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Minami-rinkan, Japan

Bunkyo University is a private university in Japan.The Chinese characters of the word "Bunkyo" mean education and learning. The university offers courses mainly in education and research of the cultural and social science, and is well known for its teacher training. Previously the school was a girls' school called Rissho Women's University; when it became coeducational in 1976 its name was changed to Bunkyo University.The administration building is located in Hatanodai, Shinagawa, Tokyo. The university is an establishment of the Legal Educational Foundation, Bunkyo University Institute. There are two campuses: the Koshigaya Campus located in the city of Koshigaya, Saitama; and the Shonan Campus located in the city of Chigasaki, Kanagawa. Dormitories for both campuses are located in Kiyosato, Takane-town, Kitakoma district, Yamanashi Prefecture. Wikipedia.

Fujimi T.J.,RIKEN | Fujimi T.J.,Bunkyo University | Hatayama M.,RIKEN | Aruga J.,RIKEN
Developmental Biology

Zic3 controls neuroectodermal differentiation and left-right patterning in Xenopus laevis embryos. Here we demonstrate that Zic3 can suppress Wnt/β-catenin signaling and control development of the notochord and Spemann's organizer. When we overexpressed Zic3 by injecting its RNA into the dorsal marginal zone of 2-cell-stage embryos, the embryos lost mesodermal dorsal midline structures and showed reduced expression of organizer markers (Siamois and Goosecoid) and a notochord marker (Xnot). Co-injection of Siamois RNA partially rescued the reduction of Xnot expression caused by Zic3 overexpression. Because the expression of Siamois in the organizer region is controlled by Wnt/β-catenin signaling, we subsequently examined the functional interaction between Zic3 and Wnt signaling. Co-injection of Xenopus Zic RNAs and β-catenin RNA with a reporter responsive to the Wnt/β-catenin cascade indicated that Zic1, Zic2, Zic3, Zic4, and Zic5 can all suppress β-catenin-mediated transcriptional activation. In addition, co-injection of Zic3 RNA inhibited the secondary axis formation caused by ventral-side injection of β-catenin RNA in Xenopus embryos. Zic3-mediated Wnt/β-catenin signal suppression required the nuclear localization of Zic3, and involved the reduction of β-catenin nuclear transport and enhancement of β-catenin degradation. Furthermore, Zic3 co-precipitated with Tcf1 (a β-catenin co-factor) and XIC (I-mfa domain containing factor required for dorsoanterior development). The findings in this report produce a novel system for fine-tuning of Wnt/β-catenin signaling. © 2011 . Source

Idei M.,Bunkyo University
Diatom Research

Three new Diploneis species are described from freshwater lakes in Japan. A complex wall structure is demonstrated in D. aokiensis sp. nov. and D. yamanakaensis sp. nov., where the basic alternation of transapical ribs (virgae) and striae is overlain by a system of secondary branches and struts supporting the external perforate surface. Diploneis linearifera sp. nov. possesses remarkable external slits, distributed irregularly around the margin of the valve and near the raphe. The grooves in the outer layer of the valve wall, which do not penetrate to the valve interior, have no known parallel in other diatoms but may be related to the angular holes noted previously in D. finnica (Ehrenberg) Cleve and D. marginestriata Cleve. © 2012 The International Society for Diatom Research. Source

Yoshiuchi K.,Bunkyo University
BioPsychoSocial Medicine

In Japan, there is a unique clinical department, "Psychosomatic Medicine", while there is not a department of behavioral science or behavioral medicine in medical schools. Although only eight medical schools have the department, psychosomatic physicians in the department have been involved with behavioral medicine. In the present manuscript, the author would like to introduce the contribution to behavioral medicine made by psychosomatic physicians in three aspects, education, clinical settings, and research, and propose some strategy for psychosomatic physicians to get more involved with behavioral medicine. © 2016 Yoshiuchi. Source

Nagano Y.,University of Tokyo | Itoh K.,Bunkyo University | Honda K.,University of Tokyo
Current Opinion in Immunology

Foxp3+ CD4+ cells are prominent immune regulatory T (Treg) cells that are most abundant in the intestine. Recent studies have suggested that intestinal Treg cells consist of thymically and extrathymically developed cells that have unique characteristics. A fraction of intestinal Treg cells express T cell receptors that recognize antigens that are derived from the gut microbiota. The presence of the gut microbiota, particularly the Clostridium species, affects the development and function of Treg cells. These intestinal bacteria-induced Treg cells are likely to play a role in the tolerance toward the gut microbiota. These recent advances provide new insight into how T cells are educated in the intestine to maintain homeostasis with the gut microbiota. © 2012 Elsevier Ltd. Source

Kadoya S.,Bunkyo University | Tajika E.,Bunkyo University
Astrophysical Journal Letters

The climatic evolution of the Earth depends strongly on the evolution of the insolation from the Sun and the amount of the greenhouse gasses, especially CO2 in the atmosphere. Here, we investigate the evolution of the climate of hypothetical Earths around stars whose masses are different from the solar mass with a luminosity evolution model of the stars, a mantle degassing model coupled with a parameterized convection model of the planetary interiors, and an energy balance climate model of the planetary surface. In the habitable zone (HZ), the climate of the planets is initially warm or hot, depending on the orbital semimajor axes. We found that, in the inner HZ, the climate of the planets becomes hotter with time owing to the increase in the luminosity of the central stars, while, in the outer HZ, it becomes colder and eventually globally ice-covered owing to the decrease in the CO2 degassing rate of the planets. The orbital condition for maintaining the warm climate similar to the present Earth becomes very limited, and more interestingly, the planet orbiting in the outer HZ becomes globally ice-covered after a certain critical age (∼3 Gyr for the hypothetical Earth with standard parameters), irrespective of the mass of the central star. This is because the critical age depends on the evolution of the planets and planetary factors, rather than on the stellar mass. The habitability of the Earth-like planet is shown to be limited with age even though it is orbiting within the HZ. © 2016. The American Astronomical Society. All rights reserved. Source

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