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Nazarenko G.I.,Medical Center | Osipov G.S.,Russian Academy of Sciences | Kleimenova E.B.,Medical Center | Smirnov I.V.,Russian Academy of Sciences | And 3 more authors.
Scientific and Technical Information Processing | Year: 2013

This paper presents a multifunctional support system for evidence-based medical technology that permits medical publications and reference information to be searched for in external information resources, makes it possible to formulate questions in medically accepted formats and to perform a critical analysis of publications according to the principles of evidence-based medicine, enables clinical and statistical calculators to be used, and permits answers to clinical questions to be automatically formed and archived. The system has been tested at a multi-profile hospital and demonstrated efficiency in clinical decision-making support. © 2013 Allerton Press, Inc.

Chelyapina M.V.,Russian Academy of Sciences | Sharova E.V.,Russian Academy of Sciences | Zaitsev O.S.,Burdenko Research Institute of Neurosurgery
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective. To determine electroencephalographic signs of dopamine deficiency syndrome during the recovery after severe brain injury (SBI). Material and methods. We studied 35 patients with SBI (23 men and 12 women, mean age 29±13 years). Results and conclusion. We identified a set of neurological symptoms (increased muscular tone of extrapyramidal type, rest tremor, autonomic disorders, which were most characteristic of the autonomic state, and some forms of mutism associated, according to current conceptions, with the dopaminergic system deficiency syndrome. This clinical picture was accompanied by stable EEG changes: an increase in the severity of beta activity of 13-14 Hz, enhanced in the frontal and anterior temporal areas, synchronized with equivalent dipole source localization in subcortical and frontal/basal areas. Dopamine deficiency regression syndrome was accompanied by an increase in beta EEG activity (from 13 to 16 Hz), but with the persistent abnormal enhancement of coherent hemispheric relations, especially in the occipital- temporal areas. © 2015, Media Sphera. All rights reserved.

Karlov V.A.,Moscow State University | Lebedeva A.V.,Vladimirsky Moscow Regional Research Clinical Institute | Stepanenko A.Y.,Vladimirsky Moscow Regional Research Clinical Institute | Rudakova I.G.,Russian National Research Medical University | And 5 more authors.
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

The literature data on using intravenous forms of AEDs that expand treatment possibilities for patients with epilepsy are presented. AEDs can be used in different situations, when patients are not able to take AEDs in per os. These situations can include seizure emergencies (recurrent seizures, clusters, status epilepticus), caused by disease decompensation; acute symptomatic seizures; perioperative preparation in the case of surgery; dysphagia; gastrointestinal problems; psychiatric disorders, and others. This article is based on a review of International and Russian expert consensus practice guidelines for management of clinical situations mentioned above. The authors present data on available Russian parenteral forms of drugs used today (valproats, levetiracetam, lacosamide, diazepam, midazolam, propofol, thiopental potassium). It has been concluded that an ideal intravenous AED should be highly effective, acts fast, has no severe adverse effects, has low drug-drug interactions, does not require frequent plasma concentration monitoring, and should be easily switched to a per os form without any additional titration. The importance of separate treatment approaches on different stages of medical help is emphasized. The choice of drug used can be influenced by a particular clinical situation, indications/contraindications, the recommended infusion speed, side effects, possible drug-drug interactions with other AEDs and other drugs used for the treatment of concomitant diseases, availability of a particular drug at the moment and the level of a physician's knowledge of usage of intravenous forms of AEDs.

Koshkin P.A.,Russian National Research Medical University | Chistiakov D.A.,Russian National Research Medical University | Nikitin A.G.,Russian National Research Medical University | Konovalov A.N.,Burdenko Research Institute of Neurosurgery | And 6 more authors.
Clinica Chimica Acta | Year: 2014

Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of key biological processes. Different miRNAs with pro-oncogenic and anti-oncogenic properties have been identified in glioblastomas. We decided to analyze expression profiles of 10 mature miRNAs (miR-7-1, miR-10a, miR-17, miR-20a, miR-21, miR-23a, miR-26a, miR-137, and miR-222) in post-surgery glioma specimens of different grades in order to find whether the expression level correlates with tumor grades. We also measured expression of six key genes such as PTEN, p21/CDKN1A, MDR1, ABCG2, BAX, and BCL-2 involved in the regulation of critical glioma signaling pathways to establish the effect of miRNAs on these signaling mechanisms. Methods: Using RT-PCR, we performed expression analysis of 25 tumor fresh samples (grades II-IV). Results: We found gradual increase in miR-21 and miR-23a levels in all tumor grades whereas miR-7 and miR-137 were significantly down-regulated depending on the glioma grade. MDR, ABCG2, and p21/CDKN1A levels were significantly up-regulated while expression of PTEN was down-regulated in tumor samples compared to the normal brain tissue. Conclusions: These observations provide new insights into molecular pathogenic mechanisms of glioma progression and suggest about a potential value of miRNAs as a putative diagnostic marker of brain tumors. © 2014 Elsevier B.V.

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