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Bunkyo-ku, Japan

Bunkyo Gakuin University is a coeducational university located in Bunkyō, Tokyo, Japan, near the University of Tokyo. Bunkyo Gakuin University was founded in April 1991 in Kamekubo, Ōimachi, Iruma, Saitama by Ishiko Shimada. In 2001, it opened the Faculty of Foreign Studies on what had been the Tokyo campus of Bunkyo Women's College . There is another campus located northwest of Tokyo in Fujimino, Saitama. The university was originally called Bunkyo Women's University . It was renamed Bunkyo Gakuin University in 2002 and became coeducational in 2005. The current president of Bunkyo University is Akiko Shimada. One of the unique features of the university is its "Chat Lounge", where students can practice their conversational language skills free of charge. Two "chat partners" staff the English facility from Monday to Friday. The Chinese Chat Lounge space, staffed by one native Chinese speaker, is located next to the English Chat Lounge space and open in the afternoon. The university also has three student dormitories in Hongo, Nishikata, and Fujimino, a dormitory for foreign exchange students next to the Hongo campus, a junior and senior girls' high school in Komagome, Tokyo, and a kindergarten across the street from the Hongo campus. Bunkyo Gakuin University celebrated its 85th anniversary in 2009. Wikipedia.

Kawakami Y.,Bunkyo Gakuin University
Rinsho byori. The Japanese journal of clinical pathology | Year: 2013

Randall's plaque theory is regarded as the most plausible mechanism of urinary stone formation; however, we speculated that urine proteins are necessarily involved in the process of stone formation. We focused on alpha 1-antitrypsin (alpha1-AT), a protein verified to be present in urinary calculi, and which is considered as a protein of inflammation, comparing its presence in healthy subjects and patients with urolithiasis. Quantitative analysis of alpha1-AT was performed with ELISA, whereas qualitative analysis was performed with SDS PAGE, two-dimensional electrophoresis, and western blotting. The results revealed a molecular heterogeneity in alpha1-AT, which can be classified into four patterns, a concentration-independent difference in alpha1-AT molecules found in the urine of patients and healthy subjects. A wider distribution of protein isoelectric points was found in urolithiasis (3.0-8.0) than in healthy subjects (4.0-5.0). We suggest that this new finding with molecular heterogeneity was due to the urolithiasis.

Seki N.,Kanagawa Institute of Technology | Asano Y.,Kanagawa Institute of Technology | Ochi H.,Kanagawa Institute of Technology | Abe F.,Kanagawa Institute of Technology | And 2 more authors.
Asia Pacific Journal of Clinical Nutrition | Year: 2013

Background: It has been reported that adequate calcium intake decreases body fat and appropriate intakes of magnesium suppress the development of the metabolic syndrome. Furthermore, lactulose increases the absorption of calcium and magnesium. An optimal combination of calcium, magnesium and lactulose may therefore reduce body fat mass. Methods: An open-label randomized controlled trial was conducted to investigate the body fatreducing effects of a test food containing 300 mg calcium, 150 mg magnesium, and 4.0 g lactulose. Body composition parameters and blood hormone and urine mineral concentrations were measured at baseline and at 6 and 12 months thereafter. Whole-body fat mass was measured with dual-energy x-ray absorptiometry. Results: Seventy- six middle-aged Japanese women (47.5±4.7 years) were randomized to the intake group (n=48) or the nonintake control group (n=28). At 12 months the difference in body fat mass change between the two groups (intake group - control group) was -0.8 kg (95% CI: -1.5 - 0.0 kg, p=0.046), although there were no differences in anthropometric data between the two groups. Body fat percentage at 12 months tended to be lower in the intake group, but the difference was not significant (p=0.09). Conclusions: These findings may suggest that calcium in combination with magnesium and lactulose can reduce body fat mass in middle-aged Japanese women. However, the contribution of magnesium and lactulose are unclear in this study. Further studies are needed to clarify these contributions.

Sato K.,Fukuoka Womens University | Yamaguchi Y.,Fukuoka Womens University | Ishida Y.,Bunkyo Gakuin University
International Journal of Peptide Research and Therapeutics | Year: 2013

Seven analogs of μ-conotoxin GIIIA (μ-GIIIA), a specific blocker of muscle sodium channels, were synthesized by replacing stepwise the three cystine residues with Ala. The circular dichroism spectra of the analogs suggested that the deletion of disulfide bonds gradually randamized a conformation. The inhibitory effects on the twitch contractions of the rat diaphragm showed that the deletion of one disulfide bond reduced the potency to less than 1 % of control. Monocyclic analogs and a linear analog were almost inactive. Therefore, all three disulfide bridges are essential for stabilizing the specific conformation of μ-GIIIA to show biological activity. © 2013 Springer Science+Business Media New York.

Nakayama A.,Bunkyo Gakuin University
Rinsho byori. The Japanese journal of clinical pathology | Year: 2011

We examined the relationship between oxidative damage and molecular instability of urinary albumin in the urine of patients with IgA nephropathy (IgAN). As measure of oxidation, we detected the free thiol group at Cys34 in albumin (albumin-Cys34) using maleimide-PEG2-biotin reagent; because decreased levels of albumin-Cys34 are correlated with increased oxidation. The urine albumin-Cys34 level in all 30 patients with IgAN was decreased to varying extents. No correlations were found between urinary albumin/creatinine ratio and decreased urinary albumin-Cys34 level. Furthermore, decreases in urinary albumin-Cys34 were not accompanied by changes in serum albumin-Cys34. In diagonal-two-dimensional SDS PAGE analysis which reveals reduction-induced degradation of H2O2-treated human serum albumin, a similar pattern of albumin degradation was also detected in urine samples from patients with IgAN, indicating that structural alterations resulting from oxidative stress may be involved. Our findings suggest that redox state, in addition to urinary albumin concentration, may be an important indicator of post-translational modification and a potentially useful predictor of the kidney disease.

Yamaguchi T.,Tokyo Medical University | Okamura S.,Bunkyo Gakuin University | Miura Y.,Tokyo Medical University | Koyama S.,Miroku Medical Laboratory Inc. | And 2 more authors.
Microbial Drug Resistance | Year: 2015

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is now endemic in the United States. In Japan, CA-MRSA infections and CA-MRSA surveillance have been scarcely reported. In this study, we conducted a nationwide survey of CA-MRSA in Japan. We collected MRSA strains isolated from outpatients with skin and soft-tissue infection (SSTI) at 107 medical facilities from 24 prefectures in 2010 and 2012. Among 10,385 clinical samples from SSTI patients, 3,581 S. aureus isolates (35%) were obtained and 673 of the S. aureus strains (19%) were identified as MRSA. Among 625 MRSA strains tested in this study, 266 strains (43%) and 114 strains (18%) were classified as SCCmec types IV and V, respectively. Detection of virulence genes was as follows: Panton-Valentine leukocidin (PVL) gene (57 strains, 9%), exfoliative toxin (ET) gene (179 strains, 29%), toxic shock syndrome toxin-1 (TSST-1) gene (195 strains, 31%), or none. PVL-positive strains were classified into eight sequence types (STs) (i.e., ST1, ST5, ST8, ST22, ST30, ST452, ST59, and ST154) and six clonal complexes (i.e., CC1, CC5, CC8, CC22, CC30, and CC59). Only 10 PVL-positive strains (2%) were pulsed-field type USA300 clone. There were a wide variety of CA-MRSA clones in Japan, which were different from the situation in the United States. © Mary Ann Liebert, Inc. 2015.

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