hit the market. The fact that this isn't being done has put us in a situation that should be considered a consumer protection crisis." According to NBC News, facilities like the University of Colorado Hospital Burn Center and the Harborview Medical Center in Seattle have noted an increase in the number of injuries caused by exploding e-cigarette batteries. North Carolina Jaycee Burn Center at UNC Hospitals have reported treating 10 patients with injuries caused by exploding e-cigarettes since the beginning of 2016. Many of the explosions come from the use of lithium-ion batteries, which have also caused issues in cell-phones, laptops and hover boards. There are many questions about why these batteries are exploding, Louthian said. He asks if it is a case of consumers not being told by manufacturers the importance of using the appropriate charger, or if they are defective in other ways. "The truth is we don't even know the depths of this problem because there is inadequate oversight, but it's clear that it is incredibly serious," Louthian said. "Medical facilities that treat injured e-cigarette users are sounding the alarm. It's time we heed their calls." Bert Louthian practices law in Columbia, South Carolina. Along with his father, Herb, they provide representation to those who have been injured due to someone else's negligence. Learn more about Louthian Law Firm P.A. by visiting http://www.louthianlaw.com/