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South Burlington, VT, United States

Burlington College is a private liberal arts college located in Burlington, Vermont that offers associate, bachelor's, and master's degrees, as well as several professional certificate programs. Although the College is accredited by the New England Association of Schools and Colleges, it is currently on probation for "failing to meet the accreditor's standard for financial resources." The college's severe financial difficulties have also resulted in votes of no confidence from both the student union and the college's faculty and staff union.The goals of the College are to engage the student body in activities promoting social and community involvement on a local and international scale, while also providing traditional university level education through degree programs. The College also allows students to pursue degrees not traditionally offered by competing universities, and to specifically tailor their own degree through an individualized major program. Burlington College allows students the option of participating in a narrative evaluation system. Wikipedia.

Mathews D.M.,Burlington College | Clark L.,University of Louisville | Johansen J.,Emory University | Matute E.,Hospital Sanitas la Moraleja | Seshagiri C.V.,Covidien
Anesthesia and Analgesia | Year: 2012

BACKGROUND: sBIS, the variability of the Bispectral Index (BIS), sEMG, the variability of facial electromyogram power (EMG), and the Composite Variability Index (CVI) are 3 new measures of electroencephalogram and EMG variability. CVI is a single measure of the combined variability in BIS and EMG. We investigated whether increases in these variables are associated with intraoperative somatic responses. METHODS: This multicenter study included 120 patients undergoing elective, noncardiac surgery from 4 different sites. General anesthesia was maintained using propofol and remifentanil at 2 of the sites and sevoflurane and remifentanil at the 2 other sites. Propofol or sevoflurane was adjusted to maintain BIS between 45 and 60. Clinicians were blinded to CVI (v2.0) at all times, and remifentanil infusions were adjusted at the discretion of the clinician. The times of all intraoperative somatic events, defined as movement, grimacing, or eye opening, were recorded. Offline, the maintenance phase of each case was divided into consecutive, nonoverlapping, 10-minute segments. Segments were identified as containing a somatic event or containing no events. For each segment, mean sBIS, sEMG, and CVI and the heart rate (HR) range and mean arterial blood pressure range were calculated. To quantify how effectively each variable discriminated between somatic event segments and nonevent segments, we computed the area under the receiver operating characteristic (ROC) curve for each variable. Finally, we observed the time course of sBIS, sEMG, CVI, and the HR range before each somatic event and characterized the earliest time before the somatic event at which each variable was able to discriminate between the somatic events and a specified set of nonevents. RESULTS: The analysis included 33 somatic event segments and 829 nonevent segments from 105 surgical cases. The areas under the ROC curve (±SE) for sBIS, sEMG, and CVI were 0.83 ± 0.04, 0.92 ± 0.02, and 0.89 ± 0.03, respectively. The areas under the ROC curve for HR range and mean arterial blood pressure range were 0.77 ± 0.03 and 0.68 ± 0.05, respectively. CVI, sBIS, and sEMG all demonstrated higher average values before upcoming somatic events when compared with nonevents. HR range only showed a difference within a few seconds before the somatic event. CONCLUSION: sBIS, sEMG, and CVI, measures of electroencephalogram and EMG variability, increased when intraoperative somatic events occurred. sBIS, sEMG, and CVI discriminated between 10-minute segments that contained a somatic event and those segments that did not contain an event better than changes in HR and mean arterial blood pressure. Furthermore, CVI increases before somatic events began earlier than HR changes and may provide caregivers with an early warning of potentially inadequate antinociception. Copyright © 2012 International Anesthesia Research Society. Source

Leib E.,Burlington College | Winzenrieth R.,Med Imaps | Aubry-Rozier B.,University of Lausanne | Hans D.,University of Lausanne
Bone | Year: 2014

Introduction: Although osteoporosis is considered a disease of women, 25% of the individuals with osteoporosis are men. BMD measurement by DXA is the gold standard used to diagnose osteoporosis and assess fracture risk. Nevertheless, BMD does not take into account alterations of microarchitecture. TBS is an index of bone microarchitecture extracted from the spine DXA. Previous studies have reported the ability of the spine TBS to predict osteoporotic fractures in women. This is the first case-controlled study in men to evaluate the potential diagnostic value of TBS as a complement to bone mineral density (BMD), by comparing men with and without fractures. Methods: To be eligible for this study, subjects had to be non-Hispanic US white men aged 40 and older. Furthermore, subjects were excluded if they have or have had previously any treatment or illness that may influence bone metabolism. Fractured subjects were included if the presence of at least one fracture was confirmed. Cases were matched for age (±3years) and BMD (±0.04g/cm2) with three controls. BMD and TBS were first retrospectively evaluated at AP spine (L1-L4) with a Prodigy densitometer (GE-Lunar, Madison, USA) and TBS iNsight® (Med-Imaps, France) in Lausanne University Hospital blinded from clinical outcome. Inter-group comparisons were undertaken using Student's t-tests or Wilcoxon signed rank tests. Odds ratios were calculated per one standard deviation decrease as well as areas under the receiver operating curve (AUC). Results: After applying inclusion/exclusion criteria, a group of 180 male subjects was obtained. This group consists of 45 fractured subjects (age=63.3±12.6years, BMI=27.1±4.2kg/m2) and 135 control subjects (age=62.9±11.9years, BMI=26.7±3.9kg/m2) matched for age (p=0.86) and BMD (p=0.20). A weak correlation was obtained between TBS and BMD and between TBS and BMI (r=0.27 and r=-0.28, respectively, p<0.01). Subjects with fracture have a significant lower TBS compared to control subjects (p=0.013), whereas no differences were obtained for BMI, height and weight (p>0.10). TBS OR per standard deviation is 1.55 [1.09-2.20] for all fracture type. When considering vertebral fracture only TBS OR reached 2.07 [1.14-3.74]. Conclusion: This study showed the potential use of TBS in men. TBS revealed a significant difference between fractured and age- and spine BMD-matched nonfractured subjects. These results are consistent with those previously reported on for men of other nationalities. © 2013 Elsevier Inc. Source

