Bunkyo University is a private university in Japan.The Chinese characters of the word "Bunkyo" mean education and learning. The university offers courses mainly in education and research of the cultural and social science, and is well known for its teacher training. Previously the school was a girls' school called Rissho Women's University; when it became coeducational in 1976 its name was changed to Bunkyo University.The administration building is located in Hatanodai, Shinagawa, Tokyo. The university is an establishment of the Legal Educational Foundation, Bunkyo University Institute. There are two campuses: the Koshigaya Campus located in the city of Koshigaya, Saitama; and the Shonan Campus located in the city of Chigasaki, Kanagawa. Dormitories for both campuses are located in Kiyosato, Takane-town, Kitakoma district, Yamanashi Prefecture. Wikipedia.
Fujimi T.J.,RIKEN |
Fujimi T.J.,Bunkyo University |
Hatayama M.,RIKEN |
Developmental Biology | Year: 2012
Zic3 controls neuroectodermal differentiation and left-right patterning in Xenopus laevis embryos. Here we demonstrate that Zic3 can suppress Wnt/β-catenin signaling and control development of the notochord and Spemann's organizer. When we overexpressed Zic3 by injecting its RNA into the dorsal marginal zone of 2-cell-stage embryos, the embryos lost mesodermal dorsal midline structures and showed reduced expression of organizer markers (Siamois and Goosecoid) and a notochord marker (Xnot). Co-injection of Siamois RNA partially rescued the reduction of Xnot expression caused by Zic3 overexpression. Because the expression of Siamois in the organizer region is controlled by Wnt/β-catenin signaling, we subsequently examined the functional interaction between Zic3 and Wnt signaling. Co-injection of Xenopus Zic RNAs and β-catenin RNA with a reporter responsive to the Wnt/β-catenin cascade indicated that Zic1, Zic2, Zic3, Zic4, and Zic5 can all suppress β-catenin-mediated transcriptional activation. In addition, co-injection of Zic3 RNA inhibited the secondary axis formation caused by ventral-side injection of β-catenin RNA in Xenopus embryos. Zic3-mediated Wnt/β-catenin signal suppression required the nuclear localization of Zic3, and involved the reduction of β-catenin nuclear transport and enhancement of β-catenin degradation. Furthermore, Zic3 co-precipitated with Tcf1 (a β-catenin co-factor) and XIC (I-mfa domain containing factor required for dorsoanterior development). The findings in this report produce a novel system for fine-tuning of Wnt/β-catenin signaling. © 2011 .
Nagano Y.,University of Tokyo |
Itoh K.,Bunkyo University |
Honda K.,University of Tokyo
Current Opinion in Immunology | Year: 2012
Foxp3+ CD4+ cells are prominent immune regulatory T (Treg) cells that are most abundant in the intestine. Recent studies have suggested that intestinal Treg cells consist of thymically and extrathymically developed cells that have unique characteristics. A fraction of intestinal Treg cells express T cell receptors that recognize antigens that are derived from the gut microbiota. The presence of the gut microbiota, particularly the Clostridium species, affects the development and function of Treg cells. These intestinal bacteria-induced Treg cells are likely to play a role in the tolerance toward the gut microbiota. These recent advances provide new insight into how T cells are educated in the intestine to maintain homeostasis with the gut microbiota. © 2012 Elsevier Ltd.
Hongo C.,Bunkyo University |
Kayanne H.,Bunkyo University
Marine Geology | Year: 2011
Cores from Holocene reefs provided a growth history and species-level identification of corals and demonstrated the most important reef builders during the formation stage. This knowledge is important to determine a principle for reef formation and to provide preservation plans in the near future. A biological and sedimentological study of sediment cores recovered from the Palau Islands and Yoron Island, northwest Pacific, revealed four major facies: corymbose Acropora, arborescent Acropora, massive Porites, and detritus. Species-level observations show that arborescent Acropora (A. muricata and A. intermedia) contributed to reef growth under low- to moderate-energy conditions, whereas corymbose and tabular Acropora (A. digitifera, A. hyacinthus, and A. robusta/. A. abrotanoides) and I. palifera were key species for reef formation under high-energy conditions during Holocene sea-level rise and the ensuing period of sea-level stability. Once sea level had stabilized, massive Porites became restricted to areas subjected to low-energy, turbid conditions. These key species are successful corals because the ecological strategy is rapid growth, determinate growth, a high degree of colony integration, strongly resistant to wave action, and rapid local dispersion via fragmentation. Moreover, the western boundary current (Kuroshio) flows along the reefs in the northwest Pacific and it is easy for key species to distribute throughout the region during the period of Holocene sea-level rise and stabilization. These features are a principle for reef formation during sea-level changes. These key species played a significant role in Holocene reef formation in the northwest Pacific; however, coral mortality, caused by climate change, has recently been widely reported. Moreover, the decrease in key species abundance in present-day reefs has been more severe than that in any other species. These geological findings have important implications regarding the appropriate use of coral transplantation and decisions regarding the optimal location and size of marine protected areas. © 2010 Elsevier B.V.
