Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin

Berlin, Germany

Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin

Berlin, Germany
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Peter R.,University of Ulm | Hasselhorn H.M.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2013

Research into the associations between work, age, and health and the impact of these associations on employment status has focused on health as a crucial determinant of staying on the job. In our paper, we ask whether concentrating on health is still feasible, particularly when considering the change in demographics and the increasing proportion of older people in the workplace. We introduce a theoretical model describing health as a variable that indirectly influences leaving employment. According to our model, the immediate decision to leave employment is due to work motivation and work ability. These two factors may require intervention activities different from those needed to improve health. Our model explains employment participation as a result of complex associations between work, socioeconomic status, lifestyle, and health especially with work ability and work motivation. The complexity of these processes should be considered in studies by conducting longitudinal investigations like the German lidA study (http://www.lida-studie.de). If the model is verified in scientific studies like lidA, it can be used as a basis for preventive and intervening activities in practice, i.e., in politics, enterprises, and science. © Springer-Verlag Berlin Heidelberg 2013.


Schafer J.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin | Kampfer P.,Justus Liebig University | Jackel U.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin
Annals of Occupational Hygiene | Year: 2011

The thermophilic actinomycete species Saccharopolyspora rectivirgula has been associated with the exogen allergic alveolitis (EAA). EAA is caused by the inhalation of high amounts of airborne spores that can be found for example in environments of agricultural production, compost facilities, mushroom cultivation rooms, or rooms with technical air moistening. Because of the medical relevance of S. rectivirgula, a reliable detection system is needed. Therefore, a quantitative real-time polymerase chain reaction (qPCR) primer system was designed, targeting the 16S rRNA gene of the type strain S. rectivirgula DSM 43747T and six other S. rectivirgula reference strains. Our investigation showed that S. rectivirgula presumably own four operons of the 16S rRNA gene, which has to be considered for estimation of cell equivalents. Furthermore, the DNA recovery efficiency from these strains was tested in combination with bioaerosol or material sample as well as the influence of non-target DNA to the recovery rate. Results showed a recovery DNA efficiency of 7-55%. The recovery rate of DNA in a mixture with non-target DNA resulted in ∼87%. In summary, a high amplification efficiency using real-time PCR was found, for which estimated concentrations revealed cell numbers of 2.7 × 105 cells m-3 in bioaerosol and 2.8 × 106 cells g-1 fw-1 in material samples from a duck house. The specificity of the new developed quantification system was shown by generation of two clone libraries from bioarosol samples, from a duck house, and from a composting plant. Totally, the results clearly show the specificity and practicability of the established qPCR assay for detection of S. rectivirgula. © The Author 2011.


Paul R.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin
Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Ergonomie | Year: 2014

Occupational medical prevention was separated from the hazardous substances ordinance (Gefahrstoffverordnung, GefStoffV) and in 2008 was allocated its own ordinance, the ordinance on occupational medical prevention (arbeitsmedizinischen Vorsorge, ArbMedVV). As a result it became necessary to create regulations similar to the technical regulations for hazardous substances (Technische Regeln für Gefahrstoffe, TRGS), which reflect the recent technical standards of different aspects of the GefStoffV. The occupational medical regulation 6.2 on biomonitoring (Arbeitsmedizinische Regel 6.2—Biomonitoring, AMR 6.2) replaces in this context the technical regulation for hazardous substances 710. This article deals with important aspects of AMR 6.2 to which special attention should be paid during the realization of biomonitoring and exceeds the subject matter of TRGS 710. © 2014, Springer-Verlag Berlin Heidelberg.


Paul R.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin
Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Ergonomie | Year: 2012

Human biological monitoring (HBM) has attracted increasing attention over the last years. In the EU significant efforts are being made to coordinate the HBM activities in Europe and to use it for the determination of the effects of hazardous substances on the human health. Biomonitoring is a valuable tool for the assessment of exposure and risk in the context of the REACH procedure for the regulation of hazardous substances. Besides the environmental and consumer exposure, the occupational exposure at workplaces is still an important route for the uptake of hazardous substances. The Federal Institute for Occupational Safety and Health organizes biannually the workshop "biomonitoring in practice". The workshop has taken place the 6th time since 1999 and is well accepted by occupational health professionals. The session addressed professionals who were interested in the protection against hazardous substances in workplaces and the assessment of exposure and risk in the work area. The presentations covered a wide range of topics starting from basics, biomonitoring in carcinogenic substances, quality assessment of human biomonitoring etc., to the realization of biomonitoring studies in the routine of occupational physicians. The participants used the workshop for intensive discussions of the presentations. Some special questions, e.g. the choice of an appropriate laboratory arose and were intensively discussed. The broad interest of the participants motivates us to succeed this series of workshops.


Background and Methods: This article describes representative data on the availability of and individual participation in workplace health promotion (WHP) in Germany. These data are based on responses of 17 870 employees which were collected within the Labour Force Survey 2011/12 of the Federal Institute for Vocational Education and Training and the Federal Institute for Occupational Safety and Health. By comparison with data from the previous wave of the survey carried out in 2005/06 (N=17 803), medium-term trends in WHP are identified. Results: In 2012, 44% of the employees reported WHP activities in their companies, as against 38% in 2006. Increasing WHP prevalences were observed in all company sizes and economic sectors. In both surveys, employees in small companies reported significantly less WHP than those in large companies. Of all economic sectors, industrial manufacturing still showed the largest diffusion of WHP, even though the gap to other sectors has narrowed since 2006. The proportion of respondents who individually participated in WHP (if available) has slightly declined. The most striking difference in participation rates - which has even increased over time - is between small and large companies. Conclusions: Our findings indicate a moderately increased prevalence of WHP in Germany. At the same time, data still suggest a considerable need for WHP-related advice and support, particularly in small companies. On the basis of the analysed data, however, no statements can be made about qualitative characteristics of WHP activities in Germany. © Georg Thieme Verlag KG Stuttgart · New York.


