Bukovinian State Medical University

Chernivtsi, Ukraine

Bukovinian State Medical University is one of the largest higher educational establishment in Chernivtsi. It has recently celebrated the 65th anniversary of its foundation. It is a modern multiprofile educational institution of the IV accreditation level, included into the general register of the WHO, Magna Charta Universitatum , the Association of the Carpathian Region Universities that provides qualified training according to the grade system of education. The University includes a medical lyceum, Chernivtsi, Vashkivtsi, Novoselytsia and Kovel’ Medical Colleges, 4 medical faculties, stomatological and pharmaceutical faculties, the department of post-graduate education, preparatory department for foreign students.The development of BSMU is associated with the names of famous scientists and founders.BSMU graduates work successfully in medical, pharmaceutical, economic, educational, scientific, social and cultural fields.Post-graduate education of doctors is realized at the Internship and Mastership, and the Doctoring Departments, in Clinical Residency, at the post-residence courses, as well as via pre-attestation course, the course of improvement of medical knowledge, specialization and professional courses. Wikipedia.

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Ivanchuk M.A.,Bukovinian State Medical University | Malyk I.V.,Chernivtsi National University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2017

We propose a new approach for solving the classification problem, which is based on the using ϵ-nets theory. It is showed that for separating two sets one can use their ϵ-nets, which considerably reduce the complexity of the separating algorithm for large sets’ sizes. The necessary and sufficient conditions of separable ϵ-netsoftwosetsare proved. The algorithm of building separable ϵ-nets is proposed. The ϵ-nets, constructed according to this algorithm, have size O(1/ε), which does not depended on the size of set. The set of possible values of ϵ for ϵ-nets of both sets is considered. The properties of this set and the theorem of its convergence are proved. The proposed algorithm of solving the classification problem using the ϵ-nets has the same computational complexity as Support Vector Machine O(n ln n) and its accuracy is comparable with SVM results. © Springer International Publishing AG 2017.

Savka I.,Bukovinian State Medical University
Georgian medical news | Year: 2017

Сontemporary forensic practice requires evaluation of the influence of long bones macroarchitecture on the mechanics of their destruction in case of blunt injuries, which finally might enhance validity and evidence of expert's reports. Therefore objective of the study is obtaining new scientific knowledge concerning macroarchitectural characteristics of the major portions of long bones of the lower limbs, detection of their influence on the regularities of destructive processes of bones in case of blunt injuries. 128 cases with fractures of the lower extremity long bones were examined from forensic-medical practical work, removed from male and female bio mannequins aged from 18 to 65 while conducting forensic expertise. The main morphological parameters (circumference, compact osseous tissue thickness, size and square of the medullar canal) characterizing macroarchitectonics of the femoral, tibial and fibular bones are studied. Their importance and role in occurring fractures of the given bones in forensic practical work are indicated. Different portions of the lower limb long bones possess considerable amount of the structural-functional characteristics. The sizes of the medullar canal (in the form of medullar parameter) and its square influence on the formation of fracture the most considerably among macroarchitectural characteristics.

Popovitch D.T.,Bukovinian State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2012

This paper presents a description of the principles defining period of death by polarimetric study temporal dynamics of changes in optical anisotropy of the cerebrospinal fluid of the human body. The optical model of polycrystalline networks of human body liquor is suggested. The results of investigating the interrelation between the values of statistical (statistical moments of the 1st-4th order), correlation (correlation area, asymmetry coefficient and autocorrelation function excess) and fractal (dispersion of logarithmic dependencies of power spectra) parameters are presented. They characterize the coordinate distributions of absolute value and phase of complex degree of mutual polarization in the points of laser images of liquor and temporal dynamics of optical anisotropy of human body liquor. The diagnostic criteria of death coming prescription are determined. © 2012 SPIE.

Moysyuk T.G.,Bukovinian State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2012

This article presents the principles of laser fluorescence diagnostic method used to diagnose pathological conditions of the stomach. In it, the new criteria are proposed - the total area and integrated fluorescence intensity as the differentiation of pathological conditions. The results of investigating the interrelation between the values of intensity and area of laser fluorescence are presented. They characterize the coordinate distributions of reradiation in the points of polarizationally filtered laser images of stomach histological sections. The criteria of laser polarization fluorescent diagnostics of stomach cancer nascency and its severity degree differentiation are determined. © 2012 SPIE.

Ivanchuk M.A.,Bukovinian State Medical University | Malyk I.V.,Chernivtsi National University
Cybernetics and Systems Analysis | Year: 2015

We compare cluster analysis, Wald’s sequential analysis, and the method of coordinate system rotation for the classification of patients with acute destructive pancreatitis and patients with acute combined radiation damage for early detection of complications. In the first case, the Wald analysis is efficient. In the second case, k-means cluster analysis and coordinate rotation method are proposed © 2015, Springer Science+Business Media New York.

Sopova I.Y.,Bukovinian State Medical University
Biophysics (Russian Federation) | Year: 2014

The influence of acute hypoxia on the motility of rats under conditions of an altered photoperiod in the open field test was studied. Thus, keeping the animals in constant darkness after modeling of acute hypoxia leads to depression of locomotive and exploratory components of behavior. At the same time the animals that were kept under conditions of constant light show a change in the correlation between the components of motility after the action of hypoxia. © 2014, Pleiades Publishing, Inc.

