South Burlington, VT, United States
South Burlington, VT, United States

Burlington College is a private liberal arts college located in Burlington, Vermont that offers associate, bachelor's, and master's degrees, as well as several professional certificate programs. Although the College is accredited by the New England Association of Schools and Colleges, it is currently on probation for "failing to meet the accreditor's standard for financial resources." The college's severe financial difficulties have also resulted in votes of no confidence from both the student union and the college's faculty and staff union.The goals of the College are to engage the student body in activities promoting social and community involvement on a local and international scale, while also providing traditional university level education through degree programs. The College also allows students to pursue degrees not traditionally offered by competing universities, and to specifically tailor their own degree through an individualized major program. Burlington College allows students the option of participating in a narrative evaluation system. Wikipedia.

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Yang H.,The Ninth Peoples Hospital of Chongqing | Li D.,Burlington College | Cheng C.,HB7400 | Cheng C.,Quantitative Medicine
BMC Genomics | Year: 2014

Background: Previous studies have shown that CpG dinucleotides are enriched in a subset of promoters and the CpG content of promoters is positively correlated with gene expression levels. But the relationship between divergence of CpG content and gene expression evolution has not been investigated. Here we calculate the normalized CpG (nCpG) content in DNA regions around transcription start site (TSS) and transcription terminal site (TTS) of genes in nine organisms, and relate them with expression levels measured by RNA-seq.Results: The nCpG content of TSS shows a bimodal distribution in all organisms except platypus, whereas the nCpG content of TTS only has a single peak. When the nCpG contents are compared between different organisms, we observe a different evolution pattern between TSS and TTS: compared with TTS, TSS exhibits a faster divergence rate between closely related species but are more conserved between distant species. More importantly, we demonstrate the link between gene expression evolution and nCpG content changes: up-/down- regulation of genes in an organism is accompanied by the nCpG content increase/decrease in their TSS and TTS proximal regions.Conclusions: Our results suggest that gene expression changes between different organisms are correlated with the alterations in normalized CpG contents of promoters. Our analyses provide evidences for the impact of nCpG content on gene expression evolution. © 2014 Yang et al.; licensee BioMed Central Ltd.

Minajigi A.,Burlington College | Francklyn C.S.,Burlington College | Francklyn C.S.,University of Vermont
Biochemistry | Year: 2011

In all living systems, the fidelity of translation is maintained in part by the editing mechanisms of aminoacyl-tRNA synthetases (ARSs). Some nonproteogenic amino acids, including β-hydroxynorvaline (HNV) are nevertheless efficiently aminoacylated and become incorporated into proteins. To investigate the basis of HNV's ability to function in protein synthesis, the utilization of HNV by Escherichia coli threonyl-tRNA synthetase (ThrRS) was investigated through both in vitro functional experiments and bacterial growth studies. The measured specificity constant (kcat/KM) for HNV was found to be only 20-30-fold less than that of cognate threonine. The rate of aminoacyl transfer (10.4 s-1) was 10-fold higher than the multiple turnover kcat value (1 s-1), indicating that, as for cognate threonine, amino acid activation is likely to be the rate-limiting step. Like noncognate serine, HNV enhances the ATPase function of the synthetic site, at a rate not increased by nonaminoacylatable (3′-dA76) tRNA. ThrRS also failed to exhibit posttransfer editing activity against HNV. In growing bacteria, the addition of HNV dramatically suppressed growth rates, which indicates either negative phenotypic consequences associated with its incorporation into protein or inhibition of an unidentified metabolic reaction. The inability of wild ThrRS to prevent utilization of HNV as a substrate illustrates that, for at least one ARS, the naturally occurring enzyme lacks the capability to effectively discriminate against nonproteogenic amino acids that are not encountered under normal physiological conditions. Other examples of "fidelity escape" in the ARSs may serve as useful starting points in the design of ARSs with specificity for unnatural amino acids. © 2011 American Chemical Society.