Physical work load (e.g. manual handling of loads) is still frequently reported and can be associated with high psychosocial work exposures (e.g. time pressure). Occupational groups with unfavourable physical working conditions (agriculture, manual workers, low qualified service workers) have relatively high numbers of sickness absence due to musculoskeletal diseases. They are relevant in terms of the number of workers. Prevention of the work-related health effects remains relevant for Public Health.


Schafer J.,Justus Liebig University | Jackel U.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin | Kampfer P.,Justus Liebig University
Systematic and Applied Microbiology | Year: 2010

Mould-colonized water damaged building materials are frequently co-colonized by actinomycetes. Here, we report the results of the analyses of Actinobacteria on different wall materials from water damaged buildings obtained by both cultivation-dependent and cultivation-independent methods. Actinobacteria were detected in all but one of the investigated materials by both methods. The detected concentrations of Actinobacteria ranged between 1.8×104 and 7.6×107CFUg-1 of investigated material. A total of 265 isolates from 17 materials could be assigned to 31 different genera of the class Actinobacteria on the basis of 16S rRNA gene sequence analyses. On the basis of the cultivation-independent approach, 16S rRNA gene inserts of 800 clones (50%) were assigned to 47 different genera. Representatives of the genera Streptomyces, Amycolatopsis, Nocardiopsis, Saccharopolyspora, Promicromonospora, and Pseudonocardia were found most frequently. The results derived from both methods indicated a high abundance and variety of Actinobacteria in water damaged buildings. Four bioaerosol samples were investigated by the cultivation-based approach in order to compare the communities of Actinobacteria in building material and associated air samples. A comparison of the detected genera of bioaerosol samples with those directly obtained from material samples resulted in a congruent finding of 9 of the overall 35 detected genera (25%), whereas four genera were only detected in bioaerosol samples. © 2010 Elsevier GmbH.


Martin E.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin | Fallschissel K.,Justus Liebig University | Kampfer P.,Justus Liebig University | Jackel U.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin
Systematic and Applied Microbiology | Year: 2010

Investigations of bioaerosols collected from turkey, chicken and duck houses, as well as from a duck slaughterhouse, each in triplicate, revealed that 4-18% of 16S rRNA gene sequences in investigated 16S rRNA gene clone libraries were closely related to Jeotgalicoccus spp. J. halotolerans- and J. psychrophilus-related sequences were obtained in all investigated bioaerosol samples and formed a distinct group with sequences of both species type strains, which were collectively entitled Jeot-cluster-I. For a quantification of Jeot-cluster-I bacteria, a group specific PCR primer combination targeting the 16S rRNA genes was developed. Estimated concentrations by quantitative real-time PCR analyses revealed cell numbers between 104 and 106Jeotgalicoccus cellsm-3 air in turkey, duck, and chicken houses, respectively. These results indicated the remarkable proportion (1-39%) of total cell counts and the hitherto unknown wide distribution of Jeotgalicoccus spp. in the poultry rearing industry. © 2010 Elsevier GmbH.


Hasselhorn H.M.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin | Rauch A.,Institute For Arbeitsmarkt Und Berufsforschung
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Year: 2013

The German population is aging and shrinking. This will have a significant impact on the labor market, because labor supply will start to shrink. Consequently, there is a need to develop additional labor market resources. In this setting, a crucial issue is the health and employment of the older working population. This article discusses - on the basis of nine articles in this special issue - the health of the working population in the context of work, age, and labor participation. It shows the diversity of morbidity in the work force in general and particularly in older age, and it identifies older labor force groups with good health and those with bad health. The latter shows that "working while having a bad state of health" is today's reality. Labor market participation is less dependent on health than on the "work ability" and/or the "motivation to work" of older workers. The employment dynamics of an aging population will be a key issue in future political debate. A reliable knowledge base is needed for proper discussion, judgment, and action in the economic, political, and social fields. Current research is often focused on subtopics or on subgroups; however, a network of all the related scientific disciplines and the establishment of new comprehensive research approaches are needed in this area. © Springer-Verlag Berlin Heidelberg 2013.


Schafer J.,Justus Liebig University | Jackel U.,Bundesanstalt fur Arbeitsschutz und Arbeitsmedizin | Kampfer P.,Justus Liebig University
FEMS Microbiology Letters | Year: 2010

The occurrence of Actinobacteria in water-damaged building materials as well as the clinical relevance of some Actinobacteria (e.g. Saccharopolyspora spp., Mycobacterium spp., Nocardia spp., etc.), led us to develop a detection system to examine the actinobacterial community. A new primer system, Com2xf/Ac1186r (16S rRNA gene based) specific for Actinobacteria was designed. The adequacy for the intended use of the primer system was first investigated in silico using sequences of 164 different species belonging to 75 different genera of the class Actinobacteria. To test the primer specificity in complex environmental samples, four 16S rRNA gene clone libraries were generated (plaster material, compost material, compost plant- and duck house bioaerosols). Overall, 87% of obtained sequences were assigned to actinobacterial genera. To verify the applicability of the new designed primer system in water-damaged building material, 16S rRNA gene clone libraries of 18 different water-damaged materials were screened for their affiliation to Actinobacteria. A total of 88% of all 'Actinobacteria-positive' detected plasmid inserts were affiliated correctly. Results of SSCP-fingerprinting clearly showed differences of the species detected by the Actinobacteria-specific primer system within the different samples. Overall results obtained in this study indicate the applicability of the developed primer system for its intended use. © 2010 Federation of European Microbiological Societies.

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