Zamorskii I.I.,Bukovinian State Medical University | Shchudrova T.S.,Bukovinian State Medical University
Biophysics (Russian Federation) | Year: 2014

The influence of the organospecific peptides — kidney tripeptides T-31 and T-35, pineal tetrapeptide epitalon on the main mechanisms of kidney injury caused by experimental rhabdomyolysis — toxic injury of tubular cells, development of oxidative stress and energetic misbalance, leading to significant disturbances of the functional state of kidneys and development of acute kidney failure was studied. The renoprotective effect of oligopeptides realized by impact on all of the indicated mechanisms of kidney injury and confirmed by correlation between them was estimated. © 2014, Pleiades Publishing, Inc.

Klepikovskii A.,Bukovinian State Medical University
Modern Problems of Radio Engineering, Telecommunications and Computer Science - Proceedings of the 11th International Conference, TCSET'2012 | Year: 2012

The research paper reveals the method of reliability assessment of thermoregulation systems based on thermoelectric elements, allowing to take into account along with the electric strength of the elements material their mechanical stability in many cascade structures. © 2012 Lviv Polytechnic Natl Univ.

The connection of Pro12Ala polymorphism of PPAR-γ gene with blood biochemical parameters in patients with nonalcoholic fatty liver disease (NAFLD) and nonviral chronic hepatitis (CH) were analyzed. The frequency of incidence of minor Ala-allele of PPAR-γ gene in those patients was not found to be significantly different from that in healthy individuals. Aspartate aminotransferase activity in NAFLD patients, Ala-allele carriers, was significantly higher on 55,5% (p=0,007) than in patients with Pro/Pro-genotype. At the same time, alanine aminotransferase activity in patients with Ala-allele was significantly higher on 80,0% (p=0,03) than in patients with Pro/Pro -genotype PPAR-γ gene. In this cohort of patients with minor Ala-allele high gamma-glutamyltransferase activity was diagnosed, which in 2,1 times (p=0,04) prevailed that in patients, Pro/Pro-genotype carriers. Patients with CH showed no significant association between Pro12Ala polymorphism of PPAR-γ gene and activity of biochemical markers of pathological process in the liver.

Sydorchuk L.P.,Bukovinian State Medical University | Amosova K.M.,National Medical University gomoletc
New Armenian Medical Journal | Year: 2011

Aim: To evaluate daily blood pressure monitoring (DBPM) data changes in patients with essential arterial hypertension (EAH) under the influence of pharmacogenetically determined treatment depending on genes polymorphisms of angiotensin-converting enzyme (ACE, I/D), angiotensin II first type receptor (AGTR1, A1166C), endothelial NO-synthase (eNOS, T894G), peroxisome proliferators-activated receptor- γ2 (PPAR-γ2, Pro12Ala), β1-adrenergic receptor (ADRB1, Arg389Gly). Material and Methods: 249 patients with EAH I-III stages (48.2% - women, 51.8% - men, mean ages 50.5±10.4 years) and 50 practically healthy persons were observed. Alleles of polymorphic locus were assessed by polymerase chain reaction (PCR) based method. DBPM was performed according to standard protocol. Patients were split by genotypes and treatment type into 6 groups: • 1st group: I-allele of ACE gene carriers (n=60) took Hydrochlorothiazide (HCTZ) and angiotensin II receptor blocker (ARB II); • 2nd group: I/D-genotype carriers (n=34) took HCTZ+β1-adrenobloker (β1-AB); • 3rd group: I/D-genotype carriers (n=50) took HCTZ+ACE-inhibitor (ACEI); • 4th group: DD-genotype carriers (n=15) took calcium channels bloker (CCB)+ ARB II; • 5th group: DD-genotype carriers (n=15) took CCB+β1-AB; • 6th group: DD-genotype carriers (n=27) took CCB+ACEI. Treatment efficacy was analyzed according to European Guidelines (2007). Results: Pharmacogenetically determined treatment of EAH patients during 9-12 months caused daily, day, and night blood pressure (BP) decrease below the "threshold" level in 154 (76.6%) patients. That did not significantly differ from the frequency of "target" office BP achievement: 149 (74.1%). The number of patients with normal BP daily profile "dipper" increased reliably by 10.1% (r<0.001), with "non-dipper" and "night-peaker" patients amount diminishing (r<0.05). Longterm combined therapy caused achievement of "target" average daily BP24 (DBPM) depending on types of treatment combination: after HCTZ+ARB II - in 55 (91.7%) patients; after HCTZ+β1-AB - in 25 (73.5%) persons; after HCTZ+ACEI - in 33 (66.0%) patients; after CCB+ARB II - in 11 (73.3%) persons, without a reliable difference between genotypes; after CCB+β1-AB - in 11 (73.3%) patients (easier in Ala-allele carriers of PPAR-γ2 gene, r=0.002); after CCB+ACEI - in 19 (70.4%) patients (easier in AlaAla-genotype carriers of PPAR-γ2 gene, r=0.007). Conclusions: Prescription of HCTZ+ARB II drugs combination is more effective in treatment of EAH I-allele carriers of ACE gene patients than HCTZ+β1-AB or HCTZ+ACEI - 91.7% vs 66.0 or 73.5%, accordingly (r<0.001); for DD-genotype carrier hypertensive patients the combination of CCB+ARB II and CCB+β1-AB is more effective than CCB+ACEI - 73.3% vs 70.4%, accordingly.

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