Bukovinskii State Medical University

Chernivtsi, Ukraine

Bukovinskii State Medical University

Chernivtsi, Ukraine
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The effect of an altered photoperiod on the proteolytic activity in the basal nuclei, including the caudate nucleus, globus pallidus, nucleus accumbens, and amygdala complex, and rat behavior in the openfield test was studied. The altered photoperiod modulated the functional state of the basal nuclei, which was reflected in the locomotor activity of the animals. © 2016, Pleiades Publishing, Inc.


Sopova I.Yu.,Bukovinskii State Medical University | Zamorskii I.I.,Bukovinskii State Medical University
Neuroscience and Behavioral Physiology | Year: 2012

The effects of acute hypoxia on the intensity of free-radical processes in the basal nuclei (caudate nucleus, globus pallidus, nucleus accumbens, amygdalar complex) and the behavior of rats in an open field were studied in conditions of an altered photoperiod. Constant darkness was found to eliminate the effects of acute hypoxia on the intensity of lipid peroxidation (LPO), to preserve superoxide dismutase and catalase activities at higher levels, and to decrease glutathione peroxidase activity. In the light, there were increases in the sensitivity of neurons in the basal nuclei to acute hypoxia, which was manifest as intensification of LPO due to increased formation of diene conjugates. Catalase activity in almost all structures was significantly greater even than in intact rats. Altered photoperiods were found to modulate the effects of acute hypoxia on measures of activity in rats in the open field, the nature of the changes depending on the nature of the change in photophases. © 2012 Springer Science+Business Media New York.


Chornous V.A.,Bukovinskii State Medical University | Grozav A.M.,Bukovinskii State Medical University | Rusanov E.B.,Ukrainian Academy of Sciences | Nesterenko A.M.,Ukrainian Academy of Sciences | Vovk M.V.,Ukrainian Academy of Sciences
Russian Journal of Organic Chemistry | Year: 2011

1-Alkyl(aryl)imidazolidine-2,4-diones reacted with Vilsmeier-Haack reagent affording 1-alkyl(aryl)-2,4-dichloro-1H-imidazole-5-carbaldehydes whose reactions with sodium azide, sodium alkoholates, with phenols, thiols, and secondary cycloalkylamines led to the substitution of chlorine in the position 2 of the imidazole ring. The reaction with primary amines resulted in the condensation products at the aldehyde group. © Pleiades Publishing, Ltd., 2011.


Chornous V.A.,Bukovinskii State Medical University | Grozav A.N.,Bukovinskii State Medical University | Vovk M.V.,Ukrainian Academy of Sciences
Russian Journal of Organic Chemistry | Year: 2011

1-Aryl-4-chloro(2,4-dichloro)-1H-imidazole-5-carbaldehydes reacted with N-bromosuccinimide affording bromides of 1-aryl-2-bromo(2,4-dichloro)-1H- imidazole-5-carboxylic acids which were converted into the corresponding acids, esters, and amides. © 2011 Pleiades Publishing, Ltd.

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