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Barddhamān, India

Hemoglobinopathies are common genetic disorders of hemoglobin, which can be prevented by population screening and offering genetic counseling. In absence of population-based screening for hemoglobinopathies, the hospital-based diagnosis register provide idea about the extent of problem in the community. The present study was undertaken to find out the burden of hemoglobinopathies and spectrum of this disorders among the population who were screened in the hospital-based screening program. A record-basedanalysis of subjects who underwent screening for hemoglobinopathies in Burdwan Medical College and Hospital over a period of 3 years and 4 months revealed that overall 29.3% of subjects were positive for hemoglobinopathies. Beta thalassemia heterozygous was the most commonhemoglobinopathy in this region closely followed by hemoglobin E heterozygous. In view of high prevalence of hemoglobinopathies in this region, a routine premarital screening program is needed for identification and prevention of high-risk marriages. Source

Background aims: Dendritic cell (DC)-based therapies could be important strategies for lymphoma treatment. Methods: AKR/J mice with Dalton's lymphoma were treated with recombinant interleukin-15 (rIL-15)-activated autologous DCs and pulsed with whole tumor cell lysates in the presence or absence of suboptimal doses of the STAT3 inhibitor cucurbitacin I. One group of treated mice received an additional dose of rIL-15 to boost the DC-based adoptive cell therapy (ACT). Kaplan-Meier survival analysis and multiple immunologic and enzymatic parameters were assessed to demonstrate the efficacy of the vaccination protocol. Results: Therapy with tumor lysate-pulsed, rIL-15-activated DCs plus cucurbitacin I significantly prolongs the survival of tumor-bearing mice but fails to provide a complete cure. Additional treatment of vaccinated mice with rIL-15 dramatically improves the therapeutic efficacy and provides a lifelong cure with no relapse. DCs derived from the surviving vaccinated mice regained their anti-tumor potential against the lymphoma cells with respect to growth inhibition and cytotoxicity. Both cluster of differentiation (CD)4+ and CD8+ T cells were mobilized in metastatic organs of successfully vaccinated mice in large numbers and demonstrated antigen-specific proliferation and tumor cell cytotoxicity. ACT also augments DC function by upregulating tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-α expression. In addition, combinatorial immunotherapy restores the levels of antioxidant enzymes and liver function enzyme activities that are severely repressed in untreated tumor-bearing mice. Conclusions: Effective vaccination for a complete cure against aggressive lymphoma requires DC-based ACT in combination with chemotherapy and cytokine therapy. © 2015 International Society for Cellular Therapy. Source

Mazumdar G.,Burdwan Medical College | Shome K.,West Dermatology
Indian Journal of Pharmacology

Metronidazole alone rarely causes Stevens-Johnson syndrome (SJS). We present a case of an elderly male patient who, following metronidazole use, developed neurological symptoms followed by pain and blisters on both soles, erythema of face and neck, scrotal itching and erosion, and hemorrhagic encrustation around the lips and oral mucous membrane. Initial neurological symptoms followed by mucocutaneous manifestation of SJS following metronidazole use is probably a new presentation of this case. Source

Hyoid is a U-shaped bone present in the ventral aspect of neck at the level of fourth cervical vertebra. It is a small bone placed between the root of tongue and the thyroid cartilage. Fracture of hyoid has great significance and importance in forensic pathology. It is well documented that fracture of hyoid is a recognized finding and indicator of strangulation (more common in manual or throttling than by ligature). Fracture of hyoid is less frequently reported in hanging. Discriminant function analysis was used with all predictors (width of hyoid, antero-posterior length of hyoid and length of greater cornu) were entered together. The analysis showed that 96.0% of original grouped cases could be correctly classified. © 2010 Elsevier Ireland Ltd. All rights reserved. Source

Mukhopadhyay P.P.,Burdwan Medical College
Journal of Forensic and Legal Medicine

Hyoid is a U-shaped bone present in the ventral aspect of neck at the level of fourth cervical vertebra. Morphological variants of hyoid are well documented. The present study was designed to identify these morphological features and examine the sexual dimorphism of adult hyoid bone in Indian Bengali population. The present work consisted of direct measurement in autopsy cases in a population specific sample. It was observed that the hyoid was larger in males regarding width, antero-posterior length and slope of cornu. Using t-Test with alpha level of 0.05 the length of greater cornu was found to be the only variable not significantly different in the two sexes (p = .116). © 2010 Elsevier Ltd. All rights reserved. Source

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