Bukovinian State Medical University

Chernivtsi, Ukraine

Bukovinian State Medical University is one of the largest higher educational establishment in Chernivtsi. It has recently celebrated the 65th anniversary of its foundation. It is a modern multiprofile educational institution of the IV accreditation level, included into the general register of the WHO, Magna Charta Universitatum , the Association of the Carpathian Region Universities that provides qualified training according to the grade system of education. The University includes a medical lyceum, Chernivtsi, Vashkivtsi, Novoselytsia and Kovel’ Medical Colleges, 4 medical faculties, stomatological and pharmaceutical faculties, the department of post-graduate education, preparatory department for foreign students.The development of BSMU is associated with the names of famous scientists and founders.BSMU graduates work successfully in medical, pharmaceutical, economic, educational, scientific, social and cultural fields.Post-graduate education of doctors is realized at the Internship and Mastership, and the Doctoring Departments, in Clinical Residency, at the post-residence courses, as well as via pre-attestation course, the course of improvement of medical knowledge, specialization and professional courses. Wikipedia.

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Prysyazhnyuk V.P.,Bukovinian State Medical University | Sydorchuk L.P.,Bukovinian State Medical University
Archives of the Balkan Medical Union | Year: 2016

Background: One of the key gene involved in chronic diffuse liver diseases pathogenesis, including nonalcoholic fatty liver disease are genes encoding the synthesis of glutathione-S-transferases. The objective of the study was to investigate a possible link between A313G polymorphism of the GSTP1 gene and biochemical blood parameters in nonalcoholic fatty liver disease patients. Methods: Gene polymorphism of GSTP1 (A313G) in 64 nonalcoholic fatty liver disease patients and 20 healthy individuals (control group) was studied. The range of investigated biochemical blood parameters included: total bilirubin and its fractions, cholesterol, triglycerides, uric acid, total protein and albumin, urea, creatinine, plasma enzyme activity. Results: G-allele significantly more frequently by 2.47 times (OR = 2.47, CI = 1.01-6.03, p<0.05) occurred in observed patients compared with healthy individuals. Total bilirubin level in blood of patients with GG-genotype was by 19.7% (p = 0.03) and by 36.9% (p = 0.04) higher compared with AA-genotype and AGgenotype carriers respectively. Presence of G-allele was associated with increased alanine aminotransferase activity, which was significantly higher in observed patients AG-and GG-genotypes carriers compared to patients with-AA genotype at 60.7% (p = 0.03) and 51.0% (p = 0.04) respectively. Conclusions: Frequency of G-allele of GSTP1 gene was in 2.47 times (OR = 2.47, CI = 1.01-6.03, p<0.05) higher in nonalcoholic fatty liver disease patients compared with healthy individuals in Ukrainian population. Presence of G-allele was associated with increased concentration of total bilirubin and higher activity of cytolytic syndrome in observed patients.

Popovitch D.T.,Bukovinian State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2012

This paper presents a description of the principles defining period of death by polarimetric study temporal dynamics of changes in optical anisotropy of the cerebrospinal fluid of the human body. The optical model of polycrystalline networks of human body liquor is suggested. The results of investigating the interrelation between the values of statistical (statistical moments of the 1st-4th order), correlation (correlation area, asymmetry coefficient and autocorrelation function excess) and fractal (dispersion of logarithmic dependencies of power spectra) parameters are presented. They characterize the coordinate distributions of absolute value and phase of complex degree of mutual polarization in the points of laser images of liquor and temporal dynamics of optical anisotropy of human body liquor. The diagnostic criteria of death coming prescription are determined. © 2012 SPIE.

Moysyuk T.G.,Bukovinian State Medical University
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2012

This article presents the principles of laser fluorescence diagnostic method used to diagnose pathological conditions of the stomach. In it, the new criteria are proposed - the total area and integrated fluorescence intensity as the differentiation of pathological conditions. The results of investigating the interrelation between the values of intensity and area of laser fluorescence are presented. They characterize the coordinate distributions of reradiation in the points of polarizationally filtered laser images of stomach histological sections. The criteria of laser polarization fluorescent diagnostics of stomach cancer nascency and its severity degree differentiation are determined. © 2012 SPIE.

Belikova N.,Bukovinian State Medical University
Georgian medical news | Year: 2013

The aim of this study was biomechanical rationale for splinting mobile teeth with periodontitis according to the height and slope of teeth crowns, their degree of mobility, and type of occlusion. The research studied the effect of axial vertical and horizontal loads on the functioning of the proposed method of splinting. Set clear indications and contraindications for the use of the method of splinting. Biomechanically proven unreasonableness includes teeth with III degree of mobility in the splinted construction. Clinical variant of splinting is only possible at the height of the anatomical crowns of the teeth of at least 7 mm, otherwise the preferred laboratory methods for the manufacture of tires.

Ivanchuk M.A.,Bukovinian State Medical University | Malyk I.V.,Chernivtsi National University
Cybernetics and Systems Analysis | Year: 2015

We compare cluster analysis, Wald’s sequential analysis, and the method of coordinate system rotation for the classification of patients with acute destructive pancreatitis and patients with acute combined radiation damage for early detection of complications. In the first case, the Wald analysis is efficient. In the second case, k-means cluster analysis and coordinate rotation method are proposed © 2015, Springer Science+Business Media New York.

Sopova I.Y.,Bukovinian State Medical University
Biophysics (Russian Federation) | Year: 2014

The influence of acute hypoxia on the motility of rats under conditions of an altered photoperiod in the open field test was studied. Thus, keeping the animals in constant darkness after modeling of acute hypoxia leads to depression of locomotive and exploratory components of behavior. At the same time the animals that were kept under conditions of constant light show a change in the correlation between the components of motility after the action of hypoxia. © 2014, Pleiades Publishing, Inc.

