BUCHI Labortechnik AG

Flawil, Switzerland

BUCHI Labortechnik AG

Flawil, Switzerland
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Vranic B.Z.,University of Basel | Vranic B.Z.,BUCHI Labortechnik AG | Vandamme T.F.,University of Strasbourg
Pharmaceutical Development and Technology | Year: 2015

A preliminary study of the feasibility of using near-infrared spectroscopy (NIRS) for the offline simultaneous determination of metoprolol tartrate (MTP) and hydrochlorothiazide (HTZ) in powders and tablets has been carried out. An industrial tableting process was simulated using an instrumented tablet press replicator - Presster™. Conventional reference analytics were replaced with gravimetric analysis. The NIRS models for powder and tablet analysis were developed using 55 samples, and tested on 80 independent samples. Powder mixture components were weighed in glass vials to collect reference values, mixed and manually transferred to a tablet press replicator and compacted to form tablets. NIRS calibration models were developed using spectral and gravimetric reference data. The two model drugs were simultaneously quantified exhibiting root mean-squared error of prediction (RMSEP) of 1.69 and 1.31mg for HTZ powder and tablet samples, respectively, and RMSEP of 3.15 and 3.00 mg for MTP powder and tablet samples, respectively. NIRS analysis of MTP and HTZ in powder and tablet form has not been reported elsewhere. © 2015 Informa Healthcare USA, Inc.


Vranic B.Z.,University of Basel | Vranic B.Z.,BUCHI Labortechnik AG | Vandamme T.F.,University of Strasbourg
Pharmaceutical Development and Technology | Year: 2015

Near-infrared spectroscopy (NIRS) is used in the pharmaceutical industry for monitoring drug content during the tablet manufacturing process. It is of critical importance to understand the effect of process factors on NIRS performance. Design of Experiments (DoE) methodology was applied in this work for the systematic study of the effects of compression pressure, precompression pressure and tableting speed on an average Euclidean distance (AED), which reflects spectral features of the tablets, and root mean-squared error of prediction (RMSEP) as key performance indicator of NIRS calibration models. Caffeine tablets were manufactured in 17 experimental runs in accordance with D-optimal design. Developed diffuse transmittance (DT) and diffuse reflectance (DR) calibration models were tested on five independent test sets to confirm the conclusions of the DoE. Compression pressure and tableting speed have shown significant effect on the studied responses in DT mode, whereas all three studied factors have shown a significant effect in DR mode. Significant factors were considered in the development of the global calibration models. The authors suggest further study of RMSEP and AED responses to draw reliable conclusions on the effects of tableting process factors. The global calibration model in DT mode has shown superior performance compared to DR mode. © 2015 Informa Healthcare USA, Inc.


Li X.,CNRS Laboratory of Design and Application of Bioactive Molecules | Anton N.,CNRS Laboratory of Design and Application of Bioactive Molecules | Arpagaus C.,Buchi Labortechnik AG | Belleteix F.,Buchi Labortechnik AG | Vandamme T.F.,CNRS Laboratory of Design and Application of Bioactive Molecules
Journal of Controlled Release | Year: 2010

Spray drying technology is widely known and used to transform liquids (solutions, emulsions, suspension, slurries, pastes or even melts) into solid powders. Its main applications are found in the food, chemical and materials industries to enhance ingredient conservation, particle properties, powder handling and storage etc. However, spray drying can also be used for specific applications in the formulation of pharmaceuticals for drug delivery (e.g. particles for pulmonary delivery). Büchi is a reference in the development of spray drying technology, notably for laboratory scale devices. This study presents the Nano Spray Dryer B-90, a revolutionary new sprayer developed by Büchi, use of which can lower the size of the produced dried particles by an order of magnitude attaining submicron sizes. In this paper, results are presented with a panel of five representative polymeric wall materials (arabic gum, whey protein, polyvinyl alcohol, modified starch, and maltodextrin) and the potentials to encapsulate nano-emulsions, or to formulate nano-crystals (e.g. from furosemide) are also shown. © 2010 Elsevier B.V.