Erazo K.,Burlington College | Hernandez E.M.,Burlington College
Earthquake Engineering and Structural Dynamics | Year: 2016

This paper proposes a model-based state observer to perform high-definition response estimation in partially instrumented building structures. The proposed estimator is verified in a simulated five-story shear-building structure and validated using measurements from a seven-story reinforced concrete building slice tested at the NEES-University of California at San Diego shake table. In both cases the proposed estimator yielded satisfactory results by estimating the time history of shear forces, bending moments, displacements, and strains at various points/sections of interest. The proposed algorithm can be used in instrumented buildings for various practical applications such as post-earthquake damage assessment, structural control, and building code calibration. Copyright © 2016 John Wiley & Sons, Ltd.

Mathews D.M.,Burlington College | Clark L.,University of Louisville | Johansen J.,Emory University | Matute E.,Hospital Sanitas la Moraleja | Seshagiri C.V.,Covidien
Anesthesia and Analgesia | Year: 2012

BACKGROUND: sBIS, the variability of the Bispectral Index (BIS), sEMG, the variability of facial electromyogram power (EMG), and the Composite Variability Index (CVI) are 3 new measures of electroencephalogram and EMG variability. CVI is a single measure of the combined variability in BIS and EMG. We investigated whether increases in these variables are associated with intraoperative somatic responses. METHODS: This multicenter study included 120 patients undergoing elective, noncardiac surgery from 4 different sites. General anesthesia was maintained using propofol and remifentanil at 2 of the sites and sevoflurane and remifentanil at the 2 other sites. Propofol or sevoflurane was adjusted to maintain BIS between 45 and 60. Clinicians were blinded to CVI (v2.0) at all times, and remifentanil infusions were adjusted at the discretion of the clinician. The times of all intraoperative somatic events, defined as movement, grimacing, or eye opening, were recorded. Offline, the maintenance phase of each case was divided into consecutive, nonoverlapping, 10-minute segments. Segments were identified as containing a somatic event or containing no events. For each segment, mean sBIS, sEMG, and CVI and the heart rate (HR) range and mean arterial blood pressure range were calculated. To quantify how effectively each variable discriminated between somatic event segments and nonevent segments, we computed the area under the receiver operating characteristic (ROC) curve for each variable. Finally, we observed the time course of sBIS, sEMG, CVI, and the HR range before each somatic event and characterized the earliest time before the somatic event at which each variable was able to discriminate between the somatic events and a specified set of nonevents. RESULTS: The analysis included 33 somatic event segments and 829 nonevent segments from 105 surgical cases. The areas under the ROC curve (±SE) for sBIS, sEMG, and CVI were 0.83 ± 0.04, 0.92 ± 0.02, and 0.89 ± 0.03, respectively. The areas under the ROC curve for HR range and mean arterial blood pressure range were 0.77 ± 0.03 and 0.68 ± 0.05, respectively. CVI, sBIS, and sEMG all demonstrated higher average values before upcoming somatic events when compared with nonevents. HR range only showed a difference within a few seconds before the somatic event. CONCLUSION: sBIS, sEMG, and CVI, measures of electroencephalogram and EMG variability, increased when intraoperative somatic events occurred. sBIS, sEMG, and CVI discriminated between 10-minute segments that contained a somatic event and those segments that did not contain an event better than changes in HR and mean arterial blood pressure. Furthermore, CVI increases before somatic events began earlier than HR changes and may provide caregivers with an early warning of potentially inadequate antinociception. Copyright © 2012 International Anesthesia Research Society.

Leib E.,Burlington College | Winzenrieth R.,Med Imaps | Aubry-Rozier B.,University of Lausanne | Hans D.,University of Lausanne
Bone | Year: 2014