Spang D.I.,Burlington College
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2014

The bureau of labor statistics notes that the current number of open positions in the United States is approximately 3.7 million, yet the official unemployment rate (U-3) remains at 7.3% representing 11.3 million people, while an alternative and more inclusive measure of unemployment (U-6) is 13.7% and represents 21.2 million people1. The existence of unfilled and available positions, as compared to the total number of unemployed persons, is significantly influenced by the availability of qualified candidates in areas for which there is an apparent skills gap, i.e. jobs for which there are few or no qualified candidates. This skills gap compounds the already pressing employment and economic problems in the United States, and in the world. A sound approach to address and eliminate the skills gap is to align curriculum with the needs of employers and give students a seamless and transparent pathway toward achieving a credential such as an Associates degree, Baccalaureate degree, or certificate. Additionally, care must be taken to supply students with an opportunity to achieve these academic milestones with little or no debt, and by means of flexible delivery modes that accommodate work and life responsibilities. This is somewhat different than the current model of higher education and career-technical education. Additionally, a process of continuous review and improvement is needed to ensure curriculum alignment with industry and employer needs, along with reliable means of assessment to objectively measure and verify that students have gained the requisite competencies. This paper describes the efforts of a Community College Partnership Network (CCPN) involving Associates degree and Baccalaureate degree granting institutions, secondary schools, and County and State governmental agencies, to address the real-time needs of employers for the purposes of preparing a well-educated and high value-added professional workforce. Interactive mechanisms of collaboration such as advisory committees, student employment opportunities, undergraduate research programs, an applications-based curricular approach, and continuous improvement and assessment mechanisms are outlined and are central to the effort. © American Society for Engineering Education, 2014. Source

Yang H.,The Ninth Peoples Hospital of Chongqing | Li D.,Burlington College | Cheng C.,HB7400 | Cheng C.,Quantitative Medicine
BMC Genomics | Year: 2014

Background: Previous studies have shown that CpG dinucleotides are enriched in a subset of promoters and the CpG content of promoters is positively correlated with gene expression levels. But the relationship between divergence of CpG content and gene expression evolution has not been investigated. Here we calculate the normalized CpG (nCpG) content in DNA regions around transcription start site (TSS) and transcription terminal site (TTS) of genes in nine organisms, and relate them with expression levels measured by RNA-seq.Results: The nCpG content of TSS shows a bimodal distribution in all organisms except platypus, whereas the nCpG content of TTS only has a single peak. When the nCpG contents are compared between different organisms, we observe a different evolution pattern between TSS and TTS: compared with TTS, TSS exhibits a faster divergence rate between closely related species but are more conserved between distant species. More importantly, we demonstrate the link between gene expression evolution and nCpG content changes: up-/down- regulation of genes in an organism is accompanied by the nCpG content increase/decrease in their TSS and TTS proximal regions.Conclusions: Our results suggest that gene expression changes between different organisms are correlated with the alterations in normalized CpG contents of promoters. Our analyses provide evidences for the impact of nCpG content on gene expression evolution. © 2014 Yang et al.; licensee BioMed Central Ltd. Source

Kernan W.N.,Yale University | Viscoli C.M.,Yale University | Furie K.L.,Brown University | Young L.H.,Yale University | And 25 more authors.
New England Journal of Medicine | Year: 2016

BACKGROUND: Patients with ischemic stroke or transient ischemic attack (TIA) are at increased risk for future cardiovascular events despite current preventive therapies. The identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease. METHODS: In this multicenter, double-blind trial, we randomly assigned 3876 patients who had had a recent ischemic stroke or TIA to receive either pioglitazone (target dose, 45 mg daily) or placebo. Eligible patients did not have diabetes but were found to have insulin resistance on the basis of a score of more than 3.0 on the homeostasis model assessment of insulin resistance (HOMA-IR) index. The primary outcome was fatal or nonfatal stroke or myocardial infarction. RESULTS: By 4.8 years, a primary outcome had occurred in 175 of 1939 patients (9.0%) in the pioglitazone group and in 228 of 1937 (11.8%) in the placebo group (hazard ratio in the pioglitazone group, 0.76; 95% confidence interval [CI], 0.62 to 0.93; P = 0.007). Diabetes developed in 73 patients (3.8%) and 149 patients (7.7%), respectively (hazard ratio, 0.48; 95% CI, 0.33 to 0.69; P<0.001). There was no significant between-group difference in all-cause mortality (hazard ratio, 0.93; 95% CI, 0.73 to 1.17; P = 0.52). Pioglitazone was associated with a greater frequency of weight gain exceeding 4.5 kg than was placebo (52.2% vs. 33.7%, P<0.001), edema (35.6% vs. 24.9%, P<0.001), and bone fracture requiring surgery or hospitalization (5.1% vs. 3.2%, P = 0.003). CONCLUSIONS: In this trial involving patients without diabetes who had insulin resistance along with a recent history of ischemic stroke or TIA, the risk of stroke or myocardial infarction was lower among patients who received pioglitazone than among those who received placebo. Pioglitazone was also associated with a lower risk of diabetes but with higher risks of weight gain, edema, and fracture. Copyright © 2016 Massachusetts Medical Society. Source

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