Bunkyo-ku, Japan
Bunkyo-ku, Japan

Bunkyo Gakuin University is a coeducational university located in Bunkyō, Tokyo, Japan, near the University of Tokyo. Bunkyo Gakuin University was founded in April 1991 in Kamekubo, Ōimachi, Iruma, Saitama by Ishiko Shimada. In 2001, it opened the Faculty of Foreign Studies on what had been the Tokyo campus of Bunkyo Women's College . There is another campus located northwest of Tokyo in Fujimino, Saitama. The university was originally called Bunkyo Women's University . It was renamed Bunkyo Gakuin University in 2002 and became coeducational in 2005. The current president of Bunkyo University is Akiko Shimada. One of the unique features of the university is its "Chat Lounge", where students can practice their conversational language skills free of charge. Two "chat partners" staff the English facility from Monday to Friday. The Chinese Chat Lounge space, staffed by one native Chinese speaker, is located next to the English Chat Lounge space and open in the afternoon. The university also has three student dormitories in Hongo, Nishikata, and Fujimino, a dormitory for foreign exchange students next to the Hongo campus, a junior and senior girls' high school in Komagome, Tokyo, and a kindergarten across the street from the Hongo campus. Bunkyo Gakuin University celebrated its 85th anniversary in 2009. Wikipedia.


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Saito E.,Tokyo Metroplitan University | Ueki S.,Tohoku Bunka Gakuen University | Yamazaki S.,Bunkyo Gakuin University | Yasumura S.,Fukushima Medical University
BMC Geriatrics | Year: 2014

Background: Although the number of elderly people needing care is increasing rapidly in the home setting in Japan, family size and ability to provide such support are declining. The purpose of this study was to identify the risk factors of functional disability by household composition among community-dwelling elderly people.Methods: A total of 1347 elderly people aged 70 years and over participated in a baseline geriatric health examination for this prospective cohort study. In the health examination, we conducted an interview survey using a questionnaire in July 2004 and July 2005. Questionnaire items covered the following: age, sex, household, medical history, instrumental activities of daily living, intellectual activity, social role, Motor Fitness Scale, falls experienced during the past year, Dietary Variety Score, frequency of going outdoors, cognitive impairment, and depressive status. We defined the occurrence of functional disability as certification for long-term care needs of the subjects.The certification process started with a home visit for an initial assessment to evaluate nursing care needs using a questionnaire on current physical and mental status. The onset of functional disability was followed from July 2004 to March 2011. Cox proportional hazard regression analysis was used to estimate the risk factors related to the onset of functional disability, adjusted for age and sex.Results: Of the 1084 participants, 433 were male (39.9%), and the average age was 77.8 (standard deviation, 5.4). Up to March 2011, functional disabilities occurred in 226 participants (20.9%). Elderly people living only with their children demonstrated a significantly higher risk for functional disability than the three-generation household group (hazard ratio, 1.61; 95% confidence interval, 1.08-2.40). The risk factors for functional disability varied according to household group.Conclusions: In Japan, the number of vulnerable households with elderly people in need of care has increased steadily over the years. Appropriately identifying the risks related to functional disability requires a means of assessment that takes the household composition into consideration. © 2014 Saito et al.


Seki N.,Kanagawa Institute of Technology | Asano Y.,Kanagawa Institute of Technology | Ochi H.,Kanagawa Institute of Technology | Abe F.,Kanagawa Institute of Technology | And 2 more authors.
Asia Pacific Journal of Clinical Nutrition | Year: 2013

Background: It has been reported that adequate calcium intake decreases body fat and appropriate intakes of magnesium suppress the development of the metabolic syndrome. Furthermore, lactulose increases the absorption of calcium and magnesium. An optimal combination of calcium, magnesium and lactulose may therefore reduce body fat mass. Methods: An open-label randomized controlled trial was conducted to investigate the body fatreducing effects of a test food containing 300 mg calcium, 150 mg magnesium, and 4.0 g lactulose. Body composition parameters and blood hormone and urine mineral concentrations were measured at baseline and at 6 and 12 months thereafter. Whole-body fat mass was measured with dual-energy x-ray absorptiometry. Results: Seventy- six middle-aged Japanese women (47.5±4.7 years) were randomized to the intake group (n=48) or the nonintake control group (n=28). At 12 months the difference in body fat mass change between the two groups (intake group - control group) was -0.8 kg (95% CI: -1.5 - 0.0 kg, p=0.046), although there were no differences in anthropometric data between the two groups. Body fat percentage at 12 months tended to be lower in the intake group, but the difference was not significant (p=0.09). Conclusions: These findings may suggest that calcium in combination with magnesium and lactulose can reduce body fat mass in middle-aged Japanese women. However, the contribution of magnesium and lactulose are unclear in this study. Further studies are needed to clarify these contributions.


