Bureau of Forensic Medical Expertise

Belgorod, Russia

Bureau of Forensic Medical Expertise

Belgorod, Russia
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Grigor'Ev A.M.,Bureau of Forensic Medical Expertise | Savchuk S.A.,Moscow State University | Mel'Nik A.A.,Bureau of Forensic Medical Expertise | Ershov M.B.,Clinical Narcological Hospital | And 5 more authors.
Journal of Analytical Chemistry | Year: 2012

The consumption of JWH-018, an agonist of cannabinoid receptors within a number of smoking mixtures, can be established though the detection of its metabolites in human blood and urine. Using gas and liquid chromatography coupled with mass spectrometry, we identified 14 metabolites of JWH-018, products of mono- and dihydroxylation of aromatic and aliphatic moieties in the initial structure, carboxylation, dealkylation, and dealkylation followed by hydroxylation processes, in human and rat urine. The predominant metabolites excreted with urine, which can also be detected in human blood serum, were found to be products of monohydroxylation and in urine of rats, products of dealkylation with monohydroxylation. © 2012 Pleiades Publishing, Ltd.


Nazarov Y.V.,Bureau of Forensic Medical Expertise | Bozhchenko A.P.,Bureau of Forensic Medical Expertise | Tolmachev I.A.,Bureau of Forensic Medical Expertise | Moiseenko S.A.,Sm Kirov Military Medical Academy
Sudebno-meditsinskaia ekspertiza | Year: 2016

In connection with the variability and as a consequence of the poor diagnostic value of the external (planimetric) parameters of the palm traces, the new system of absolute and relative dimensional attributes based on the stable palmoglyphic reference points is considered. The purpose of the present study was the search for the new biological markers of biological age. The material for the study consisted of the palm prints obtained from 180 men and 120 women of the Caucasoid stock at the age from 16 to 80 years. The use of the descriptive statistics methods yielded the basic statistical characteristics of the traits being investigated and revealed the limits of their variability in the groups of men and women belonging to the age groups from 16 to 29 and from 30 to 80 years. The method of threshold values made it possible to identify 13 attributes the excess of which allows, with the probability of no less than 0.95, to perform diagnostics of the age group of an unknown subject.Abstract available from the publisher.


PubMed | Sm Kirov Military Medical Academy and Bureau of Forensic Medical Expertise
Type: Journal Article | Journal: Sudebno-meditsinskaia ekspertiza | Year: 2016

In connection with the variability and as a consequence of the poor diagnostic value of the external (planimetric) parameters of the palm traces, the new system of absolute and relative dimensional attributes based on the stable palmoglyphic reference points is considered. The purpose of the present study was the search for the new biological markers of biological age. The material for the study consisted of the palm prints obtained from 180 men and 120 women of the Caucasoid stock at the age from 16 to 80 years. The use of the descriptive statistics methods yielded the basic statistical characteristics of the traits being investigated and revealed the limits of their variability in the groups of men and women belonging to the age groups from 16 to 29 and from 30 to 80 years. The method of threshold values made it possible to identify 13 attributes the excess of which allows, with the probability of no less than 0.95, to perform diagnostics of the age group of an unknown subject.


Kavanagh P.,Trinity College Dublin | Grigoryev A.,Bureau of Forensic Medical Expertise | Melnik A.,Bureau of Forensic Medical Expertise | Simonov A.,Clinical Narcological Hospital
Journal of Analytical Toxicology | Year: 2012

3-(4-Methoxybenzoyl)-1-pentylindole (RCS-4), a synthetic indolederived cannabimimetic, was first reported to the European Monitoring Centre for Drugs and Drug Addiction via the Early Warning System by Hungarian authorities in 2010 and later identified in head shop test purchases in Ireland. Using gas chromatography-mass spectrometry, we have identified a series of RCS-4 metabolites in urine samples from individuals admitted to hospitals with symptoms of drug intoxication. The metabolites were tentatively identified as products of (i) aromatic monohydroxylation; (ii) dihydroxylation; (iii) aromatic hydroxylation/oxidation of the N-pentyl chain to a ketone; (iv) O-demethylation; (v) O-demethylation/monohydroxylation of N-pentyl chain; (vi) O-demethylation/oxidationof the N-pentyl chain to a ketone; (vii) O-demethylation/aromatic hydroxylation/oxidation of the N-pentyl chain to a ketone; (viii) N-depentylation/aromatic monohydroxylation; and (ix) N and O-dealkylation. The parent compound was not detected. The O-demethylated metabolites were found to be the most useful metabolic markers for the identification of RCS-4 ingestion. © The Author [2012]. Published by Oxford University Press. All rights reserved.


