Bukovmian State Medical University

Ukraine

Bukovmian State Medical University

Ukraine
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Gerush I.,Bukovmian State Medical University | Gerush O.,Bukovmian State Medical University
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia | Year: 2010

It was established thattotal single irradiation of rats in the dose of 0.3 Gy caused activation of lipid peroxidation in the liver and considerable changes in the liver antioxidant system. Administration of Echinacea tincture to the irradiated rats contributed to normalization of SOD and catalase activity as well as glutathione system enzymes. Biologic effectiveness of the preparation in the destruction of peroxidation products and their toxic metabolites, stabilization of the organism's antioxidant system state has been caused by biologically active substances in its composition. The use of the tincture before and after the exposure proved to be more effective than that only after irradiation.


Meshchyshen I.,Bukovmian State Medical University | Kushnir O.,Bukovmian State Medical University | Yaremii I.,Bukovmian State Medical University
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia | Year: 2010

This study investigated the possible protective effects of melatonin as an antioxidant against alloxan-induced diabetic liver injury in rats. The introduction of melatonin to alloxan diabetic rats is conducive to a decrease in them of the level of basal glycemia BG and HbAlc, as well as stabilization of the indices of the body's antioxidant defense disturbed, namely total antioxidant activity (TAOA) of blood plasma, malonic dialdehyde (MDA) and glutathione (G-SH) in rats liver.

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