Time filter

Source Type

South Milwaukee, WI, United States

Zimmerman M.P.,Bucyrus
American Health and Drug Benefits | Year: 2015

Despite advances in the approach toward treating hypercholesterolemia and widespread access to statin medications, not all people are able to reach target low-density lipoprotein cholesterol (LDL-C) levels to reduce their cardiovascular risk. Some of the reasons include the inability to tolerate statin therapy, LDL-C levels that remain high even in the presence of statin therapy, and a familial disorder that is characterized by extremely high levels of LDL-C. A new therapeutic class, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, represents a novel and promising approach to reducing LDL-C levels using a mechanism at the LDL receptor level. The recent approval of the first 2 PCSK9 inhibitors and the anticipated approval of the third agent in this class within approximately 1 year may provide clinicians powerful new weapons to lower LDL-C levels in patients who are not satisfactorily managed with statins. However, the results of long-term studies of the ability of these new medications to influence cardiovascular outcomes will not be known for several years. © 2015 Engage Healthcare Communications, Inc. All rights reserved.

Li Y.,Bucyrus | Liu W.,Washington University in St. Louis
Engineering Failure Analysis | Year: 2013

In this study, the three-dimensional (3D) dynamic dragline models are developed for investigating the dynamic dragline performance and front-end structural strength. A virtual prototype of the dragline is created by the dynamic integration of the mechanical and electrical system models using Newton-Euler equations. The mechanical model is modeled as a rigid multi-body system to catch the major kinematics and dynamics behavior of the whole dragline. The electrical model is employed to represent the motors and controls. The dragline front-end is modeled as a flexible multi-body system for the structural strength evaluation using Lagrange equations and finite element analysis (FEA) method. A co-operative simulation (co-simulation) is carried out with the dragline motion, electrical motor/control and the structural flexibility models. The major motions, the machine behavior, the machine operation loads, and structural member stresses are recovered from the simulation. The results of stress-time history are used for structural fatigue life evaluation by Palmgren-Miner's rule. The results show the boom structural members have lower fatigue lives than tri-structure structural members. The study is significant to provide a solid foundation for further study of failure life analysis of the whole dragline components. © 2013 Elsevier Ltd.

Li Y.,Bucyrus | Liu W.,Washington University in St. Louis
International Journal of Advanced Manufacturing Technology | Year: 2014

Two dynamics dragline models are developed and compared for efficient dragline maintenance and numerical analysis. The first model is built in MATLAB/Simulink interface by the simultaneous constraint method based on the Newton-Euler equations. The second model is created in ADAMS environment using virtual prototype technology with Lagrange equations. Both models are of the rigid multi-body systems to catch the major kinematics and dynamics behavior of the dragline front-end. The front-end motions and the rope loads time history are recovered from the simulation. The numerical results are compared between the two models. The models are evaluated in terms of structural loading, model structural member's simplification, and parameterized modeling development. The study is significant to provide a solid foundation for further mining machinery dynamics analysis. © 2014 Springer-Verlag London.

Bucyrus | Date: 2011-02-14

An articulated pre-skimmer mount for a pre-skimmer associated with a drill bit feed unit comprises a feed mounting arm mounted to the drill bit feed unit. A first end is configured for attachment to the drill feed unit and a second end includes a cylindrical mounting shaft and an axial positioning plate. An intermediate arm has a first end comprising a cylindrical sleeve mounted thereto. The cylindrical sleeve has an inner cylindrical opening configured for sliding engagement with the cylindrical mounting shaft and a mating plate configured for locking, face-to-face engagement with the axial positioning plate. A second end comprises a pre-skimmer mounting assembly configured for attachment to the pre-skimmer, wherein an axial positioning plate and a mating plate are operable to disengage, for rotation of the intermediate arm about an axis of the feed mounting arm for alignment of the pre-skimmer.

Bucyrus | Date: 2010-03-11

A breakout wrench for use with a rock drill string includes a frame adapted for mounting to a rock drill feed guide structure, and a sub-frame rotatably connected to the frame about a drill string longitudinal axis. The sub-frame supports a pair of jaw members adapted for radial movement towards and away from one another and to releasably engage a first section of a drill string. The breakout wrench also includes a clamping member supported by the rock drill feed guide structure. The clamping member is adapted to releasably engage a second section of the drill string spaced axially from the first section.

Discover hidden collaborations