Moret S.,University of Udine | Scolaro M.,University of Udine | Barp L.,University of Udine | Purcaro G.,University of Udine | And 2 more authors.
Food Chemistry | Year: 2014

Pressurised liquid extraction (PLE) represents a powerful technique which can be conveniently used for rapid extraction of mineral oil saturated (MOSH) and aromatic hydrocarbons (MOAH) from dry foods with a low fat content, such as semolina pasta, rice, and other cereals. Two different PLE methods, one for rapid determination of superficial contamination mainly from the packaging, the other for efficient extraction of total contamination from different sources, have been developed and optimised. The two methods presented good performance characteristics in terms of repeatability (relative standard deviation lower than 5%) and recoveries (higher than 95%). To show their potentiality, the two methods have been applied in combination on semolina pasta and rice packaged in direct contact with recycled cardboard. In the case of semolina pasta it was possible to discriminate between superficial contamination coming from the packaging, and pre-existing contamination (firmly enclosed into the matrix). © 2014 Elsevier Ltd. All rights reserved.


Moret S.,University of Udine | Sander M.,BUCHI Labortechnik AG | Purcaro G.,University of Udine | Scolaro M.,University of Udine | And 2 more authors.
Talanta | Year: 2013

Packaging can represent a primary source of food contamination with mineral oil saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH), especially when recycled cardboard or mineral oil based printing inks are used. A pressurized liquid extraction (PLE) method, followed by on-line LC-GC analysis, has been optimized for rapid mineral oil determination in cardboard and paper samples. The proposed method involves extraction with hexane (2 cycles) at 60 C for 5 min, and allows for the processing of up to 6 samples in parallel with minimal sample manipulation and solvent consumption. It gave good repeatability (coefficient of variation lower than 5%) and practically quantitative extraction yield (less than 2% of the total contamination found in a third separate cycle). The method was applied to different cardboards and paper materials intended for food contact. Results obtained were similar to those obtained by applying classical solvent extraction with hexane/ethanol 1:1 (v/v) as described by Lorenzini et al. [20]. © 2013 Elsevier B.V.


Arpagaus C.,BUCHI Labortechnik AG
Drying Technology | Year: 2012

This paper reviews the advances in nanoparticle spray drying performed in a laboratory environment and with the Nano Spray Dryer B-90, which was introduced by BUCHI Labortechnik AG in 2009. Special regard will be paid to relevant published works. The technological novelty of the patented Nano Spray Dryer B-90 lies in the gentle laminar drying flow, the vibrating mesh spray technology, and the highly efficient electrostatic particle collector.Recent studies prove the successful use of this spray dryer for a variety of drug delivery applications, such as poorly soluble drugs (e.g., griseofulvin, furosemide), enzymes (e.g., galactosidase), proteins (bovine serum albumin, whey protein), amino acids (e.g., leucine), polysaccharides (e.g., trehalose, lactose), salts, encapsulation of nano-emulsions in polymeric wall materials, as well as materials science applications (e.g., battery-grade lithium carbonate).The Nano Spray Dryer B-90 makes it possible to produce spray-dried particles in the submicron scale and to create tiny particles of down to only 350-500 nm. In contrast to traditional laboratory-scale spray dryers, it can achieve uniquely high yields of up to 94% for powder amounts down to the milligram scale (e.g., 3.0-500 mg). © 2012 Copyright Taylor and Francis Group, LLC.


Schafroth N.,BuCHI Labortechnik AG | Arpagaus C.,BuCHI Labortechnik AG | Jadhav U.Y.,University of Greenwich | Makne S.,University of Greenwich | Douroumis D.,University of Greenwich
Colloids and Surfaces B: Biointerfaces | Year: 2012

In the current study nano and microparticle engineering of water insoluble drugs was conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and dexamethasone (DEX) were encapsulated in biodegradable poly(d,. l-lactide-co-glycolide) (PLGA) grades of different molecular weights. Spray-drying studies carried out with the Nano Spray Dryer B-90 employed with piezoelectric driven actuator. The processing parameters including inlet temperature, spray mesh diameter, sample flow rate, spray rate, applied pressure and sample concentration were examined in order to optimize the particle size and the obtained yield. The process parameters and the solute concentration showed a profound effect on the particle engineering and the obtained product yield. The produced powder presented consistent and reproducible spherical particles with narrow particle size distribution. Cyclosporin was found to be molecularly dispersed while dexamethasone was in crystalline state within the PLGA nanoparticles. Further evaluation revealed excellent drug loading, encapsulation efficiency and production yield. In vitro studies demonstrated sustained release patterns for the active substances. This novel spray-drying process proved to be efficient for nano and microparticle engineering of water insoluble active substances. © 2011 Elsevier B.V.