Yamanaka T.,Bunkyo University
Journal of Physics: Conference Series | Year: 2011
The FastCaloSim calorimeter simulation was developed to provide a reasonably accurate but still fast simulation of the ATLAS calorimeter system. Parameterizations of electromagnetic and hadronic calorimeter showers are used to deposit particle energies in the detailed calorimeter structure. In the present document a short overview of the fast calorimeter simulation principle is presented. This is followed by a comparison of individual particle signatures and event properties to the full Geant 4 based ATLAS detector simulation.
Idei M.,Bunkyo University
Diatom Research | Year: 2013
Three new Diploneis species are described from freshwater lakes in Japan. A complex wall structure is demonstrated in D. aokiensis sp. nov. and D. yamanakaensis sp. nov., where the basic alternation of transapical ribs (virgae) and striae is overlain by a system of secondary branches and struts supporting the external perforate surface. Diploneis linearifera sp. nov. possesses remarkable external slits, distributed irregularly around the margin of the valve and near the raphe. The grooves in the outer layer of the valve wall, which do not penetrate to the valve interior, have no known parallel in other diatoms but may be related to the angular holes noted previously in D. finnica (Ehrenberg) Cleve and D. marginestriata Cleve. © 2012 The International Society for Diatom Research.
Abe H.,Bunkyo University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2015
With social media sites, such as Twitter, providing a visual record of the daily interests and concerns of users in the form of tweets and tweeting behaviors, there is growing demand among users, such as corporations, to identify other interested users. However, accurately determining whether users who receive information (such as tweets) from enterprise users have a genuine interest in it can be difficult. In this study, the user behavior of resending information received on Twitter (retweeting) is analyzed with the aim of developing a method for constructing a model for predicting retweeting behavior using the content of past tweeting history via evaluation indices of words and phrases in the users’ tweets. This paper analyzes the tweets sent by large online retail websites and by the followers who receive them, comparing the feature words obtained from the retweets with those in the tweets sent by the followers. This paper also discusses the feasibility of constructing a behavior prediction model by extracting temporal patterns of evaluation indices that are created from the usage frequencies of feature words and phrases obtained from followers’ tweets. © Springer International Publishing Switzerland 2015.
Hongo C.,Bunkyo University |
Kayanne H.,Bunkyo University
Palaeogeography, Palaeoclimatology, Palaeoecology | Year: 2010
Holocene sea-level change provides direct evidence of the melting of ice sheets; however, our understanding of the timing and course of such change is limited by a lack of information regarding environmental condition of corals. For example, Holocene sea-level curves are compiled based on water depths estimated from the occurrence of a small number of coral species, as species identification is difficult work. The error associated with this method of estimating sea level exceeds ± 2.5 m. In addition, there generally occurs a difference in the living-water depth of corals between high-energy reefs and low- to moderate-energy reefs. This difference in living-water depth also results in an error in reconstructed sea-level curves. In the present study, we analyzed drill core and recorded the vertical distribution of corals at the high-energy Ibaruma reef and low- to moderate-energy Fukido reef, Ishigaki Island, Ryukyu Islands, Japan. Analyses of corymbose Acropora (A. digitifera), massive Goniastrea (G. retiformis), massive Pocillopora (P. verrucosa), massive Platygyra (P. ryukyuensis), and other corals enables the accurate reconstruction of a sea-level curve because these species are distributed in a narrow range, with a weighted mean (Mw) error of between ± 0.5 and ± 2.5 m. These observation data from Ibaruma and Fukido reefs can be used to reconstruct Holocene sea-level curves based on drill core data from Ibaruma reef; however, the two reefs yield contrasting sea-level curves: the curve reconstructed based on data from Fukido reef is several meters deeper than that reconstructed based on data from Ibaruma reef. This discrepancy reflects the different energy levels of the two reefs (high-energy at Ibaruma reef and low- to moderate-energy at Fukido reef). Therefore, the accurate reconstruction of a Holocene sea-level curve requires the identification of species from drill core and observations of the vertical distribution of species at the present-day reef at a location close to the drilling site. The Holocene sea-level curve reconstructed based on drill core data from Ibaruma reef reveals a rapid sea-level rise of approximately 7.5 m kyr- 1 between 8000 and 6000 cal. years BP. The rate of sea-level rise decreased from 7.5 to 3.5 m kyr- 1 between 6000 and 5000 cal. years BP. A mid-Holocene highstand occurred at around 5000 cal. years BP, at a level of approximately 3 ± 2.5 m above the present mean sea level. The increase in ocean volume corresponding to this sea-level rise indicates that melting of the Antarctic ice sheet continued beyond 6000 cal. years BP, as most of the Northern Hemisphere ice sheets had melted by 6000 cal. years BP, resulting in sea levels similar to those of the present day. © 2010 Elsevier B.V. All rights reserved.