Zamorskii I.I.,Bukovinian State Medical University | Shchudrova T.S.,Bukovinian State Medical University
Biophysics (Russian Federation) | Year: 2014

The influence of the organospecific peptides — kidney tripeptides T-31 and T-35, pineal tetrapeptide epitalon on the main mechanisms of kidney injury caused by experimental rhabdomyolysis — toxic injury of tubular cells, development of oxidative stress and energetic misbalance, leading to significant disturbances of the functional state of kidneys and development of acute kidney failure was studied. The renoprotective effect of oligopeptides realized by impact on all of the indicated mechanisms of kidney injury and confirmed by correlation between them was estimated. © 2014, Pleiades Publishing, Inc.

Klepikovskii A.,Bukovinian State Medical University
Modern Problems of Radio Engineering, Telecommunications and Computer Science - Proceedings of the 11th International Conference, TCSET'2012 | Year: 2012

The research paper reveals the method of reliability assessment of thermoregulation systems based on thermoelectric elements, allowing to take into account along with the electric strength of the elements material their mechanical stability in many cascade structures. © 2012 Lviv Polytechnic Natl Univ.

The connection of Pro12Ala polymorphism of PPAR-γ gene with blood biochemical parameters in patients with nonalcoholic fatty liver disease (NAFLD) and nonviral chronic hepatitis (CH) were analyzed. The frequency of incidence of minor Ala-allele of PPAR-γ gene in those patients was not found to be significantly different from that in healthy individuals. Aspartate aminotransferase activity in NAFLD patients, Ala-allele carriers, was significantly higher on 55,5% (p=0,007) than in patients with Pro/Pro-genotype. At the same time, alanine aminotransferase activity in patients with Ala-allele was significantly higher on 80,0% (p=0,03) than in patients with Pro/Pro -genotype PPAR-γ gene. In this cohort of patients with minor Ala-allele high gamma-glutamyltransferase activity was diagnosed, which in 2,1 times (p=0,04) prevailed that in patients, Pro/Pro-genotype carriers. Patients with CH showed no significant association between Pro12Ala polymorphism of PPAR-γ gene and activity of biochemical markers of pathological process in the liver.

Sydorchuk L.P.,Bukovinian State Medical University | Amosova K.M.,National Medical University gomoletc
New Armenian Medical Journal | Year: 2011

Aim: To evaluate daily blood pressure monitoring (DBPM) data changes in patients with essential arterial hypertension (EAH) under the influence of pharmacogenetically determined treatment depending on genes polymorphisms of angiotensin-converting enzyme (ACE, I/D), angiotensin II first type receptor (AGTR1, A1166C), endothelial NO-synthase (eNOS, T894G), peroxisome proliferators-activated receptor- γ2 (PPAR-γ2, Pro12Ala), β1-adrenergic receptor (ADRB1, Arg389Gly). Material and Methods: 249 patients with EAH I-III stages (48.2% - women, 51.8% - men, mean ages 50.5±10.4 years) and 50 practically healthy persons were observed. Alleles of polymorphic locus were assessed by polymerase chain reaction (PCR) based method. DBPM was performed according to standard protocol. Patients were split by genotypes and treatment type into 6 groups: • 1st group: I-allele of ACE gene carriers (n=60) took Hydrochlorothiazide (HCTZ) and angiotensin II receptor blocker (ARB II); • 2nd group: I/D-genotype carriers (n=34) took HCTZ+β1-adrenobloker (β1-AB); • 3rd group: I/D-genotype carriers (n=50) took HCTZ+ACE-inhibitor (ACEI); • 4th group: DD-genotype carriers (n=15) took calcium channels bloker (CCB)+ ARB II; • 5th group: DD-genotype carriers (n=15) took CCB+β1-AB; • 6th group: DD-genotype carriers (n=27) took CCB+ACEI. Treatment efficacy was analyzed according to European Guidelines (2007). Results: Pharmacogenetically determined treatment of EAH patients during 9-12 months caused daily, day, and night blood pressure (BP) decrease below the "threshold" level in 154 (76.6%) patients. That did not significantly differ from the frequency of "target" office BP achievement: 149 (74.1%). The number of patients with normal BP daily profile "dipper" increased reliably by 10.1% (r<0.001), with "non-dipper" and "night-peaker" patients amount diminishing (r<0.05). Longterm combined therapy caused achievement of "target" average daily BP24 (DBPM) depending on types of treatment combination: after HCTZ+ARB II - in 55 (91.7%) patients; after HCTZ+β1-AB - in 25 (73.5%) persons; after HCTZ+ACEI - in 33 (66.0%) patients; after CCB+ARB II - in 11 (73.3%) persons, without a reliable difference between genotypes; after CCB+β1-AB - in 11 (73.3%) patients (easier in Ala-allele carriers of PPAR-γ2 gene, r=0.002); after CCB+ACEI - in 19 (70.4%) patients (easier in AlaAla-genotype carriers of PPAR-γ2 gene, r=0.007). Conclusions: Prescription of HCTZ+ARB II drugs combination is more effective in treatment of EAH I-allele carriers of ACE gene patients than HCTZ+β1-AB or HCTZ+ACEI - 91.7% vs 66.0 or 73.5%, accordingly (r<0.001); for DD-genotype carrier hypertensive patients the combination of CCB+ARB II and CCB+β1-AB is more effective than CCB+ACEI - 73.3% vs 70.4%, accordingly.

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