Elzoghby A.O.,Alexandria University | Vranic B.Z.,BUCHI Labortechnik AG | Samy W.M.,Alexandria University | Elgindy N.A.,Alexandria University
International Journal of Pharmaceutics | Year: 2015

In this study, spray-dried alfuzosin hydrochloride (ALF)-loaded casein (CAS) nanoparticles were successfully used for the preparation of a swellable floating matrix via direct compression. The developed NIR calibration model was able to assess ALF and CAS levels in five different batches of drug-loaded nanoparticles. The calibration and prediction plots exhibited good linearity with correlation coefficients of more than 0.9. The standard error of calibration and cross-validation was less than 5% of the measured values, confirming the accuracy of the model. A linear relationship was obtained correlating the actual drug entrapped and the predicted values obtained from the NIR partial least squares regression model. The un-crosslinked tablet demonstrated a substantial weight gain (317% after 2 h) and completely disintegrated after 3-4 h whereas both 10 and 40% w/w genipin-crosslinked tablets showed lower weight gain (114 and 42% after 2 h, respectively). A rapid floating of the tablets within 5-15 min (compared to 45 min for the marketed tablet) was observed, with maintained floating for 24 h. Marketed and prepared tablets succeeded to prolong ALF release for 24 h. The development of drug-loaded CAS nanoparticles using spray-drying represents a new alternative for the preparation of swellable floating tablets for prolonged drug release. © 2015 Elsevier B.V. All rights reserved.


PubMed | Alexandria University and BUCHI Labortechnik AG
Type: Journal Article | Journal: International journal of pharmaceutics | Year: 2015

In this study, spray-dried alfuzosin hydrochloride (ALF)-loaded casein (CAS) nanoparticles were successfully used for the preparation of a swellable floating matrix via direct compression. The developed NIR calibration model was able to assess ALF and CAS levels in five different batches of drug-loaded nanoparticles. The calibration and prediction plots exhibited good linearity with correlation coefficients of more than 0.9. The standard error of calibration and cross-validation was less than 5% of the measured values, confirming the accuracy of the model. A linear relationship was obtained correlating the actual drug entrapped and the predicted values obtained from the NIR partial least squares regression model. The un-crosslinked tablet demonstrated a substantial weight gain (317% after 2h) and completely disintegrated after 3-4h whereas both 10 and 40% w/w genipin-crosslinked tablets showed lower weight gain (114 and 42% after 2h, respectively). A rapid floating of the tablets within 5-15min (compared to 45min for the marketed tablet) was observed, with maintained floating for 24h. Marketed and prepared tablets succeeded to prolong ALF release for 24h. The development of drug-loaded CAS nanoparticles using spray-drying represents a new alternative for the preparation of swellable floating tablets for prolonged drug release.


PubMed | BUCHI Labortechnik AG
Type: | Journal: Colloids and surfaces. B, Biointerfaces | Year: 2011

In the current study nano and microparticle engineering of water insoluble drugs was conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and dexamethasone (DEX) were encapsulated in biodegradable poly(D,L-lactide-co-glycolide) (PLGA) grades of different molecular weights. Spray-drying studies carried out with the Nano Spray Dryer B-90 employed with piezoelectric driven actuator. The processing parameters including inlet temperature, spray mesh diameter, sample flow rate, spray rate, applied pressure and sample concentration were examined in order to optimize the particle size and the obtained yield. The process parameters and the solute concentration showed a profound effect on the particle engineering and the obtained product yield. The produced powder presented consistent and reproducible spherical particles with narrow particle size distribution. Cyclosporin was found to be molecularly dispersed while dexamethasone was in crystalline state within the PLGA nanoparticles. Further evaluation revealed excellent drug loading, encapsulation efficiency and production yield. In vitro studies demonstrated sustained release patterns for the active substances. This novel spray-drying process proved to be efficient for nano and microparticle engineering of water insoluble active substances.

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