Grigoryev A.,Bureau of Forensic Medical Expertise | Kavanagh P.,Trinity College Dublin | Melnik A.,Bureau of Forensic Medical Expertise
Drug Testing and Analysis | Year: 2013

AM-694 (1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone), a synthetic indole-based cannabimimetic, was first reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS) by Irish authorities in 2010. Using gas chromatography-mass spectrometry (GC-MS), we have identified six AM-694 metabolites in post-ingestion samples. The metabolites were tentatively identified as products of (1) hydrolytic defluorination, (2) carboxylation, (3) monohydroxylation of N-alkyl chain, and (4) hydrolytic defluorination combined with monohydroxylation of N-alkyl chain. The parent compound was not detected. The excretion of major metabolites was observed up to 117h following administration. One metabolite (a product of hydrolytic defluorination) was also identified in urine samples from two individuals admitted to hospital suffering from suspected drug overdoses. Copyright © 2012 John Wiley & Sons, Ltd. Six metabolites of AM-694 the psychoactive ingredient some of herbal smoking mixtures were identified in human post-administration urine samples. The major metabolites were found to be products of metabolic hydrolytic defluorination and oxidative ones. Both parent AM-694 and its N-defluoropentylated metabolites were not found in one of the samples. © 2012 John Wiley & Sons, Ltd.


Grigoryev A.,Bureau of Forensic Medical Expertise | Kavanagh P.,Trinity College Dublin | Melnik A.,Bureau of Forensic Medical Expertise
Drug Testing and Analysis | Year: 2012

3-[(Adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a synthetic cannabimimetic, was identified in head shop products in Ireland in 2010. German authorities also reported it to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS) in 2011. As indole-derived cannabimimetics, such as JWH-018, JWH-073, and JWH-250, undergo extensive metabolism, it was expected that AB-001 would behave similarly. To include it in our toxicological screening protocols, we have identified its urinary metabolites in humans following oral administration. The major metabolites were found to be adamantane mono-hydroxylated and adamantane mono-hydroxylated/N-dealkylated products. No parent compound was found in urine, and metabolites were detectable for up to 160h following administration. © 2011 John Wiley & Sons, Ltd.


PubMed | Bureau of Forensic Medical Expertise
Type: Journal Article | Journal: Drug testing and analysis | Year: 2012

3-[(Adamantan-1-yl)carbonyl]-1-pentylindole (AB-001), a synthetic cannabimimetic, was identified in head shop products in Ireland in 2010. German authorities also reported it to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS) in 2011. As indole-derived cannabimimetics, such as JWH-018, JWH-073, and JWH-250, undergo extensive metabolism, it was expected that AB-001 would behave similarly. To include it in our toxicological screening protocols, we have identified its urinary metabolites in humans following oral administration. The major metabolites were found to be adamantane mono-hydroxylated and adamantane mono-hydroxylated/N-dealkylated products. No parent compound was found in urine, and metabolites were detectable for up to 160h following administration.


AM-694 (1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone), a synthetic indole-based cannabimimetic, was first reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) via the Early Warning System (EWS) by Irish authorities in 2010. Using gas chromatography-mass spectrometry (GC-MS), we have identified six AM-694 metabolites in post-ingestion samples. The metabolites were tentatively identified as products of (1) hydrolytic defluorination, (2) carboxylation, (3) monohydroxylation of N-alkyl chain, and (4) hydrolytic defluorination combined with monohydroxylation of N-alkyl chain. The parent compound was not detected. The excretion of major metabolites was observed up to 117h following administration. One metabolite (a product of hydrolytic defluorination) was also identified in urine samples from two individuals admitted to hospital suffering from suspected drug overdoses.

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