Kawarazaki Y.,Bunkyo University |
Ichijo H.,Bunkyo University |
Naguro I.,Bunkyo University
Expert Opinion on Therapeutic Targets | Year: 2014
Introduction: All organisms are ordinarily exposed to various stresses. It is important for organisms to possess appropriate stress response mechanisms and to maintain homeostasis because the disruption of a stress response system can cause various diseases. Apoptosis signal-regulating kinase 1 (ASK1) is one of the stress-responsive MAP3Ks. ASK1 plays an important role in the response to reactive oxygen species (ROS), endoplasmic reticulum stress and pro-inflammatory cytokines, and it is involved in the pathogenesis of various diseases. Areas covered: In this review, the authors describe recent literature concerning the intricate and elaborate regulation system of ASK1, the function of ASK1 during a cellular stress response and the involvement of ASK1 in many diseases, including cancer, neurodegenerative diseases, infections, diabetes and cardiovascular diseases. Expert opinion: In certain disease conditions, ASK1 plays a protective role, whereas ASK1 can exacerbate the pathology of other diseases. Although ASK1 is involved in various diseases, there is no therapy or drug that targets ASK1 for use in a clinical setting. Recently, ASK1 inhibitors (K811 and MSC2032964A) have emerged, and their therapeutic potentials have been tested in vivo. ASK1 is currently receiving considerable attention as a new therapeutic target. © 2014 Informa UK, Ltd.
Xiao Q.,Bunkyo University |
Meng X.,Bunkyo University |
Kanai M.,Bunkyo University |
Kuninobu Y.,Bunkyo University
Angewandte Chemie - International Edition | Year: 2014
Treatment of 2-phenylpyridines with amino(1,3,2-dioxaborolan-2-yl) diphenylsilane produced fluorosilylated 2-phenylpyridines in good to excellent yields under palladium catalysis. This reaction is the first example of Ci-H fluorosilylation. Single-crystal X-ray structure analysis revealed a Lewis acid-base interaction between the silicon and nitrogen atoms, and the obtained fluorosilylated products are silafluorene equivalents. The fluorosilylated products showed stronger fluorescence than the corresponding silafluorene derivative. Treatment of 2-phenylpyridines with amino(1,3,2-dioxaborolan-2-yl) diphenylsilane produced fluorosilylated 2-phenylpyridines in good to excellent yields under palladium catalysis. This reaction is the first example of Ci-H fluorosilylation. A Lewis acid-base interaction exists between the silicon and nitrogen atoms, and the obtained fluorosilylated products can be regarded as silafluorene equivalents. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Hosoya H.,Bunkyo University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010
Mammalian visual cortex is known to have various neuronal response properties that depend on stimuli outside classical receptive fields. In this article, we give a probabilistic explanation to one such property called border-ownership signals, by interpreting them as posterior joint probabilities of a low-level edge property and a high-level figure property. We show that such joint probabilities can be found in a hierarchical Bayesian network mimicking visual cortex, and indeed they exhibit simulational responses qualitatively similar to physiological data. © 2010 Springer-Verlag.