Harada Y.,Bunkyo Gakuin University | Harada H.,Bunkyo Gakuin University
[Rinshō ketsueki] The Japanese journal of clinical hematology | Year: 2016

Chronic myelomonocytic leukemia (CMML) is one of the clonal myeloid neoplasms characterized by persistent monocytosis and dysplasia of myeloid lineage cells. Thus, CMML includes characteristics of both myelodysplastic syndromes and myeloproliferative neoplasms. Clinical features of CMML are quite heterogeneous. There are no disease-specific gene mutations although more than 90% of CMML patients have one or more gene mutations, and most mutations detected in CMML are also seen in other myeloid malignancies. Among these mutations, ASXL1 mutations negatively affect the disease outcome. Moreover, it has been clarified that the clonal architecture of CMML is characterized by linear accumulation of mutations. Recently, international consortium perspectives in diagnostic recommendations and response criteria were published, and clinical reports on CMML, including a new diagnostic method, molecularly integrated CMML-specific prognostic models and therapeutic trials, are increasing. However, despite the existence of several prognostic models of CMML, formal guidelines for the management of CMML are still lacking. An international consortium proposal of uniform guidelines for management of CMML based on a uniform prognostic scoring system is eagerly awaited.


Kimura K.,Kwansei Gakuin University | Izawa S.,Japanese National Institute for Occupational Safety and Health | Sugaya N.,Tokyo Metropolitan Institute of Medical Science | Ogawa N.,Waseda University | And 6 more authors.
Psychoneuroendocrinology | Year: 2013

Organisms prefer to receive rewards sooner rather than later because they excessively discount the subjective value of future rewards, a phenomenon called delay discounting. Recent studies have reported an association between cortisol-which is secreted by the hypothalamic-pituitary-adrenal (HPA) axis-and delay discounting. However, no study has examined whether acutely induced psychosocial stress modulates delay discounting. Thus, the present study examined the effect of acute psychosocial stress and its hormonal and inflammatory correlates on the rate of delay discounting. To accomplish this purpose, we assessed the participants' discounting rates using the questionnaire version with inter-temporal choice before and after an acute psychosocial stress task (the Trier Social Stress Test; TSST). The results demonstrated that TSST increased rates of delay discounting in only cortisol responders (not in non-responders), indicating the possible influence of the pathway from the HPA axis to the dopaminergic systems under acute stress. Furthermore, the findings of correlation analysis indicated a U-shaped relationship between baseline level of C-reactive protein and delay discounting rate, suggesting a complex relationship between inflammatory markers and delay discounting rate. © 2013 Elsevier Ltd.


This article examines the unique roles of NGOs with special attention to the changing socio-political contexts of NGOs in terms of their partnerships with Rights-Holder Organizations (RHOs), which claim the rights of particular groups of excluded population. It reviews an example of the NGO working with RHOs in Nepal. NGO relationships with RHOs are delicate and not always equitable due to their different backgrounds and expertise. NGOs, comprising mostly people who are not members of the rights-holding groups, use their expertise to work for others over fixed periods, whilst RHOs work for their own constituencies through movements. Until the 1990s, NGOs supported so-called 'beneficiaries' who were members of excluded groups whose rights were being denied. Today, RHOs are formed directly by excluded groups. Some NGOs are trying to change their role to become promoters for RHOs, whilst others remain as their proxies, which merely creates an extra layer between RHOs and donors. The article attempts to prove that building equitable relationships between NGOs and RHOs is possible if NGOs have professionalism, expertise in capacity development and a readiness to become more inclusive. Though there are still several challenges ahead, such efforts by NGOs make it possible to change funding flows for RHOs and contribute to inclusive aid. © 2010 International Society for Third-Sector Research and The John's Hopkins University.


Kawakami Y.,Bunkyo Gakuin University
Rinsho byori. The Japanese journal of clinical pathology | Year: 2013

Randall's plaque theory is regarded as the most plausible mechanism of urinary stone formation; however, we speculated that urine proteins are necessarily involved in the process of stone formation. We focused on alpha 1-antitrypsin (alpha1-AT), a protein verified to be present in urinary calculi, and which is considered as a protein of inflammation, comparing its presence in healthy subjects and patients with urolithiasis. Quantitative analysis of alpha1-AT was performed with ELISA, whereas qualitative analysis was performed with SDS PAGE, two-dimensional electrophoresis, and western blotting. The results revealed a molecular heterogeneity in alpha1-AT, which can be classified into four patterns, a concentration-independent difference in alpha1-AT molecules found in the urine of patients and healthy subjects. A wider distribution of protein isoelectric points was found in urolithiasis (3.0-8.0) than in healthy subjects (4.0-5.0). We suggest that this new finding with molecular heterogeneity was due to the urolithiasis.


