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Hulunbeier, China

Chen B.-L.,Bureau of Scientific Research | Wang D.-A.,Zhejiang University | Wang D.-A.,University of Tennessee Health Science Center
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: As the cardiovascular device, biomaterials applied under the blood-contact conditions should have anti-thrombotic, anti-biodegradable and anti-infective properties. OBJECTIVE: To develop novel polymer materials for implantation and intervention in cardiovascular tissue engineering and to explore the biocompatibility, blood compatibility and cytocompatibility of the surface-modified polymer biomaterials based on the coagulant and anti-coagulant coating modification. METHODS: We retrieved PubMed and WanFang databases for relevant articles publishing from 1983 to 2014. The key words were "biocompatibility, blood compatibility, biomedical materials, biomedical polymer materials" in English and Chinese, respectively. Those unrelated, outdated and repetitive papers were excluded. Literatures addressing the blood compatibility of biomedical polymer materials were summarized. RESULTS AND CONCLUSION: The blood-implant interaction and the anti-coagulant surface modification of biomaterials were analyzed. The biocompatibility, blood compatibility and cytocompatibility of the surface-modified polymer biomaterials were determined based on the coagulant and anti-coagulant coating modification. The coagulant and anti-coagulant surface modification of polymer biomaterials and the research on their biocompatibility and endothelial cell compatibility are crucial for developing novel polymer materials for implantation and intervention in cardiovascular tissue engineering. Through in-depth studies of the types and applications of polymer biomaterials, cardiovascular medical devices and implantable soft tissue substitutes, the differences between the surface and the body will be reflected in the many layers of molecules extending from the surface to the body. Two major factors, surface energy and molecular mobility, determine the body/surface behaviors that include body/surface differences and phase separation. Considering the difference between the body/surface composition, an additional determinant is indispensable, that is the crystallization behavior of each component. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source


Chen B.-L.,Bureau of Scientific Research | Wang D.-A.,Zhejiang University | Wang D.-A.,University of Tennessee Health Science Center | Feng L.-X.,Zhejiang University
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

This paper aimed to present the surface modification of tissue engineering materials and its correlation with cell compatibility from the aspects of cell-compatibility polymer surface group transformation and bioactive molecule immobilization. Source


Chen B.-L.,Bureau of Scientific Research | Wang D.-A.,Zhejiang University | Wang D.-A.,University of Tennessee Health Science Center
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: Biomaterials for the treatment of cardiovascular diseases must have anti-thrombotic, anti-biodegradability and anti-infective ability in the blood-contact condition. Objective: To investigate the biocompatibility, blood compatibility and cytocompatibility of new implantable (interfered) polymer material (surface) used in cardiovascular tissue engineering. Methods: The PubMed database and Wanfang database were retrieved for the related articles from 1967 to 2012 with the key words of "biocompatibility, lood compatibility, biomedical materials, biomedical polymer materials". Resutls and Conclusion: The graft copolymer surface and a block copolymer surfactant that can be used as biological materials were in-depth analyzed though analyzing the design requirements of type, application, cardiovascular medical devices and implantable soft tissue substitutes of polymeric biomaterials used for cardiovascular medicine. The results showed that the difference between the surface and noumenon will be reflected on many molecular layers that extended from the surface to the noumenon, while the two main factors of surface energy and molecular motion determined the noumenon/surface behavior including the noumenon/surface difference and surface phase separation. If the understanding of the noumenon/surface consisting difference should be taking into consideration, the other determinant should be added too, that was the crystallization behavior of each competent. If the one of the components contained in the graft copolymer surface and a block copolymer surfactant had higher crystallinity, the other components will be squeezed out; crystallization could also hindered the motion and diffusion of molecules, and eventually, the incompatibility degree of two components of copolymers will affect the phase separation tendency in the noumenon and surface layers. Source

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