Introduction: Although osteoporosis is considered a disease of women, 25% of the individuals with osteoporosis are men. BMD measurement by DXA is the gold standard used to diagnose osteoporosis and assess fracture risk. Nevertheless, BMD does not take into account alterations of microarchitecture. TBS is an index of bone microarchitecture extracted from the spine DXA. Previous studies have reported the ability of the spine TBS to predict osteoporotic fractures in women. This is the first case-controlled study in men to evaluate the potential diagnostic value of TBS as a complement to bone mineral density (BMD), by comparing men with and without fractures. Methods: To be eligible for this study, subjects had to be non-Hispanic US white men aged 40 and older. Furthermore, subjects were excluded if they have or have had previously any treatment or illness that may influence bone metabolism. Fractured subjects were included if the presence of at least one fracture was confirmed. Cases were matched for age (±3years) and BMD (±0.04g/cm2) with three controls. BMD and TBS were first retrospectively evaluated at AP spine (L1-L4) with a Prodigy densitometer (GE-Lunar, Madison, USA) and TBS iNsight® (Med-Imaps, France) in Lausanne University Hospital blinded from clinical outcome. Inter-group comparisons were undertaken using Student's t-tests or Wilcoxon signed rank tests. Odds ratios were calculated per one standard deviation decrease as well as areas under the receiver operating curve (AUC). Results: After applying inclusion/exclusion criteria, a group of 180 male subjects was obtained. This group consists of 45 fractured subjects (age=63.3±12.6years, BMI=27.1±4.2kg/m2) and 135 control subjects (age=62.9±11.9years, BMI=26.7±3.9kg/m2) matched for age (p=0.86) and BMD (p=0.20). A weak correlation was obtained between TBS and BMD and between TBS and BMI (r=0.27 and r=-0.28, respectively, p<0.01). Subjects with fracture have a significant lower TBS compared to control subjects (p=0.013), whereas no differences were obtained for BMI, height and weight (p>0.10). TBS OR per standard deviation is 1.55 [1.09-2.20] for all fracture type. When considering vertebral fracture only TBS OR reached 2.07 [1.14-3.74]. Conclusion: This study showed the potential use of TBS in men. TBS revealed a significant difference between fractured and age- and spine BMD-matched nonfractured subjects. These results are consistent with those previously reported on for men of other nationalities. © 2013 Elsevier Inc.

Randall M.J.,Burlington College | Hristova M.,Burlington College | Van Der Vliet A.,Burlington College
FEBS Letters | Year: 2013

Acrolein, a reactive aldehyde found in cigarette smoke, is thought to induce its biological effects primarily by irreversible adduction to cellular nucleophiles such as cysteine thiols. Here, we demonstrate that acrolein rapidly inactivates the seleno-enzyme thioredoxin reductase (TrxR) in human bronchiolar epithelial HBE1 cells, which recovered over 4-8 h by a mechanism depending on the presence of cellular GSH and thioredoxin 1 (Trx1), and corresponding with reversal of protein-acrolein adduction. Our findings indicate that acrolein-induced protein alkylation is not necessarily a feature of irreversible protein damage, but may reflect a reversible signaling mechanism that is regulated by GSH and Trx1. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Spang D.I.,Burlington College
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2014

The bureau of labor statistics notes that the current number of open positions in the United States is approximately 3.7 million, yet the official unemployment rate (U-3) remains at 7.3% representing 11.3 million people, while an alternative and more inclusive measure of unemployment (U-6) is 13.7% and represents 21.2 million people1. The existence of unfilled and available positions, as compared to the total number of unemployed persons, is significantly influenced by the availability of qualified candidates in areas for which there is an apparent skills gap, i.e. jobs for which there are few or no qualified candidates. This skills gap compounds the already pressing employment and economic problems in the United States, and in the world. A sound approach to address and eliminate the skills gap is to align curriculum with the needs of employers and give students a seamless and transparent pathway toward achieving a credential such as an Associates degree, Baccalaureate degree, or certificate. Additionally, care must be taken to supply students with an opportunity to achieve these academic milestones with little or no debt, and by means of flexible delivery modes that accommodate work and life responsibilities. This is somewhat different than the current model of higher education and career-technical education. Additionally, a process of continuous review and improvement is needed to ensure curriculum alignment with industry and employer needs, along with reliable means of assessment to objectively measure and verify that students have gained the requisite competencies. This paper describes the efforts of a Community College Partnership Network (CCPN) involving Associates degree and Baccalaureate degree granting institutions, secondary schools, and County and State governmental agencies, to address the real-time needs of employers for the purposes of preparing a well-educated and high value-added professional workforce. Interactive mechanisms of collaboration such as advisory committees, student employment opportunities, undergraduate research programs, an applications-based curricular approach, and continuous improvement and assessment mechanisms are outlined and are central to the effort. © American Society for Engineering Education, 2014.