Sato K.,Fukuoka Women's University | Yamaguchi Y.,Fukuoka Women's University | Ishida Y.,Bunkyo Gakuin University
International Journal of Peptide Research and Therapeutics | Year: 2013

Seven analogs of μ-conotoxin GIIIA (μ-GIIIA), a specific blocker of muscle sodium channels, were synthesized by replacing stepwise the three cystine residues with Ala. The circular dichroism spectra of the analogs suggested that the deletion of disulfide bonds gradually randamized a conformation. The inhibitory effects on the twitch contractions of the rat diaphragm showed that the deletion of one disulfide bond reduced the potency to less than 1 % of control. Monocyclic analogs and a linear analog were almost inactive. Therefore, all three disulfide bridges are essential for stabilizing the specific conformation of μ-GIIIA to show biological activity. © 2013 Springer Science+Business Media New York.


Nakayama A.,Bunkyo Gakuin University
Rinsho byori. The Japanese journal of clinical pathology | Year: 2011

We examined the relationship between oxidative damage and molecular instability of urinary albumin in the urine of patients with IgA nephropathy (IgAN). As measure of oxidation, we detected the free thiol group at Cys34 in albumin (albumin-Cys34) using maleimide-PEG2-biotin reagent; because decreased levels of albumin-Cys34 are correlated with increased oxidation. The urine albumin-Cys34 level in all 30 patients with IgAN was decreased to varying extents. No correlations were found between urinary albumin/creatinine ratio and decreased urinary albumin-Cys34 level. Furthermore, decreases in urinary albumin-Cys34 were not accompanied by changes in serum albumin-Cys34. In diagonal-two-dimensional SDS PAGE analysis which reveals reduction-induced degradation of H2O2-treated human serum albumin, a similar pattern of albumin degradation was also detected in urine samples from patients with IgAN, indicating that structural alterations resulting from oxidative stress may be involved. Our findings suggest that redox state, in addition to urinary albumin concentration, may be an important indicator of post-translational modification and a potentially useful predictor of the kidney disease.


Yamaguchi T.,Tokyo Medical University | Okamura S.,Bunkyo Gakuin University | Miura Y.,Tokyo Medical University | Koyama S.,Miroku Medical Laboratory Co. | And 2 more authors.
Microbial Drug Resistance | Year: 2015

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is now endemic in the United States. In Japan, CA-MRSA infections and CA-MRSA surveillance have been scarcely reported. In this study, we conducted a nationwide survey of CA-MRSA in Japan. We collected MRSA strains isolated from outpatients with skin and soft-tissue infection (SSTI) at 107 medical facilities from 24 prefectures in 2010 and 2012. Among 10,385 clinical samples from SSTI patients, 3,581 S. aureus isolates (35%) were obtained and 673 of the S. aureus strains (19%) were identified as MRSA. Among 625 MRSA strains tested in this study, 266 strains (43%) and 114 strains (18%) were classified as SCCmec types IV and V, respectively. Detection of virulence genes was as follows: Panton-Valentine leukocidin (PVL) gene (57 strains, 9%), exfoliative toxin (ET) gene (179 strains, 29%), toxic shock syndrome toxin-1 (TSST-1) gene (195 strains, 31%), or none. PVL-positive strains were classified into eight sequence types (STs) (i.e., ST1, ST5, ST8, ST22, ST30, ST452, ST59, and ST154) and six clonal complexes (i.e., CC1, CC5, CC8, CC22, CC30, and CC59). Only 10 PVL-positive strains (2%) were pulsed-field type USA300 clone. There were a wide variety of CA-MRSA clones in Japan, which were different from the situation in the United States. © Mary Ann Liebert, Inc. 2015.


Suzuki S.,Tokyo Medical and Dental University | Suzuki S.,Bunkyo Gakuin University | Kudo H.,Bunkyo Gakuin University | Koyama T.,Tokyo Medical and Dental University
International Journal of Laboratory Hematology | Year: 2014

Introduction: When measuring platelet aggregation using laser light scattering, small aggregates forming without the addition of agonists may be observed. This event is called 'spontaneous platelet aggregation (SPA)'. The platelet hyperactivity observed in arterial thrombotic diseases can be detected with relative ease by measuring SPA. Standardization is urgently needed because of differences between measurement conditions among various laboratories. Methods: We conducted a systematic study of factors that affect SPA measurement, compared SPA results to flow cytometry detection of surface antigens expressed on activated platelet membranes (P-selectin, activated glycoprotein IIb/IIIa), and determined conditions that yield stable measurements. Results and Conclusions: We evaluated results from 125 healthy volunteers and established conditions for a stable measurement of SPA. As the occurrence of SPA tended to increase with age, we determined conditions valid for subjects aged 20-60 years. Blood should be collected using a syringe, and the sample should be prepared after allowing the whole blood to rest for 30 min after collection. To isolate platelet-rich plasma, a 2-mL tube should be used and centrifuged at 150 g. The sample should be stored at room temperature, the platelet count of the sample should be (250 ± 10) × 109/L, and the measurement should be completed within 90 min of blood collection. © 2014 John Wiley & Sons Ltd.

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