Spang D.I.,Burlington College | Strang K.E.,Burlington College
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2016

It is desirable to educators, and important for students, that a sound outcomes assessment methodology be employed in technology-based and hands-on intensive courses to measure and ensure that requisite competencies are obtained by students. It is expected that a working knowledge of these important competencies can help a two-year college graduate more effectively demonstrate mastery of the necessary skills and knowledge, and therefore add more value to a potential employer's operations. While assessment of student learning can be straightforward for general education courses, meaningful measurement of student learning within the context of technology-based and hands-on curricula are often more difficult. Furthermore, continuous improvement efforts as a result of assessment, whether or not the defined criteria for success have been met, often involve very detailed and specific adjustments to the curriculum and instructional delivery. However, several elements of an assessment methodology can be employed that are helpful in measuring student learning according to preset benchmarks, when student learning is demonstrated in such environments. Important assessment elements include a sound understanding of the relevant competencies to be gained, the formulation of descriptive outcome statements, the setting of realistic benchmarks, and the implementation of repeatable measurement techniques. A feedback mechanism, for the purpose of continuous improvement whether or not the predetermined benchmark is met, is also a key element. The effective use of these elements are outlined and developed within the context of technology-based and hands-on course delivery in two-year colleges, and with a strong focus on measuring and reporting student learning. © American Society for Engineering Education, 2016.

Beder J.,Yeshiva University | Postiglione P.,Albany Stratton Medical Center | Strolin-Goltzman J.,Burlington College
Social Work in Health Care | Year: 2012

Social workers in the Veterans Administration (VA) hospital system are faced with numerous challenges to best address the ongoing health and mental health needs of those who serve in the military. Social workers in the VA system serve diverse roles on the multidisciplinary medical teams and mental health services and are integral to the VA hospital environment. Most social workers feel positive about their work and their contributions to the care of the military. Despite positive feelings about their work, social workers are also prone to compassion fatigue and burnout as the work, especially with returning veterans from Afghanistan/Iraq, often extracts a toll. This article details the experience of social workers in the VA hospital system; it describes the impact of the work on the social workers, noting levels of compassion satisfaction, compassion fatigue, and burnout. © 2012 Copyright Taylor and Francis Group, LLC.

Agency: NSF | Branch: Standard Grant | Program: | Phase: ADVANCED TECH EDUCATION PROG | Award Amount: 768.27K | Year: 2016

Rowan College at Burlington County, in partnership with Rowan University, is conducting the project entitled Comprehensive Integration of Advanced Manufacturing Competencies throughout an Associates Degree and a Stackable Certificate Curricula. The motivating rationale for this project stems from direct observations and experiences supporting the fact that there is a tremendous regional and national need for graduates to possess the skills and competencies valued by industry. This project leverages past NSF-funded work as well as new workforce development initiatives to emphasize the critical skills and competencies needed to support advanced manufacturing curricula and industry.

The goals of this project are to strengthen and expand an Engineering Technology program and to serve as a conduit for the creation of programs and educational pathways that address unmet training needs and the needs of emergent high growth industries, both in the region and nationally. These goals will be accomplished by highlighting technical and non-technical skills across the curriculum, by developing an applications library that will serve as a curriculum resource to incorporate direct examples of relevant principles, by creating and strengthening industrial advisory committees, and by creating new advanced manufacturing educational pathways including degree and certificate programs, and facilities. This project involves the close collaboration between educational, industrial, and professional partners to develop flexible educational pathways, a comprehensive and strategic regional network, and a clearinghouse of accessible and effective resources, all for the purpose of preparing students to meet the needs of advanced manufacturing employers.

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